{"id":"https://openalex.org/W1578276312","doi":"https://doi.org/10.1109/isbi.2006.1625043","title":"The Epitheliome Project: Multiscale Agent-Based Modeling of Epithelial Cells","display_name":"The Epitheliome Project: Multiscale Agent-Based Modeling of Epithelial Cells","publication_year":2006,"publication_date":"2006-05-25","ids":{"openalex":"https://openalex.org/W1578276312","doi":"https://doi.org/10.1109/isbi.2006.1625043","mag":"1578276312"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2006.1625043","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2006.1625043","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3rd IEEE International Symposium on Biomedical Imaging: Macro to Nano, 2006.","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007726301","display_name":"R. H. Smallwood","orcid":"https://orcid.org/0000-0003-0134-0632"},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"R. Smallwood","raw_affiliation_strings":["Department of Computer Science, University of Sheffield, Sheffield, UK","Dept. of Comput. Sci., Sheffield Univ., , UK"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Sheffield, Sheffield, UK","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Dept. of Comput. Sci., Sheffield Univ., , UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031576868","display_name":"Mike Holcombe","orcid":null},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. Holcombe","raw_affiliation_strings":["Department of Computer Science, University of Sheffield, Sheffield, UK","Dept. of Comput. Sci., Sheffield Univ., , UK"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Sheffield, Sheffield, UK","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Dept. of Comput. Sci., Sheffield Univ., , UK","institution_ids":["https://openalex.org/I91136226"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007726301"],"corresponding_institution_ids":["https://openalex.org/I91136226"],"apc_list":null,"apc_paid":null,"fwci":0.3724,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.57121304,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"816","last_page":"819"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9876999855041504,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9865000247955322,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adherens-junction","display_name":"Adherens junction","score":0.8586697578430176},{"id":"https://openalex.org/keywords/epithelial-tissue","display_name":"Epithelial tissue","score":0.6214154958724976},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"Tissue engineering","score":0.5198493599891663},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.48480144143104553},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.48229220509529114},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.43743765354156494},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.4370858669281006},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3845493793487549},{"id":"https://openalex.org/keywords/cadherin","display_name":"Cadherin","score":0.3265211582183838},{"id":"https://openalex.org/keywords/epithelium","display_name":"Epithelium","score":0.2897002696990967}],"concepts":[{"id":"https://openalex.org/C201508349","wikidata":"https://www.wikidata.org/wiki/Q45173","display_name":"Adherens junction","level":4,"score":0.8586697578430176},{"id":"https://openalex.org/C2910796902","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelial tissue","level":3,"score":0.6214154958724976},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.5198493599891663},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.48480144143104553},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48229220509529114},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.43743765354156494},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4370858669281006},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3845493793487549},{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.3265211582183838},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.2897002696990967},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2006.1625043","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2006.1625043","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3rd IEEE International Symposium on Biomedical Imaging: Macro to Nano, 2006.","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.49000000953674316}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1580131439","https://openalex.org/W1996449803","https://openalex.org/W2046314718","https://openalex.org/W2126087366","https://openalex.org/W2130929414","https://openalex.org/W2141211778","https://openalex.org/W2497987513","https://openalex.org/W6634588679"],"related_works":["https://openalex.org/W2123863025","https://openalex.org/W2406356237","https://openalex.org/W3173336874","https://openalex.org/W2010710842","https://openalex.org/W2037222832","https://openalex.org/W4245622537","https://openalex.org/W4250648966","https://openalex.org/W2224875367","https://openalex.org/W2068374025","https://openalex.org/W4245142356"],"abstract_inverted_index":{"The":[0,109,137],"aim":[1],"of":[2,12,18,61,67,76,79,85,91,103,106,111,115,122,134],"the":[3,16,41,56,74,77,92,104],"Epitheliome":[4],"Project":[5],"is":[6,27,94,99,118,141],"to":[7,29,50,52,65],"develop":[8],"a":[9,101,112,119],"computational":[10],"model":[11,90,121],"cell":[13,86,93],"behaviour":[14],"within":[15],"context":[17],"tissue":[19,30,97],"architecture,":[20],"differentiation,":[21],"wound":[22],"repair":[23],"and":[24,37,47,71,96,124],"malignancy.":[25],"Integration":[26],"central":[28],"development":[31,66,78,98],"for":[32],"skin,":[33],"integration":[34,72],"between":[35],"mesenchymal":[36],"epithelial":[38],"tissue;":[39,54],"at":[40,55],"physical":[42],"level":[43,58],"from":[44,59],"focal":[45],"adhesions":[46],"adherens":[48],"junctions":[49],"cytoskeleton":[51],"whole":[53],"signaling":[57],"control":[60],"gene":[62],"expression":[63],"through":[64],"gradients":[68],"controlling":[69],"histodifferentiation;":[70],"in":[73],"sense":[75],"tissues":[80],"as":[81],"an":[82],"emergent":[83],"property":[84],"behaviour.":[87],"An":[88],"individual-based":[89],"used,":[95],"thus":[100],"result":[102],"interaction":[105],"individual":[107,116,125],"cells.":[108],"limit":[110],"large":[113],"number":[114],"cells":[117,126],"continuum":[120,129],"tissue,":[123],"can":[127],"contain":[128],"or":[130],"differential":[131],"equation":[132],"models":[133],"cellular":[135],"mechanisms.":[136],"hierarchical":[138],"modeling":[139],"paradigm":[140],"described":[142]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}