{"id":"https://openalex.org/W1898288811","doi":"https://doi.org/10.1109/isbi.2002.1029214","title":"Novel method for imaging biodegradable polymeric microparticles using MRI: application toward monitoring drug delivery","display_name":"Novel method for imaging biodegradable polymeric microparticles using MRI: application toward monitoring drug delivery","publication_year":2003,"publication_date":"2003-06-25","ids":{"openalex":"https://openalex.org/W1898288811","doi":"https://doi.org/10.1109/isbi.2002.1029214","mag":"1898288811"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2002.1029214","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2002.1029214","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings IEEE International Symposium on Biomedical Imaging","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064613398","display_name":"H.H. Chen","orcid":"https://orcid.org/0000-0001-5443-2173"},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"H.H. Chen","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA","Dept. of Biomed. Eng., Johns Hopkins Univ. Sch. of Med., Baltimore, MD, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Dept. of Biomed. Eng., Johns Hopkins Univ. Sch. of Med., Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007269886","display_name":"Catherine Le Visage","orcid":"https://orcid.org/0000-0003-1816-1649"},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Le Visage","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA","Dept. of Biomed. Eng., Johns Hopkins Univ. Sch. of Med., Baltimore, MD, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Dept. of Biomed. Eng., Johns Hopkins Univ. Sch. of Med., Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103946661","display_name":"Bensheng Qiu","orcid":null},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bensheng Qiu","raw_affiliation_strings":["Department of Radiology, Johns Hopkins School of Medicine, Baltimore, MD, USA","Department of Radiology, Johns Hopkins School of Medicine, Baltimore, Md, USA"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, Johns Hopkins School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Radiology, Johns Hopkins School of Medicine, Baltimore, Md, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083797099","display_name":"Xiangying Du","orcid":"https://orcid.org/0000-0002-0995-2046"},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiangying Du","raw_affiliation_strings":["Department of Radiology, Johns Hopkins School of Medicine, Baltimore, MD, USA","Department of Radiology, Johns Hopkins School of Medicine, Baltimore, Md, USA"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, Johns Hopkins School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Radiology, Johns Hopkins School of Medicine, Baltimore, Md, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040675660","display_name":"Ronald Ouwerkerk","orcid":"https://orcid.org/0000-0003-3882-9757"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Ouwerkerk","raw_affiliation_strings":["Department of Radiology, Johns Hopkins School of Medicine, Baltimore, MD, USA","Department of Radiology, Johns Hopkins School of Medicine, Baltimore, Md, USA"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, Johns Hopkins School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Radiology, Johns Hopkins School of Medicine, Baltimore, Md, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050822671","display_name":"Kam W. Leong","orcid":"https://orcid.org/0000-0002-8133-4955"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K.W. Leong","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA","[Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA]"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"[Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA]","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101914682","display_name":"Xiaoming Yang","orcid":"https://orcid.org/0000-0003-2482-8673"},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoming Yang","raw_affiliation_strings":["Department of Radiology, Johns Hopkins School of Medicine, Baltimore, MD, USA","Department of Radiology, Johns Hopkins School of Medicine, Baltimore, Md, USA"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, Johns Hopkins School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Radiology, Johns Hopkins School of Medicine, Baltimore, Md, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5064613398"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05361475,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":null,"first_page":"145","last_page":"148"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11815","display_name":"Urological Disorders and Treatments","score":0.9944000244140625,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-delivery","display_name":"Drug delivery","score":0.7594075202941895},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.7488994598388672},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.7069305181503296},{"id":"https://openalex.org/keywords/urothelium","display_name":"Urothelium","score":0.5886030197143555},{"id":"https://openalex.org/keywords/particle","display_name":"Particle (ecology)","score":0.5653901100158691},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.5120964050292969},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.49610480666160583},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.48426195979118347},{"id":"https://openalex.org/keywords/particle-size","display_name":"Particle size","score":0.4446926414966583},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2696276903152466},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.2674604654312134},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.18345487117767334},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.14361608028411865},{"id":"https://openalex.org/keywords/urinary-bladder","display_name":"Urinary bladder","score":0.13176503777503967},{"id":"https://openalex.org/keywords/surgery","display_name":"Surgery","score":0.12189525365829468}],"concepts":[{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.7594075202941895},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7488994598388672},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.7069305181503296},{"id":"https://openalex.org/C2777540882","wikidata":"https://www.wikidata.org/wiki/Q11878994","display_name":"Urothelium","level":3,"score":0.5886030197143555},{"id":"https://openalex.org/C2778517922","wikidata":"https://www.wikidata.org/wiki/Q7140482","display_name":"Particle (ecology)","level":2,"score":0.5653901100158691},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5120964050292969},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.49610480666160583},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.48426195979118347},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.4446926414966583},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2696276903152466},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2674604654312134},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.18345487117767334},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14361608028411865},{"id":"https://openalex.org/C2779762690","wikidata":"https://www.wikidata.org/wiki/Q9382","display_name":"Urinary bladder","level":2,"score":0.13176503777503967},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.12189525365829468},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi.2002.1029214","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2002.1029214","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings IEEE International Symposium on Biomedical Imaging","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.41999998688697815,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1532961821","https://openalex.org/W1988824537","https://openalex.org/W2022726129","https://openalex.org/W2024055402","https://openalex.org/W2033311505","https://openalex.org/W2048120028","https://openalex.org/W2049605540","https://openalex.org/W2113287037","https://openalex.org/W6677092949"],"related_works":["https://openalex.org/W1968035688","https://openalex.org/W1978476178","https://openalex.org/W2050448556","https://openalex.org/W2381690247","https://openalex.org/W189777751","https://openalex.org/W2160069794","https://openalex.org/W1988243620","https://openalex.org/W2043612946","https://openalex.org/W3008506738","https://openalex.org/W2034799960"],"abstract_inverted_index":{"We":[0],"have":[1],"developed":[2],"a":[3],"novel,":[4],"non-invasive":[5,91],"method":[6,92],"to":[7,12,58,67,85],"monitor":[8],"intravesical":[9],"drug":[10,108],"delivery":[11,109],"the":[13,48,68,81,94,104],"bladder":[14,49],"using":[15],"MRI":[16,74],"by":[17,73],"encapsulating":[18],"Gd-DTPA":[19],"into":[20],"biodegradable":[21],"polymeric":[22],"microparticles.":[23],"In":[24],"in":[25,40,47,100],"vitro":[26],"experiments,":[27],"Gd-DTPA-loaded":[28],"particles":[29,35],"could":[30,50],"be":[31,51],"differentiated":[32],"from":[33,39],"blank":[34],"and":[36,53,70,88],"water.":[37],"Images":[38],"vivo":[41],"experiments":[42],"demonstrated":[43],"that":[44,54],"particle":[45,61,98],"distribution":[46,99],"assessed":[52],"signal":[55],"intensity":[56],"appeared":[57],"correspond":[59],"with":[60],"population.":[62],"The":[63],"microparticles":[64],"were":[65,71],"adherent":[66],"urothelium":[69],"detectable":[72],"for":[75],"at":[76],"least":[77],"4":[78],"days":[79],"after":[80],"initial":[82],"instillation":[83],"due":[84],"their":[86],"muco-adhesiveness":[87],"stability.":[89],"This":[90],"enables":[93],"evaluation":[95],"of":[96,106],"local":[97],"vivo,":[101],"thereby":[102],"enhancing":[103],"value":[105],"particle-based":[107],"systems.":[110]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}