{"id":"https://openalex.org/W2120181753","doi":"https://doi.org/10.1109/isbi.2008.4541038","title":"Chromosome pairing for karyotyping purposes using mutual information","display_name":"Chromosome pairing for karyotyping purposes using mutual information","publication_year":2008,"publication_date":"2008-05-01","ids":{"openalex":"https://openalex.org/W2120181753","doi":"https://doi.org/10.1109/isbi.2008.4541038","mag":"2120181753"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2008.4541038","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2008.4541038","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051039594","display_name":"Artem Khmelinskii","orcid":"https://orcid.org/0000-0002-2665-7380"},"institutions":[{"id":"https://openalex.org/I4210166615","display_name":"INESC TEC","ror":"https://ror.org/05fa8ka61","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210125590","https://openalex.org/I4210166615"]},{"id":"https://openalex.org/I4387152517","display_name":"Instituto Superior T\u00e9cnico","ror":"https://ror.org/03db2by73","country_code":null,"type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4387152517"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Artem Khmelinskii","raw_affiliation_strings":["Institute for Systems and Robotics, Instituto Superior Technico, Lisboa, Portugal","Inst. for Syst. & Robot., Lisbon"],"affiliations":[{"raw_affiliation_string":"Institute for Systems and Robotics, Instituto Superior Technico, Lisboa, Portugal","institution_ids":["https://openalex.org/I4210166615","https://openalex.org/I4387152517"]},{"raw_affiliation_string":"Inst. for Syst. & Robot., Lisbon","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052413681","display_name":"Rodrigo Ventura","orcid":"https://orcid.org/0000-0002-5655-9562"},"institutions":[{"id":"https://openalex.org/I4387152517","display_name":"Instituto Superior T\u00e9cnico","ror":"https://ror.org/03db2by73","country_code":null,"type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4387152517"]},{"id":"https://openalex.org/I4210166615","display_name":"INESC TEC","ror":"https://ror.org/05fa8ka61","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210125590","https://openalex.org/I4210166615"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Rodrigo Ventura","raw_affiliation_strings":["Institute for Systems and Robotics, Instituto Superior Technico, Lisboa, Portugal","Inst. for Syst. & Robot., Lisbon"],"affiliations":[{"raw_affiliation_string":"Institute for Systems and Robotics, Instituto Superior Technico, Lisboa, Portugal","institution_ids":["https://openalex.org/I4210166615","https://openalex.org/I4387152517"]},{"raw_affiliation_string":"Inst. for Syst. & Robot., Lisbon","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053559436","display_name":"Jo\u00e3o Sanches","orcid":"https://orcid.org/0000-0001-9089-2740"},"institutions":[{"id":"https://openalex.org/I4210166615","display_name":"INESC TEC","ror":"https://ror.org/05fa8ka61","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210125590","https://openalex.org/I4210166615"]},{"id":"https://openalex.org/I4387152517","display_name":"Instituto Superior T\u00e9cnico","ror":"https://ror.org/03db2by73","country_code":null,"type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4387152517"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Joao Sanches","raw_affiliation_strings":["Institute for Systems and Robotics, Instituto Superior Technico, Lisboa, Portugal","Inst. for Syst. & Robot., Lisbon"],"affiliations":[{"raw_affiliation_string":"Institute for Systems and Robotics, Instituto Superior Technico, Lisboa, Portugal","institution_ids":["https://openalex.org/I4210166615","https://openalex.org/I4387152517"]},{"raw_affiliation_string":"Inst. for Syst. & Robot., Lisbon","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5051039594"],"corresponding_institution_ids":["https://openalex.org/I4210166615","https://openalex.org/I4387152517"],"apc_list":null,"apc_paid":null,"fwci":0.5585,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.72759945,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"1","issue":null,"first_page":"484","last_page":"487"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9929999709129333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.9914000034332275,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pairing","display_name":"Pairing","score":0.7890642285346985},{"id":"https://openalex.org/keywords/karyotype","display_name":"Karyotype","score":0.6355829834938049},{"id":"https://openalex.org/keywords/cytogenetics","display_name":"Cytogenetics","score":0.6082895994186401},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5948599576950073},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.529617428779602},{"id":"https://openalex.org/keywords/classifier","display_name":"Classifier (UML)","score":0.5264597535133362},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4827410578727722},{"id":"https://openalex.org/keywords/metaphase","display_name":"Metaphase","score":0.4797136187553406},{"id":"https://openalex.org/keywords/mutual-information","display_name":"Mutual information","score":0.44862890243530273},{"id":"https://openalex.org/keywords/chromosome","display_name":"Chromosome","score":0.39078301191329956},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.32573625445365906},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2796248197555542},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2647656798362732},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.11377954483032227},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.07927259802818298}],"concepts":[{"id":"https://openalex.org/C14103023","wikidata":"https://www.wikidata.org/wiki/Q11681459","display_name":"Pairing","level":3,"score":0.7890642285346985},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.6355829834938049},{"id":"https://openalex.org/C174475383","wikidata":"https://www.wikidata.org/wiki/Q246128","display_name":"Cytogenetics","level":4,"score":0.6082895994186401},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5948599576950073},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.529617428779602},{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.5264597535133362},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4827410578727722},{"id":"https://openalex.org/C70278784","wikidata":"https://www.wikidata.org/wiki/Q574427","display_name":"Metaphase","level":4,"score":0.4797136187553406},{"id":"https://openalex.org/C152139883","wikidata":"https://www.wikidata.org/wiki/Q252973","display_name":"Mutual information","level":2,"score":0.44862890243530273},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.39078301191329956},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.32573625445365906},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2796248197555542},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2647656798362732},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11377954483032227},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07927259802818298},{"id":"https://openalex.org/C54101563","wikidata":"https://www.wikidata.org/wiki/Q124131","display_name":"Superconductivity","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2008.4541038","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2008.4541038","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1498719334","https://openalex.org/W1513416384","https://openalex.org/W2038232770","https://openalex.org/W2056450868","https://openalex.org/W2116209816","https://openalex.org/W2120646766","https://openalex.org/W2122410182","https://openalex.org/W2126391689","https://openalex.org/W2165384045","https://openalex.org/W2545557069","https://openalex.org/W6729111221"],"related_works":["https://openalex.org/W3015473028","https://openalex.org/W3201176751","https://openalex.org/W2098625105","https://openalex.org/W2146803315","https://openalex.org/W2066597280","https://openalex.org/W2064623028","https://openalex.org/W2988122616","https://openalex.org/W4214699236","https://openalex.org/W31794660","https://openalex.org/W3119805132"],"abstract_inverted_index":{"Cytogenetics":[0],"is":[1,30,70,93,97,107,176,199],"the":[2,6,36,39,47,60,64,71,74,78,121,126,129,137,143,159,166,180,189,213,247,252,255,262],"preferred":[3],"tool":[4],"in":[5,35,53,73,125],"diagnosis":[7],"of":[8,16,33,38,46,56,63,128,254],"genetic":[9],"diseases":[10],"such":[11,20,147],"as":[12,21,242],"leukemia":[13,133],"and":[14,51,87,96,154,240],"detection":[15],"aquired":[17],"chromosomal":[18],"abnormalities,":[19],"translocations,":[22],"deletions,":[23],"monosomies":[24],"or":[25],"trisomies,":[26],"etc.":[27],"The":[28,68,196],"karyotyping":[29,75,130],"a":[31,43,204,225,243,266],"set":[32],"procedures,":[34],"scope":[37,127],"cytogenetics,":[40],"that":[41],"produces":[42],"visual":[44],"representation":[45],"46":[48],"chromosomes,":[49,146],"paired":[50,82,237],"arranged":[52],"decreasing":[54],"order":[55],"size,":[57],"observed":[58],"during":[59],"metaphase":[61],"step":[62],"cellular":[65],"division":[66],"(meiosis).":[67],"pairing":[69,105,123,191,214,248],"procedure":[72],"process":[76,92,131,249],"where":[77],"homologous":[79],"chromosomes":[80],"are":[81],"according":[83],"to":[84,119,141,164,178,211,250],"dimensional,":[85],"morphological":[86],"textural":[88,167],"similarity":[89,144,168],"criteria.":[90],"This":[91],"time":[94],"consuming":[95],"usually":[98],"performed":[99],"manually":[100,236],"by":[101,194,238],"experts.":[102],"An":[103],"automatic":[104,122],"algorithm":[106,207],"still":[108],"an":[109],"open":[110],"problem.":[111],"In":[112],"this":[113],"paper":[114],"we":[115,157],"present":[116],"new":[117],"contributions":[118],"solve":[120],"problem":[124],"for":[132,215,246],"diagnostic":[134],"purposes.":[135],"Besides":[136],"traditional":[138],"features":[139,182],"used":[140,241],"compute":[142,212],"between":[145,169],"as,":[148],"normalized":[149],"area,":[150],"ellipsis":[151],"axis":[152],"length":[153],"banding":[155],"profiles,":[156],"introduce":[158],"Mutual":[160],"Information":[161],"(MI)":[162],"measure":[163],"assess":[165,251],"two":[170],"chromosomes.":[171],"A":[172],"supervised":[173],"linear":[174],"classifier":[175,198],"trained":[177],"combine":[179],"different":[181],"computed":[183],"from":[184],"each":[185],"pair,":[186],"aiming":[187],"at":[188],"correct":[190],"(as":[192],"given":[193,217],"experts).":[195],"resulting":[197],"then":[200],"employed,":[201],"together":[202],"with":[203,224,261,265],"combinatorial":[205],"optimization":[206],"based":[208],"on":[209],"A*,":[210],"any":[216],"image.":[218],"Simulations":[219],"using":[220],"real":[221],"images,":[222],"obtained":[223,264],"Leicatrade":[226,267],"Optical":[227],"Microscope":[228],"DM":[229],"2500,":[230],"were":[231,235,272],"performed.":[232,274],"These":[233],"images":[234],"experts":[239],"ground":[244],"truth":[245],"performance":[253],"proposed":[256],"classifier.":[257],"Furthermore,":[258],"qualitative":[259],"comparisons":[260],"results":[263],"CW":[268],"4000":[269],"Karyo":[270],"software":[271],"also":[273]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}