{"id":"https://openalex.org/W2114401058","doi":"https://doi.org/10.1109/isbi.2011.5872390","title":"Quantification of frap experiments in live cell image sequences by combining segmentation and registration","display_name":"Quantification of frap experiments in live cell image sequences by combining segmentation and registration","publication_year":2011,"publication_date":"2011-03-01","ids":{"openalex":"https://openalex.org/W2114401058","doi":"https://doi.org/10.1109/isbi.2011.5872390","mag":"2114401058"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2011.5872390","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2011.5872390","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065563340","display_name":"Il-Han Kim","orcid":null},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Il-Han Kim","raw_affiliation_strings":["Department Bioinformatics and Functional Genomics, Biomedical Computer Vision Group,BIOQUANT, IPMB, and DKFZ Heidelberg, University of Heidelberg, Heidelberg, Germany","University of Heidelberg, BIOQUANT, IPMB, and DKFZ Heidelberg, Dept. Bioinformatics and Functional Genomics, Biomedical Computer Vision Group, Im Neuenheimer Feld 267, 69120, Germany"],"affiliations":[{"raw_affiliation_string":"Department Bioinformatics and Functional Genomics, Biomedical Computer Vision Group,BIOQUANT, IPMB, and DKFZ Heidelberg, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"University of Heidelberg, BIOQUANT, IPMB, and DKFZ Heidelberg, Dept. Bioinformatics and Functional Genomics, Biomedical Computer Vision Group, Im Neuenheimer Feld 267, 69120, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073241401","display_name":"Catharina Cadmus","orcid":null},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Catharina Cadmus","raw_affiliation_strings":["Department Bioinformatics and Functional Genomics, Biomedical Computer Vision Group,BIOQUANT, IPMB, and DKFZ Heidelberg, University of Heidelberg, Heidelberg, Germany","University of Heidelberg, BIOQUANT, IPMB, and DKFZ Heidelberg, Dept. Bioinformatics and Functional Genomics, Biomedical Computer Vision Group, Im Neuenheimer Feld 267, 69120, Germany"],"affiliations":[{"raw_affiliation_string":"Department Bioinformatics and Functional Genomics, Biomedical Computer Vision Group,BIOQUANT, IPMB, and DKFZ Heidelberg, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"University of Heidelberg, BIOQUANT, IPMB, and DKFZ Heidelberg, Dept. Bioinformatics and Functional Genomics, Biomedical Computer Vision Group, Im Neuenheimer Feld 267, 69120, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110880738","display_name":"Andr\u00e9a Pfeifer","orcid":null},"institutions":[{"id":"https://openalex.org/I4210151100","display_name":"DKFZ-ZMBH Alliance","ror":"https://ror.org/05x8b4491","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I4210151100"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andrea C. Pfeifer","raw_affiliation_strings":["DKFZ Heidelberg, Systems Biology of Signal Transduction, Heidelberg, Germany","DKFZ Heidelberg, Systems Biology of Signal Transduction, Im Neuenheimer Feld 267, 69120, Germany"],"affiliations":[{"raw_affiliation_string":"DKFZ Heidelberg, Systems Biology of Signal Transduction, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210151100","https://openalex.org/I223822909"]},{"raw_affiliation_string":"DKFZ Heidelberg, Systems Biology of Signal Transduction, Im Neuenheimer Feld 267, 69120, Germany","institution_ids":["https://openalex.org/I4210151100","https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063690344","display_name":"Ursula Klingm\u00fcller","orcid":"https://orcid.org/0000-0001-9845-3099"},"institutions":[{"id":"https://openalex.org/I4210151100","display_name":"DKFZ-ZMBH Alliance","ror":"https://ror.org/05x8b4491","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I4210151100"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ursula Klingmuller","raw_affiliation_strings":["DKFZ Heidelberg, Systems Biology of Signal Transduction, Heidelberg, Germany","DKFZ Heidelberg, Systems Biology of Signal Transduction, Im Neuenheimer Feld 267, 69120, Germany"],"affiliations":[{"raw_affiliation_string":"DKFZ Heidelberg, Systems Biology of Signal Transduction, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210151100","https://openalex.org/I223822909"]},{"raw_affiliation_string":"DKFZ Heidelberg, Systems Biology of Signal Transduction, Im Neuenheimer Feld 267, 69120, Germany","institution_ids":["https://openalex.org/I4210151100","https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044191947","display_name":"Roland Eils","orcid":"https://orcid.org/0000-0002-0034-4036"},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Roland Eils","raw_affiliation_strings":["Department Bioinformatics and Functional Genomics, Biomedical Computer Vision Group,BIOQUANT, IPMB, and DKFZ Heidelberg, University of Heidelberg, Heidelberg, Germany","University of Heidelberg, BIOQUANT, IPMB, and DKFZ Heidelberg, Dept. Bioinformatics and Functional Genomics, Biomedical Computer Vision Group, Im Neuenheimer Feld 267, 69120, Germany"],"affiliations":[{"raw_affiliation_string":"Department Bioinformatics and Functional Genomics, Biomedical Computer Vision Group,BIOQUANT, IPMB, and DKFZ Heidelberg, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"University of Heidelberg, BIOQUANT, IPMB, and DKFZ Heidelberg, Dept. Bioinformatics and Functional Genomics, Biomedical Computer Vision Group, Im Neuenheimer Feld 267, 69120, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105166471","display_name":"Karl Rohr","orcid":null},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karl Rohr","raw_affiliation_strings":["Department Bioinformatics and Functional Genomics, Biomedical Computer Vision Group,BIOQUANT, IPMB, and DKFZ Heidelberg, University of Heidelberg, Heidelberg, Germany","University of Heidelberg, BIOQUANT, IPMB, and DKFZ Heidelberg, Dept. Bioinformatics and Functional Genomics, Biomedical Computer Vision Group, Im Neuenheimer Feld 267, 69120, Germany"],"affiliations":[{"raw_affiliation_string":"Department Bioinformatics and Functional Genomics, Biomedical Computer Vision Group,BIOQUANT, IPMB, and DKFZ Heidelberg, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"University of Heidelberg, BIOQUANT, IPMB, and DKFZ Heidelberg, Dept. Bioinformatics and Functional Genomics, Biomedical Computer Vision Group, Im Neuenheimer Feld 267, 69120, Germany","institution_ids":["https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5065563340"],"corresponding_institution_ids":["https://openalex.org/I223822909"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0827803,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"212","last_page":"215"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9939000010490417,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9879000186920166,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluorescence-recovery-after-photobleaching","display_name":"Fluorescence recovery after photobleaching","score":0.9096240997314453},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.7583135366439819},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.7079759836196899},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6362614631652832},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.6111857295036316},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.5982227921485901},{"id":"https://openalex.org/keywords/photobleaching","display_name":"Photobleaching","score":0.5463306903839111},{"id":"https://openalex.org/keywords/cytoplasm","display_name":"Cytoplasm","score":0.5143634080886841},{"id":"https://openalex.org/keywords/nucleus","display_name":"Nucleus","score":0.4813443124294281},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4510972201824188},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.4156127870082855},{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.2138487994670868},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.14122378826141357},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.10834962129592896},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.06987369060516357},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.06459763646125793}],"concepts":[{"id":"https://openalex.org/C26659971","wikidata":"https://www.wikidata.org/wiki/Q729923","display_name":"Fluorescence recovery after photobleaching","level":3,"score":0.9096240997314453},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.7583135366439819},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.7079759836196899},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6362614631652832},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.6111857295036316},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.5982227921485901},{"id":"https://openalex.org/C31332276","wikidata":"https://www.wikidata.org/wiki/Q899750","display_name":"Photobleaching","level":3,"score":0.5463306903839111},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.5143634080886841},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.4813443124294281},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4510972201824188},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.4156127870082855},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.2138487994670868},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14122378826141357},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.10834962129592896},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.06987369060516357},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.06459763646125793}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2011.5872390","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2011.5872390","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1500029988","https://openalex.org/W1538819847","https://openalex.org/W1977946246","https://openalex.org/W1993434836","https://openalex.org/W2010308130","https://openalex.org/W2093834886","https://openalex.org/W2100383758","https://openalex.org/W2156875677","https://openalex.org/W2162245111","https://openalex.org/W2317729913","https://openalex.org/W4212781311"],"related_works":["https://openalex.org/W1518240974","https://openalex.org/W2410074698","https://openalex.org/W113297786","https://openalex.org/W1997452518","https://openalex.org/W1978769331","https://openalex.org/W2140320154","https://openalex.org/W1976055993","https://openalex.org/W2143611296","https://openalex.org/W2789311093","https://openalex.org/W1574396544"],"abstract_inverted_index":{"Fluorescence":[0],"recovery":[1],"after":[2],"photobleaching":[3],"(FRAP)":[4],"is":[5],"an":[6,68,106],"important":[7],"technique":[8],"for":[9,70],"analyzing":[10],"subcellular":[11],"processes":[12],"in":[13,81],"living":[14],"cells.":[15],"To":[16,61],"quantify":[17,62],"the":[18,21,25,28,43,48,71,74,77],"acquired":[19],"data,":[20],"fluorescence":[22],"signal":[23],"within":[24],"cytoplasm":[26,75],"and":[27,45,57,76,91,105],"nucleus":[29,78],"of":[30,47,73,79],"a":[31],"target":[32],"cell":[33,49],"needs":[34],"to":[35,100],"be":[36],"determined":[37],"at":[38],"each":[39],"time":[40],"point.":[41],"However,":[42],"movement":[44],"deformation":[46],"as":[50,52],"well":[51],"low":[53],"contrast":[54],"render":[55],"manual":[56,110],"automatic":[58],"analysis":[59],"difficult.":[60],"FRAP":[63,103],"experiments":[64,104],"we":[65],"have":[66],"developed":[67],"approach":[69,95],"segmentation":[72,90,112],"cells":[80],"dynamic":[82],"microscopy":[83],"image":[84,92],"sequences":[85],"which":[86],"combines":[87],"level":[88],"set":[89],"registration.":[93],"Our":[94],"has":[96,113],"been":[97,114],"successfully":[98],"applied":[99],"images":[101],"from":[102],"experimental":[107],"comparison":[108],"with":[109],"expert":[111],"carried":[115],"out.":[116]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
