{"id":"https://openalex.org/W2115804750","doi":"https://doi.org/10.1109/isbi.2006.1624976","title":"A Shape Analysis Method to Detect Dendritic Spine in 3D Optical Microscopy Image","display_name":"A Shape Analysis Method to Detect Dendritic Spine in 3D Optical Microscopy Image","publication_year":2006,"publication_date":"2006-05-25","ids":{"openalex":"https://openalex.org/W2115804750","doi":"https://doi.org/10.1109/isbi.2006.1624976","mag":"2115804750"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2006.1624976","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2006.1624976","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3rd IEEE International Symposium on Biomedical Imaging: Macro to Nano, 2006.","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104023584","display_name":"Xiaoyin Xu","orcid":null},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoyin Xu","raw_affiliation_strings":["Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA","Harvard Center for Neurodegeneration and Repair, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Harvard Center for Neurodegeneration and Repair, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023190435","display_name":"Jie Cheng","orcid":"https://orcid.org/0000-0002-7620-4507"},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Cheng","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Northeastern University, Boston, MA, USA","Harvard Center for Neurodegeneration and Repair, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Northeastern University, Boston, MA, USA","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"Harvard Center for Neurodegeneration and Repair, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027061259","display_name":"Rochelle M. Witt","orcid":"https://orcid.org/0000-0001-9099-6398"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.M. Witt","raw_affiliation_strings":["Department of Neurobiology, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043679513","display_name":"Bernardo L. Sabatini","orcid":"https://orcid.org/0000-0003-0095-9177"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B.L. Sabatini","raw_affiliation_strings":["Department of Neurobiology, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015077092","display_name":"Stephen T.C. Wong","orcid":"https://orcid.org/0000-0001-9188-6502"},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.T.C. Wong","raw_affiliation_strings":["Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA","Harvard Center for Neurodegeneration and Repair, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Harvard Center for Neurodegeneration and Repair, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8178,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.66473891,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"75","issue":null,"first_page":"554","last_page":"557"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dendritic-spine","display_name":"Dendritic spine","score":0.8844398260116577},{"id":"https://openalex.org/keywords/spine","display_name":"SPINE (molecular biology)","score":0.6081352829933167},{"id":"https://openalex.org/keywords/confocal-laser-scanning-microscopy","display_name":"Confocal laser scanning microscopy","score":0.5028101801872253},{"id":"https://openalex.org/keywords/boundary","display_name":"Boundary (topology)","score":0.5016326904296875},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.48247841000556946},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.4566257894039154},{"id":"https://openalex.org/keywords/dendrite","display_name":"Dendrite (mathematics)","score":0.44172921776771545},{"id":"https://openalex.org/keywords/optical-microscope","display_name":"Optical microscope","score":0.4328049123287201},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.35758110880851746},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.352694571018219},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.337741494178772},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.331228107213974},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.3302467465400696},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.18737491965293884},{"id":"https://openalex.org/keywords/scanning-electron-microscope","display_name":"Scanning electron microscope","score":0.16826751828193665},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1659432351589203},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.1633487045764923},{"id":"https://openalex.org/keywords/geometry","display_name":"Geometry","score":0.1538279950618744},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.14081600308418274},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.12757766246795654},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.07531914114952087}],"concepts":[{"id":"https://openalex.org/C174884520","wikidata":"https://www.wikidata.org/wiki/Q902079","display_name":"Dendritic spine","level":3,"score":0.8844398260116577},{"id":"https://openalex.org/C205383261","wikidata":"https://www.wikidata.org/wiki/Q7392570","display_name":"SPINE (molecular biology)","level":2,"score":0.6081352829933167},{"id":"https://openalex.org/C88412794","wikidata":"https://www.wikidata.org/wiki/Q902045","display_name":"Confocal laser scanning microscopy","level":2,"score":0.5028101801872253},{"id":"https://openalex.org/C62354387","wikidata":"https://www.wikidata.org/wiki/Q875399","display_name":"Boundary (topology)","level":2,"score":0.5016326904296875},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.48247841000556946},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4566257894039154},{"id":"https://openalex.org/C84248122","wikidata":"https://www.wikidata.org/wiki/Q5256671","display_name":"Dendrite (mathematics)","level":2,"score":0.44172921776771545},{"id":"https://openalex.org/C77017923","wikidata":"https://www.wikidata.org/wiki/Q912313","display_name":"Optical microscope","level":3,"score":0.4328049123287201},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.35758110880851746},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.352694571018219},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.337741494178772},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.331228107213974},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3302467465400696},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.18737491965293884},{"id":"https://openalex.org/C26771246","wikidata":"https://www.wikidata.org/wiki/Q321095","display_name":"Scanning electron microscope","level":2,"score":0.16826751828193665},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1659432351589203},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.1633487045764923},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.1538279950618744},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.14081600308418274},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.12757766246795654},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.07531914114952087},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2006.1624976","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2006.1624976","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3rd IEEE International Symposium on Biomedical Imaging: Macro to Nano, 2006.","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.41999998688697815,"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1859826371","https://openalex.org/W1980574091","https://openalex.org/W1995589239","https://openalex.org/W2011209444","https://openalex.org/W2045331793","https://openalex.org/W2061464631","https://openalex.org/W2083060092","https://openalex.org/W2124683806","https://openalex.org/W2145768048","https://openalex.org/W2399193266","https://openalex.org/W6712999928"],"related_works":["https://openalex.org/W2169505641","https://openalex.org/W1996493542","https://openalex.org/W2136747326","https://openalex.org/W3132088562","https://openalex.org/W4317935580","https://openalex.org/W2120160245","https://openalex.org/W2528820646","https://openalex.org/W1989838035","https://openalex.org/W4285601116","https://openalex.org/W2056677165"],"abstract_inverted_index":{"Dendritic":[0],"spines":[1,33,55,58,77,85],"play":[2],"an":[3,45],"important":[4],"role":[5],"in":[6,101],"synaptic":[7],"transmission.":[8],"Spines":[9],"are":[10,21,34],"small":[11],"protrusions":[12],"formed":[13],"on":[14,50],"the":[15,60,74,82,93,98,105,114,117],"shafts":[16],"of":[17,23,30,76,104,116],"dendrites":[18,31,61],"and":[19,32,38,56,78,86],"they":[20],"manifest":[22],"many":[24],"neurological":[25],"conditions.":[26],"Three":[27],"dimensional":[28],"images":[29],"obtained":[35],"by":[36],"confocal":[37],"two-photon":[39],"laser":[40],"scanning":[41],"microscopy.":[42],"We":[43,108],"present":[44],"image":[46],"processing":[47],"method":[48,66,118],"based":[49],"shape":[51],"analysis":[52],"to":[53,71,112],"detect":[54],"separate":[57],"from":[59],"for":[62],"quantitative":[63],"study.":[64],"The":[65,88],"applies":[67],"two":[68],"grassfire":[69,106],"procedures":[70],"first":[72],"find":[73],"tips":[75],"then":[79],"reversely":[80],"locate":[81],"boundary":[83,89],"between":[84],"dendrites.":[87],"is":[90],"determined":[91],"as":[92],"propagation":[94],"front":[95],"that":[96],"undergoes":[97],"maximum":[99],"change":[100],"plane":[102],"area":[103],"procedure.":[107],"use":[109],"real":[110],"data":[111],"demonstrate":[113],"performance":[115]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
