{"id":"https://openalex.org/W2123662367","doi":"https://doi.org/10.1109/isbi.2006.1624883","title":"Robust 3-D Modeling of Tumor Microvasculature Using Superellipsoids","display_name":"Robust 3-D Modeling of Tumor Microvasculature Using Superellipsoids","publication_year":2006,"publication_date":"2006-05-25","ids":{"openalex":"https://openalex.org/W2123662367","doi":"https://doi.org/10.1109/isbi.2006.1624883","mag":"2123662367"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2006.1624883","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2006.1624883","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3rd IEEE International Symposium on Biomedical Imaging: Macro to Nano, 2006.","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112487420","display_name":"James Tyrrell","orcid":"https://orcid.org/0000-0002-2344-737X"},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.A. Tyrrell","raw_affiliation_strings":["Department of Electrical, Computer and Systems Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical, Computer and Systems Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090480130","display_name":"Badrinath Roysam","orcid":"https://orcid.org/0000-0002-8310-1389"},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Roysam","raw_affiliation_strings":["Department of Electrical, Computer and Systems Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical, Computer and Systems Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019864381","display_name":"Emmanuelle di Tomaso","orcid":null},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. di Tomaso","raw_affiliation_strings":["Edwin L. Steele Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Edwin L. Steele Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109932994","display_name":"R. Tong","orcid":null},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Tong","raw_affiliation_strings":["Edwin L. Steele Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Edwin L. Steele Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047492118","display_name":"Edward B. Brown","orcid":"https://orcid.org/0000-0002-5367-5330"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E.B. Brown","raw_affiliation_strings":["Edwin L. Steele Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Edwin L. Steele Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037210075","display_name":"R K Jain","orcid":"https://orcid.org/0000-0001-8122-3836"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.K. Jain","raw_affiliation_strings":["Edwin L. Steele Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Edwin L. Steele Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6228,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.78394377,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"185","last_page":"188"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10481","display_name":"Computer Graphics and Visualization Techniques","score":0.9818000197410583,"subfield":{"id":"https://openalex.org/subfields/1704","display_name":"Computer Graphics and Computer-Aided Design"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9782999753952026,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/traverse","display_name":"Traverse","score":0.7339566349983215},{"id":"https://openalex.org/keywords/medial-axis","display_name":"Medial axis","score":0.573141872882843},{"id":"https://openalex.org/keywords/branching","display_name":"Branching (polymer chemistry)","score":0.572803258895874},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5567128658294678},{"id":"https://openalex.org/keywords/point","display_name":"Point (geometry)","score":0.5482885241508484},{"id":"https://openalex.org/keywords/boundary","display_name":"Boundary (topology)","score":0.49351465702056885},{"id":"https://openalex.org/keywords/degree","display_name":"Degree (music)","score":0.4205247759819031},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.37198105454444885},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3101770877838135},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3060956597328186},{"id":"https://openalex.org/keywords/geometry","display_name":"Geometry","score":0.1921042501926422},{"id":"https://openalex.org/keywords/mathematical-analysis","display_name":"Mathematical analysis","score":0.09221383929252625},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.09137952327728271}],"concepts":[{"id":"https://openalex.org/C176809094","wikidata":"https://www.wikidata.org/wiki/Q15401496","display_name":"Traverse","level":2,"score":0.7339566349983215},{"id":"https://openalex.org/C185877587","wikidata":"https://www.wikidata.org/wiki/Q1757407","display_name":"Medial axis","level":2,"score":0.573141872882843},{"id":"https://openalex.org/C206175624","wikidata":"https://www.wikidata.org/wiki/Q595731","display_name":"Branching (polymer chemistry)","level":2,"score":0.572803258895874},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5567128658294678},{"id":"https://openalex.org/C28719098","wikidata":"https://www.wikidata.org/wiki/Q44946","display_name":"Point (geometry)","level":2,"score":0.5482885241508484},{"id":"https://openalex.org/C62354387","wikidata":"https://www.wikidata.org/wiki/Q875399","display_name":"Boundary (topology)","level":2,"score":0.49351465702056885},{"id":"https://openalex.org/C2775997480","wikidata":"https://www.wikidata.org/wiki/Q586277","display_name":"Degree (music)","level":2,"score":0.4205247759819031},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.37198105454444885},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3101770877838135},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3060956597328186},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.1921042501926422},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.09221383929252625},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09137952327728271},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C13280743","wikidata":"https://www.wikidata.org/wiki/Q131089","display_name":"Geodesy","level":1,"score":0.0},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2006.1624883","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2006.1624883","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3rd IEEE International Symposium on Biomedical Imaging: Macro to Nano, 2006.","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1587350429","https://openalex.org/W1928655906","https://openalex.org/W1974954013","https://openalex.org/W1979887297","https://openalex.org/W2023751161","https://openalex.org/W2066887829","https://openalex.org/W2122888449","https://openalex.org/W6640268104"],"related_works":["https://openalex.org/W2377402383","https://openalex.org/W2380835401","https://openalex.org/W2381912691","https://openalex.org/W2350381577","https://openalex.org/W2353618196","https://openalex.org/W2348074676","https://openalex.org/W2385033175","https://openalex.org/W2116251909","https://openalex.org/W2112871239","https://openalex.org/W1984178488"],"abstract_inverted_index":{"This":[0],"paper":[1],"presents":[2],"automated":[3],"methods":[4],"for":[5,36,57],"robust":[6],"modeling":[7],"and":[8,41,70,95],"analysis":[9],"of":[10,24,39,90,107],"3-D":[11],"tumor":[12,108],"microvasculature.":[13],"Our":[14],"methodology":[15,80],"uses":[16],"a":[17,54,61,75,87,104],"cylindroidal":[18],"superellipsoid":[19],"to":[20,92],"model":[21,29],"localized":[22],"segments":[23],"vasculature.":[25],"The":[26,78],"proposed":[27,79],"vessel":[28],"has":[30],"an":[31],"explicit,":[32],"low-order":[33],"parameterization,":[34],"allowing":[35],"joint":[37],"estimation":[38],"boundary":[40],"centerline":[42],"information,":[43],"thereby":[44],"approximating":[45],"the":[46],"medial":[47],"axis.":[48],"Further,":[49],"this":[50],"explicit":[51],"parameterization":[52],"provides":[53],"geometric":[55],"framework":[56],"traversing":[58],"vessels":[59],"in":[60,110],"directed":[62],"manner.":[63],"Topological":[64],"information":[65],"like":[66],"branch":[67],"point":[68],"location":[69],"connectivity":[71],"is":[72],"provided":[73],"as":[74],"side":[76],"effect.":[77],"behaves":[81],"quite":[82],"well":[83],"across":[84],"scalespace,":[85],"shows":[86],"high":[88],"degree":[89],"insensitivity":[91],"adjacent":[93],"structures":[94],"implicitly":[96],"handles":[97],"branching.":[98],"Exemplar":[99],"results":[100],"are":[101],"presented":[102],"from":[103],"pre-clinical":[105],"study":[106],"microvasculature":[109],"mice":[111]},"counts_by_year":[{"year":2012,"cited_by_count":2}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}