{"id":"https://openalex.org/W2153946182","doi":"https://doi.org/10.1109/isbi.2010.5490227","title":"Single molecule detection of tuberculosis nucleic acid using dark field Tethered Particle Motion","display_name":"Single molecule detection of tuberculosis nucleic acid using dark field Tethered Particle Motion","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2153946182","doi":"https://doi.org/10.1109/isbi.2010.5490227","mag":"2153946182"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2010.5490227","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2010.5490227","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055086356","display_name":"Sanneke Brinkers","orcid":null},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sanneke Brinkers","raw_affiliation_strings":["Quantitative Imaging Group, Faculty of Applied Sciences, Delft University of Technnology, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quantitative Imaging Group, Faculty of Applied Sciences, Delft University of Technnology, Netherlands","institution_ids":["https://openalex.org/I98358874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111822289","display_name":"Heidelinde R. C. Dietrich","orcid":null},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Heidelinde R.C. Dietrich","raw_affiliation_strings":["Quantitative Imaging Group, Faculty of Applied Sciences, Delft University of Technnology, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quantitative Imaging Group, Faculty of Applied Sciences, Delft University of Technnology, Netherlands","institution_ids":["https://openalex.org/I98358874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045262040","display_name":"Sjoerd Stallinga","orcid":"https://orcid.org/0000-0003-4978-3272"},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sjoerd Stallinga","raw_affiliation_strings":["Quantitative Imaging Group, Faculty of Applied Sciences, Delft University of Technnology, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quantitative Imaging Group, Faculty of Applied Sciences, Delft University of Technnology, Netherlands","institution_ids":["https://openalex.org/I98358874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024121461","display_name":"Jurriaan J. Mes","orcid":"https://orcid.org/0000-0002-3589-8434"},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jurriaan J. Mes","raw_affiliation_strings":["Quantitative Imaging Group, Faculty of Applied Sciences, Delft University of Technnology, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quantitative Imaging Group, Faculty of Applied Sciences, Delft University of Technnology, Netherlands","institution_ids":["https://openalex.org/I98358874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072691740","display_name":"Ian Young","orcid":"https://orcid.org/0000-0002-5575-5174"},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ian T. Young","raw_affiliation_strings":["Quantitative Imaging Group, Faculty of Applied Sciences, Delft University of Technnology, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quantitative Imaging Group, Faculty of Applied Sciences, Delft University of Technnology, Netherlands","institution_ids":["https://openalex.org/I98358874"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048898725","display_name":"Bernd Rieger","orcid":"https://orcid.org/0000-0001-9215-9307"},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Bernd Rieger","raw_affiliation_strings":["Quantitative Imaging Group, Faculty of Applied Sciences, Delft University of Technnology, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quantitative Imaging Group, Faculty of Applied Sciences, Delft University of Technnology, Netherlands","institution_ids":["https://openalex.org/I98358874"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3841,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.79139358,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"1269","last_page":"1272"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10490","display_name":"Orbital Angular Momentum in Optics","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nucleic-acid","display_name":"Nucleic acid","score":0.7568459510803223},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.49480217695236206},{"id":"https://openalex.org/keywords/particle","display_name":"Particle (ecology)","score":0.45569437742233276},{"id":"https://openalex.org/keywords/multiplexing","display_name":"Multiplexing","score":0.43115001916885376},{"id":"https://openalex.org/keywords/tracking","display_name":"Tracking (education)","score":0.4139944016933441},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.391834020614624},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3168351948261261},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3165662884712219},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15806949138641357},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.11824488639831543}],"concepts":[{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.7568459510803223},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.49480217695236206},{"id":"https://openalex.org/C2778517922","wikidata":"https://www.wikidata.org/wiki/Q7140482","display_name":"Particle (ecology)","level":2,"score":0.45569437742233276},{"id":"https://openalex.org/C19275194","wikidata":"https://www.wikidata.org/wiki/Q222903","display_name":"Multiplexing","level":2,"score":0.43115001916885376},{"id":"https://openalex.org/C2775936607","wikidata":"https://www.wikidata.org/wiki/Q466845","display_name":"Tracking (education)","level":2,"score":0.4139944016933441},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.391834020614624},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3168351948261261},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3165662884712219},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15806949138641357},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11824488639831543},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C19417346","wikidata":"https://www.wikidata.org/wiki/Q7922","display_name":"Pedagogy","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2010.5490227","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2010.5490227","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5699999928474426}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1976310910","https://openalex.org/W2036475903","https://openalex.org/W2037713324","https://openalex.org/W2069377381","https://openalex.org/W2075030758","https://openalex.org/W2078833563","https://openalex.org/W2141570059","https://openalex.org/W2146404768","https://openalex.org/W2152617069","https://openalex.org/W2161822005","https://openalex.org/W2165140463","https://openalex.org/W2171820152","https://openalex.org/W4298027966","https://openalex.org/W6668935540"],"related_works":["https://openalex.org/W1971444612","https://openalex.org/W1543504406","https://openalex.org/W633173308","https://openalex.org/W2383750441","https://openalex.org/W1572021523","https://openalex.org/W2802691951","https://openalex.org/W2061946247","https://openalex.org/W2135990064","https://openalex.org/W2028694594","https://openalex.org/W2535308487"],"abstract_inverted_index":{"Current":[0],"methods":[1],"for":[2,20,122],"tuberculosis":[3],"nucleic":[4,112,139],"acid":[5],"detection":[6,12,22],"require":[7],"amplification":[8],"and":[9,69,107,124],"labeling":[10],"before":[11],"is":[13,78,102,114,120],"possible.":[14],"We":[15],"propose":[16],"here":[17],"a":[18,32,52,65,94,98],"method":[19,101,119,133],"direct":[21],"using":[23,93],"Tethered":[24],"Particle":[25],"Motion:":[26],"gold":[27],"nanoparticles":[28],"are":[29,62],"tethered":[30],"to":[31,44,110],"glass":[33],"substrate":[34],"by":[35,50,64,104],"single-stranded":[36],"DNA":[37],"molecules":[38],"consisting":[39],"of":[40,57,85,129,134,138],"the":[41,45,55,58,86,108,127,136],"complementary":[42],"sequence":[43],"target.":[46],"Detection":[47],"takes":[48],"place":[49],"observing":[51],"change":[53],"in":[54],"motion":[56],"nanoparticles.":[59],"The":[60,100],"particles":[61],"imaged":[63],"dark":[66],"field":[67],"microscope":[68],"captured":[70],"on":[71,97],"an":[72,130],"EMCCD":[73],"camera.":[74],"Single":[75],"particle":[76],"tracking":[77],"carried":[79],"out":[80],"through":[81],"maximum":[82],"likelihood":[83],"estimation":[84],"Poisson":[87],"noise":[88],"limited":[89],"Gaussian":[90],"image":[91],"profile":[92],"parallelized":[95],"algorithm":[96],"GPU.":[99],"characterized":[103],"biophysical":[105],"modeling":[106],"ability":[109],"detect":[111],"acids":[113,140],"shown.":[115],"This":[116],"single":[117],"molecule":[118],"suitable":[121],"multiplexing":[123],"could":[125],"form":[126],"basis":[128],"exquisitely":[131],"sensitive":[132],"detecting":[135],"presence":[137],"derived":[141],"from":[142,146],"human":[143],"pathogens":[144],"directly":[145],"patient":[147],"material.":[148]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
