{"id":"https://openalex.org/W2143876464","doi":"https://doi.org/10.1109/isbi.2004.1398466","title":"Microbubbles for ultrasound diagnosis and therapy","display_name":"Microbubbles for ultrasound diagnosis and therapy","publication_year":2005,"publication_date":"2005-04-12","ids":{"openalex":"https://openalex.org/W2143876464","doi":"https://doi.org/10.1109/isbi.2004.1398466","mag":"2143876464"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2004.1398466","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2004.1398466","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano (IEEE Cat No. 04EX821)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088298096","display_name":"J. Brian Fowlkes","orcid":"https://orcid.org/0000-0002-4536-3919"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J.B. Fowlkes","raw_affiliation_strings":["Department of Biomedical Engineering, University of Michigan, USA","Department of Radiology, University of Michigan Health Systems, Ann Arbor, MI, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Michigan, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Radiology, University of Michigan Health Systems, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064991115","display_name":"Oliver D. Kripfgans","orcid":"https://orcid.org/0000-0003-2905-1496"},"institutions":[{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"O.D. Kripfgans","raw_affiliation_strings":["Department of Radiology, University of Michigan Health Systems, Ann Arbor, MI, USA"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, University of Michigan Health Systems, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022985471","display_name":"Paul L. Carson","orcid":"https://orcid.org/0000-0003-3543-7424"},"institutions":[{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P.L. Carson","raw_affiliation_strings":["Department of Biomedical Engineering, University of Michigan, USA","Department of Radiology, University of Michigan Health Systems, Ann Arbor, MI, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Michigan, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Radiology, University of Michigan Health Systems, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5088298096"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.19122769,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"2","issue":null,"first_page":"29","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11842","display_name":"Ultrasound and Cavitation Phenomena","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10727","display_name":"Ultrasound Imaging and Elastography","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microbubbles","display_name":"Microbubbles","score":0.9747343063354492},{"id":"https://openalex.org/keywords/therapeutic-ultrasound","display_name":"Therapeutic ultrasound","score":0.779645562171936},{"id":"https://openalex.org/keywords/ultrasound","display_name":"Ultrasound","score":0.748838484287262},{"id":"https://openalex.org/keywords/cavitation","display_name":"Cavitation","score":0.6781375408172607},{"id":"https://openalex.org/keywords/bubble","display_name":"Bubble","score":0.6120671629905701},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.5596792697906494},{"id":"https://openalex.org/keywords/diagnostic-ultrasound","display_name":"Diagnostic ultrasound","score":0.48851239681243896},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.4796157777309418},{"id":"https://openalex.org/keywords/ultrasonic-imaging","display_name":"Ultrasonic imaging","score":0.4336879551410675},{"id":"https://openalex.org/keywords/medical-ultrasound","display_name":"Medical ultrasound","score":0.42717617750167847},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2865337133407593},{"id":"https://openalex.org/keywords/acoustics","display_name":"Acoustics","score":0.21949496865272522},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.20026671886444092},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.18731218576431274},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.07806485891342163}],"concepts":[{"id":"https://openalex.org/C64012434","wikidata":"https://www.wikidata.org/wiki/Q6839290","display_name":"Microbubbles","level":3,"score":0.9747343063354492},{"id":"https://openalex.org/C2779727089","wikidata":"https://www.wikidata.org/wiki/Q564875","display_name":"Therapeutic ultrasound","level":3,"score":0.779645562171936},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.748838484287262},{"id":"https://openalex.org/C207057113","wikidata":"https://www.wikidata.org/wiki/Q201666","display_name":"Cavitation","level":2,"score":0.6781375408172607},{"id":"https://openalex.org/C157915830","wikidata":"https://www.wikidata.org/wiki/Q2928001","display_name":"Bubble","level":2,"score":0.6120671629905701},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5596792697906494},{"id":"https://openalex.org/C3018313082","wikidata":"https://www.wikidata.org/wiki/Q234904","display_name":"Diagnostic ultrasound","level":3,"score":0.48851239681243896},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4796157777309418},{"id":"https://openalex.org/C2989478337","wikidata":"https://www.wikidata.org/wiki/Q234904","display_name":"Ultrasonic imaging","level":3,"score":0.4336879551410675},{"id":"https://openalex.org/C2992165143","wikidata":"https://www.wikidata.org/wiki/Q234904","display_name":"Medical ultrasound","level":3,"score":0.42717617750167847},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2865337133407593},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.21949496865272522},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.20026671886444092},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18731218576431274},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07806485891342163},{"id":"https://openalex.org/C173608175","wikidata":"https://www.wikidata.org/wiki/Q232661","display_name":"Parallel computing","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2004.1398466","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2004.1398466","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano (IEEE Cat No. 04EX821)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W23693727","https://openalex.org/W1970935015","https://openalex.org/W1978054090","https://openalex.org/W1995464422","https://openalex.org/W2037253046","https://openalex.org/W2070402794","https://openalex.org/W2094097178","https://openalex.org/W2096970792","https://openalex.org/W2167623882"],"related_works":["https://openalex.org/W2047869095","https://openalex.org/W2910728952","https://openalex.org/W2143876464","https://openalex.org/W3160960949","https://openalex.org/W2073210322","https://openalex.org/W2548445147","https://openalex.org/W2377144827","https://openalex.org/W2107356379","https://openalex.org/W1999550466","https://openalex.org/W2048385528"],"abstract_inverted_index":{"Methods":[0],"for":[1,12,81,96],"the":[2,23,34,43,50,75,89],"local":[3],"production":[4],"of":[5,25,42,55],"microbubbles":[6],"in":[7,14,67],"vivo":[8],"are":[9,65],"being":[10,57],"developed":[11],"applications":[13],"both":[15,105],"diagnostic":[16,108],"and":[17,47,53,107],"therapeutic":[18,60,106],"ultrasound.":[19,38],"The":[20],"techniques":[21],"involve":[22],"use":[24],"superheated":[26],"perfluorocarbon":[27],"droplets":[28],"that":[29],"can":[30,77,100],"be":[31,101],"vaporized":[32],"by":[33],"application":[35],"on":[36],"focused":[37],"This":[39],"provides":[40],"localization":[41],"resulting":[44],"gas":[45,63],"bubbles":[46,56,64,76,90],"control":[48],"over":[49],"number":[51,87],"density":[52],"size":[54],"released.":[58],"For":[59],"ultrasound,":[61],"large":[62],"produced":[66],"numbers":[68],"sufficient":[69],"to":[70,103],"restrict":[71],"blood":[72],"flow":[73],"or":[74],"act":[78],"as":[79],"nuclei":[80],"cavitation-based":[82],"tissue":[83],"disruption.":[84],"In":[85],"lower":[86],"density,":[88],"provide":[91],"targets":[92],"with":[93],"ideal":[94],"properties":[95],"aberration":[97],"correction,":[98],"which":[99],"used":[102],"improve":[104],"fields.":[109]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}