{"id":"https://openalex.org/W2132162500","doi":"https://doi.org/10.1109/isbi.2009.5193250","title":"A method for normalizing histology slides for quantitative analysis","display_name":"A method for normalizing histology slides for quantitative analysis","publication_year":2009,"publication_date":"2009-06-01","ids":{"openalex":"https://openalex.org/W2132162500","doi":"https://doi.org/10.1109/isbi.2009.5193250","mag":"2132162500"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2009.5193250","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2009.5193250","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018540199","display_name":"Marc Macenko","orcid":null},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc Macenko","raw_affiliation_strings":["Departments of Computer Science, North Carolina State University, Chapel Hill, NC, USA","Dept. of Computer Science, University of North Carolina-Chapel Hill, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Computer Science, North Carolina State University, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"Dept. of Computer Science, University of North Carolina-Chapel Hill, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108610850","display_name":"Marc Niethammer","orcid":null},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc Niethammer","raw_affiliation_strings":["Biomedical Research Imaging Center, North Carolina State University, Chapel Hill, NC, USA","Dept. of Computer Science, University of North Carolina-Chapel Hill, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Imaging Center, North Carolina State University, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I137902535"]},{"raw_affiliation_string":"Dept. of Computer Science, University of North Carolina-Chapel Hill, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060651495","display_name":"J. S. Marron","orcid":null},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I87097829","display_name":"University of North Carolina at Asheville","ror":"https://ror.org/017c6at71","country_code":"US","type":"education","lineage":["https://openalex.org/I87097829"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. S. Marron","raw_affiliation_strings":["University of North Carolina at Asheville, Asheville, NC, US","Department of Statistics & Operations Research, University of North Carolina, Chapel Hill, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Asheville, Asheville, NC, US","institution_ids":["https://openalex.org/I87097829"]},{"raw_affiliation_string":"Department of Statistics & Operations Research, University of North Carolina, Chapel Hill, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001966756","display_name":"David Borland","orcid":"https://orcid.org/0000-0002-0162-4080"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I69048370","display_name":"Renaissance Computing Institute","ror":"https://ror.org/01s91ey96","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535","https://openalex.org/I170897317","https://openalex.org/I69048370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Borland","raw_affiliation_strings":["Renaissance Computing Institute, North Carolina State University, Chapel Hill, NC, USA","Department of Renaissance Computing Institute, University of North Carolina, Chapel Hill, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renaissance Computing Institute, North Carolina State University, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I69048370"]},{"raw_affiliation_string":"Department of Renaissance Computing Institute, University of North Carolina, Chapel Hill, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090269307","display_name":"John T. Woosley","orcid":"https://orcid.org/0000-0001-5876-3068"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John T. Woosley","raw_affiliation_strings":["Pathology and Laboratory Medicine, North Carolina State University, Chapel Hill, NC, USA","Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology and Laboratory Medicine, North Carolina State University, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I137902535"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101013218","display_name":"Xiaojun Guan","orcid":null},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I69048370","display_name":"Renaissance Computing Institute","ror":"https://ror.org/01s91ey96","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535","https://openalex.org/I170897317","https://openalex.org/I69048370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaojun Guan","raw_affiliation_strings":["Renaissance Computing Institute, North Carolina State University, Chapel Hill, NC, USA","Department of Renaissance Computing Institute, University of North Carolina, Chapel Hill, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renaissance Computing Institute, North Carolina State University, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I69048370"]},{"raw_affiliation_string":"Department of Renaissance Computing Institute, University of North Carolina, Chapel Hill, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084726442","display_name":"Charles Schmitt","orcid":"https://orcid.org/0000-0002-3148-2263"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I69048370","display_name":"Renaissance Computing Institute","ror":"https://ror.org/01s91ey96","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535","https://openalex.org/I170897317","https://openalex.org/I69048370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Schmitt","raw_affiliation_strings":["Renaissance Computing Institute, North Carolina State University, Chapel Hill, NC, USA","Department of Renaissance Computing Institute, University of North Carolina, Chapel Hill, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renaissance Computing Institute, North Carolina State University, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I69048370"]},{"raw_affiliation_string":"Department of Renaissance Computing Institute, University of North Carolina, Chapel Hill, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049066352","display_name":"Nancy E. Thomas","orcid":"https://orcid.org/0000-0002-2230-1328"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]},{"id":"https://openalex.org/I87097829","display_name":"University of North Carolina at Asheville","ror":"https://ror.org/017c6at71","country_code":"US","type":"education","lineage":["https://openalex.org/I87097829"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy E. Thomas","raw_affiliation_strings":["University of North Carolina at Asheville, Asheville, NC, US","Department of Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Asheville, Asheville, NC, US","institution_ids":["https://openalex.org/I87097829"]},{"raw_affiliation_string":"Department of Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USA","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1348,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1107","last_page":"1110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7537455558776855},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.5588356256484985},{"id":"https://openalex.org/keywords/quantitative-analysis","display_name":"Quantitative analysis (chemistry)","score":0.5515539050102234},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3782496154308319},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.08271780610084534},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.0754675567150116}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7537455558776855},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.5588356256484985},{"id":"https://openalex.org/C95986675","wikidata":"https://www.wikidata.org/wiki/Q185168","display_name":"Quantitative analysis (chemistry)","level":2,"score":0.5515539050102234},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3782496154308319},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.08271780610084534},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0754675567150116},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2009.5193250","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2009.5193250","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W285609025","https://openalex.org/W1597336200","https://openalex.org/W2007527993","https://openalex.org/W2012758140","https://openalex.org/W2051142023","https://openalex.org/W2056263701","https://openalex.org/W2071352953","https://openalex.org/W2100471550","https://openalex.org/W2131819768","https://openalex.org/W2162664205","https://openalex.org/W6610248056","https://openalex.org/W6674968941"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"Inconsistencies":[0],"in":[1,31],"the":[2,28,32],"preparation":[3],"of":[4,27],"histology":[5],"slides":[6,37],"make":[7],"it":[8],"difficult":[9],"to":[10,52],"perform":[11],"quantitative":[12,55],"analysis":[13],"on":[14],"their":[15],"results.":[16],"In":[17],"this":[18],"paper":[19],"we":[20],"provide":[21],"two":[22],"mechanisms":[23],"for":[24],"overcoming":[25],"many":[26],"known":[29],"inconsistencies":[30],"staining":[33],"process,":[34],"thereby":[35],"bringing":[36],"that":[38],"were":[39],"processed":[40],"or":[41],"stored":[42],"under":[43],"very":[44],"different":[45],"conditions":[46],"into":[47],"a":[48],"common,":[49],"normalized":[50],"space":[51],"enable":[53],"improved":[54],"analysis.":[56]},"counts_by_year":[{"year":2026,"cited_by_count":101},{"year":2025,"cited_by_count":182},{"year":2024,"cited_by_count":172},{"year":2023,"cited_by_count":159},{"year":2022,"cited_by_count":167},{"year":2021,"cited_by_count":164},{"year":2020,"cited_by_count":125},{"year":2019,"cited_by_count":97},{"year":2018,"cited_by_count":57},{"year":2017,"cited_by_count":41},{"year":2016,"cited_by_count":29},{"year":2015,"cited_by_count":21},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}