{"id":"https://openalex.org/W2118719140","doi":"https://doi.org/10.1109/isbi.2004.1398533","title":"MRI-guided laser thermal ablation: model and parameter estimates relating MR thermometry images to cell death","display_name":"MRI-guided laser thermal ablation: model and parameter estimates relating MR thermometry images to cell death","publication_year":2005,"publication_date":"2005-04-12","ids":{"openalex":"https://openalex.org/W2118719140","doi":"https://doi.org/10.1109/isbi.2004.1398533","mag":"2118719140"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2004.1398533","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2004.1398533","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano (IEEE Cat No. 04EX821)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016540759","display_name":"Michael S. Breen","orcid":"https://orcid.org/0000-0002-2078-5015"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M.S. Breen","raw_affiliation_strings":["Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074206670","display_name":"Kim Butts","orcid":null},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Butts","raw_affiliation_strings":["Department of Radiology, University of Stanford, Stanford, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, University of Stanford, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031953865","display_name":"L. Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Chen","raw_affiliation_strings":["Fox Chase Cancer Center, Philadelphia, PA, USA"],"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050315994","display_name":"Gerald M. Saidel","orcid":"https://orcid.org/0000-0003-2159-2343"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G.M. Saidel","raw_affiliation_strings":["Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059314323","display_name":"David L. Wilson","orcid":"https://orcid.org/0000-0001-9763-1463"},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"funder","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.L. Wilson","raw_affiliation_strings":["Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA","Department of Radiology, University Hospitals of Cleveland, Cleveland, OH, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Radiology, University Hospitals of Cleveland, Cleveland, OH, USA","institution_ids":["https://openalex.org/I2799343972"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5016540759"],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17946462,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":null,"first_page":"296","last_page":"299"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12994","display_name":"Infrared Thermography in Medicine","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/voxel","display_name":"Voxel","score":0.882810115814209},{"id":"https://openalex.org/keywords/interventional-magnetic-resonance-imaging","display_name":"Interventional magnetic resonance imaging","score":0.723613977432251},{"id":"https://openalex.org/keywords/ablation","display_name":"Ablation","score":0.6240555047988892},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.5745593309402466},{"id":"https://openalex.org/keywords/boundary","display_name":"Boundary (topology)","score":0.49962663650512695},{"id":"https://openalex.org/keywords/laser-ablation","display_name":"Laser ablation","score":0.4711250960826874},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.38923248648643494},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3818897604942322},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3811831474304199},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.37464839220046997},{"id":"https://openalex.org/keywords/nuclear-magnetic-resonance","display_name":"Nuclear magnetic resonance","score":0.37047046422958374},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.29453688859939575},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.291667640209198},{"id":"https://openalex.org/keywords/laser","display_name":"Laser","score":0.2680124342441559},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.24956634640693665},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.24302294850349426},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.14635774493217468},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.13671496510505676}],"concepts":[{"id":"https://openalex.org/C54170458","wikidata":"https://www.wikidata.org/wiki/Q663554","display_name":"Voxel","level":2,"score":0.882810115814209},{"id":"https://openalex.org/C186594802","wikidata":"https://www.wikidata.org/wiki/Q6057371","display_name":"Interventional magnetic resonance imaging","level":3,"score":0.723613977432251},{"id":"https://openalex.org/C2778902805","wikidata":"https://www.wikidata.org/wiki/Q322177","display_name":"Ablation","level":2,"score":0.6240555047988892},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5745593309402466},{"id":"https://openalex.org/C62354387","wikidata":"https://www.wikidata.org/wiki/Q875399","display_name":"Boundary (topology)","level":2,"score":0.49962663650512695},{"id":"https://openalex.org/C2779188808","wikidata":"https://www.wikidata.org/wiki/Q1806547","display_name":"Laser ablation","level":3,"score":0.4711250960826874},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.38923248648643494},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3818897604942322},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3811831474304199},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.37464839220046997},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.37047046422958374},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.29453688859939575},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.291667640209198},{"id":"https://openalex.org/C520434653","wikidata":"https://www.wikidata.org/wiki/Q38867","display_name":"Laser","level":2,"score":0.2680124342441559},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.24956634640693665},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.24302294850349426},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14635774493217468},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.13671496510505676},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2004.1398533","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2004.1398533","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano (IEEE Cat No. 04EX821)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8399999737739563,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W8892817","https://openalex.org/W1975434080","https://openalex.org/W1981630544","https://openalex.org/W2000144812","https://openalex.org/W2018734293","https://openalex.org/W2034432063","https://openalex.org/W2052376206","https://openalex.org/W2057028373","https://openalex.org/W2061736253","https://openalex.org/W2089663341","https://openalex.org/W2099371543","https://openalex.org/W2171074980","https://openalex.org/W6600374767"],"related_works":["https://openalex.org/W2080766278","https://openalex.org/W2081305085","https://openalex.org/W1940885666","https://openalex.org/W2147794715","https://openalex.org/W1989570877","https://openalex.org/W2560330190","https://openalex.org/W1966577812","https://openalex.org/W2896812212","https://openalex.org/W2052524705","https://openalex.org/W3143833596"],"abstract_inverted_index":{"Solid":[0],"tumors":[1],"and":[2,31,118,122],"other":[3],"pathologies":[4],"can":[5,145],"be":[6,146],"treated":[7],"using":[8,55,91],"laser":[9],"thermal":[10],"ablation":[11],"under":[12],"interventional":[13],"magnetic":[14],"resonance":[15],"imaging":[16],"(iMRI)":[17],"guidance.":[18],"We":[19,40,61],"developed":[20],"a":[21,56,115],"model":[22,113,150],"to":[23,34,46,97,151],"predict":[24,152],"cell":[25,80],"death":[26],"from":[27,50,84,105],"MR":[28,43,73],"thermometry":[29],"measurements":[30],"applied":[32,96],"it":[33],"in":[35,70,101,155],"vivo":[36],"rabbit":[37],"brain":[38],"data.":[39],"aligned":[41],"post-ablation":[42,72],"lesion":[44,74],"images":[45,104],"gradient":[47],"echo":[48],"images,":[49],"which":[51],"temperature":[52,110,143],"is":[53,138],"derived,":[54],"mutual":[57],"information":[58],"registration":[59],"method.":[60],"used":[62,147],"the":[63,67,71,77,133],"outer":[64],"boundary":[65,78],"of":[66,120,132],"hyperintense":[68],"rim":[69],"image":[75],"as":[76,82],"for":[79],"death,":[81],"verified":[83],"histology.":[85],"Model":[86],"parameters":[87],"were":[88,128],"simultaneously":[89],"estimated":[90],"an":[92],"iterative":[93],"optimization":[94],"algorithm":[95],"every":[98],"interesting":[99],"voxel":[100,116,131],"over":[102],"185":[103],"multiple":[106],"experiments":[107],"having":[108],"various":[109],"histories.":[111],"The":[112],"gave":[114],"sensitivity":[117],"specificity":[119],"86.9%":[121],"98.8%,":[123],"respectively.":[124],"Mislabeled":[125],"voxels":[126],"typically":[127],"within":[129],"one":[130],"segmented":[134],"necrotic":[135],"boundary.":[136],"This":[137],"good":[139],"evidence":[140],"that":[141],"iMRI":[142],"maps":[144],"with":[148],"our":[149],"therapeutic":[153],"regions":[154],"real-time.":[156]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}