{"id":"https://openalex.org/W2132400335","doi":"https://doi.org/10.1109/isbi.2008.4541272","title":"System sensitivity in preclinical small animal imaging","display_name":"System sensitivity in preclinical small animal imaging","publication_year":2008,"publication_date":"2008-05-01","ids":{"openalex":"https://openalex.org/W2132400335","doi":"https://doi.org/10.1109/isbi.2008.4541272","mag":"2132400335"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2008.4541272","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2008.4541272","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://doi.org/10.1109/ISBI.2008.4541272","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054681352","display_name":"Arion F. Chatziioannou","orcid":null},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arion F. Chatziioannou","raw_affiliation_strings":["Crump Institute for Molecular Imaging, University of California, Los Angeles, CA, USA","Crump Inst. for Mol. Imaging, California Univ., Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Crump Institute for Molecular Imaging, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Crump Inst. for Mol. Imaging, California Univ., Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109210273","display_name":"Qinan Bao","orcid":null},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qinan Bao","raw_affiliation_strings":["Crump Institute for Molecular Imaging, University of California, Los Angeles, CA, USA","Crump Inst. for Mol. Imaging, California Univ., Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Crump Institute for Molecular Imaging, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Crump Inst. for Mol. Imaging, California Univ., Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018357052","display_name":"Nicolas A. Karakatsanis","orcid":"https://orcid.org/0000-0001-7326-3053"},"institutions":[{"id":"https://openalex.org/I174458059","display_name":"National Technical University of Athens","ror":"https://ror.org/03cx6bg69","country_code":"GR","type":"education","lineage":["https://openalex.org/I174458059"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"N. Karakatsanis","raw_affiliation_strings":["Electrical and Computer Engineering, Athens, Greece","Department of Electrical and Computer Engineering, NTUA, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electrical and Computer Engineering, Athens, Greece","institution_ids":[]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, NTUA, Athens, Greece","institution_ids":["https://openalex.org/I174458059"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2584,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.67494747,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"302","issue":null,"first_page":"1417","last_page":"1420"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11216","display_name":"Radiation Detection and Scintillator Technologies","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9886999726295471,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.687200665473938},{"id":"https://openalex.org/keywords/positron-emission-tomography","display_name":"Positron emission tomography","score":0.6709768176078796},{"id":"https://openalex.org/keywords/scintillator","display_name":"Scintillator","score":0.6538742780685425},{"id":"https://openalex.org/keywords/detector","display_name":"Detector","score":0.5908677577972412},{"id":"https://openalex.org/keywords/focus","display_name":"Focus (optics)","score":0.5584918260574341},{"id":"https://openalex.org/keywords/monte-carlo-method","display_name":"Monte Carlo method","score":0.5031334757804871},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.49142611026763916},{"id":"https://openalex.org/keywords/medical-physics","display_name":"Medical physics","score":0.46428170800209045},{"id":"https://openalex.org/keywords/pet-imaging","display_name":"Pet imaging","score":0.4151607155799866},{"id":"https://openalex.org/keywords/electronic-engineering","display_name":"Electronic engineering","score":0.30205243825912476},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.24526327848434448},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.193452388048172},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.17170393466949463},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.14433634281158447},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.12055954337120056},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.07817816734313965}],"concepts":[{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.687200665473938},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.6709768176078796},{"id":"https://openalex.org/C161694136","wikidata":"https://www.wikidata.org/wiki/Q910990","display_name":"Scintillator","level":3,"score":0.6538742780685425},{"id":"https://openalex.org/C94915269","wikidata":"https://www.wikidata.org/wiki/Q1834857","display_name":"Detector","level":2,"score":0.5908677577972412},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.5584918260574341},{"id":"https://openalex.org/C19499675","wikidata":"https://www.wikidata.org/wiki/Q232207","display_name":"Monte Carlo method","level":2,"score":0.5031334757804871},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49142611026763916},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.46428170800209045},{"id":"https://openalex.org/C3017724952","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Pet imaging","level":3,"score":0.4151607155799866},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.30205243825912476},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.24526327848434448},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.193452388048172},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.17170393466949463},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14433634281158447},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.12055954337120056},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.07817816734313965},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/isbi.2008.4541272","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2008.4541272","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"},{"id":"pmh:oai:dspace.lib.ntua.gr:123456789/32402","is_oa":true,"landing_page_url":"http://doi.org/10.1109/ISBI.2008.4541272","pdf_url":null,"source":{"id":"https://openalex.org/S4377196837","display_name":"DSpace - NTUA (National Technical University of Athens)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I174458059","host_organization_name":"National Technical University of Athens","host_organization_lineage":["https://openalex.org/I174458059"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, Proceedings, ISBI","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":{"id":"pmh:oai:dspace.lib.ntua.gr:123456789/32402","is_oa":true,"landing_page_url":"http://doi.org/10.1109/ISBI.2008.4541272","pdf_url":null,"source":{"id":"https://openalex.org/S4377196837","display_name":"DSpace - NTUA (National Technical University of Athens)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I174458059","host_organization_name":"National Technical University of Athens","host_organization_lineage":["https://openalex.org/I174458059"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, Proceedings, ISBI","raw_type":"info:eu-repo/semantics/conferenceObject"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1947979310","https://openalex.org/W1972781324","https://openalex.org/W2000662365","https://openalex.org/W2002718660","https://openalex.org/W2032861454","https://openalex.org/W2057605474","https://openalex.org/W2129762484","https://openalex.org/W2136597795","https://openalex.org/W2138884296","https://openalex.org/W2150941474","https://openalex.org/W2152754744","https://openalex.org/W6679638411","https://openalex.org/W6680043884","https://openalex.org/W6682422747"],"related_works":["https://openalex.org/W2186218760","https://openalex.org/W2473498105","https://openalex.org/W2919691020","https://openalex.org/W2769989561","https://openalex.org/W2189154756","https://openalex.org/W2168768514","https://openalex.org/W4389219344","https://openalex.org/W2088646614","https://openalex.org/W3029637811","https://openalex.org/W2319489245"],"abstract_inverted_index":{"Preclinical":[0],"small":[1],"animal":[2],"imaging":[3,23,39],"is":[4,24,29],"an":[5],"important":[6],"tool":[7],"at":[8],"the":[9,15,54,79,85,132],"disposition":[10],"of":[11,17,30,56,81],"biological":[12,35],"researchers.":[13],"While":[14],"range":[16],"studies":[18],"performed":[19],"by":[20],"non-invasive":[21],"preclinical":[22,72,108],"greatly":[25],"varied,":[26],"high":[27,48],"sensitivity":[28,50],"key":[31],"importance":[32],"in":[33,92],"any":[34],"experiment":[36],"with":[37],"molecular":[38],"probes.":[40],"The":[41,104],"technologies":[42],"that":[43,107,115],"are":[44],"used":[45],"to":[46,137],"achieve":[47],"system":[49,76,94],"mostly":[51],"focus":[52,89],"on":[53,84,112],"use":[55],"large":[57],"solid":[58],"angles":[59],"and":[60,69,78,96,99,120],"dense":[61],"scintillator":[62,97],"materials.":[63],"In":[64],"this":[65],"work,":[66],"we":[67],"investigate":[68],"discuss":[70],"different":[71],"Positron":[73],"Emission":[74],"Tomography":[75],"designs":[77,83],"effects":[80],"these":[82],"overall":[86],"sensitivity.":[87],"We":[88],"our":[90],"investigations":[91],"hypothetical":[93],"geometries":[95],"materials":[98,114],"perform":[100],"Monte":[101],"Carlo":[102],"simulations.":[103],"results":[105],"indicate":[106],"PET":[109],"systems":[110],"based":[111],"detector":[113],"have":[116],"minimal":[117],"intrinsic":[118],"background":[119],"higher":[121],"effective":[122],"atomic":[123],"number,":[124],"might":[125],"offer":[126],"performance":[127],"advantages":[128],"for":[129],"situations":[130],"where":[131],"weakest":[133],"signal":[134],"possible":[135],"needs":[136],"be":[138],"detected.":[139]},"counts_by_year":[{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}