{"id":"https://openalex.org/W4312605409","doi":"https://doi.org/10.1109/ijcnn55064.2022.9891992","title":"Development of Deep Learning approaches to predict relationships between chemical structures and sweetness","display_name":"Development of Deep Learning approaches to predict relationships between chemical structures and sweetness","publication_year":2022,"publication_date":"2022-07-18","ids":{"openalex":"https://openalex.org/W4312605409","doi":"https://doi.org/10.1109/ijcnn55064.2022.9891992"},"language":"en","primary_location":{"id":"doi:10.1109/ijcnn55064.2022.9891992","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ijcnn55064.2022.9891992","pdf_url":null,"source":{"id":"https://openalex.org/S4363607707","display_name":"2022 International Joint Conference on Neural Networks (IJCNN)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 International Joint Conference on Neural Networks (IJCNN)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/1822/80454","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056807631","display_name":"Jo\u00e3o Capela","orcid":"https://orcid.org/0000-0002-1235-2922"},"institutions":[{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Joao Capela","raw_affiliation_strings":["Centre of Biological Engineering, University of Minho,Braga,Portugal","Centre of Biological Engineering, University of Minho, Braga, Portugal"],"affiliations":[{"raw_affiliation_string":"Centre of Biological Engineering, University of Minho,Braga,Portugal","institution_ids":["https://openalex.org/I99682543"]},{"raw_affiliation_string":"Centre of Biological Engineering, University of Minho, Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025761868","display_name":"Jo\u00e3o Correia","orcid":"https://orcid.org/0000-0001-5190-4825"},"institutions":[{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Joao Correia","raw_affiliation_strings":["Centre of Biological Engineering, University of Minho,Braga,Portugal","Centre of Biological Engineering, University of Minho, Braga, Portugal"],"affiliations":[{"raw_affiliation_string":"Centre of Biological Engineering, University of Minho,Braga,Portugal","institution_ids":["https://openalex.org/I99682543"]},{"raw_affiliation_string":"Centre of Biological Engineering, University of Minho, Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009025832","display_name":"V\u00edtor Pereira","orcid":"https://orcid.org/0000-0002-8661-9626"},"institutions":[{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Vitor Pereira","raw_affiliation_strings":["Centre of Biological Engineering, University of Minho,Braga,Portugal","Centre of Biological Engineering, University of Minho, Braga, Portugal"],"affiliations":[{"raw_affiliation_string":"Centre of Biological Engineering, University of Minho,Braga,Portugal","institution_ids":["https://openalex.org/I99682543"]},{"raw_affiliation_string":"Centre of Biological Engineering, University of Minho, Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040524717","display_name":"Miguel Rocha","orcid":"https://orcid.org/0000-0001-8439-8172"},"institutions":[{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Miguel Rocha","raw_affiliation_strings":["Centre of Biological Engineering, University of Minho,Braga,Portugal","Centre of Biological Engineering, University of Minho, Braga, Portugal"],"affiliations":[{"raw_affiliation_string":"Centre of Biological Engineering, University of Minho,Braga,Portugal","institution_ids":["https://openalex.org/I99682543"]},{"raw_affiliation_string":"Centre of Biological Engineering, University of Minho, Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5056807631"],"corresponding_institution_ids":["https://openalex.org/I99682543"],"apc_list":null,"apc_paid":null,"fwci":1.6032,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.84545046,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11667","display_name":"Advanced Chemical Sensor Technologies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11667","display_name":"Advanced Chemical Sensor Technologies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.9896000027656555,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sweetness","display_name":"Sweetness","score":0.8689926862716675},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.7028432488441467},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.6497891545295715},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6052758097648621},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.5992600321769714},{"id":"https://openalex.org/keywords/repurposing","display_name":"Repurposing","score":0.5803086161613464},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.5613096952438354},{"id":"https://openalex.org/keywords/deep-neural-networks","display_name":"Deep neural networks","score":0.4356086552143097},{"id":"https://openalex.org/keywords/taste","display_name":"Taste","score":0.3347727060317993},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.24537450075149536},{"id":"https://openalex.org/keywords/food-science","display_name":"Food science","score":0.11065918207168579},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.11031332612037659}],"concepts":[{"id":"https://openalex.org/C2779476700","wikidata":"https://www.wikidata.org/wiki/Q460453","display_name":"Sweetness","level":3,"score":0.8689926862716675},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.7028432488441467},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.6497891545295715},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6052758097648621},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.5992600321769714},{"id":"https://openalex.org/C519536355","wikidata":"https://www.wikidata.org/wiki/Q21021151","display_name":"Repurposing","level":2,"score":0.5803086161613464},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.5613096952438354},{"id":"https://openalex.org/C2984842247","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep neural networks","level":3,"score":0.4356086552143097},{"id":"https://openalex.org/C8868529","wikidata":"https://www.wikidata.org/wiki/Q124794","display_name":"Taste","level":2,"score":0.3347727060317993},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24537450075149536},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.11065918207168579},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.11031332612037659},{"id":"https://openalex.org/C548081761","wikidata":"https://www.wikidata.org/wiki/Q180388","display_name":"Waste management","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/ijcnn55064.2022.9891992","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ijcnn55064.2022.9891992","pdf_url":null,"source":{"id":"https://openalex.org/S4363607707","display_name":"2022 International Joint Conference on Neural Networks (IJCNN)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 International Joint Conference on Neural Networks (IJCNN)","raw_type":"proceedings-article"},{"id":"pmh:oai:repositorium.sdum.uminho.pt:1822/80454","is_oa":true,"landing_page_url":"https://hdl.handle.net/1822/80454","pdf_url":null,"source":{"id":"https://openalex.org/S4306400354","display_name":"Reposit\u00f3riUM (Universidade do Minho)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I99682543","host_organization_name":"University of Minho","host_organization_lineage":["https://openalex.org/I99682543"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null}],"best_oa_location":{"id":"pmh:oai:repositorium.sdum.uminho.pt:1822/80454","is_oa":true,"landing_page_url":"https://hdl.handle.net/1822/80454","pdf_url":null,"source":{"id":"https://openalex.org/S4306400354","display_name":"Reposit\u00f3riUM (Universidade do Minho)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I99682543","host_organization_name":"University of Minho","host_organization_lineage":["https://openalex.org/I99682543"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G160550121","display_name":null,"funder_award_id":"-FEDER-","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G1716593420","display_name":null,"funder_award_id":"-FEDER-","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G3284537356","display_name":null,"funder_award_id":"SFRH/B","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G3838636553","display_name":null,"funder_award_id":"-01-0247-","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G4385197441","display_name":null,"funder_award_id":"PhD fellowship","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G5348594205","display_name":null,"funder_award_id":"FEDER","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G5818630289","display_name":null,"funder_award_id":"SFRH/BD/","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G6268071741","display_name":null,"funder_award_id":"NORTE-01-0247-FEDER-039831","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G7049410507","display_name":null,"funder_award_id":"Portuguese Foundation for Science","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G724804869","display_name":null,"funder_award_id":"SFRH/","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G8562927013","display_name":null,"funder_award_id":"DFA/BD/08789/2021","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G943999617","display_name":null,"funder_award_id":"Technology","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"}],"funders":[{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1328637","https://openalex.org/W1512526457","https://openalex.org/W1832693441","https://openalex.org/W1968681158","https://openalex.org/W2029282364","https://openalex.org/W2060127427","https://openalex.org/W2076231257","https://openalex.org/W2085738117","https://openalex.org/W2093674381","https://openalex.org/W2157080550","https://openalex.org/W2314013466","https://openalex.org/W2547314954","https://openalex.org/W2599178458","https://openalex.org/W2796932608","https://openalex.org/W2809595040","https://openalex.org/W2951080103","https://openalex.org/W2964015378","https://openalex.org/W2964113829","https://openalex.org/W2975866056","https://openalex.org/W2987881105","https://openalex.org/W3035302862","https://openalex.org/W3087318293","https://openalex.org/W3121678941","https://openalex.org/W3138781613","https://openalex.org/W3148473420","https://openalex.org/W3185653699","https://openalex.org/W3211388180","https://openalex.org/W4242588385","https://openalex.org/W4285723986","https://openalex.org/W6685350579","https://openalex.org/W6726873649","https://openalex.org/W6816886924"],"related_works":["https://openalex.org/W4221040227","https://openalex.org/W2080569495","https://openalex.org/W39346000","https://openalex.org/W3196135651","https://openalex.org/W1993646413","https://openalex.org/W1975733106","https://openalex.org/W3146486293","https://openalex.org/W2326418441","https://openalex.org/W2623240653","https://openalex.org/W2428252480"],"abstract_inverted_index":{"The":[0,74,84],"non-caloric":[1],"sweeteners":[2,90,161],"market":[3,9],"is":[4,81,210],"catching":[5],"up":[6],"with":[7,34,229],"the":[8,16,45,63,103,157],"of":[10,18,65,78,105,143,159,181,188],"conventionally":[11],"used":[12],"sugars":[13],"due":[14],"to":[15,61,155,197,217],"benefits":[17],"preventing":[19],"obesity,":[20],"tooth":[21],"decay":[22],"and":[23,38,91,97,108,119,136,162,225],"other":[24],"health":[25],"problems.":[26],"Developing":[27],"strategies":[28],"for":[29,44,212],"designing":[30,226],"easier-to-produce":[31],"novel":[32,227],"molecules":[33,67,80,118,200,228],"a":[35,179,230],"sweet":[36,72,79,231],"taste":[37],"less":[39],"toxicity":[40],"are":[41],"up-to-date":[42],"motivations":[43],"food":[46,219],"industry.":[47],"In":[48,121],"this":[49,122],"sense,":[50],"Machine":[51,107],"Learning":[52,110,150],"(ML)":[53],"approaches":[54],"have":[55],"been":[56],"reported":[57,201],"as":[58,202],"cutting-edge":[59],"technologies":[60],"guide":[62,156],"design":[64,158],"new":[66,160,214],"towards":[68,112],"specific":[69],"objectives,":[70],"including":[71],"taste.":[73,232],"largest":[75],"known":[76],"dataset":[77,85,101,180],"here":[82],"provided.":[83],"contains":[86],"fully":[87],"integrated":[88],"9541":[89],"1141":[92],"bitterants":[93],"from":[94,169],"FooDB,":[95],"FlavorDB":[96],"literature.":[98],"This":[99],"robust":[100],"allowed":[102,195],"development":[104],"standard":[106],"Deep":[109,137,149],"pipelines":[111],"conceiving":[113],"Structure-Activity":[114],"Relationships":[115],"(SAR)":[116],"between":[117],"sweetness.":[120],"work,":[123],"we":[124,177],"showcase":[125],"that":[126,184,207],"Textual":[127],"Convolutional":[128,133],"Neural":[129,138],"Networks":[130,134,139],"(TextCNN),":[131],"Graph":[132],"(GCN),":[135],"(DNNs)":[140],"outperformed":[141],"most":[142],"traditional":[144],"\u201cshallow\u201d":[145],"learning":[146],"approaches.":[147],"These":[148],"(DL)":[151],"models":[152],"produced":[153],"platforms":[154],"repurposing":[163,222],"existing":[164,223],"compounds.":[165],"Sixty":[166],"million":[167],"compounds":[168,183],"PubChem":[170],"were":[171],"evaluated":[172],"using":[173],"these":[174],"models.":[175],"Herein,":[176],"deliver":[178],"67724":[182],"present":[185],"high":[186],"probabilities":[187],"being":[189],"sweet.":[190],"Quick":[191],"searches":[192],"in":[193],"literature":[194],"us":[196],"find":[198],"13":[199],"potent":[203],"sweetening":[204],"agents,":[205],"revealing":[206],"our":[208],"approach":[209],"suitable":[211],"finding":[213],"sweeteners,":[215],"valuable":[216],"expand":[218],"chemistry":[220],"databases,":[221],"chemicals":[224]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3}],"updated_date":"2026-04-11T08:14:18.477133","created_date":"2025-10-10T00:00:00"}
