{"id":"https://openalex.org/W1485474627","doi":"https://doi.org/10.1109/iros.2003.1249217","title":"ACAPELLA-5K, a high-throughput automated genome and chemical analysis system","display_name":"ACAPELLA-5K, a high-throughput automated genome and chemical analysis system","publication_year":2004,"publication_date":"2004-07-08","ids":{"openalex":"https://openalex.org/W1485474627","doi":"https://doi.org/10.1109/iros.2003.1249217","mag":"1485474627"},"language":"en","primary_location":{"id":"doi:10.1109/iros.2003.1249217","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iros.2003.1249217","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings 2003 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS 2003) (Cat. No.03CH37453)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113654966","display_name":"D.R. Meldrum","orcid":null},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.R. Meldrum","raw_affiliation_strings":["Department of Electrical Engineering, University of Washington, Seattle, WA, USA","[Dept. of Electr. Eng., Washington Univ., Seattle, WA, USA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"[Dept. of Electr. Eng., Washington Univ., Seattle, WA, USA]","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110887552","display_name":"C. H. Fisher","orcid":null},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.H. Fisher","raw_affiliation_strings":["Department of Electrical Engineering, University of Washington, Seattle, WA, USA","[Dept. of Electr. Eng., Washington Univ., Seattle, WA, USA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"[Dept. of Electr. Eng., Washington Univ., Seattle, WA, USA]","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023628614","display_name":"Michael P. Moore","orcid":"https://orcid.org/0000-0002-8255-4247"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.P. Moore","raw_affiliation_strings":["Department of Electrical Engineering, University of Washington, Seattle, WA, USA","[Dept. of Electr. Eng., Washington Univ., Seattle, WA, USA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"[Dept. of Electr. Eng., Washington Univ., Seattle, WA, USA]","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006285282","display_name":"Mohan S. Saini","orcid":null},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Saini","raw_affiliation_strings":["Department of Electrical Engineering, University of Washington, Seattle, WA, USA","[Dept. of Electr. Eng., Washington Univ., Seattle, WA, USA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"[Dept. of Electr. Eng., Washington Univ., Seattle, WA, USA]","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071323218","display_name":"Mark R. Holl","orcid":null},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.R. Holl","raw_affiliation_strings":["Department of Electrical Engineering, University of Washington, Seattle, WA, USA","[Dept. of Electr. Eng., Washington Univ., Seattle, WA, USA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"[Dept. of Electr. Eng., Washington Univ., Seattle, WA, USA]","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007590945","display_name":"William H. Pence","orcid":null},"institutions":[{"id":"https://openalex.org/I4210105869","display_name":"Photonic Systems (United States)","ror":"https://ror.org/016s82z56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210105869"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W.H. Pence","raw_affiliation_strings":["Orca Photonic Systems, Inc., Redmond, WA, USA","ORCA Photonic Systems, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orca Photonic Systems, Inc., Redmond, WA, USA","institution_ids":["https://openalex.org/I4210105869"]},{"raw_affiliation_string":"ORCA Photonic Systems, Inc","institution_ids":["https://openalex.org/I4210105869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110117829","display_name":"Stephen E. Moody","orcid":null},"institutions":[{"id":"https://openalex.org/I4210105869","display_name":"Photonic Systems (United States)","ror":"https://ror.org/016s82z56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210105869"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.E. Moody","raw_affiliation_strings":["Orca Photonic Systems, Inc., Redmond, WA, USA","ORCA Photonic Systems, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orca Photonic Systems, Inc., Redmond, WA, USA","institution_ids":["https://openalex.org/I4210105869"]},{"raw_affiliation_string":"ORCA Photonic Systems, Inc","institution_ids":["https://openalex.org/I4210105869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005328234","display_name":"D. L. Cunningham","orcid":null},"institutions":[{"id":"https://openalex.org/I4210105869","display_name":"Photonic Systems (United States)","ror":"https://ror.org/016s82z56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210105869"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.L. Cunningham","raw_affiliation_strings":["Orca Photonic Systems, Inc., Redmond, WA, USA","ORCA Photonic Systems, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orca Photonic Systems, Inc., Redmond, WA, USA","institution_ids":["https://openalex.org/I4210105869"]},{"raw_affiliation_string":"ORCA Photonic Systems, Inc","institution_ids":["https://openalex.org/I4210105869"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110731603","display_name":"Peter Wiktor","orcid":null},"institutions":[{"id":"https://openalex.org/I4210139749","display_name":"Engineering Arts (United States)","ror":"https://ror.org/04g1y2z78","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139749"]},{"id":"https://openalex.org/I4210140922","display_name":"Mercer Island School District","ror":"https://ror.org/04eerm638","country_code":"US","type":"education","lineage":["https://openalex.org/I4210140922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P.J. Wiktor","raw_affiliation_strings":["Engineering Arts, Mercer Island, WA, USA","Engineering Arts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Engineering Arts, Mercer Island, WA, USA","institution_ids":["https://openalex.org/I4210140922","https://openalex.org/I4210139749"]},{"raw_affiliation_string":"Engineering Arts","institution_ids":["https://openalex.org/I4210139749"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5965,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.67657452,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"3","issue":null,"first_page":"2321","last_page":"2328"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9889000058174133,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5696595311164856},{"id":"https://openalex.org/keywords/automation","display_name":"Automation","score":0.5519923567771912},{"id":"https://openalex.org/keywords/pipeline-transport","display_name":"Pipeline transport","score":0.44309180974960327},{"id":"https://openalex.org/keywords/protocol","display_name":"Protocol (science)","score":0.4358726739883423},{"id":"https://openalex.org/keywords/throughput","display_name":"Throughput","score":0.4145488440990448},{"id":"https://openalex.org/keywords/embedded-system","display_name":"Embedded system","score":0.33627551794052124},{"id":"https://openalex.org/keywords/computer-hardware","display_name":"Computer hardware","score":0.33316710591316223},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2625826597213745},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.11990681290626526},{"id":"https://openalex.org/keywords/operating-system","display_name":"Operating system","score":0.08823239803314209}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5696595311164856},{"id":"https://openalex.org/C115901376","wikidata":"https://www.wikidata.org/wiki/Q184199","display_name":"Automation","level":2,"score":0.5519923567771912},{"id":"https://openalex.org/C175309249","wikidata":"https://www.wikidata.org/wiki/Q725864","display_name":"Pipeline transport","level":2,"score":0.44309180974960327},{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.4358726739883423},{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.4145488440990448},{"id":"https://openalex.org/C149635348","wikidata":"https://www.wikidata.org/wiki/Q193040","display_name":"Embedded system","level":1,"score":0.33627551794052124},{"id":"https://openalex.org/C9390403","wikidata":"https://www.wikidata.org/wiki/Q3966","display_name":"Computer hardware","level":1,"score":0.33316710591316223},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2625826597213745},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.11990681290626526},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.08823239803314209},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/iros.2003.1249217","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iros.2003.1249217","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings 2003 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS 2003) (Cat. No.03CH37453)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W55274681","https://openalex.org/W140099632","https://openalex.org/W155369643","https://openalex.org/W1973203937","https://openalex.org/W1978195973","https://openalex.org/W1993715247","https://openalex.org/W2001321345","https://openalex.org/W2036383542","https://openalex.org/W2036773785","https://openalex.org/W2081326066","https://openalex.org/W2105312882","https://openalex.org/W2106951027","https://openalex.org/W2117817813","https://openalex.org/W2122989565","https://openalex.org/W2134422873","https://openalex.org/W2158917199","https://openalex.org/W2162127981","https://openalex.org/W2167427779","https://openalex.org/W2292835948","https://openalex.org/W2320448700","https://openalex.org/W2417630483","https://openalex.org/W2983363128","https://openalex.org/W6605795884","https://openalex.org/W6678318188","https://openalex.org/W6684630879"],"related_works":["https://openalex.org/W2136583354","https://openalex.org/W1995889332","https://openalex.org/W2111238207","https://openalex.org/W3104163240","https://openalex.org/W2760721665","https://openalex.org/W3008693296","https://openalex.org/W4312283151","https://openalex.org/W2381158465","https://openalex.org/W2218202131","https://openalex.org/W2359178629"],"abstract_inverted_index":{"A":[0,44],"capillary-based":[1],"fluid":[2],"handling":[3],"system":[4,16,63,102],"bas":[5],"been":[6,104],"developed":[7],"to":[8,50,84],"process":[9,47],"5000":[10],"samples":[11,24,58],"in":[12,31,87],"8":[13],"hours.":[14],"The":[15],"takes":[17],"deoxyribonucleic":[18],"acid":[19],"(DNA)":[20],"or":[21,76],"other":[22],"chemical":[23],"and":[25,41,54,73,95,135],"automatically":[26],"processes":[27],"them":[28],"as":[29],"specified":[30],"a":[32,82],"user-defined":[33],"protocol":[34],"with":[35,106],"aspiration,":[36],"dispensing,":[37],"mixing,":[38],"thermal":[39],"cycling,":[40],"imaging":[42],"steps.":[43],"serial":[45],"pipeline":[46],"is":[48],"used":[49],"provide":[51],"flexibility,":[52],"reproducibility,":[53],"reliability":[55],"for":[56,114],"the":[57,101,107],"prepared.":[59],"This":[60],"laboratory":[61],"automation":[62],"dispenses":[64],"40-100":[65],"pL":[66],"droplet":[67],"volumes":[68],"using":[69],"piezoelectric":[70],"reagent":[71,88],"dispensers":[72],"prepares":[74],"1":[75],"2-/spl":[77],"mu/L":[78],"final":[79],"reaction":[80],"volumes,":[81],"3":[83],"5-fold":[85],"reduction":[86],"usage":[89],"over":[90],"current":[91],"(2003)":[92],"state-of-the-art":[93],"manual":[94],"automated":[96],"instrumentation.":[97],"Extensive":[98],"testing":[99],"of":[100,109],"has":[103],"performed":[105],"University":[108],"Washington":[110],"Genome":[111],"Center.":[112],"Applications":[113],"ACAPELLA-5K":[115],"include":[116],"DNA":[117],"sequencing,":[118],"diagnostics,":[119],"minimal":[120],"residual":[121],"disease":[122],"quantification,":[123],"drug":[124],"discovery,":[125],"environmental":[126],"testing,":[127],"forensics,":[128],"protein":[129],"crystallography,":[130],"Polymerase":[131],"Chain":[132],"Reaction":[133],"(PCR)":[134],"so":[136],"on.":[137]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}