{"id":"https://openalex.org/W2141540497","doi":"https://doi.org/10.1109/isbi.2009.5192985","title":"Robust estimation of pharmacokinetic parameters in DCE-MRI analysis of rectal tumours","display_name":"Robust estimation of pharmacokinetic parameters in DCE-MRI analysis of rectal tumours","publication_year":2009,"publication_date":"2009-06-01","ids":{"openalex":"https://openalex.org/W2141540497","doi":"https://doi.org/10.1109/isbi.2009.5192985","mag":"2141540497"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2009.5192985","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2009.5192985","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041269663","display_name":"Lydia Tanner","orcid":null},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"L. N. Tanner","raw_affiliation_strings":["Department of Engineering Science, University of Oxford, Oxford, UK","Dept of Engineering Science, University of Oxford, UK"],"affiliations":[{"raw_affiliation_string":"Department of Engineering Science, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Dept of Engineering Science, University of Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111976108","display_name":"N. P. Hughes","orcid":null},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"N. P. Hughes","raw_affiliation_strings":["Department of Engineering Science, University of Oxford, Oxford, UK","Dept of Engineering Science, University of Oxford, UK"],"affiliations":[{"raw_affiliation_string":"Department of Engineering Science, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Dept of Engineering Science, University of Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111893231","display_name":"Sir Michael Brady","orcid":null},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sir Michael Brady","raw_affiliation_strings":["Department of Engineering Science, University of Oxford, Oxford, UK","Dept of Engineering Science, University of Oxford, UK"],"affiliations":[{"raw_affiliation_string":"Department of Engineering Science, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Dept of Engineering Science, University of Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044309630","display_name":"Mark Anderson","orcid":"https://orcid.org/0000-0003-3848-084X"},"institutions":[{"id":"https://openalex.org/I2801179840","display_name":"Churchill Hospital","ror":"https://ror.org/009vheq40","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801179840","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. Anderson","raw_affiliation_strings":["Department of Radiology, Churchill Hospital, Oxford Radcliffe Hospitals NHS Trust, UK","Department of Radiology, Churchill Hospital, Oxford Radcliffe Hospitals, UK"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, Churchill Hospital, Oxford Radcliffe Hospitals NHS Trust, UK","institution_ids":["https://openalex.org/I2801179840"]},{"raw_affiliation_string":"Department of Radiology, Churchill Hospital, Oxford Radcliffe Hospitals, UK","institution_ids":["https://openalex.org/I2801179840"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071189596","display_name":"Fergus Gleeson","orcid":"https://orcid.org/0000-0002-5121-3917"},"institutions":[{"id":"https://openalex.org/I2801179840","display_name":"Churchill Hospital","ror":"https://ror.org/009vheq40","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801179840","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"F. V. Gleeson","raw_affiliation_strings":["Department of Radiology, Churchill Hospital, Oxford Radcliffe Hospitals NHS Trust, UK","Department of Radiology, Churchill Hospital, Oxford Radcliffe Hospitals, UK"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, Churchill Hospital, Oxford Radcliffe Hospitals NHS Trust, UK","institution_ids":["https://openalex.org/I2801179840"]},{"raw_affiliation_string":"Department of Radiology, Churchill Hospital, Oxford Radcliffe Hospitals, UK","institution_ids":["https://openalex.org/I2801179840"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5041269663"],"corresponding_institution_ids":["https://openalex.org/I40120149"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.22871204,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":null,"first_page":"69","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/voxel","display_name":"Voxel","score":0.6810685992240906},{"id":"https://openalex.org/keywords/contrast","display_name":"Contrast (vision)","score":0.6057466268539429},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5954158306121826},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5247671604156494},{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.5094171166419983},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"Pharmacokinetics","score":0.42638808488845825},{"id":"https://openalex.org/keywords/estimation-theory","display_name":"Estimation theory","score":0.42510220408439636},{"id":"https://openalex.org/keywords/relaxation","display_name":"Relaxation (psychology)","score":0.4191087484359741},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.33251041173934937},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.20155343413352966},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.1305345594882965},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.07690709829330444}],"concepts":[{"id":"https://openalex.org/C54170458","wikidata":"https://www.wikidata.org/wiki/Q663554","display_name":"Voxel","level":2,"score":0.6810685992240906},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.6057466268539429},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5954158306121826},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5247671604156494},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.5094171166419983},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.42638808488845825},{"id":"https://openalex.org/C167928553","wikidata":"https://www.wikidata.org/wiki/Q1376021","display_name":"Estimation theory","level":2,"score":0.42510220408439636},{"id":"https://openalex.org/C2776029896","wikidata":"https://www.wikidata.org/wiki/Q3935810","display_name":"Relaxation (psychology)","level":2,"score":0.4191087484359741},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.33251041173934937},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20155343413352966},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.1305345594882965},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07690709829330444},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/isbi.2009.5192985","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2009.5192985","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:deafb1e4-aaf2-4dea-b906-89ed2a9942d9","is_oa":false,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:deafb1e4-aaf2-4dea-b906-89ed2a9942d9","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symplectic Elements at Oxford","raw_type":"Conference"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1977314580","https://openalex.org/W1977411036","https://openalex.org/W2019190989","https://openalex.org/W2041837270","https://openalex.org/W2072626310","https://openalex.org/W2098973661","https://openalex.org/W2113576511","https://openalex.org/W2184231212"],"related_works":["https://openalex.org/W3027020613","https://openalex.org/W2016533837","https://openalex.org/W2352350815","https://openalex.org/W2991030316","https://openalex.org/W3167885074","https://openalex.org/W2908757458","https://openalex.org/W2892386716","https://openalex.org/W1998563493","https://openalex.org/W2887865523","https://openalex.org/W4306164210"],"abstract_inverted_index":{"Dynamic":[0],"contrast-enhanced":[1],"(DCE)":[2],"MRI":[3],"is":[4,82],"a":[5,54,59,99,125],"powerful":[6],"tool":[7],"for":[8,13,102,124],"assessing":[9],"tumour":[10,44],"vasculature":[11],"and":[12,90,112],"predicting":[14],"patient":[15,95],"response":[16],"to":[17,47,84,91],"therapy.":[18],"DCE-MRI":[19],"data":[20],"can":[21],"be":[22],"quantified":[23],"using":[24],"pharmacokinetic":[25,50],"models,":[26],"allowing":[27],"extraction":[28],"of":[29,37,62,77,94,130],"physiologically":[30],"meaningful":[31],"parameters.":[32,51],"However,":[33],"in":[34,86,105,128],"clinical":[35],"scans":[36],"rectal":[38,131],"tumours":[39],"many":[40],"voxels":[41],"within":[42],"the":[43,63,67,87,92,108,122],"volume":[45],"fail":[46],"produce":[48],"valid":[49],"By":[52],"performing":[53],"sensitivity":[55],"analysis,":[56],"we":[57],"find":[58],"high":[60],"dependence":[61],"model":[64],"parameters":[65],"on":[66],"pre-contrast":[68],"relaxation":[69],"time":[70,89],"T":[71,78],"<sub":[72,79],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[73,80],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">10</sub>":[74,81],".":[75],"Estimation":[76],"sensitive":[83],"variations":[85,104],"repetition":[88],"effects":[93],"motion.":[96],"We":[97],"develop":[98],"new":[100],"method":[101],"incorporating":[103],"TR":[106],"into":[107],"parameter":[109],"estimation":[110],"process":[111],"combine":[113],"it":[114],"with":[115],"non-rigid":[116],"image":[117],"registration.":[118],"Our":[119],"approach":[120],"offers":[121],"potential":[123],"substantial":[126],"improvement":[127],"characterisation":[129],"tumours.":[132]},"counts_by_year":[],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}
