{"id":"https://openalex.org/W2156970597","doi":"https://doi.org/10.1109/isbi.2008.4541088","title":"Massive-training artificial neural networks for CAD for detection of polyps in CT colonography: False-negative cases in a large multicenter clinical trial","display_name":"Massive-training artificial neural networks for CAD for detection of polyps in CT colonography: False-negative cases in a large multicenter clinical trial","publication_year":2008,"publication_date":"2008-05-01","ids":{"openalex":"https://openalex.org/W2156970597","doi":"https://doi.org/10.1109/isbi.2008.4541088","mag":"2156970597"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2008.4541088","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2008.4541088","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050949810","display_name":"Kenji Suzuki","orcid":"https://orcid.org/0000-0002-3993-8309"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kenji Suzuki","raw_affiliation_strings":["Department of Radiology, University of Chicago, Chicago, IL, USA"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110026338","display_name":"M. Epstein","orcid":null},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Epstein","raw_affiliation_strings":["Department of Radiology, University of Chicago, Chicago, IL, USA"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080085519","display_name":"Ivan Sheu","orcid":null},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivan Sheu","raw_affiliation_strings":["Department of Radiology, University of Chicago, Chicago, IL, USA"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006990020","display_name":"Ryan Kohlbrenner","orcid":"https://orcid.org/0000-0002-2479-0698"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Kohlbrenner","raw_affiliation_strings":["Department of Radiology, University of Chicago, Chicago, IL, USA"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043752774","display_name":"Don C. Rockey","orcid":"https://orcid.org/0000-0002-3751-2961"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"education","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Don C. Rockey","raw_affiliation_strings":["Department of Internal Medicine, University of Texas Southwestern Medical Centre, Dallas, TX, USA"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Texas Southwestern Medical Centre, Dallas, TX, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030721229","display_name":"Abraham H. Dachman","orcid":"https://orcid.org/0000-0002-7035-2752"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abraham H. Dachman","raw_affiliation_strings":["Department of Radiology, University of Chicago, Chicago, IL, USA"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5050949810"],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":null,"apc_paid":null,"fwci":0.2901,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.62554835,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"684","last_page":"687"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9912999868392944,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cad","display_name":"CAD","score":0.8729246258735657},{"id":"https://openalex.org/keywords/false-positive-paradox","display_name":"False positive paradox","score":0.8143593072891235},{"id":"https://openalex.org/keywords/computer-aided-diagnosis","display_name":"Computer-aided diagnosis","score":0.6082523465156555},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5402779579162598},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.5092288255691528},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.4996070861816406},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4473758935928345},{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.44030851125717163},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3697727918624878},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.19195392727851868}],"concepts":[{"id":"https://openalex.org/C194789388","wikidata":"https://www.wikidata.org/wiki/Q17855283","display_name":"CAD","level":2,"score":0.8729246258735657},{"id":"https://openalex.org/C64869954","wikidata":"https://www.wikidata.org/wiki/Q1859747","display_name":"False positive paradox","level":2,"score":0.8143593072891235},{"id":"https://openalex.org/C2779549770","wikidata":"https://www.wikidata.org/wiki/Q1122413","display_name":"Computer-aided diagnosis","level":2,"score":0.6082523465156555},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5402779579162598},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.5092288255691528},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.4996070861816406},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4473758935928345},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.44030851125717163},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3697727918624878},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19195392727851868},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C199639397","wikidata":"https://www.wikidata.org/wiki/Q1788588","display_name":"Engineering drawing","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2008.4541088","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2008.4541088","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1972482030","https://openalex.org/W1976975876","https://openalex.org/W1994127966","https://openalex.org/W2012138347","https://openalex.org/W2023159440","https://openalex.org/W2023522838","https://openalex.org/W2027751334","https://openalex.org/W2038839211","https://openalex.org/W2072941425","https://openalex.org/W2095344271","https://openalex.org/W2114973443","https://openalex.org/W2127085684","https://openalex.org/W2128988020","https://openalex.org/W2132715022","https://openalex.org/W2137865578","https://openalex.org/W2138797814","https://openalex.org/W2144198467","https://openalex.org/W2157469204","https://openalex.org/W3141967957","https://openalex.org/W4231644065","https://openalex.org/W4235329037"],"related_works":["https://openalex.org/W1589419489","https://openalex.org/W4229543669","https://openalex.org/W1783185948","https://openalex.org/W615772105","https://openalex.org/W2999505641","https://openalex.org/W2401866201","https://openalex.org/W2945629533","https://openalex.org/W1554029525","https://openalex.org/W2031523410","https://openalex.org/W2013631688"],"abstract_inverted_index":{"A":[0],"major":[1],"challenge":[2],"in":[3,9,46,78],"computer-aided":[4],"detection":[5,15],"(CAD)":[6],"of":[7,16,39,64,87,101,106,113,127,129],"polyps":[8,18,60,66,89,131],"CT":[10],"colonography":[11],"(CTC)":[12],"is":[13],"the":[14,37,79,102,111,125,130],"\"difficult\"":[17],"which":[19],"radiologists":[20,77],"are":[21],"likely":[22],"to":[23,28,57,119],"miss.":[24],"Our":[25,81],"purpose":[26],"was":[27,117],"develop":[29],"massive-training":[30],"artificial":[31],"neural":[32],"networks":[33],"(MTANNs)":[34],"for":[35],"improving":[36],"performance":[38,112],"a":[40,47],"CAD":[41,83,115],"scheme":[42,84,116],"on":[43,69],"false-negative":[44],"cases":[45],"large":[48],"multicenter":[49],"clinical":[50],"trial.":[51,80],"We":[52],"developed":[53],"3D":[54],"MTANNs":[55,98],"designed":[56],"differentiate":[58],"between":[59],"and":[61,67],"several":[62],"types":[63],"non-":[65],"tested":[68],"14":[70],"polyps/masses":[71],"that":[72],"were":[73],"actually":[74],"\"missed\"":[75,88,132],"by":[76,133],"initial":[82],"detected":[85],"71.4%":[86,128],"with":[90],"18.9":[91],"false":[92],"positives":[93],"(FPs)":[94],"per":[95,122],"case.":[96],"The":[97],"removed":[99],"75%":[100],"FPs":[103,121],"without":[104],"loss":[105],"any":[107],"true":[108],"positives;":[109],"thus,":[110],"our":[114],"improved":[118],"4.8":[120],"case":[123],"at":[124],"sensitivity":[126],"radiologists.":[134]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
