{"id":"https://openalex.org/W2102668710","doi":"https://doi.org/10.1109/isbi.2004.1398515","title":"Computed simultaneous imaging of multiple functional biomarkers","display_name":"Computed simultaneous imaging of multiple functional biomarkers","publication_year":2005,"publication_date":"2005-04-12","ids":{"openalex":"https://openalex.org/W2102668710","doi":"https://doi.org/10.1109/isbi.2004.1398515","mag":"2102668710"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2004.1398515","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2004.1398515","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano (IEEE Cat No. 04EX821)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112684346","display_name":"Yue Wang","orcid":"https://orcid.org/0009-0003-5310-2713"},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yue Wang","raw_affiliation_strings":["Virginia Polytechnic Institute and State University, Alexandria, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virginia Polytechnic Institute and State University, Alexandria, VA, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084871742","display_name":"Rujirutana Srikanchana","orcid":"https://orcid.org/0000-0001-7938-7137"},"institutions":[{"id":"https://openalex.org/I1299022934","display_name":"United States Department of Health and Human Services","ror":"https://ror.org/033jnv181","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Srikanchana","raw_affiliation_strings":["National Institutes of Health DHHS, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health DHHS, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111886611","display_name":"Jianhua Xuan","orcid":null},"institutions":[{"id":"https://openalex.org/I168959743","display_name":"University of America","ror":"https://ror.org/03s0c9350","country_code":"US","type":"education","lineage":["https://openalex.org/I168959743"]},{"id":"https://openalex.org/I84470341","display_name":"Catholic University of America","ror":"https://ror.org/047yk3s18","country_code":"US","type":"education","lineage":["https://openalex.org/I84470341"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianhua Xuan","raw_affiliation_strings":["Catholic University of America, Washington D.C., DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Catholic University of America, Washington D.C., DC, USA","institution_ids":["https://openalex.org/I168959743","https://openalex.org/I84470341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109860432","display_name":"Zolt\u00e0n Szab\u00f2","orcid":null},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Z. Szabo","raw_affiliation_strings":["Johns Hopkins Medical Institutions, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Medical Institutions, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082080836","display_name":"Peter L. Choyke","orcid":"https://orcid.org/0000-0003-1086-8826"},"institutions":[{"id":"https://openalex.org/I1299022934","display_name":"United States Department of Health and Human Services","ror":"https://ror.org/033jnv181","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Choyke","raw_affiliation_strings":["National Institutes of Health DHHS, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health DHHS, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":null,"first_page":"225","last_page":"228"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11447","display_name":"Blind Source Separation Techniques","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1711","display_name":"Signal Processing"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11447","display_name":"Blind Source Separation Techniques","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1711","display_name":"Signal Processing"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10688","display_name":"Image and Signal Denoising Methods","score":0.9927999973297119,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9921000003814697,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6711511611938477},{"id":"https://openalex.org/keywords/independent-component-analysis","display_name":"Independent component analysis","score":0.5910560488700867},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.5651599764823914},{"id":"https://openalex.org/keywords/functional-magnetic-resonance-imaging","display_name":"Functional magnetic resonance imaging","score":0.5175832509994507},{"id":"https://openalex.org/keywords/visualization","display_name":"Visualization","score":0.512087345123291},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.5075844526290894},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4985349178314209},{"id":"https://openalex.org/keywords/blind-signal-separation","display_name":"Blind signal separation","score":0.45209744572639465},{"id":"https://openalex.org/keywords/image-resolution","display_name":"Image resolution","score":0.4496125876903534},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1251421868801117},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.10150754451751709}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6711511611938477},{"id":"https://openalex.org/C51432778","wikidata":"https://www.wikidata.org/wiki/Q1259145","display_name":"Independent component analysis","level":2,"score":0.5910560488700867},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.5651599764823914},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.5175832509994507},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.512087345123291},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5075844526290894},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4985349178314209},{"id":"https://openalex.org/C120317606","wikidata":"https://www.wikidata.org/wiki/Q17105967","display_name":"Blind signal separation","level":3,"score":0.45209744572639465},{"id":"https://openalex.org/C205372480","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"Image resolution","level":2,"score":0.4496125876903534},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1251421868801117},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.10150754451751709},{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.0},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2004.1398515","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2004.1398515","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano (IEEE Cat No. 04EX821)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7200000286102295}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1548802052","https://openalex.org/W1902027874","https://openalex.org/W1921179220","https://openalex.org/W2111065746","https://openalex.org/W2121895507","https://openalex.org/W2160392474","https://openalex.org/W4205778870","https://openalex.org/W6640290211"],"related_works":["https://openalex.org/W2390344110","https://openalex.org/W2046761971","https://openalex.org/W2364896863","https://openalex.org/W2361066326","https://openalex.org/W2182042810","https://openalex.org/W2130656060","https://openalex.org/W2156932837","https://openalex.org/W2380698615","https://openalex.org/W374502268","https://openalex.org/W2103029460"],"abstract_inverted_index":{"Dynamic":[0],"functional":[1,34,49],"imaging":[2,118],"techniques":[3],"promise":[4],"powerful":[5],"tools":[6],"for":[7,119],"the":[8,104,107],"visualization":[9],"and":[10,72],"elucidation":[11],"of":[12,44,52,106],"important":[13],"disease-causing":[14],"physiologic":[15],"processes":[16],"in":[17],"living":[18],"tissue.":[19],"Most":[20],"applications":[21],"aim":[22],"to":[23,67,122],"find":[24],"temporal-spatial":[25],"patterns":[26],"associated":[27],"with":[28],"different":[29],"disease":[30],"stages.":[31],"When":[32],"multiple":[33],"biomarkers":[35],"are":[36,93],"targeted,":[37],"imagery":[38],"signals":[39],"often":[40],"represent":[41],"a":[42,58,86],"composite":[43],"more":[45],"than":[46],"one":[47],"distinct":[48],"source":[50,61,70],"independent":[51,99],"spatial":[53],"resolution.":[54],"Here":[55],"we":[56],"introduce":[57],"hybrid":[59],"blind":[60],"separation":[62],"method":[63],"that":[64],"is":[65,83],"able":[66],"factorize":[68],"underlying":[69],"images":[71],"time":[73],"activity":[74],"curves":[75],"from":[76],"dynamically":[77],"mixed":[78],"image":[79],"sequence.":[80],"The":[81],"algorithm":[82],"based":[84],"on":[85,109],"compartment":[87],"latent":[88],"variable":[89],"model,":[90],"whose":[91],"parameters":[92],"estimated":[94],"using":[95,113],"multivariate":[96],"clustering":[97],"and/or":[98],"component":[100],"analysis.":[101],"We":[102],"demonstrate":[103],"principle":[105],"approach":[108],"tumor":[110],"microvascular":[111],"characterization":[112],"dynamic":[114],"contrast-enhanced":[115],"magnetic":[116],"resonance":[117],"monitoring":[120],"response":[121],"anti-angiogenic":[123],"therapies.":[124]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}