{"id":"https://openalex.org/W2151560686","doi":"https://doi.org/10.1109/isbi.2008.4541006","title":"Towards high-throughput FLIM for protein-protein interaction screening of live cells and tissue microarrays","display_name":"Towards high-throughput FLIM for protein-protein interaction screening of live cells and tissue microarrays","publication_year":2008,"publication_date":"2008-05-01","ids":{"openalex":"https://openalex.org/W2151560686","doi":"https://doi.org/10.1109/isbi.2008.4541006","mag":"2151560686"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2008.4541006","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2008.4541006","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057992394","display_name":"Paul R. Barber","orcid":"https://orcid.org/0000-0002-8595-1141"},"institutions":[{"id":"https://openalex.org/I2801038905","display_name":"Mount Vernon Hospital","ror":"https://ror.org/04am5a125","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799786270","https://openalex.org/I2801038905"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P.R. Barber","raw_affiliation_strings":["Mount Vernon Hospital, University of Oxford, Northwood, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Vernon Hospital, University of Oxford, Northwood, UK","institution_ids":["https://openalex.org/I2801038905","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059432087","display_name":"Glenn Palen Pierce","orcid":null},"institutions":[{"id":"https://openalex.org/I2801038905","display_name":"Mount Vernon Hospital","ror":"https://ror.org/04am5a125","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799786270","https://openalex.org/I2801038905"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G.P. Pierce","raw_affiliation_strings":["Mount Vernon Hospital, University of Oxford, Northwood, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Vernon Hospital, University of Oxford, Northwood, UK","institution_ids":["https://openalex.org/I2801038905","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038869356","display_name":"Simon Ameer\u2010Beg","orcid":"https://orcid.org/0000-0001-5227-575X"},"institutions":[{"id":"https://openalex.org/I4210119896","display_name":"King's College School","ror":"https://ror.org/02bbqcn27","country_code":"GB","type":"education","lineage":["https://openalex.org/I4210119896"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S.M. Ameer-Beg","raw_affiliation_strings":["Randall Division of Cell & Molecular Biophysics, King''s College, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Randall Division of Cell & Molecular Biophysics, King''s College, UK","institution_ids":["https://openalex.org/I4210119896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107837738","display_name":"D.R. Matthews","orcid":null},"institutions":[{"id":"https://openalex.org/I4210119896","display_name":"King's College School","ror":"https://ror.org/02bbqcn27","country_code":"GB","type":"education","lineage":["https://openalex.org/I4210119896"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D.R. Matthews","raw_affiliation_strings":["Randall Division of Cell & Molecular Biophysics, King''s College, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Randall Division of Cell & Molecular Biophysics, King''s College, UK","institution_ids":["https://openalex.org/I4210119896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067662754","display_name":"Leo M. Carlin","orcid":"https://orcid.org/0000-0001-7172-5234"},"institutions":[{"id":"https://openalex.org/I4210119896","display_name":"King's College School","ror":"https://ror.org/02bbqcn27","country_code":"GB","type":"education","lineage":["https://openalex.org/I4210119896"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L.M. Carlin","raw_affiliation_strings":["Randall Division of Cell & Molecular Biophysics, King''s College, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Randall Division of Cell & Molecular Biophysics, King''s College, UK","institution_ids":["https://openalex.org/I4210119896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081925401","display_name":"Matthias Epple","orcid":"https://orcid.org/0000-0002-1641-7068"},"institutions":[{"id":"https://openalex.org/I4210119896","display_name":"King's College School","ror":"https://ror.org/02bbqcn27","country_code":"GB","type":"education","lineage":["https://openalex.org/I4210119896"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. Keppler","raw_affiliation_strings":["Randall Division of Cell & Molecular Biophysics, King''s College, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Randall Division of Cell & Molecular Biophysics, King''s College, UK","institution_ids":["https://openalex.org/I4210119896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110971585","display_name":"Muireann Kelleher","orcid":null},"institutions":[{"id":"https://openalex.org/I4210119896","display_name":"King's College School","ror":"https://ror.org/02bbqcn27","country_code":"GB","type":"education","lineage":["https://openalex.org/I4210119896"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. Kelleher","raw_affiliation_strings":["Randall Division of Cell & Molecular Biophysics, King''s College, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Randall Division of Cell & Molecular Biophysics, King''s College, UK","institution_ids":["https://openalex.org/I4210119896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003493938","display_name":"Frederic Festy","orcid":"https://orcid.org/0000-0002-3939-8437"},"institutions":[{"id":"https://openalex.org/I4210119896","display_name":"King's College School","ror":"https://ror.org/02bbqcn27","country_code":"GB","type":"education","lineage":["https://openalex.org/I4210119896"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"F. Festy","raw_affiliation_strings":["Randall Division of Cell & Molecular Biophysics, King''s College, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Randall Division of Cell & Molecular Biophysics, King''s College, UK","institution_ids":["https://openalex.org/I4210119896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055450638","display_name":"Cheryl Gillett","orcid":"https://orcid.org/0000-0003-3643-4057"},"institutions":[{"id":"https://openalex.org/I4210153400","display_name":"King's College Hospital","ror":"https://ror.org/044nptt90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210111135","https://openalex.org/I4210153400"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C. Gillett","raw_affiliation_strings":["Breast Tissue & Data Bank, King''s College, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Tissue & Data Bank, King''s College, UK","institution_ids":["https://openalex.org/I4210153400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110386370","display_name":"R. Springall","orcid":null},"institutions":[{"id":"https://openalex.org/I4210153400","display_name":"King's College Hospital","ror":"https://ror.org/044nptt90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210111135","https://openalex.org/I4210153400"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. Springall","raw_affiliation_strings":["Breast Tissue & Data Bank, King''s College, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Tissue & Data Bank, King''s College, UK","institution_ids":["https://openalex.org/I4210153400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012486076","display_name":"Tony Ng","orcid":"https://orcid.org/0000-0003-3894-5619"},"institutions":[{"id":"https://openalex.org/I4210119896","display_name":"King's College School","ror":"https://ror.org/02bbqcn27","country_code":"GB","type":"education","lineage":["https://openalex.org/I4210119896"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"T.C. Ng","raw_affiliation_strings":["Randall Division of Cell & Molecular Biophysics, King''s College, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Randall Division of Cell & Molecular Biophysics, King''s College, UK","institution_ids":["https://openalex.org/I4210119896"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044642169","display_name":"Borivoj Vojnovic","orcid":"https://orcid.org/0000-0001-9013-3816"},"institutions":[{"id":"https://openalex.org/I2801038905","display_name":"Mount Vernon Hospital","ror":"https://ror.org/04am5a125","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799786270","https://openalex.org/I2801038905"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"B. Vojnovic","raw_affiliation_strings":["Mount Vernon Hospital, University of Oxford, Northwood, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Vernon Hospital, University of Oxford, Northwood, UK","institution_ids":["https://openalex.org/I2801038905","https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1389,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.56327879,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"356","last_page":"359"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/f\u00f6rster-resonance-energy-transfer","display_name":"F\u00f6rster resonance energy transfer","score":0.8676093816757202},{"id":"https://openalex.org/keywords/fluorescence-lifetime-imaging-microscopy","display_name":"Fluorescence-lifetime imaging microscopy","score":0.661772608757019},{"id":"https://openalex.org/keywords/modular-design","display_name":"Modular design","score":0.5775119066238403},{"id":"https://openalex.org/keywords/throughput","display_name":"Throughput","score":0.5704474449157715},{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.5323349237442017},{"id":"https://openalex.org/keywords/fluorescence-microscope","display_name":"Fluorescence microscope","score":0.4883255660533905},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.4641045331954956},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.462301641702652},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.43872344493865967},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.4350488483905792},{"id":"https://openalex.org/keywords/microscope","display_name":"Microscope","score":0.4250972867012024},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.18801993131637573},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.09850513935089111}],"concepts":[{"id":"https://openalex.org/C96305047","wikidata":"https://www.wikidata.org/wiki/Q367473","display_name":"F\u00f6rster resonance energy transfer","level":3,"score":0.8676093816757202},{"id":"https://openalex.org/C57477423","wikidata":"https://www.wikidata.org/wiki/Q1434196","display_name":"Fluorescence-lifetime imaging microscopy","level":3,"score":0.661772608757019},{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.5775119066238403},{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.5704474449157715},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.5323349237442017},{"id":"https://openalex.org/C169274487","wikidata":"https://www.wikidata.org/wiki/Q840211","display_name":"Fluorescence microscope","level":3,"score":0.4883255660533905},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4641045331954956},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.462301641702652},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.43872344493865967},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.4350488483905792},{"id":"https://openalex.org/C67649825","wikidata":"https://www.wikidata.org/wiki/Q196538","display_name":"Microscope","level":2,"score":0.4250972867012024},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.18801993131637573},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.09850513935089111},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1109/isbi.2008.4541006","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2008.4541006","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"},{"id":"pmh:oai:eprints.gla.ac.uk:221980","is_oa":false,"landing_page_url":"http://eprints.gla.ac.uk/221980/","pdf_url":null,"source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":false,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conference Proceedings"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/151e545b-4af3-4970-8f81-88784b93ae38","is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/151e545b-4af3-4970-8f81-88784b93ae38","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Barber , P R , Pierce , G P , Ameer-Beg , S , Matthews , D , Carlin , L , Keppler , M , Festy , F , Gillett , C , Springall , R , Ng , T &amp; Vojnovic , B 2008 , Towards high-throughput FLIM for protein-protein interaction screening of live cells and tissue microarrays . in Biomedical Imaging: From Nano to Macro . pp. 356-359 . https://doi.org/10.1109/ISBI.2008.4541006","raw_type":"contributionToPeriodical"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:d067185a-d95c-4470-9a3d-291b9a957e2d","is_oa":false,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:d067185a-d95c-4470-9a3d-291b9a957e2d","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symplectic Elements at Oxford","raw_type":"Conference"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/7","score":0.8500000238418579,"display_name":"Affordable and clean energy"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1981101976","https://openalex.org/W1990339779","https://openalex.org/W2025155947","https://openalex.org/W2034525269","https://openalex.org/W2061746732","https://openalex.org/W2078804581","https://openalex.org/W2086472052","https://openalex.org/W2087810003","https://openalex.org/W2096791952","https://openalex.org/W2112246628","https://openalex.org/W2117524604","https://openalex.org/W2125551363","https://openalex.org/W2134073082","https://openalex.org/W2154008781","https://openalex.org/W2167158605","https://openalex.org/W2171037141"],"related_works":["https://openalex.org/W3006392130","https://openalex.org/W2115937329","https://openalex.org/W4211107619","https://openalex.org/W2043196634","https://openalex.org/W1991368749","https://openalex.org/W4394873536","https://openalex.org/W2161433272","https://openalex.org/W2100235831","https://openalex.org/W2027597586","https://openalex.org/W2037608610"],"abstract_inverted_index":{"Studying":[0],"cellular":[1],"protein-protein":[2],"interactions":[3],"in":[4],"situ":[5],"requires":[6],"a":[7,64],"technique":[8],"such":[9],"as":[10],"fluorescence":[11,30,55],"resonance":[12],"energy":[13],"transfer":[14],"(FRET)":[15],"which":[16],"is":[17,25],"sensitive":[18],"on":[19],"the":[20,29,33,85],"nanometer":[21],"scale.":[22],"Observing":[23],"FRET":[24],"significantly":[26],"simplified":[27],"if":[28],"lifetime":[31,56],"of":[32,79],"donor":[34],"can":[35],"be":[36],"monitored.":[37],"Results":[38],"from":[39,48],"live":[40],"cells":[41],"and":[42,61,67,77],"tissue":[43],"micro":[44],"arrays":[45],"are":[46],"presented":[47],"an":[49],"automated":[50],"microscope":[51],"incorporating":[52],"time-domain":[53],"TCSPC":[54],"imaging":[57],"(FLIM).":[58],"Novel":[59],"hardware":[60],"software":[62],"with":[63],"modular":[65],"approach":[66],"scripting":[68],"abilities":[69],"allow":[70],"us":[71],"to":[72,81],"work":[73],"towards":[74],"speed-optimized":[75],"acquisition":[76],"ease":[78],"use":[80],"bring":[82],"FLIM":[83],"into":[84],"high-throughput":[86],"regime.":[87]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}
