{"id":"https://openalex.org/W2073058761","doi":"https://doi.org/10.1109/isbi.2010.5490129","title":"Spatiotemporal network alterations in experimental focal cortical epilepsy: MRI-based longitudinal functional connectivity and weighted graph analysis","display_name":"Spatiotemporal network alterations in experimental focal cortical epilepsy: MRI-based longitudinal functional connectivity and weighted graph analysis","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2073058761","doi":"https://doi.org/10.1109/isbi.2010.5490129","mag":"2073058761"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2010.5490129","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2010.5490129","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013830811","display_name":"Willem M. Otte","orcid":"https://orcid.org/0000-0003-1511-6834"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"W.M. Otte","raw_affiliation_strings":["Rudolf Magnus Institute of Neuroscience, University Medical Centre, Netherlands","Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rudolf Magnus Institute of Neuroscience, University Medical Centre, Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075016511","display_name":"Rick M. Dijkhuizen","orcid":"https://orcid.org/0000-0002-4623-4078"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"R.M. Dijkhuizen","raw_affiliation_strings":["Image Sciences Institute, University Medical Centre, Netherlands","Image Sciences Institute, University Medical Center Utrecht, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Image Sciences Institute, University Medical Centre, Netherlands","institution_ids":[]},{"raw_affiliation_string":"Image Sciences Institute, University Medical Center Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015546124","display_name":"Cornelis J. Stam","orcid":"https://orcid.org/0000-0001-9163-7274"},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"C.J. Stam","raw_affiliation_strings":["Department of Clinical Neurophysiology, VU University Medical Center, Netherlands","Department of Clinical Neurophysiology, VU University Medical Center, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Neurophysiology, VU University Medical Center, Netherlands","institution_ids":["https://openalex.org/I911458345"]},{"raw_affiliation_string":"Department of Clinical Neurophysiology, VU University Medical Center, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031300516","display_name":"Kajo van der Marel","orcid":"https://orcid.org/0000-0003-1099-9498"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"K. van der Marel","raw_affiliation_strings":["Image Sciences Institute, University Medical Centre, Netherlands","Image Sciences Institute, University Medical Center Utrecht, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Image Sciences Institute, University Medical Centre, Netherlands","institution_ids":[]},{"raw_affiliation_string":"Image Sciences Institute, University Medical Center Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111654822","display_name":"Maurits P. A. van Meer","orcid":null},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M.P.A. van Meer","raw_affiliation_strings":["Universiteit Utrecht, Utrecht, Utrecht, NL","Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universiteit Utrecht, Utrecht, Utrecht, NL","institution_ids":["https://openalex.org/I193662353"]},{"raw_affiliation_string":"Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033933581","display_name":"Max A. Viergever","orcid":"https://orcid.org/0000-0003-2582-042X"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M.A. Viergever","raw_affiliation_strings":["Image Sciences Institute, University Medical Centre, Netherlands","Image Sciences Institute, University Medical Center Utrecht, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Image Sciences Institute, University Medical Centre, Netherlands","institution_ids":[]},{"raw_affiliation_string":"Image Sciences Institute, University Medical Center Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064705806","display_name":"Kees P. J. Braun","orcid":"https://orcid.org/0000-0003-3631-0003"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"K.P.J. Braun","raw_affiliation_strings":["Rudolf Magnus Institute of Neuroscience, University Medical Centre, Netherlands","Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rudolf Magnus Institute of Neuroscience, University Medical Centre, Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3273,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.6384385,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"888","last_page":"891"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9900000095367432,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epilepsy","display_name":"Epilepsy","score":0.7901465892791748},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.5548428893089294},{"id":"https://openalex.org/keywords/power-graph-analysis","display_name":"Power graph analysis","score":0.5483662486076355},{"id":"https://openalex.org/keywords/network-topology","display_name":"Network topology","score":0.5297661423683167},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5198793411254883},{"id":"https://openalex.org/keywords/graph-theory","display_name":"Graph theory","score":0.49951791763305664},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.49466583132743835},{"id":"https://openalex.org/keywords/functional-connectivity","display_name":"Functional connectivity","score":0.4935547113418579},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.4665185213088989},{"id":"https://openalex.org/keywords/generalized-epilepsy","display_name":"Generalized epilepsy","score":0.42849400639533997},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.25804781913757324},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.24043777585029602},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.21752998232841492},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.08917537331581116},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.07866436243057251}],"concepts":[{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.7901465892791748},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.5548428893089294},{"id":"https://openalex.org/C106937863","wikidata":"https://www.wikidata.org/wiki/Q7236518","display_name":"Power graph analysis","level":3,"score":0.5483662486076355},{"id":"https://openalex.org/C199845137","wikidata":"https://www.wikidata.org/wiki/Q145490","display_name":"Network topology","level":2,"score":0.5297661423683167},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5198793411254883},{"id":"https://openalex.org/C88230418","wikidata":"https://www.wikidata.org/wiki/Q131476","display_name":"Graph theory","level":2,"score":0.49951791763305664},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.49466583132743835},{"id":"https://openalex.org/C3018011982","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Functional connectivity","level":2,"score":0.4935547113418579},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.4665185213088989},{"id":"https://openalex.org/C2779979230","wikidata":"https://www.wikidata.org/wiki/Q5532415","display_name":"Generalized epilepsy","level":3,"score":0.42849400639533997},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.25804781913757324},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.24043777585029602},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.21752998232841492},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.08917537331581116},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.07866436243057251}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/isbi.2010.5490129","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2010.5490129","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"},{"id":"pmh:oai:pure.amsterdamumc.nl:publications/6a2f312d-a348-4b64-8c66-efcf1fde0fd6","is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/6a2f312d-a348-4b64-8c66-efcf1fde0fd6","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Otte, W M, Dijkhuizen, R M, Stam, C J, Van Der Marel, K, Van Meer, M P A, Viergever, M A & Braun, K P J 2010, Spatiotemporal network alterations in experimental focal cortical epilepsy : MRI-based longitudinal functional connectivity and weighted graph analysis. in 2010 7th IEEE International Symposium on Biomedical Imaging : From Nano to Macro, ISBI 2010 - Proceedings., 5490129, 2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings, pp. 888-891, 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010, 09/08/2010. https://doi.org/10.1109/ISBI.2010.5490129","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:vumc:oai:pure.atira.dk:publications/ce65922e-1651-4639-8b0a-1cfdd57d2ab8","is_oa":false,"landing_page_url":"https://research.vumc.nl/en/publications/ce65922e-1651-4639-8b0a-1cfdd57d2ab8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings, 888 - 891","raw_type":"info:eu-repo/semantics/conferencepaper"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5299999713897705,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1923830127","https://openalex.org/W1968754325","https://openalex.org/W1980480824","https://openalex.org/W1987778722","https://openalex.org/W2001805220","https://openalex.org/W2002429132","https://openalex.org/W2009452222","https://openalex.org/W2009494091","https://openalex.org/W2011961540","https://openalex.org/W2026384313","https://openalex.org/W2038068904","https://openalex.org/W2045497522","https://openalex.org/W2047140970","https://openalex.org/W2060464767","https://openalex.org/W2070570723","https://openalex.org/W2072358297","https://openalex.org/W2077023123","https://openalex.org/W2081718320","https://openalex.org/W2089760277","https://openalex.org/W2116083905","https://openalex.org/W2131705496","https://openalex.org/W2133287637","https://openalex.org/W2151720121","https://openalex.org/W2167822639","https://openalex.org/W6679611774","https://openalex.org/W6684767083"],"related_works":["https://openalex.org/W4394861163","https://openalex.org/W4395456744","https://openalex.org/W2755787904","https://openalex.org/W3179250407","https://openalex.org/W2587413730","https://openalex.org/W2949118732","https://openalex.org/W3006690491","https://openalex.org/W4400464219","https://openalex.org/W4206763122","https://openalex.org/W996844931"],"abstract_inverted_index":{"There":[0],"is":[1],"increasing":[2],"evidence":[3],"that":[4],"the":[5],"topology":[6,19],"of":[7],"brain":[8],"networks":[9,40,58],"may":[10],"be":[11],"changed":[12],"in":[13,53,59,91],"epilepsy.":[14,92],"In":[15],"particular,":[16],"a":[17,54,66,83],"random":[18],"has":[20],"been":[21],"suggested":[22],"as":[23],"an":[24],"explanation":[25],"for":[26],"lower":[27],"seizure":[28],"thresholds.":[29],"To":[30],"test":[31],"this":[32],"hypothesis,":[33],"we":[34],"assessed":[35],"focal":[36,60],"epileptic":[37],"and":[38,48],"healthy":[39],"over":[41],"time":[42],"using":[43],"resting":[44],"state":[45],"functional":[46],"MRI":[47],"weighted":[49],"graph":[50],"theoretical":[51],"analysis":[52,81],"rat":[55],"model.":[56],"Brain":[57],"epilepsy":[61,78],"were":[62],"globally":[63],"affected,":[64],"toward":[65],"more":[67],"ordered":[68],"network":[69,89],"topology.":[70],"Networks":[71],"largely":[72],"normalized":[73],"at":[74],"ten":[75],"weeks":[76],"after":[77],"induction.":[79],"Graph":[80],"provides":[82],"promising":[84],"method":[85],"to":[86],"explore":[87],"dynamical":[88],"alterations":[90]},"counts_by_year":[{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
