{"id":"https://openalex.org/W2113956494","doi":"https://doi.org/10.1109/isbi.2006.1624930","title":"Nanoshells as Contrast Agents for Scatter-Based Optical Imaging","display_name":"Nanoshells as Contrast Agents for Scatter-Based Optical Imaging","publication_year":2006,"publication_date":"2006-05-25","ids":{"openalex":"https://openalex.org/W2113956494","doi":"https://doi.org/10.1109/isbi.2006.1624930","mag":"2113956494"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2006.1624930","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2006.1624930","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3rd IEEE International Symposium on Biomedical Imaging: Macro to Nano, 2006.","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100342779","display_name":"Min\u2010Ho Lee","orcid":"https://orcid.org/0000-0002-7028-4745"},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Min-Ho Lee","raw_affiliation_strings":["Department of Bioengineering, Rice University, Houston, TX, USA","Dept. of Bioeng., Rice Univ., Houston, TX, USA"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Rice University, Houston, TX, USA","institution_ids":["https://openalex.org/I74775410"]},{"raw_affiliation_string":"Dept. of Bioeng., Rice Univ., Houston, TX, USA","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033535031","display_name":"Vengadesan Nammalvar","orcid":null},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. Nammalvar","raw_affiliation_strings":["Department of Bioengineering, Rice University, Houston, TX, USA","Dept. of Bioeng., Rice Univ., Houston, TX, USA"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Rice University, Houston, TX, USA","institution_ids":["https://openalex.org/I74775410"]},{"raw_affiliation_string":"Dept. of Bioeng., Rice Univ., Houston, TX, USA","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113510328","display_name":"Andr\u00e9 M. Gobin","orcid":null},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Gobin","raw_affiliation_strings":["Department of Bioengineering, Rice University, Houston, TX, USA","Dept. of Bioeng., Rice Univ., Houston, TX, USA"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Rice University, Houston, TX, USA","institution_ids":["https://openalex.org/I74775410"]},{"raw_affiliation_string":"Dept. of Bioeng., Rice Univ., Houston, TX, USA","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021337936","display_name":"Jennifer K. Barton","orcid":"https://orcid.org/0000-0003-4897-9361"},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Barton","raw_affiliation_strings":["Department of Bioengineering, Rice University, Houston, TX, USA","Dept. of Bioeng., Rice Univ., Houston, TX, USA"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Rice University, Houston, TX, USA","institution_ids":["https://openalex.org/I74775410"]},{"raw_affiliation_string":"Dept. of Bioeng., Rice Univ., Houston, TX, USA","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084460488","display_name":"Jennifer L. West","orcid":"https://orcid.org/0000-0001-8550-2875"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. West","raw_affiliation_strings":["University of Arizona Tucson, Tucson, AZ, USA","University of Arizona"],"affiliations":[{"raw_affiliation_string":"University of Arizona Tucson, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"University of Arizona","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020017504","display_name":"Rebekah A. Drezek","orcid":null},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Drezek","raw_affiliation_strings":["Department of Bioengineering, Rice University, Houston, TX, USA","**Rice University;"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Rice University, Houston, TX, USA","institution_ids":["https://openalex.org/I74775410"]},{"raw_affiliation_string":"**Rice University;","institution_ids":["https://openalex.org/I74775410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5100342779"],"corresponding_institution_ids":["https://openalex.org/I74775410"],"apc_list":null,"apc_paid":null,"fwci":0.837,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.75941782,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"30","issue":null,"first_page":"371","last_page":"374"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10131","display_name":"Gold and Silver Nanoparticles Synthesis and Applications","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanoshell","display_name":"Nanoshell","score":0.9861768484115601},{"id":"https://openalex.org/keywords/scattering","display_name":"Scattering","score":0.7757107019424438},{"id":"https://openalex.org/keywords/optical-coherence-tomography","display_name":"Optical coherence tomography","score":0.7324546575546265},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.6889773011207581},{"id":"https://openalex.org/keywords/mie-scattering","display_name":"Mie scattering","score":0.6076920032501221},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.5655004978179932},{"id":"https://openalex.org/keywords/light-scattering","display_name":"Light scattering","score":0.5247564315795898},{"id":"https://openalex.org/keywords/contrast","display_name":"Contrast (vision)","score":0.43287843465805054},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.3381180763244629},{"id":"https://openalex.org/keywords/plasmon","display_name":"Plasmon","score":0.23862749338150024},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.1364484429359436}],"concepts":[{"id":"https://openalex.org/C33197981","wikidata":"https://www.wikidata.org/wiki/Q2891289","display_name":"Nanoshell","level":3,"score":0.9861768484115601},{"id":"https://openalex.org/C191486275","wikidata":"https://www.wikidata.org/wiki/Q210028","display_name":"Scattering","level":2,"score":0.7757107019424438},{"id":"https://openalex.org/C2778818243","wikidata":"https://www.wikidata.org/wiki/Q899552","display_name":"Optical coherence tomography","level":2,"score":0.7324546575546265},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6889773011207581},{"id":"https://openalex.org/C63688654","wikidata":"https://www.wikidata.org/wiki/Q901737","display_name":"Mie scattering","level":4,"score":0.6076920032501221},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.5655004978179932},{"id":"https://openalex.org/C120456961","wikidata":"https://www.wikidata.org/wiki/Q210028","display_name":"Light scattering","level":3,"score":0.5247564315795898},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.43287843465805054},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.3381180763244629},{"id":"https://openalex.org/C110879396","wikidata":"https://www.wikidata.org/wiki/Q58392","display_name":"Plasmon","level":2,"score":0.23862749338150024},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1364484429359436}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2006.1624930","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2006.1624930","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3rd IEEE International Symposium on Biomedical Imaging: Macro to Nano, 2006.","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306196","display_name":"Welch Foundation","ror":"https://ror.org/00np6vq88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1672766972","https://openalex.org/W1968009178","https://openalex.org/W2012193454","https://openalex.org/W2016205235","https://openalex.org/W2024842423","https://openalex.org/W2027507187","https://openalex.org/W2043009832","https://openalex.org/W2043789526","https://openalex.org/W2071224672","https://openalex.org/W2077026901","https://openalex.org/W2134085852","https://openalex.org/W2140150643","https://openalex.org/W2150988057","https://openalex.org/W2152947408","https://openalex.org/W2155329472","https://openalex.org/W2162034088","https://openalex.org/W2418802570","https://openalex.org/W2625885472"],"related_works":["https://openalex.org/W1966568713","https://openalex.org/W2315961926","https://openalex.org/W268862413","https://openalex.org/W2170240824","https://openalex.org/W4321519047","https://openalex.org/W2154468134","https://openalex.org/W2322021969","https://openalex.org/W1981068248","https://openalex.org/W2360647567","https://openalex.org/W2039841743"],"abstract_inverted_index":{"Optical":[0],"properties":[1],"of":[2,25,57,75,77,96],"gold":[3,58,97],"nanoshell-based":[4],"contrast":[5,101,131],"agents":[6,102],"for":[7,129],"optical":[8,27,106],"coherence":[9],"tomography":[10],"(OCT)":[11],"were":[12,34],"determined":[13],"using":[14,126],"calculations":[15],"based":[16],"on":[17],"concentric":[18],"sphere":[19],"Mie":[20],"scattering":[21,28,40,61],"theory.":[22],"Nanoshells":[23],"capable":[24],"optimal":[26],"in":[29,66,115],"the":[30,94,112,119],"near":[31],"infrared":[32],"(NIR)":[33],"subsequently":[35],"fabricated.":[36],"We":[37],"show":[38,50,72],"that":[39],"nanoshell":[41,81],"possess":[42],"higher":[43],"backscattering":[44],"efficiencies":[45],"at":[46],"longer":[47],"wavelengths.":[48],"Results":[49],"enhanced":[51],"OCT":[52,132],"signal":[53],"intensities":[54],"after":[55,80],"addition":[56,110],"nanoshells":[59,98,128],"to":[60,85,103,111],"tissue":[62],"phantoms.":[63],"In":[64,109],"addition,":[65],"vivo":[67],"mouse":[68],"tumor":[69,78],"model":[70],"studies":[71],"clear":[73],"evidence":[74],"enhancement":[76],"scatter":[79],"injection":[82],"as":[83,99],"compared":[84],"control":[86],"(phosphate":[87],"buffered":[88],"saline,":[89],"PBS)":[90],"injections,":[91],"further":[92],"demonstrating":[93],"potential":[95],"NIR":[100],"improve":[104],"scattering-based":[105],"imaging":[107],"technologies.":[108],"data":[113,125],"shown":[114],"this":[116],"preliminary":[117],"paper,":[118],"talk":[120],"will":[121],"present":[122],"more":[123],"recent":[124],"immunotargeted":[127],"molecular":[130]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}