{"id":"https://openalex.org/W2154212986","doi":"https://doi.org/10.1109/isbi.2011.5872451","title":"Statistical image reconstruction for hybrid fluorescence optical tomography and positron emission tomography","display_name":"Statistical image reconstruction for hybrid fluorescence optical tomography and positron emission tomography","publication_year":2011,"publication_date":"2011-03-01","ids":{"openalex":"https://openalex.org/W2154212986","doi":"https://doi.org/10.1109/isbi.2011.5872451","mag":"2154212986"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2011.5872451","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2011.5872451","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057150859","display_name":"Guobao Wang","orcid":"https://orcid.org/0000-0001-6526-1533"},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guobao Wang","raw_affiliation_strings":["Department of Biomedical Engineering, University of California, Davis, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of California, Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100624129","display_name":"Changqing Li","orcid":"https://orcid.org/0000-0003-4237-1494"},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Changqing Li","raw_affiliation_strings":["Department of Biomedical Engineering, University of California, Davis, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of California, Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046512654","display_name":"Simon R. Cherry","orcid":"https://orcid.org/0000-0002-0155-5644"},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simon R. Cherry","raw_affiliation_strings":["Department of Biomedical Engineering, University of California, Davis, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of California, Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010514255","display_name":"Jinyi Qi","orcid":"https://orcid.org/0000-0002-5428-0322"},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinyi Qi","raw_affiliation_strings":["Department of Biomedical Engineering, University of California, Davis, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of California, Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I84218800"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"488","last_page":"491"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11196","display_name":"Non-Invasive Vital Sign Monitoring","score":0.9858999848365784,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/positron-emission-tomography","display_name":"Positron emission tomography","score":0.852715015411377},{"id":"https://openalex.org/keywords/tomography","display_name":"Tomography","score":0.6998010277748108},{"id":"https://openalex.org/keywords/iterative-reconstruction","display_name":"Iterative reconstruction","score":0.610386312007904},{"id":"https://openalex.org/keywords/poisson-distribution","display_name":"Poisson distribution","score":0.5636392831802368},{"id":"https://openalex.org/keywords/gaussian","display_name":"Gaussian","score":0.5351352095603943},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4659370481967926},{"id":"https://openalex.org/keywords/optical-tomography","display_name":"Optical tomography","score":0.43836653232574463},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.40341421961784363},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3890116810798645},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.33049672842025757},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.32007327675819397},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.27329570055007935},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.19445398449897766},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.14493680000305176},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.07625654339790344}],"concepts":[{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.852715015411377},{"id":"https://openalex.org/C163716698","wikidata":"https://www.wikidata.org/wiki/Q841267","display_name":"Tomography","level":2,"score":0.6998010277748108},{"id":"https://openalex.org/C141379421","wikidata":"https://www.wikidata.org/wiki/Q6094427","display_name":"Iterative reconstruction","level":2,"score":0.610386312007904},{"id":"https://openalex.org/C100906024","wikidata":"https://www.wikidata.org/wiki/Q205692","display_name":"Poisson distribution","level":2,"score":0.5636392831802368},{"id":"https://openalex.org/C163716315","wikidata":"https://www.wikidata.org/wiki/Q901177","display_name":"Gaussian","level":2,"score":0.5351352095603943},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4659370481967926},{"id":"https://openalex.org/C2777413408","wikidata":"https://www.wikidata.org/wiki/Q1968843","display_name":"Optical tomography","level":3,"score":0.43836653232574463},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.40341421961784363},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3890116810798645},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.33049672842025757},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.32007327675819397},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.27329570055007935},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.19445398449897766},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.14493680000305176},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07625654339790344},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2011.5872451","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2011.5872451","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1992907254","https://openalex.org/W2004486677","https://openalex.org/W2017096549","https://openalex.org/W2039284087","https://openalex.org/W2106666760","https://openalex.org/W4253515568"],"related_works":["https://openalex.org/W2799023716","https://openalex.org/W2357457465","https://openalex.org/W2089158877","https://openalex.org/W1985088734","https://openalex.org/W2085165788","https://openalex.org/W2007017254","https://openalex.org/W2007798619","https://openalex.org/W2035082463","https://openalex.org/W2080382703","https://openalex.org/W2047462095"],"abstract_inverted_index":{"We":[0,41],"have":[1],"developed":[2],"a":[3,24,82],"hybrid":[4,74],"system":[5],"for":[6,27,47,54],"imaging":[7],"small":[8],"animals":[9],"using":[10,76,91],"fluorescence":[11],"optical":[12],"tomography":[13,18],"(FOT)":[14],"and":[15,38,51],"positron":[16],"emission":[17],"(PET)":[19],"simultaneously.":[20],"This":[21],"paper":[22],"presents":[23],"statistical":[25],"method":[26],"reconstructing":[28],"spatial":[29],"distribution":[30,53],"of":[31],"dual-labeled":[32],"tracers":[33],"from":[34],"the":[35,43,48,55,73],"combined":[36,77],"PET":[37,49,93],"FOT":[39,56,95],"data.":[40,57],"use":[42],"Poisson":[44],"likelihood":[45],"function":[46,61],"data":[50,79,96],"Gaussian":[52],"The":[58],"log-posterior":[59],"density":[60],"is":[62],"maximized":[63],"by":[64],"an":[65],"optimization":[66],"transfer":[67],"algorithm.":[68],"Computer":[69],"simulations":[70],"show":[71],"that":[72],"reconstruction":[75],"PET-FOT":[78],"can":[80],"achieve":[81],"better":[83],"bias":[84],"versus":[85],"standard":[86],"deviation":[87],"performance":[88],"than":[89],"reconstructions":[90],"either":[92],"or":[94],"alone.":[97]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}