{"id":"https://openalex.org/W2121277183","doi":"https://doi.org/10.1109/isbi.2008.4540958","title":"Axonal bouton modeling, detection and distribution analysis for the study of neural circuit organization and plasticity","display_name":"Axonal bouton modeling, detection and distribution analysis for the study of neural circuit organization and plasticity","publication_year":2008,"publication_date":"2008-05-01","ids":{"openalex":"https://openalex.org/W2121277183","doi":"https://doi.org/10.1109/isbi.2008.4540958","mag":"2121277183"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2008.4540958","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2008.4540958","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5098068491","display_name":"Christina A. Hallock","orcid":null},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina A. Hallock","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA, USA","Dept. of Electr. & Comput. Eng., Carnegie-Mellon Univ., Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"Dept. of Electr. & Comput. Eng., Carnegie-Mellon Univ., Pittsburgh, PA","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078003726","display_name":"Inci Ozgunes","orcid":null},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Inci Ozgunes","raw_affiliation_strings":["Department of Biomedical Engineering and Center for Bioimage Informatics, Carnegie Mellon University, Pittsburgh, PA, USA","Dept. of Biomedical Engineering and Center for Bioimage Informatics, Carnegie Mellon University, Pittsburgh, PA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and Center for Bioimage Informatics, Carnegie Mellon University, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"Dept. of Biomedical Engineering and Center for Bioimage Informatics, Carnegie Mellon University, Pittsburgh, PA, U.S.A","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050181755","display_name":"Ramamurthy Bhagavatula","orcid":null},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramamurthy Bhagavatula","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA, USA","Department of Electrical and Computer Engineering Carnegie Mellon University Pittsburgh PA U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering Carnegie Mellon University Pittsburgh PA U.S.A","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041274548","display_name":"Gustavo K. Rohde","orcid":"https://orcid.org/0000-0003-1703-9035"},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gustavo K. Rohde","raw_affiliation_strings":["Department of Biomedical Engineering and Center for Bioimage Informatics, Carnegie Mellon University, Pittsburgh, PA, USA","Dept. of Biomedical Engineering and Center for Bioimage Informatics, Carnegie Mellon University, Pittsburgh, PA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and Center for Bioimage Informatics, Carnegie Mellon University, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"Dept. of Biomedical Engineering and Center for Bioimage Informatics, Carnegie Mellon University, Pittsburgh, PA, U.S.A","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022245961","display_name":"Justin C. Crowley","orcid":null},"institutions":[{"id":"https://openalex.org/I4210086114","display_name":"Center for the Neural Basis of Cognition","ror":"https://ror.org/00jfeg660","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210086114","https://openalex.org/I74973139"]},{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin C. Crowley","raw_affiliation_strings":["Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA, USA","Dept. of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I4210086114","https://openalex.org/I74973139"]},{"raw_affiliation_string":"Dept. of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA, U.S.A","institution_ids":["https://openalex.org/I4210086114"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040290389","display_name":"Christina E. Onorato","orcid":null},"institutions":[{"id":"https://openalex.org/I4210086114","display_name":"Center for the Neural Basis of Cognition","ror":"https://ror.org/00jfeg660","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210086114","https://openalex.org/I74973139"]},{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina E. Onorato","raw_affiliation_strings":["Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA, USA","Dept. of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I4210086114","https://openalex.org/I74973139"]},{"raw_affiliation_string":"Dept. of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA, U.S.A","institution_ids":["https://openalex.org/I4210086114"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098171401","display_name":"Abhay Mavalankar","orcid":null},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhay Mavalankar","raw_affiliation_strings":["Department of Electrical and Compute Engineeringr, Carnegie Mellon University, Pittsburgh, PA, USA","Department of Electrical and Computer Engineering Carnegie Mellon University Pittsburgh PA U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Compute Engineeringr, Carnegie Mellon University, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering Carnegie Mellon University Pittsburgh PA U.S.A","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035312617","display_name":"Amina Chebira","orcid":null},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amina Chebira","raw_affiliation_strings":["Department of Biomedical Engineering and Center for Bioimage Informatics, Carnegie Mellon University, Pittsburgh, PA, USA","Dept. of Biomedical Engineering and Center for Bioimage Informatics, Carnegie Mellon University, Pittsburgh, PA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and Center for Bioimage Informatics, Carnegie Mellon University, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"Dept. of Biomedical Engineering and Center for Bioimage Informatics, Carnegie Mellon University, Pittsburgh, PA, U.S.A","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102149673","display_name":"Chuen Hwa Tan","orcid":null},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chuen Hwa Tan","raw_affiliation_strings":["Department of Biomedical Engineering and Center for Bioimage Informatics, Carnegie Mellon University, Pittsburgh, PA, USA","Dept. of Biomedical Engineering and Center for Bioimage Informatics, Carnegie Mellon University, Pittsburgh, PA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and Center for Bioimage Informatics, Carnegie Mellon University, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"Dept. of Biomedical Engineering and Center for Bioimage Informatics, Carnegie Mellon University, Pittsburgh, PA, U.S.A","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076407181","display_name":"Markus P\u00fcschel","orcid":"https://orcid.org/0000-0001-8834-8551"},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Markus Puschel","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA, USA","Department of Electrical and Computer Engineering Carnegie Mellon University Pittsburgh PA U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering Carnegie Mellon University Pittsburgh PA U.S.A","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101863660","display_name":"Jelena Kova\u010devi\u0107","orcid":"https://orcid.org/0000-0003-0139-2803"},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jelena Kovacevic","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA, USA","Dept. of Biomedical Engineering and Center for Bioimage Informatics, Carnegie Mellon University, Pittsburgh, PA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"Dept. of Biomedical Engineering and Center for Bioimage Informatics, Carnegie Mellon University, Pittsburgh, PA, U.S.A","institution_ids":["https://openalex.org/I74973139"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":null,"first_page":"165","last_page":"168"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10427","display_name":"Visual perception and processing mechanisms","score":0.9850000143051147,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.6074519157409668},{"id":"https://openalex.org/keywords/plasticity","display_name":"Plasticity","score":0.49874377250671387},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.49820470809936523},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"Neuroplasticity","score":0.4839237332344055},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.4448379576206207},{"id":"https://openalex.org/keywords/neurophysiology","display_name":"Neurophysiology","score":0.42025452852249146},{"id":"https://openalex.org/keywords/biological-neural-network","display_name":"Biological neural network","score":0.41202133893966675},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.26891085505485535},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1794295608997345},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.16054177284240723}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6074519157409668},{"id":"https://openalex.org/C79186407","wikidata":"https://www.wikidata.org/wiki/Q472074","display_name":"Plasticity","level":2,"score":0.49874377250671387},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49820470809936523},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.4839237332344055},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.4448379576206207},{"id":"https://openalex.org/C152478114","wikidata":"https://www.wikidata.org/wiki/Q660910","display_name":"Neurophysiology","level":2,"score":0.42025452852249146},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.41202133893966675},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.26891085505485535},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1794295608997345},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.16054177284240723},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/isbi.2008.4540958","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2008.4540958","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro","raw_type":"proceedings-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.156.9770","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.156.9770","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://andrew.cmu.edu/user/jelenak/Repository/08_ISBI_Boutons.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.570.542","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.570.542","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.contrib.andrew.cmu.edu/~gustavor/Hallock_ISBI_08.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1621973621","https://openalex.org/W1646910542","https://openalex.org/W1672439543","https://openalex.org/W1821468701","https://openalex.org/W1974411081","https://openalex.org/W2041812800","https://openalex.org/W2043606478","https://openalex.org/W2118323461","https://openalex.org/W2145656910","https://openalex.org/W2157035009"],"related_works":["https://openalex.org/W2016937053","https://openalex.org/W2915014248","https://openalex.org/W2372312044","https://openalex.org/W2098828199","https://openalex.org/W4225160247","https://openalex.org/W4255944537","https://openalex.org/W2083867962","https://openalex.org/W4246061543","https://openalex.org/W3124734823","https://openalex.org/W3164952982"],"abstract_inverted_index":{"We":[0,61,88,158],"propose":[1,62],"a":[2,101,116,134,161,171,185],"novel":[3,162],"method":[4,163],"for":[5,23,66,71,104,133],"axonal":[6,33,67],"bouton":[7,20,105],"modeling":[8],"and":[9,30,54,77,97,107,168,176],"automated":[10],"detection":[11,106,118,132],"in":[12,55,73,82],"populations":[13],"of":[14,26,39,51,79,85,131,137,146,155,170,173],"labeled":[15,174,186],"neurons,":[16],"as":[17,19,100,115],"well":[18],"distribution":[21,172],"analysis":[22],"the":[24,36,49,80,83,86,91,95,111,124,129,166],"study":[25],"neural":[27,40,52,58],"circuit":[28,59],"organization":[29,50],"plasticity.":[31],"Since":[32],"boutons":[34,68,147,175],"are":[35],"presynaptic":[37],"specializations":[38],"synapses,":[41],"their":[42],"locations":[43],"can":[44,122,143],"be":[45],"used":[46],"to":[47,127,164,184],"determine":[48],"circuitry,":[53],"time-lapse":[56],"studies,":[57],"dynamics.":[60],"simple":[63],"geometric":[64],"models":[65],"that":[69],"account":[70],"variations":[72],"size,":[74],"position,":[75],"rotation":[76],"curvature":[78],"axon":[81],"vicinity":[84],"bouton.":[87],"then":[89],"use":[90],"normalized":[92],"cross-correlation":[93],"between":[94],"model":[96],"image":[98],"data":[99,187],"test":[102],"statistic":[103],"position":[108],"estimation.":[109],"Thus,":[110],"problem":[112,119],"is":[113],"cast":[114],"statistical":[117],"where":[120],"we":[121,142,177],"tune":[123],"algorithm":[125],"parameters":[126],"maximize":[128],"probability":[130,136],"given":[135],"false":[138,150],"alarm.":[139],"For":[140],"example,":[141],"detect":[144],"81%":[145],"with":[148],"9%":[149],"alarm":[151],"from":[152],"noisy,":[153],"out":[154],"focus,":[156],"images.":[157],"also":[159],"present":[160],"characterize":[165],"orientation":[167],"elongation":[169],"demonstrate":[178],"its":[179],"performance":[180],"by":[181],"applying":[182],"it":[183],"set.":[188]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}