{"id":"https://openalex.org/W1843347006","doi":"https://doi.org/10.1109/ipdps.2004.1303213","title":"Large-scale simulations of Eukaryotic cell signaling processes","display_name":"Large-scale simulations of Eukaryotic cell signaling processes","publication_year":2004,"publication_date":"2004-06-10","ids":{"openalex":"https://openalex.org/W1843347006","doi":"https://doi.org/10.1109/ipdps.2004.1303213","mag":"1843347006"},"language":"en","primary_location":{"id":"doi:10.1109/ipdps.2004.1303213","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ipdps.2004.1303213","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"18th International Parallel and Distributed Processing Symposium, 2004. Proceedings.","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021738971","display_name":"John H. Miller","orcid":"https://orcid.org/0000-0001-6383-1037"},"institutions":[{"id":"https://openalex.org/I16109614","display_name":"Washington State University Tri-Cities","ror":"https://ror.org/02sjef319","country_code":"US","type":"education","lineage":["https://openalex.org/I16109614","https://openalex.org/I72951846"]},{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.H. Miller","raw_affiliation_strings":["School of Electrical Engineering and Computer Science, Washington State University, Tri-Cities, Richland, WA, USA","Sch. of Electr. Eng. & Comput. Sci., Washington State Univ., Richland, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electrical Engineering and Computer Science, Washington State University, Tri-Cities, Richland, WA, USA","institution_ids":["https://openalex.org/I16109614"]},{"raw_affiliation_string":"Sch. of Electr. Eng. & Comput. Sci., Washington State Univ., Richland, WA, USA","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001124751","display_name":"Fang Zheng","orcid":"https://orcid.org/0000-0002-5699-8063"},"institutions":[{"id":"https://openalex.org/I16109614","display_name":"Washington State University Tri-Cities","ror":"https://ror.org/02sjef319","country_code":"US","type":"education","lineage":["https://openalex.org/I16109614","https://openalex.org/I72951846"]},{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fang Zheng","raw_affiliation_strings":["School of Electrical Engineering and Computer Science, Washington State University, Tri-Cities, Richland, WA, USA","Sch. of Electr. Eng. & Comput. Sci., Washington State Univ., Richland, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electrical Engineering and Computer Science, Washington State University, Tri-Cities, Richland, WA, USA","institution_ids":["https://openalex.org/I16109614"]},{"raw_affiliation_string":"Sch. of Electr. Eng. & Comput. Sci., Washington State Univ., Richland, WA, USA","institution_ids":["https://openalex.org/I72951846"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11481007,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"193","last_page":"197"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autocrine-signalling","display_name":"Autocrine signalling","score":0.9152530431747437},{"id":"https://openalex.org/keywords/mapk/erk-pathway","display_name":"MAPK/ERK pathway","score":0.7457712292671204},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"Epidermal growth factor receptor","score":0.697881817817688},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.5870572328567505},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"Ionizing radiation","score":0.5461035370826721},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.5337304472923279},{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.5280105471611023},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.5250492095947266},{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.5000944137573242},{"id":"https://openalex.org/keywords/extracellular","display_name":"Extracellular","score":0.47870922088623047},{"id":"https://openalex.org/keywords/growth-factor","display_name":"Growth factor","score":0.45738452672958374},{"id":"https://openalex.org/keywords/tgf-alpha","display_name":"TGF alpha","score":0.45340248942375183},{"id":"https://openalex.org/keywords/cell-growth","display_name":"Cell growth","score":0.44577479362487793},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.43679752945899963},{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"Epidermal growth factor","score":0.4201476275920868},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.35936611890792847},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3394719362258911},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.3036223351955414},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.17047050595283508},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.12345179915428162},{"id":"https://openalex.org/keywords/irradiation","display_name":"Irradiation","score":0.1053377091884613}],"concepts":[{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.9152530431747437},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.7457712292671204},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.697881817817688},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5870572328567505},{"id":"https://openalex.org/C18231593","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Ionizing radiation","level":3,"score":0.5461035370826721},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5337304472923279},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5280105471611023},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5250492095947266},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5000944137573242},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.47870922088623047},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.45738452672958374},{"id":"https://openalex.org/C125555471","wikidata":"https://www.wikidata.org/wiki/Q14908037","display_name":"TGF alpha","level":4,"score":0.45340248942375183},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.44577479362487793},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43679752945899963},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.4201476275920868},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35936611890792847},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3394719362258911},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3036223351955414},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17047050595283508},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.12345179915428162},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.1053377091884613},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/ipdps.2004.1303213","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ipdps.2004.1303213","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"18th International Parallel and Distributed Processing Symposium, 2004. Proceedings.","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7599999904632568,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1574498833","https://openalex.org/W1978486653","https://openalex.org/W2028673763","https://openalex.org/W2034269086","https://openalex.org/W2041603328","https://openalex.org/W2056943748","https://openalex.org/W2075161553","https://openalex.org/W2080414061","https://openalex.org/W2094703210","https://openalex.org/W2124317989","https://openalex.org/W2134477837","https://openalex.org/W2136147374","https://openalex.org/W2138321569","https://openalex.org/W2138365635","https://openalex.org/W2161965319","https://openalex.org/W4388243180"],"related_works":["https://openalex.org/W2049319935","https://openalex.org/W2120102597","https://openalex.org/W1992212640","https://openalex.org/W2074323832","https://openalex.org/W2084144223","https://openalex.org/W2141087701","https://openalex.org/W2002766665","https://openalex.org/W2104963800","https://openalex.org/W2083825204","https://openalex.org/W2315534698"],"abstract_inverted_index":{"Summary":[0],"form":[1],"only":[2],"given.":[3],"A":[4,79,158],"database":[5],"of":[6,23,43,59,100,123,135,161,170,176,190,199],"rate":[7],"constants":[8],"and":[9,137],"related":[10],"quantities":[11],"has":[12],"been":[13],"assembled":[14],"by":[15,47,108,155,172],"Schoeberl":[16],"et":[17,110],"al.":[18,111],"for":[19],"intracellular":[20],"signaling":[21,178],"downstream":[22],"the":[24,70,133,142,149,177],"epidermal":[25],"growth":[26,92,163,195],"factor":[27,93],"receptor":[28],"(EGFR).":[29],"This":[30],"information":[31],"was":[32,130,146],"combined":[33],"with":[34,132],"data":[35,107],"on":[36,112],"metalloprotease":[37,87],"activation":[38,58,82,117],"to":[39,51,65,86,106,167],"build":[40],"a":[41,66,119,186],"model":[42,55],"autocrine":[44,98],"signal":[45],"transduction":[46],"cancer":[48,171],"cells":[49,125],"exposed":[50],"ionizing":[52],"radiation.":[53],"The":[54],"predicts":[56],"prompt":[57,136,150],"mitogen-activated-protein-kinase":[60],"(MAPK)":[61],"pathways":[62,179],"in":[63,69,126,181],"response":[64,145],"radiation-induced":[67,162],"shift":[68],"RasGDP":[71],"/spl":[72],"harr/":[73],"RasGTP":[74],"equilibrium":[75],"toward":[76],"more":[77,152],"RasGTP.":[78],"secondary":[80,138,144],"MAPK":[81],"is":[83,165],"predicted":[84,154],"due":[85],"activity":[88],"that":[89],"releases":[90],"transforming":[91],"alpha":[94],"(TGF/spl":[95],"alpha/),":[96],"an":[97],"ligand":[99],"EGFR.":[101],"Model":[102],"predictions":[103],"were":[104],"compared":[105],"Dent":[109],"extracellular":[113],"regulated":[114],"kinase":[115],"(ERK)":[116],"following":[118],"2":[120],"Gy":[121],"exposure":[122],"carcinoma":[124],"vitro.":[127],"Good":[128],"agreement":[129],"obtained":[131],"magnitude":[134],"ERK":[139],"activation;":[140],"however,":[141],"experimental":[143],"delayed":[147],"relative":[148],"peak":[151],"than":[153],"our":[156],"model.":[157],"mechanistic":[159],"understanding":[160],"factors":[164,196],"needed":[166],"improve":[168],"treatment":[169],"radiation":[173,191],"therapy.":[174],"Inhibitors":[175],"modeled":[180],"this":[182],"study":[183],"may":[184],"reduce":[185],"potentially":[187],"self-limiting":[188],"aspect":[189],"therapy":[192],"whereby":[193],"induced":[194],"accelerate":[197],"repopulation":[198],"treated":[200],"tumor":[201],"volumes.":[202]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}