{"id":"https://openalex.org/W2098937176","doi":"https://doi.org/10.1109/isbi.2010.5490298","title":"Patient-specific modeling of left heart anatomy, dynamics and hemodynamics from high resolution 4D CT","display_name":"Patient-specific modeling of left heart anatomy, dynamics and hemodynamics from high resolution 4D CT","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2098937176","doi":"https://doi.org/10.1109/isbi.2010.5490298","mag":"2098937176"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2010.5490298","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2010.5490298","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033694340","display_name":"Viorel Mihalef","orcid":"https://orcid.org/0000-0002-1743-4505"},"institutions":[{"id":"https://openalex.org/I4210137693","display_name":"Siemens (United States)","ror":"https://ror.org/04axb7e79","country_code":"US","type":"company","lineage":["https://openalex.org/I1325886976","https://openalex.org/I4210137693"]},{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Viorel Mihalef","raw_affiliation_strings":["Siemens AG Corporate Research and Development, Princeton, NJ, USA","[Siemens Corporate Res., Princeton, NJ, USA]"],"affiliations":[{"raw_affiliation_string":"Siemens AG Corporate Research and Development, Princeton, NJ, USA","institution_ids":["https://openalex.org/I4210137693"]},{"raw_affiliation_string":"[Siemens Corporate Res., Princeton, NJ, USA]","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067611389","display_name":"Razvan Ionasec","orcid":null},"institutions":[{"id":"https://openalex.org/I4210137693","display_name":"Siemens (United States)","ror":"https://ror.org/04axb7e79","country_code":"US","type":"company","lineage":["https://openalex.org/I1325886976","https://openalex.org/I4210137693"]},{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Razvan Ionasec","raw_affiliation_strings":["Siemens AG Corporate Research and Development, Princeton, NJ, USA","[Siemens Corporate Res., Princeton, NJ, USA]"],"affiliations":[{"raw_affiliation_string":"Siemens AG Corporate Research and Development, Princeton, NJ, USA","institution_ids":["https://openalex.org/I4210137693"]},{"raw_affiliation_string":"[Siemens Corporate Res., Princeton, NJ, USA]","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100322759","display_name":"Yang Wang","orcid":"https://orcid.org/0000-0002-6630-8425"},"institutions":[{"id":"https://openalex.org/I4210137693","display_name":"Siemens (United States)","ror":"https://ror.org/04axb7e79","country_code":"US","type":"company","lineage":["https://openalex.org/I1325886976","https://openalex.org/I4210137693"]},{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang Wang","raw_affiliation_strings":["Siemens AG Corporate Research and Development, Princeton, NJ, USA","[Siemens Corporate Res., Princeton, NJ, USA]"],"affiliations":[{"raw_affiliation_string":"Siemens AG Corporate Research and Development, Princeton, NJ, USA","institution_ids":["https://openalex.org/I4210137693"]},{"raw_affiliation_string":"[Siemens Corporate Res., Princeton, NJ, USA]","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051649145","display_name":"Yefeng Zheng","orcid":"https://orcid.org/0000-0003-2195-2847"},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]},{"id":"https://openalex.org/I4210137693","display_name":"Siemens (United States)","ror":"https://ror.org/04axb7e79","country_code":"US","type":"company","lineage":["https://openalex.org/I1325886976","https://openalex.org/I4210137693"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yefeng Zheng","raw_affiliation_strings":["Siemens AG Corporate Research and Development, Princeton, NJ, USA","[Siemens Corporate Res., Princeton, NJ, USA]"],"affiliations":[{"raw_affiliation_string":"Siemens AG Corporate Research and Development, Princeton, NJ, USA","institution_ids":["https://openalex.org/I4210137693"]},{"raw_affiliation_string":"[Siemens Corporate Res., Princeton, NJ, USA]","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011888340","display_name":"Bogdan Georgescu","orcid":"https://orcid.org/0000-0001-5388-5699"},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]},{"id":"https://openalex.org/I4210137693","display_name":"Siemens (United States)","ror":"https://ror.org/04axb7e79","country_code":"US","type":"company","lineage":["https://openalex.org/I1325886976","https://openalex.org/I4210137693"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bogdan Georgescu","raw_affiliation_strings":["Siemens AG Corporate Research and Development, Princeton, NJ, USA","[Siemens Corporate Res., Princeton, NJ, USA]"],"affiliations":[{"raw_affiliation_string":"Siemens AG Corporate Research and Development, Princeton, NJ, USA","institution_ids":["https://openalex.org/I4210137693"]},{"raw_affiliation_string":"[Siemens Corporate Res., Princeton, NJ, USA]","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012751147","display_name":"Dorin Comaniciu","orcid":"https://orcid.org/0000-0002-5238-8647"},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]},{"id":"https://openalex.org/I4210137693","display_name":"Siemens (United States)","ror":"https://ror.org/04axb7e79","country_code":"US","type":"company","lineage":["https://openalex.org/I1325886976","https://openalex.org/I4210137693"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dorin Comaniciu","raw_affiliation_strings":["Siemens AG Corporate Research and Development, Princeton, NJ, USA","[Siemens Corporate Res., Princeton, NJ, USA]"],"affiliations":[{"raw_affiliation_string":"Siemens AG Corporate Research and Development, Princeton, NJ, USA","institution_ids":["https://openalex.org/I4210137693"]},{"raw_affiliation_string":"[Siemens Corporate Res., Princeton, NJ, USA]","institution_ids":["https://openalex.org/I20089843"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5033694340"],"corresponding_institution_ids":["https://openalex.org/I20089843","https://openalex.org/I4210137693"],"apc_list":null,"apc_paid":null,"fwci":3.1619,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.91129089,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"504","last_page":"507"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.9714000225067139,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9577999711036682,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bicuspid-aortic-valve","display_name":"Bicuspid aortic valve","score":0.6909756660461426},{"id":"https://openalex.org/keywords/ascending-aorta","display_name":"Ascending aorta","score":0.6491566896438599},{"id":"https://openalex.org/keywords/mitral-valve","display_name":"Mitral valve","score":0.6156632304191589},{"id":"https://openalex.org/keywords/hemodynamics","display_name":"Hemodynamics","score":0.6089776754379272},{"id":"https://openalex.org/keywords/ventricle","display_name":"Ventricle","score":0.6069000959396362},{"id":"https://openalex.org/keywords/cardiac-cycle","display_name":"Cardiac cycle","score":0.5773792266845703},{"id":"https://openalex.org/keywords/aortic-valve","display_name":"Aortic valve","score":0.572014570236206},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.559489369392395},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.4790293276309967},{"id":"https://openalex.org/keywords/aorta","display_name":"Aorta","score":0.466714084148407},{"id":"https://openalex.org/keywords/intracardiac-injection","display_name":"Intracardiac injection","score":0.45684587955474854},{"id":"https://openalex.org/keywords/blood-flow","display_name":"Blood flow","score":0.4264239966869354},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4152887761592865}],"concepts":[{"id":"https://openalex.org/C2781355080","wikidata":"https://www.wikidata.org/wiki/Q860167","display_name":"Bicuspid aortic valve","level":3,"score":0.6909756660461426},{"id":"https://openalex.org/C2778249958","wikidata":"https://www.wikidata.org/wiki/Q2349469","display_name":"Ascending aorta","level":3,"score":0.6491566896438599},{"id":"https://openalex.org/C2777543888","wikidata":"https://www.wikidata.org/wiki/Q369939","display_name":"Mitral valve","level":2,"score":0.6156632304191589},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.6089776754379272},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.6069000959396362},{"id":"https://openalex.org/C99398487","wikidata":"https://www.wikidata.org/wiki/Q257319","display_name":"Cardiac cycle","level":2,"score":0.5773792266845703},{"id":"https://openalex.org/C2780714102","wikidata":"https://www.wikidata.org/wiki/Q616071","display_name":"Aortic valve","level":2,"score":0.572014570236206},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.559489369392395},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4790293276309967},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.466714084148407},{"id":"https://openalex.org/C80093799","wikidata":"https://www.wikidata.org/wiki/Q366155","display_name":"Intracardiac injection","level":2,"score":0.45684587955474854},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.4264239966869354},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4152887761592865}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2010.5490298","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2010.5490298","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.75,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W126178635","https://openalex.org/W1976675683","https://openalex.org/W2058403349","https://openalex.org/W2094206022","https://openalex.org/W2101689475","https://openalex.org/W2140748495","https://openalex.org/W2166657119","https://openalex.org/W2171963641","https://openalex.org/W2312879159","https://openalex.org/W6675412198","https://openalex.org/W6698987996"],"related_works":["https://openalex.org/W2043632467","https://openalex.org/W2348583374","https://openalex.org/W185438291","https://openalex.org/W2886902009","https://openalex.org/W2089263463","https://openalex.org/W2146161288","https://openalex.org/W2410834018","https://openalex.org/W3150165253","https://openalex.org/W151631774","https://openalex.org/W2059774183"],"abstract_inverted_index":{"There":[0],"is":[1],"a":[2,57,107,127,158,165],"growing":[3],"need":[4],"for":[5,9],"patient-specific":[6,59,101],"cardiac":[7,17,39],"models":[8,33],"intervention":[10],"planning,":[11],"outcome":[12],"prediction":[13],"or":[14],"assessment":[15,129],"of":[16,22,78,130],"disease":[18],"progression.":[19],"However,":[20],"most":[21,37],"the":[23,53,76,79,117,121,131,145],"recent":[24],"work":[25],"in":[26,75],"cardiovascular":[27],"simulation":[28,140],"relies":[29],"on":[30],"generic":[31],"heart":[32,61,123,137],"built":[34],"from":[35,64],"at":[36],"one":[38,149,156,163],"phase":[40],"with":[41,157,164],"simplified":[42],"motion,":[43],"driven":[44],"by":[45,55,116],"fluid":[46],"dynamics":[47,133],"equations.":[48],"We":[49,125],"propose":[50],"to":[51,106,135],"advance":[52],"state-of-the-art":[54],"exploiting":[56],"comprehensive,":[58],"left":[60,80,85],"model":[62,102],"extracted":[63],"4D":[65],"Computed":[66],"Tomography":[67],"(CT)":[68],"data.":[69],"Explicit":[70],"physiological":[71],"constrains":[72],"are":[73],"captured":[74],"modeling":[77],"ventricle":[81],"(including":[82,87,95],"outflow":[83],"tract),":[84],"atrium":[86],"pulmonary":[88],"veins),":[89],"mitral":[90],"valve,":[91],"and":[92,151,162],"aortic":[93,160,167],"valve":[94],"ascending":[96],"aorta).":[97],"By":[98],"using":[99],"this":[100],"as":[103],"an":[104],"input":[105],"3D":[108],"Navier-Stokes":[109],"solver":[110],"we":[111],"derive":[112],"realistic":[113],"hemodynamics,":[114],"constrained":[115],"local":[118],"anatomy,":[119],"along":[120],"entire":[122],"cycle.":[124],"present":[126],"differential":[128],"flow":[132],"corresponding":[134],"specific":[136],"conditions.":[138],"The":[139],"results":[141],"shed":[142],"light":[143],"upon":[144],"functional":[146],"differences":[147],"between":[148],"normal":[150],"two":[152],"diseased":[153],"hearts":[154],"-":[155],"dilated":[159],"root":[161],"bicuspid":[166],"valve.":[168]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}