{"id":"https://openalex.org/W2106672950","doi":"https://doi.org/10.1109/isbi.2004.1398847","title":"Assessment of radiation mediated gene therapy via multimodality imaging","display_name":"Assessment of radiation mediated gene therapy via multimodality imaging","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2106672950","doi":"https://doi.org/10.1109/isbi.2004.1398847","mag":"2106672950"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2004.1398847","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2004.1398847","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2004 2nd IEEE International Symposium on Biomedical Imaging: Nano to Macro (IEEE Cat No. 04EX821)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045523582","display_name":"Chad R. Haney","orcid":"https://orcid.org/0000-0001-5981-2925"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"C.R. Haney","raw_affiliation_strings":["Department of Radiation and Cellular Oncology (MC 1105), The University of Chicago, Chicago, IL","Dept. of Radiat. & Cellular Oncology, Chicago Univ., IL, USA"],"affiliations":[{"raw_affiliation_string":"Department of Radiation and Cellular Oncology (MC 1105), The University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Dept. of Radiat. & Cellular Oncology, Chicago Univ., IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111643621","display_name":"Charles A. Pelizzari","orcid":null},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.A. Pelizzari","raw_affiliation_strings":["Department of Radiation and Cellular Oncology (MC 1105), The University of Chicago, Chicago, IL","The University of Chicago"],"affiliations":[{"raw_affiliation_string":"Department of Radiation and Cellular Oncology (MC 1105), The University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"The University of Chicago","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ichikawa. Parasca","orcid":null},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ichikawa. Parasca","raw_affiliation_strings":["Department of Radiation and Cellular Oncology (MC 1105), The University of Chicago, Chicago, IL","Dept. of Radiat. & Cellular Oncology, Chicago Univ., IL, USA"],"affiliations":[{"raw_affiliation_string":"Department of Radiation and Cellular Oncology (MC 1105), The University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Dept. of Radiat. & Cellular Oncology, Chicago Univ., IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021340648","display_name":"Martyna Elas","orcid":"https://orcid.org/0000-0001-6296-2844"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Elas","raw_affiliation_strings":["Department of Radiation and Cellular Oncology (MC 1105), The University of Chicago, Chicago, IL","Dept. of Radiat. & Cellular Oncology, Chicago Univ., IL, USA"],"affiliations":[{"raw_affiliation_string":"Department of Radiation and Cellular Oncology (MC 1105), The University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Dept. of Radiat. & Cellular Oncology, Chicago Univ., IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061774893","display_name":"Marta Zamora","orcid":"https://orcid.org/0000-0001-6311-5663"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Zamora","raw_affiliation_strings":["Department of Radiation and Cellular Oncology (MC 1105), The University of Chicago, Chicago, IL","The University of Chicago"],"affiliations":[{"raw_affiliation_string":"Department of Radiation and Cellular Oncology (MC 1105), The University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"The University of Chicago","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089826782","display_name":"Xiaobing Fan","orcid":"https://orcid.org/0000-0001-9004-029X"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"X. Fan","raw_affiliation_strings":["Department of Radiology (MC 2026), The University of Chicago, Chicago, IL","The University of Chicago"],"affiliations":[{"raw_affiliation_string":"Department of Radiology (MC 2026), The University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"The University of Chicago","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079213983","display_name":"Gregory S. Karczmar","orcid":"https://orcid.org/0000-0002-2455-5858"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G.S. Karczmar","raw_affiliation_strings":["Department of Radiology (MC 2026), The University of Chicago, Chicago, IL","The University of Chicago"],"affiliations":[{"raw_affiliation_string":"Department of Radiology (MC 2026), The University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"The University of Chicago","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111588202","display_name":"Helena J. Mauceri","orcid":null},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H.J. Mauceri","raw_affiliation_strings":["Department of Radiology (MC 2026), The University of Chicago, Chicago, IL","The University of Chicago"],"affiliations":[{"raw_affiliation_string":"Department of Radiology (MC 2026), The University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"The University of Chicago","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054855052","display_name":"Ralph R. Weichselbaum","orcid":"https://orcid.org/0000-0002-5643-8939"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.R. Weichselbaum","raw_affiliation_strings":["Department of Radiation and Cellular Oncology (MC 1105), The University of Chicago, Chicago, IL","The University of Chicago"],"affiliations":[{"raw_affiliation_string":"Department of Radiation and Cellular Oncology (MC 1105), The University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"The University of Chicago","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007642363","display_name":"Howard J. Halpern","orcid":"https://orcid.org/0000-0001-7672-9269"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H.J. Halpern","raw_affiliation_strings":["Department of Radiation and Cellular Oncology (MC 1105), The University of Chicago, Chicago, IL","The University of Chicago"],"affiliations":[{"raw_affiliation_string":"Department of Radiation and Cellular Oncology (MC 1105), The University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"The University of Chicago","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5045523582"],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18931779,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"139","issue":null,"first_page":"1549","last_page":"1552 Vol. 2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.6976660490036011},{"id":"https://openalex.org/keywords/radiation-therapy","display_name":"Radiation therapy","score":0.6470829248428345},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.5315000414848328},{"id":"https://openalex.org/keywords/compartment","display_name":"Compartment (ship)","score":0.46407392621040344},{"id":"https://openalex.org/keywords/medical-imaging","display_name":"Medical imaging","score":0.42053544521331787},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.38371798396110535},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3499161899089813},{"id":"https://openalex.org/keywords/nuclear-magnetic-resonance","display_name":"Nuclear magnetic resonance","score":0.33888623118400574},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3253262937068939},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.3187321424484253},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.1518515646457672}],"concepts":[{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.6976660490036011},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.6470829248428345},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.5315000414848328},{"id":"https://openalex.org/C203635412","wikidata":"https://www.wikidata.org/wiki/Q17007432","display_name":"Compartment (ship)","level":2,"score":0.46407392621040344},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.42053544521331787},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.38371798396110535},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3499161899089813},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.33888623118400574},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3253262937068939},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3187321424484253},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1518515646457672},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2004.1398847","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2004.1398847","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2004 2nd IEEE International Symposium on Biomedical Imaging: Nano to Macro (IEEE Cat No. 04EX821)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6800000071525574,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320338485","display_name":"DOD Prostate Cancer Research Program","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W140530753","https://openalex.org/W1968930897","https://openalex.org/W1971137290","https://openalex.org/W1995704975","https://openalex.org/W2026654015","https://openalex.org/W2032702942","https://openalex.org/W2041998854","https://openalex.org/W2052171115","https://openalex.org/W2057816945","https://openalex.org/W2166257317","https://openalex.org/W6605761430","https://openalex.org/W6636367840"],"related_works":["https://openalex.org/W4206762368","https://openalex.org/W1989010679","https://openalex.org/W2035571162","https://openalex.org/W942260108","https://openalex.org/W2012688062","https://openalex.org/W3045690415","https://openalex.org/W2102216833","https://openalex.org/W2417512607","https://openalex.org/W68742508","https://openalex.org/W1976530484"],"abstract_inverted_index":{"Imaging":[0],"techniques":[1],"are":[2,6],"under":[3],"development":[4],"which":[5],"intended":[7],"to":[8,18,61,74,88],"facilitate":[9],"early":[10],"analysis":[11],"of":[12,15,33,92],"spatial":[13],"patterns":[14],"tumor":[16,70],"response":[17],"combined":[19],"radiation":[20],"and":[21,36,42],"antivascular":[22],"gene":[23],"therapy.":[24],"We":[25],"present":[26],"initial":[27],"results":[28],"demonstrating":[29],"treatment":[30],"related":[31],"changes":[32],"vascular":[34],"permeability":[35],"blood":[37],"volume":[38,58],"maps":[39],"using":[40,46],"MRI,":[41],"tissue":[43],"oxygenation":[44],"measurements":[45],"electron":[47],"paramagnetic":[48],"resonance":[49],"imaging":[50],"(EPRI).":[51],"Using":[52],"a":[53],"modified":[54],"Kety":[55],"model,":[56],"the":[57,62,69,80,96],"fraction":[59],"accessible":[60],"contrast":[63,93],"agent":[64,94],"was":[65],"significantly":[66],"greater":[67],"in":[68,95],"(0.81/spl":[71],"plusmn/0.11),":[72],"compared":[73],"muscle":[75],"(0.20/spl":[76],"plusmn/0.00,":[77],"p<0.05).":[78],"However,":[79],"two":[81],"compartment":[82,100],"model":[83,101],"is":[84],"probably":[85],"not":[86],"able":[87],"account":[89],"for":[90],"accumulation":[91],"tumor.":[97],"A":[98],"three":[99],"may":[102],"improve":[103],"fitting.":[104]},"counts_by_year":[],"updated_date":"2026-04-16T08:26:57.006410","created_date":"2025-10-10T00:00:00"}
