{"id":"https://openalex.org/W2130044532","doi":"https://doi.org/10.1109/isbi.2009.5193228","title":"Online three-dimensional dendritic spines mophological classification based on semi-supervised learning","display_name":"Online three-dimensional dendritic spines mophological classification based on semi-supervised learning","publication_year":2009,"publication_date":"2009-06-01","ids":{"openalex":"https://openalex.org/W2130044532","doi":"https://doi.org/10.1109/isbi.2009.5193228","mag":"2130044532","pmid":"https://pubmed.ncbi.nlm.nih.gov/21922077"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2009.5193228","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2009.5193228","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043145803","display_name":"Peng Shi","orcid":"https://orcid.org/0000-0001-7124-0210"},"institutions":[{"id":"https://openalex.org/I4210109259","display_name":"Methodist Hospital","ror":"https://ror.org/01r5p9y80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802827176","https://openalex.org/I4210109259"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peng Shi","raw_affiliation_strings":["Center for Biotechnology and Informatics, The Methodist Hospital Research Institute, and Department of Radiology, The Methodist Hospital, Weill Cornell Medical College, Houston, TX 77030, USA","Center for Biotechnology and Informatics, The Methodist Hospital Research Institute and Department of Radiology, The Methodist Hospital, Weill Cornell Medical College, Houston, TX 77030, USA"],"affiliations":[{"raw_affiliation_string":"Center for Biotechnology and Informatics, The Methodist Hospital Research Institute, and Department of Radiology, The Methodist Hospital, Weill Cornell Medical College, Houston, TX 77030, USA","institution_ids":[]},{"raw_affiliation_string":"Center for Biotechnology and Informatics, The Methodist Hospital Research Institute and Department of Radiology, The Methodist Hospital, Weill Cornell Medical College, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I4210109259","https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040883232","display_name":"Xiaobo Zhou","orcid":"https://orcid.org/0000-0001-7191-6495"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210109259","display_name":"Methodist Hospital","ror":"https://ror.org/01r5p9y80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802827176","https://openalex.org/I4210109259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaobo Zhou","raw_affiliation_strings":["Center of Biotechnology and Informatics,  The Methodist Hospital Research Institute,  and Department of Radiology, Weill Medical College of Cornell University, Houston, TX, USA","Center for Biotechnology and Informatics, The Methodist Hospital Research Institute and Department of Radiology, The Methodist Hospital, Weill Cornell Medical College, Houston, TX 77030, USA"],"affiliations":[{"raw_affiliation_string":"Center of Biotechnology and Informatics,  The Methodist Hospital Research Institute,  and Department of Radiology, Weill Medical College of Cornell University, Houston, TX, USA","institution_ids":["https://openalex.org/I4210109259","https://openalex.org/I205783295"]},{"raw_affiliation_string":"Center for Biotechnology and Informatics, The Methodist Hospital Research Institute and Department of Radiology, The Methodist Hospital, Weill Cornell Medical College, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I4210109259","https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100404047","display_name":"Qing Li","orcid":"https://orcid.org/0000-0002-0169-8098"},"institutions":[{"id":"https://openalex.org/I4210109259","display_name":"Methodist Hospital","ror":"https://ror.org/01r5p9y80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802827176","https://openalex.org/I4210109259"]},{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qing Li","raw_affiliation_strings":["Center of Biotechnology and Informatics,  The Methodist Hospital Research Institute,  and Department of Radiology, Weill Medical College of Cornell University, Houston, TX, USA","Computer Science Department, University of Houston, Houston, TX, USA","Center for Biotechnology and Informatics, The Methodist Hospital Research Institute and Department of Radiology, The Methodist Hospital, Weill Cornell Medical College, Houston, TX 77030, USA"],"affiliations":[{"raw_affiliation_string":"Center of Biotechnology and Informatics,  The Methodist Hospital Research Institute,  and Department of Radiology, Weill Medical College of Cornell University, Houston, TX, USA","institution_ids":["https://openalex.org/I4210109259","https://openalex.org/I205783295"]},{"raw_affiliation_string":"Computer Science Department, University of Houston, Houston, TX, USA","institution_ids":["https://openalex.org/I44461941"]},{"raw_affiliation_string":"Center for Biotechnology and Informatics, The Methodist Hospital Research Institute and Department of Radiology, The Methodist Hospital, Weill Cornell Medical College, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I4210109259","https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038671455","display_name":"Matthew Baron","orcid":null},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Baron","raw_affiliation_strings":["Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY, USA","Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, 10065, USA"],"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY, USA","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, 10065, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077448074","display_name":"Merilee Teylan","orcid":null},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Merilee A. Teylan","raw_affiliation_strings":["Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY, USA","Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, 10065, USA"],"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY, USA","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, 10065, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100329379","display_name":"Yong Kim","orcid":"https://orcid.org/0000-0002-1387-2962"},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Kim","raw_affiliation_strings":["Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY, USA","Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, 10065, USA"],"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY, USA","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, 10065, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015077092","display_name":"Stephen T.C. Wong","orcid":"https://orcid.org/0000-0001-9188-6502"},"institutions":[{"id":"https://openalex.org/I4210109259","display_name":"Methodist Hospital","ror":"https://ror.org/01r5p9y80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802827176","https://openalex.org/I4210109259"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen T.C. Wong","raw_affiliation_strings":["Center of Biotechnology and Informatics,  The Methodist Hospital Research Institute,  and Department of Radiology, Weill Medical College of Cornell University, Houston, TX, USA","Center for Biotechnology and Informatics, The Methodist Hospital Research Institute and Department of Radiology, The Methodist Hospital, Weill Cornell Medical College, Houston, TX 77030, USA"],"affiliations":[{"raw_affiliation_string":"Center of Biotechnology and Informatics,  The Methodist Hospital Research Institute,  and Department of Radiology, Weill Medical College of Cornell University, Houston, TX, USA","institution_ids":["https://openalex.org/I4210109259","https://openalex.org/I205783295"]},{"raw_affiliation_string":"Center for Biotechnology and Informatics, The Methodist Hospital Research Institute and Department of Radiology, The Methodist Hospital, Weill Cornell Medical College, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I4210109259","https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5043145803"],"corresponding_institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210109259"],"apc_list":null,"apc_paid":null,"fwci":0.3728,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.78136918,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"1019","last_page":"1022"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9865999817848206,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9861000180244446,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dendritic-spine","display_name":"Dendritic spine","score":0.8502501845359802},{"id":"https://openalex.org/keywords/spine","display_name":"SPINE (molecular biology)","score":0.7790572047233582},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6432303786277771},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6141648888587952},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.5445083379745483},{"id":"https://openalex.org/keywords/space","display_name":"Space (punctuation)","score":0.4486100375652313},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.403673380613327},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.17537152767181396},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1634339988231659},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.09408450126647949}],"concepts":[{"id":"https://openalex.org/C174884520","wikidata":"https://www.wikidata.org/wiki/Q902079","display_name":"Dendritic spine","level":3,"score":0.8502501845359802},{"id":"https://openalex.org/C205383261","wikidata":"https://www.wikidata.org/wiki/Q7392570","display_name":"SPINE (molecular biology)","level":2,"score":0.7790572047233582},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6432303786277771},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6141648888587952},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5445083379745483},{"id":"https://openalex.org/C2778572836","wikidata":"https://www.wikidata.org/wiki/Q380933","display_name":"Space (punctuation)","level":2,"score":0.4486100375652313},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.403673380613327},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.17537152767181396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1634339988231659},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.09408450126647949},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/isbi.2009.5193228","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2009.5193228","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"},{"id":"pmid:21922077","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21922077","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. IEEE International Symposium on Biomedical Imaging","raw_type":null},{"id":"pmh:oai:europepmc.org:2177511","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3171508","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1479807131","https://openalex.org/W2003493421","https://openalex.org/W2012454213","https://openalex.org/W2014768758","https://openalex.org/W2084735290","https://openalex.org/W2142788198","https://openalex.org/W2154455818","https://openalex.org/W6681045086","https://openalex.org/W6682494755"],"related_works":["https://openalex.org/W2169505641","https://openalex.org/W1996493542","https://openalex.org/W2136747326","https://openalex.org/W3132088562","https://openalex.org/W4317935580","https://openalex.org/W2120160245","https://openalex.org/W1989838035","https://openalex.org/W2151123745","https://openalex.org/W2528820646","https://openalex.org/W2089161864"],"abstract_inverted_index":{"Recent":[0],"studies":[1],"on":[2,76],"neuron":[3,18],"imaging":[4],"show":[5],"that":[6,111],"there":[7],"is":[8,116],"a":[9,17,58,77,93,112],"strong":[10],"relationship":[11],"between":[12,100],"the":[13,30,47,81,84,105],"functional":[14],"properties":[15],"of":[16,29,49,83],"and":[19],"its":[20,23],"morphology,":[21],"especially":[22],"dendritic":[24,50,121],"spine":[25,35,51,65],"structures.":[26],"However,":[27],"most":[28],"current":[31],"methods":[32],"for":[33],"morphological":[34],"classification":[36],"only":[37,75],"concern":[38],"features":[39,101],"in":[40,63,67],"two-dimensional":[41],"(2D)":[42],"space,":[43],"which":[44,64],"consequently":[45],"decreases":[46],"accuracy":[48],"analysis.":[52],"In":[53],"this":[54],"paper,":[55],"we":[56],"propose":[57],"semi-supervised":[59],"learning":[60],"(SSL)":[61],"framework,":[62],"phenotypes":[66],"three-dimensional":[68],"(3D)":[69],"space":[70],"are":[71],"considered.":[72],"With":[73],"training":[74,114],"few":[78],"pre-classified":[79],"inputs,":[80],"rest":[82],"spines":[85],"can":[86],"be":[87],"identified":[88],"effectively.":[89],"We":[90],"also":[91],"derived":[92],"new":[94],"scheme":[95],"using":[96],"an":[97],"affinity":[98],"matrix":[99],"to":[102,118],"further":[103],"improve":[104],"accuracy.":[106],"Our":[107],"experimental":[108],"results":[109],"indicate":[110],"small":[113],"dataset":[115],"sufficient":[117],"classify":[119],"detected":[120],"spines.":[122]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}