{"id":"https://openalex.org/W2158193149","doi":"https://doi.org/10.1109/isbi.2006.1624939","title":"Automatic Morphological Assessment in a Transgenic CACNA1A Knockin Migraine Mouse Model in In-Vivo High-Resolution MRM","display_name":"Automatic Morphological Assessment in a Transgenic CACNA1A Knockin Migraine Mouse Model in In-Vivo High-Resolution MRM","publication_year":2006,"publication_date":"2006-05-25","ids":{"openalex":"https://openalex.org/W2158193149","doi":"https://doi.org/10.1109/isbi.2006.1624939","mag":"2158193149"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2006.1624939","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2006.1624939","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3rd IEEE International Symposium on Biomedical Imaging: Macro to Nano, 2006.","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041535149","display_name":"Roald van der Landen","orcid":null},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"R. van der Landen","raw_affiliation_strings":["Department of Radiology, division of image processing, Leiden University Medical Center, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, division of image processing, Leiden University Medical Center, Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069149096","display_name":"Rob C. G. van de Ven","orcid":null},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"R.C.G. van de Ven","raw_affiliation_strings":["Department of Human Genetics, Leiden University Medical Center, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Leiden University Medical Center, Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088561967","display_name":"Louise van der Weerd","orcid":"https://orcid.org/0000-0002-5997-2125"},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"L. van der Weerd","raw_affiliation_strings":["Department of Anatomy, Leiden University Medical Center, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Leiden University Medical Center, Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089380130","display_name":"Mariann Fodor","orcid":"https://orcid.org/0000-0002-1089-3899"},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M. Fodor","raw_affiliation_strings":["Department of Anatomy, Leiden University Medical Center, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Leiden University Medical Center, Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110463814","display_name":"R.R. Frants","orcid":null},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"R.R. Frants","raw_affiliation_strings":["Department of Human Genetics, Leiden University Medical Center, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Leiden University Medical Center, Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003293171","display_name":"Robert E. Poelmann","orcid":"https://orcid.org/0000-0002-9684-3007"},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"R.E. Poelmann","raw_affiliation_strings":["Department of Anatomy, Leiden University Medical Center, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Leiden University Medical Center, Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012664216","display_name":"Arn M. J. M. van den Maagdenberg","orcid":"https://orcid.org/0000-0002-9310-5535"},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A.M.J.M. van den Maagdenberg","raw_affiliation_strings":["Department of Neurology, Leiden University Medical Center, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Leiden University Medical Center, Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028379363","display_name":"Johan H. C. Reiber","orcid":"https://orcid.org/0000-0002-0387-6417"},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J.H.C. Reiber","raw_affiliation_strings":["Department of Radiology, division of image processing, Leiden University Medical Center, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, division of image processing, Leiden University Medical Center, Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008766623","display_name":"Mark A. van Buchem","orcid":"https://orcid.org/0000-0003-1881-1998"},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M.A. van Buchem","raw_affiliation_strings":["Department of Radiology, Leiden University Medical Center, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Leiden University Medical Center, Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025917571","display_name":"Faiza Admiraal\u2010Behloul","orcid":null},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"F. Admiraal-Behloul","raw_affiliation_strings":["Department of Radiology, division of image processing, Leiden University Medical Center, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, division of image processing, Leiden University Medical Center, Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1673,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.55870863,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"406","last_page":"409"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.982699990272522,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.5536068677902222},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.5470453500747681},{"id":"https://openalex.org/keywords/genetically-modified-mouse","display_name":"Genetically modified mouse","score":0.5373827815055847},{"id":"https://openalex.org/keywords/brain-morphometry","display_name":"Brain morphometry","score":0.5204517841339111},{"id":"https://openalex.org/keywords/transgene","display_name":"Transgene","score":0.5079723000526428},{"id":"https://openalex.org/keywords/white-matter","display_name":"White matter","score":0.47352907061576843},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.4575381278991699},{"id":"https://openalex.org/keywords/genetic-model","display_name":"Genetic model","score":0.43868398666381836},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.4318539500236511},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.42518797516822815},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.3653339445590973},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.35799023509025574},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.34662097692489624},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.288221538066864},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.22815603017807007},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.22779175639152527},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.12702882289886475},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10420212149620056}],"concepts":[{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5536068677902222},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.5470453500747681},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5373827815055847},{"id":"https://openalex.org/C145940234","wikidata":"https://www.wikidata.org/wiki/Q4955830","display_name":"Brain morphometry","level":3,"score":0.5204517841339111},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5079723000526428},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.47352907061576843},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4575381278991699},{"id":"https://openalex.org/C2992519594","wikidata":"https://www.wikidata.org/wiki/Q870433","display_name":"Genetic model","level":3,"score":0.43868398666381836},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4318539500236511},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42518797516822815},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3653339445590973},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35799023509025574},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34662097692489624},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.288221538066864},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22815603017807007},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22779175639152527},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.12702882289886475},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10420212149620056}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2006.1624939","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2006.1624939","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3rd IEEE International Symposium on Biomedical Imaging: Macro to Nano, 2006.","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W2025197615","https://openalex.org/W2045404628","https://openalex.org/W2063829584","https://openalex.org/W2105202736","https://openalex.org/W2113283292","https://openalex.org/W2115077250"],"related_works":["https://openalex.org/W2407241705","https://openalex.org/W2064668712","https://openalex.org/W2158124286","https://openalex.org/W1973459962","https://openalex.org/W2398991683","https://openalex.org/W2057436807","https://openalex.org/W1973252707","https://openalex.org/W2070974215","https://openalex.org/W2030084515","https://openalex.org/W1536426327"],"abstract_inverted_index":{"Because":[0],"of":[1,28,41,49,54,102,114],"its":[2,17,97],"close":[3],"genetic":[4,31,44],"and":[5,96,112,119,127],"physiological":[6],"similarities":[7],"to":[8,99],"humans,":[9],"as":[10,12,63],"well":[11],"the":[13,22,25,38,47,79,115,120],"ease":[14],"with":[15,58],"which":[16],"genome":[18],"can":[19,74],"be":[20],"manipulated,":[21],"mouse":[23,108],"became":[24,68],"mammalian":[26],"model":[27],"choice":[29],"for":[30,130],"research.":[32],"A":[33],"first":[34],"step":[35],"in":[36,78,105],"describing":[37],"potential":[39],"impact":[40],"a":[42,88,106],"given":[43],"manipulation":[45],"is":[46,125,128],"characterization":[48,101],"general":[50],"morphology.":[51],"The":[52],"use":[53],"3-dimensional":[55],"imaging":[56,72],"techniques":[57],"high":[59],"spatial":[60],"resolution,":[61],"such":[62,71],"magnetic":[64],"resonance":[65],"microscopy":[66],"(MRM),":[67],"crucial":[69],"because":[70],"tools":[73],"expedite":[75],"anatomical":[76],"phenotyping":[77],"genetically":[80],"altered":[81],"mice.":[82],"In":[83],"this":[84],"paper":[85],"we":[86],"describe":[87],"fully":[89],"automatic":[90],"MRM":[91,132],"image":[92,133],"brain":[93,103,121],"segmentation":[94,124],"method":[95],"application":[98],"phenotypical":[100],"structures":[104],"migraine":[107],"model,":[109],"assessing":[110],"volume":[111],"morphology":[113],"cerebellar":[116],"white":[117],"matter":[118],"ventricles.":[122],"Our":[123],"atlas-based":[126],"designed":[129],"in-vivo":[131],"analysis":[134]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
