{"id":"https://openalex.org/W2129759407","doi":"https://doi.org/10.1109/isbi.2006.1624900","title":"Automated Multivariate Profiling of Drug Effects from Fluorescence Microscopy Images","display_name":"Automated Multivariate Profiling of Drug Effects from Fluorescence Microscopy Images","publication_year":2006,"publication_date":"2006-05-25","ids":{"openalex":"https://openalex.org/W2129759407","doi":"https://doi.org/10.1109/isbi.2006.1624900","mag":"2129759407"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2006.1624900","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2006.1624900","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3rd IEEE International Symposium on Biomedical Imaging: Macro to Nano, 2006.","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047207874","display_name":"Lit\u2010Hsin Loo","orcid":"https://orcid.org/0000-0001-6303-9840"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lit-Hsin Loo","raw_affiliation_strings":["Department of Pharmacology, University of Texas Southwestern Medical Centre, Dallas, TX, USA","Dept. of Pharmacology, Texas Univ., Dallas, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Texas Southwestern Medical Centre, Dallas, TX, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Dept. of Pharmacology, Texas Univ., Dallas, TX","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015397650","display_name":"Lani F. Wu","orcid":"https://orcid.org/0000-0002-0052-7537"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L.F. Wu","raw_affiliation_strings":["Department of Pharmacology, University of Texas Southwestern Medical Centre, Dallas, TX, USA","Dept. of Pharmacology, Texas Univ., Dallas, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Texas Southwestern Medical Centre, Dallas, TX, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Dept. of Pharmacology, Texas Univ., Dallas, TX","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072455858","display_name":"Steven J. Altschuler","orcid":"https://orcid.org/0000-0001-9142-0796"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.J. Altschuler","raw_affiliation_strings":["Department of Pharmacology, University of Texas Southwestern Medical Centre, Dallas, TX, USA","Dept. of Pharmacology, Texas Univ., Dallas, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Texas Southwestern Medical Centre, Dallas, TX, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Dept. of Pharmacology, Texas Univ., Dallas, TX","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.09252078,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"1","issue":null,"first_page":"251","last_page":"254"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.994700014591217,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.973800003528595,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/profiling","display_name":"Profiling (computer programming)","score":0.7793065905570984},{"id":"https://openalex.org/keywords/univariate","display_name":"Univariate","score":0.743488073348999},{"id":"https://openalex.org/keywords/fluorescence-microscope","display_name":"Fluorescence microscope","score":0.5742320418357849},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.5704115033149719},{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.5503456592559814},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5385165810585022},{"id":"https://openalex.org/keywords/hyperplane","display_name":"Hyperplane","score":0.4655483663082123},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.43921029567718506},{"id":"https://openalex.org/keywords/multivariate-analysis","display_name":"Multivariate analysis","score":0.4327704906463623},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3963976204395294},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.38366609811782837},{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.37436777353286743},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.32212895154953003},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.21137946844100952},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.15794363617897034},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.13867953419685364},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.12589582800865173},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.12445992231369019},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.10718858242034912},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.08959880471229553},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.07924976944923401}],"concepts":[{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.7793065905570984},{"id":"https://openalex.org/C199163554","wikidata":"https://www.wikidata.org/wiki/Q1681619","display_name":"Univariate","level":3,"score":0.743488073348999},{"id":"https://openalex.org/C169274487","wikidata":"https://www.wikidata.org/wiki/Q840211","display_name":"Fluorescence microscope","level":3,"score":0.5742320418357849},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.5704115033149719},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.5503456592559814},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5385165810585022},{"id":"https://openalex.org/C68693459","wikidata":"https://www.wikidata.org/wiki/Q657586","display_name":"Hyperplane","level":2,"score":0.4655483663082123},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.43921029567718506},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.4327704906463623},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3963976204395294},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.38366609811782837},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.37436777353286743},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.32212895154953003},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.21137946844100952},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.15794363617897034},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13867953419685364},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12589582800865173},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12445992231369019},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.10718858242034912},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.08959880471229553},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07924976944923401},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2006.1624900","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2006.1624900","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3rd IEEE International Symposium on Biomedical Imaging: Macro to Nano, 2006.","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5799999833106995,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1528620860","https://openalex.org/W1797956629","https://openalex.org/W1967660686","https://openalex.org/W1993669821","https://openalex.org/W2023564846","https://openalex.org/W2085662298","https://openalex.org/W2145752049"],"related_works":["https://openalex.org/W1828158523","https://openalex.org/W2049578243","https://openalex.org/W2000145235","https://openalex.org/W2122079181","https://openalex.org/W1985848810","https://openalex.org/W2889939530","https://openalex.org/W3121881699","https://openalex.org/W2748838164","https://openalex.org/W2066015000","https://openalex.org/W2912721996"],"abstract_inverted_index":{"Fluorescence":[0],"microscopy":[1,23],"is":[2],"a":[3,43,56,108],"useful":[4],"tool":[5],"for":[6,50],"building":[7,51],"quantitative":[8,76],"profiles":[9,30,53,77,95,105],"of":[10,71,100],"drug":[11,52,102],"effects.":[12],"Although":[13],"features":[14,34],"with":[15,81,88],"rich":[16],"information":[17],"can":[18],"be":[19],"extracted":[20,33],"from":[21,31,91,107],"fluorescence":[22],"images,":[24],"most":[25],"current":[26],"profiling":[27],"methods":[28],"build":[29],"the":[32,101],"using":[35,55,64],"either":[36],"univariate":[37,110],"or":[38],"non-automated":[39],"methods.":[40],"We":[41,74],"propose":[42],"new":[44],"multivariate,":[45],"automated":[46],"and":[47,85],"scalable":[48],"method":[49,60,111],"by":[54,63],"decision":[57],"hyperplane.":[58],"The":[59],"was":[61],"evaluated":[62],"23":[65],"compounds":[66],"belonging":[67],"to":[68],"four":[69],"groups":[70],"known":[72],"mechanisms.":[73],"produced":[75],"that":[78],"group":[79],"drugs":[80,87],"similar":[82],"mechanisms":[83,90],"together,":[84],"separate":[86],"dissimilar":[89],"each":[92],"other.":[93],"These":[94],"resulted":[96],"in":[97],"better":[98],"characterizations":[99],"effects":[103],"than":[104],"obtained":[106],"previous":[109]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-06-26T08:34:08.712188","created_date":"2025-10-10T00:00:00"}