{"id":"https://openalex.org/W2131719738","doi":"https://doi.org/10.1109/isbi.2008.4541031","title":"Quantitative genetic modeling of lateral ventricular shape and volume using multi-atlas fluid image alignment in twins","display_name":"Quantitative genetic modeling of lateral ventricular shape and volume using multi-atlas fluid image alignment in twins","publication_year":2008,"publication_date":"2008-05-01","ids":{"openalex":"https://openalex.org/W2131719738","doi":"https://doi.org/10.1109/isbi.2008.4541031","mag":"2131719738"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2008.4541031","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2008.4541031","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111975911","display_name":"Yi\u2010Yu Chou","orcid":null},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi-Yu Chou","raw_affiliation_strings":["UCLA Department of Neurology, Laboratory of Neuro Imaging, Los Angeles, CA, USA","Dept. of Neurology, Lab. of Neuro Imaging, UCLA, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA Department of Neurology, Laboratory of Neuro Imaging, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Dept. of Neurology, Lab. of Neuro Imaging, UCLA, Los Angeles, CA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053267424","display_name":"Natasha Lepor\u00e9","orcid":"https://orcid.org/0000-0002-8379-674X"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natasha Lepore","raw_affiliation_strings":["UCLA Department of Neurology, Laboratory of Neuro Imaging, Los Angeles, CA, USA","Dept. of Neurology, Lab. of Neuro Imaging, UCLA, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA Department of Neurology, Laboratory of Neuro Imaging, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Dept. of Neurology, Lab. of Neuro Imaging, UCLA, Los Angeles, CA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045129866","display_name":"Marina Barysheva","orcid":null},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marina Barysheva","raw_affiliation_strings":["UCLA Department of Neurology, Laboratory of Neuro Imaging, Los Angeles, CA, USA","Dept. of Neurology, Lab. of Neuro Imaging, UCLA, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA Department of Neurology, Laboratory of Neuro Imaging, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Dept. of Neurology, Lab. of Neuro Imaging, UCLA, Los Angeles, CA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ming-Chang Chiang","orcid":null},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming-Chang Chiang","raw_affiliation_strings":["UCLA Department of Neurology, Laboratory of Neuro Imaging, Los Angeles, CA, USA","Dept. of Neurology, Lab. of Neuro Imaging, UCLA, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA Department of Neurology, Laboratory of Neuro Imaging, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Dept. of Neurology, Lab. of Neuro Imaging, UCLA, Los Angeles, CA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006318043","display_name":"Katie L. McMahon","orcid":"https://orcid.org/0000-0002-6357-615X"},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Katie McMahon","raw_affiliation_strings":["Centre for Magnetic Resonance, University of Queensland, Brisbane, Australia","[Centre for Magnetic Resonance, University of Queensland, Brisbane, Australia]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Magnetic Resonance, University of Queensland, Brisbane, Australia","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"[Centre for Magnetic Resonance, University of Queensland, Brisbane, Australia]","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036061196","display_name":"Greig I. de Zubicaray","orcid":"https://orcid.org/0000-0003-4506-0579"},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Greig de Zubicaray","raw_affiliation_strings":["Centre for Magnetic Resonance, University of Queensland, Brisbane, Australia","[Centre for Magnetic Resonance, University of Queensland, Brisbane, Australia]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Magnetic Resonance, University of Queensland, Brisbane, Australia","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"[Centre for Magnetic Resonance, University of Queensland, Brisbane, Australia]","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108692749","display_name":"Matthew Meredith","orcid":null},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Matthew Meredith","raw_affiliation_strings":["Centre for Magnetic Resonance, University of Queensland, Brisbane, Australia","[Centre for Magnetic Resonance, University of Queensland, Brisbane, Australia]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Magnetic Resonance, University of Queensland, Brisbane, Australia","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"[Centre for Magnetic Resonance, University of Queensland, Brisbane, Australia]","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052245802","display_name":"Margaret J. Wright","orcid":"https://orcid.org/0000-0001-7133-4970"},"institutions":[{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Margaret Wright","raw_affiliation_strings":["Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia","institution_ids":["https://openalex.org/I217937681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102799042","display_name":"Arthur W. Toga","orcid":"https://orcid.org/0000-0003-1454-8643"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I2799798094","display_name":"UCLA Health","ror":"https://ror.org/01d88se56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur W. Toga","raw_affiliation_strings":["UCLA Department of Neurology, Laboratory of Neuro Imaging, Los Angeles, CA, USA","Laboratory of Neuro Imaging, UCLA Dept. of Neurology, Los Angeles, CA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA Department of Neurology, Laboratory of Neuro Imaging, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Laboratory of Neuro Imaging, UCLA Dept. of Neurology, Los Angeles, CA, U.S.A","institution_ids":["https://openalex.org/I2799798094","https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100606557","display_name":"Paul M. Thompson","orcid":"https://orcid.org/0000-0002-4720-8867"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I2799798094","display_name":"UCLA Health","ror":"https://ror.org/01d88se56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul M. Thompson","raw_affiliation_strings":["UCLA Department of Neurology, Laboratory of Neuro Imaging, Los Angeles, CA, USA","Laboratory of Neuro Imaging, UCLA Dept. of Neurology, Los Angeles, CA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA Department of Neurology, Laboratory of Neuro Imaging, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Laboratory of Neuro Imaging, UCLA Dept. of Neurology, Los Angeles, CA, U.S.A","institution_ids":["https://openalex.org/I2799798094","https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16513313,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":null,"first_page":"456","last_page":"459"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12417","display_name":"Morphological variations and asymmetry","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2608","display_name":"Geometry and Topology"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12417","display_name":"Morphological variations and asymmetry","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2608","display_name":"Geometry and Topology"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9695000052452087,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.965499997138977,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.640846848487854},{"id":"https://openalex.org/keywords/polygon-mesh","display_name":"Polygon mesh","score":0.6275496482849121},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5717177987098694},{"id":"https://openalex.org/keywords/parameterized-complexity","display_name":"Parameterized complexity","score":0.5125236511230469},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4921674132347107},{"id":"https://openalex.org/keywords/heritability","display_name":"Heritability","score":0.4641479253768921},{"id":"https://openalex.org/keywords/atlas","display_name":"Atlas (anatomy)","score":0.45464760065078735},{"id":"https://openalex.org/keywords/brain-atlas","display_name":"Brain atlas","score":0.45191699266433716},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.4432099461555481},{"id":"https://openalex.org/keywords/genetic-algorithm","display_name":"Genetic algorithm","score":0.421913743019104},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3609420955181122},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.32935887575149536},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22982004284858704},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.19696176052093506},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.19676727056503296},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.18478992581367493}],"concepts":[{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.640846848487854},{"id":"https://openalex.org/C31487907","wikidata":"https://www.wikidata.org/wiki/Q1154597","display_name":"Polygon mesh","level":2,"score":0.6275496482849121},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5717177987098694},{"id":"https://openalex.org/C165464430","wikidata":"https://www.wikidata.org/wiki/Q1570441","display_name":"Parameterized complexity","level":2,"score":0.5125236511230469},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4921674132347107},{"id":"https://openalex.org/C161890455","wikidata":"https://www.wikidata.org/wiki/Q1503548","display_name":"Heritability","level":2,"score":0.4641479253768921},{"id":"https://openalex.org/C2776673561","wikidata":"https://www.wikidata.org/wiki/Q655357","display_name":"Atlas (anatomy)","level":2,"score":0.45464760065078735},{"id":"https://openalex.org/C2780972224","wikidata":"https://www.wikidata.org/wiki/Q17047956","display_name":"Brain atlas","level":2,"score":0.45191699266433716},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.4432099461555481},{"id":"https://openalex.org/C8880873","wikidata":"https://www.wikidata.org/wiki/Q187787","display_name":"Genetic algorithm","level":2,"score":0.421913743019104},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3609420955181122},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.32935887575149536},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22982004284858704},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.19696176052093506},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.19676727056503296},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.18478992581367493},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.0},{"id":"https://openalex.org/C121684516","wikidata":"https://www.wikidata.org/wiki/Q7600677","display_name":"Computer graphics (images)","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2008.4541031","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2008.4541031","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","score":0.6100000143051147,"display_name":"Life in Land"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1577941315","https://openalex.org/W1994137501","https://openalex.org/W2059206901","https://openalex.org/W2080822231","https://openalex.org/W2099326256","https://openalex.org/W2141088880","https://openalex.org/W2143956675"],"related_works":["https://openalex.org/W3214912135","https://openalex.org/W4387252449","https://openalex.org/W4319337879","https://openalex.org/W2012519212","https://openalex.org/W4249039539","https://openalex.org/W1523541591","https://openalex.org/W2592984741","https://openalex.org/W2056259617","https://openalex.org/W1967068856","https://openalex.org/W1592689442"],"abstract_inverted_index":{"Despite":[0],"substantial":[1],"progress":[2],"in":[3,11,38],"measuring":[4],"the":[5,12,70,96,149],"3D":[6,124,159],"profile":[7],"of":[8,63,90,98,143],"anatomical":[9],"variations":[10],"human":[13],"brain,":[14,150],"their":[15,128],"genetic":[16,31,86,104,146,152],"and":[17,29,32,115,127,131],"environmental":[18,33,109,118,144],"causes":[19],"remain":[20],"enigmatic.":[21],"We":[22,43,83],"developed":[23],"an":[24],"automated":[25],"system":[26],"to":[27,53,79,94,102,112,154],"identify":[28],"map":[30],"effects":[34],"on":[35,148],"brain":[36,40,136],"structure":[37],"large":[39],"MRI":[41],"databases.":[42],"applied":[44],"our":[45],"multi-template":[46],"segmentation":[47,81],"approach":[48],"(\u201cMulti-Atlas":[49],"Fluid":[50],"Image":[51],"Alignment\u201d)":[52],"fluidly":[54],"propagate":[55],"hand-labeled":[56],"parameterized":[57],"surface":[58,92],"meshes":[59],"into":[60],"116":[61],"scans":[62],"twins":[64],"(60":[65],"identical,":[66],"56":[67],"fraternal),":[68],"labeling":[69],"lateral":[71],"ventricles.":[72],"Mesh":[73],"surfaces":[74],"were":[75],"averaged":[76],"within":[77],"subjects":[78],"minimize":[80],"error.":[82],"fitted":[84],"quantitative":[85],"models":[87,153],"at":[88],"each":[89,113],"30,000":[91],"points":[93],"measure":[95],"proportion":[97],"shape":[99],"variance":[100],"attributable":[101],"(1)":[103],"differences":[105],"among":[106],"subjects,":[107],"(2)":[108],"influences":[110,147],"unique":[111],"individual,":[114],"(3)":[116],"shared":[117],"effects.":[119],"Surface-based":[120],"statistical":[121],"maps":[122,139],"revealed":[123],"heritability":[125],"patterns,":[126],"significance,":[129],"with":[130],"without":[132],"adjustments":[133],"for":[134],"global":[135],"scale.":[137],"These":[138],"visualized":[140],"detailed":[141],"profiles":[142],"versus":[145],"extending":[151],"spatially":[155],"detailed,":[156],"automatically":[157],"computed,":[158],"maps.":[160]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
