{"id":"https://openalex.org/W2977400410","doi":"https://doi.org/10.1109/ijcnn.2019.8852245","title":"Deep Learning Of P73 Biomarker Expression In Rectal Cancer Patients","display_name":"Deep Learning Of P73 Biomarker Expression In Rectal Cancer Patients","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2977400410","doi":"https://doi.org/10.1109/ijcnn.2019.8852245","mag":"2977400410"},"language":"en","primary_location":{"id":"doi:10.1109/ijcnn.2019.8852245","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ijcnn.2019.8852245","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 International Joint Conference on Neural Networks (IJCNN)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009439842","display_name":"Tuan D. Pham","orcid":"https://orcid.org/0000-0002-4255-5130"},"institutions":[{"id":"https://openalex.org/I102134673","display_name":"Link\u00f6ping University","ror":"https://ror.org/05ynxx418","country_code":"SE","type":"education","lineage":["https://openalex.org/I102134673"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Tuan D. Pham","raw_affiliation_strings":["Center for Medical Image Science and Visualization, Linkoping University, Linkoping, Sweden"],"affiliations":[{"raw_affiliation_string":"Center for Medical Image Science and Visualization, Linkoping University, Linkoping, Sweden","institution_ids":["https://openalex.org/I102134673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100661115","display_name":"Chuanwen Fan","orcid":"https://orcid.org/0000-0001-5804-9374"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuanwen Fan","raw_affiliation_strings":["Institute of Digestive Surgery, Sichuan University, Chengdu, China"],"affiliations":[{"raw_affiliation_string":"Institute of Digestive Surgery, Sichuan University, Chengdu, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100430241","display_name":"Hong Zhang","orcid":"https://orcid.org/0000-0001-7670-626X"},"institutions":[{"id":"https://openalex.org/I26437253","display_name":"\u00d6rebro University","ror":"https://ror.org/05kytsw45","country_code":"SE","type":"education","lineage":["https://openalex.org/I26437253"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Hong Zhang","raw_affiliation_strings":["Department of Medical Sciences, Orebro University, Orebro, Sweden"],"affiliations":[{"raw_affiliation_string":"Department of Medical Sciences, Orebro University, Orebro, Sweden","institution_ids":["https://openalex.org/I26437253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033083323","display_name":"Xiao\u2010Feng Sun","orcid":"https://orcid.org/0000-0003-1253-1901"},"institutions":[{"id":"https://openalex.org/I102134673","display_name":"Link\u00f6ping University","ror":"https://ror.org/05ynxx418","country_code":"SE","type":"education","lineage":["https://openalex.org/I102134673"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Xiao-Feng Sun","raw_affiliation_strings":["Department of Oncology Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden"],"affiliations":[{"raw_affiliation_string":"Department of Oncology Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden","institution_ids":["https://openalex.org/I102134673"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5009439842"],"corresponding_institution_ids":["https://openalex.org/I102134673"],"apc_list":null,"apc_paid":null,"fwci":0.8467,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.75245493,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13110","display_name":"Colorectal and Anal Carcinomas","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biopsy","display_name":"Biopsy","score":0.7009153962135315},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"Colorectal cancer","score":0.6928987503051758},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.6658265590667725},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"Immunohistochemistry","score":0.6176272630691528},{"id":"https://openalex.org/keywords/primary-tumor","display_name":"Primary tumor","score":0.5838671326637268},{"id":"https://openalex.org/keywords/metastasis","display_name":"Metastasis","score":0.5779767036437988},{"id":"https://openalex.org/keywords/distant-metastasis","display_name":"Distant metastasis","score":0.5491358637809753},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.548963725566864},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.5446003675460815},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"Lymph node metastasis","score":0.5187592506408691},{"id":"https://openalex.org/keywords/lymph-node","display_name":"Lymph node","score":0.5178771018981934},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.49431562423706055},{"id":"https://openalex.org/keywords/lymph","display_name":"Lymph","score":0.4344395101070404},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.18316632509231567},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.13252145051956177}],"concepts":[{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.7009153962135315},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6928987503051758},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6658265590667725},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6176272630691528},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.5838671326637268},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5779767036437988},{"id":"https://openalex.org/C3019926457","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Distant metastasis","level":4,"score":0.5491358637809753},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.548963725566864},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5446003675460815},{"id":"https://openalex.org/C2992571226","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node metastasis","level":4,"score":0.5187592506408691},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.5178771018981934},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49431562423706055},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.4344395101070404},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18316632509231567},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13252145051956177},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/ijcnn.2019.8852245","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ijcnn.2019.8852245","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 International Joint Conference on Neural Networks (IJCNN)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1501276988","https://openalex.org/W1546411676","https://openalex.org/W1585172067","https://openalex.org/W1723934317","https://openalex.org/W1764840447","https://openalex.org/W1980128193","https://openalex.org/W1987012261","https://openalex.org/W1993301396","https://openalex.org/W2025623420","https://openalex.org/W2111808908","https://openalex.org/W2135975717","https://openalex.org/W2152375843","https://openalex.org/W2155988062","https://openalex.org/W2185605786","https://openalex.org/W2266594984","https://openalex.org/W2302003756","https://openalex.org/W2423190751","https://openalex.org/W2435090885","https://openalex.org/W2504150216","https://openalex.org/W2624968784","https://openalex.org/W2626019598","https://openalex.org/W2768976639","https://openalex.org/W2919115771","https://openalex.org/W2985131423","https://openalex.org/W4211147392","https://openalex.org/W4234157358","https://openalex.org/W6632670727","https://openalex.org/W6770125268"],"related_works":["https://openalex.org/W2008553569","https://openalex.org/W4361257721","https://openalex.org/W203485574","https://openalex.org/W1966798989","https://openalex.org/W2020142317","https://openalex.org/W1973402430","https://openalex.org/W4361237345","https://openalex.org/W2079912968","https://openalex.org/W2032187574","https://openalex.org/W2406121188"],"abstract_inverted_index":{"By":[0],"applying":[1],"deep":[2],"learning,":[3],"we":[4],"were":[5,37],"able":[6],"to":[7],"compare":[8],"p73":[9],"protein":[10],"expression":[11],"patterns":[12],"of":[13,106,116,133],"different":[14],"tissue":[15,72],"types":[16],"including":[17],"normal":[18],"mucosa,":[19],"primary":[20,61,85,89],"tumor":[21,62,75],"and":[22,46,63,76,80,84,88,94,100,129],"lymph":[23,64,91,97],"node":[24,65,92,98],"metastasis":[25,66,93,99],"in":[26,50,120,126,137],"rectal":[27,127],"cancer":[28,128,138],"patients":[29],"using":[30],"immunohistochemical":[31],"slides.":[32],"The":[33],"pair-wise":[34],"pattern":[35,58],"comparisons":[36],"automatedly":[38],"carried":[39],"out":[40],"by":[41],"considering":[42],"color,":[43],"edge,":[44],"blobs,":[45],"other":[47,71],"morphological":[48],"information":[49],"the":[51,57],"images.":[52],"We":[53],"discovered":[54],"that":[55],"when":[56],"dissimilarity":[59],"between":[60],"is":[67],"relatively":[68],"low":[69],"among":[70],"pairs":[73],"(primary":[74],"distant":[77,81,95],"normal,":[78,82,96],"biopsy":[79,83,87],"tumor,":[86,90],"biopsy),":[101],"there":[102],"was":[103],"an":[104],"implication":[105],"short-time":[107],"survival.":[108],"This":[109],"original":[110],"result":[111],"suggests":[112],"a":[113],"novel":[114],"application":[115],"advanced":[117],"artificial":[118],"intelligence":[119],"machine":[121],"learning":[122],"for":[123],"clinical":[124],"finding":[125],"encourages":[130],"relevant":[131],"study":[132],"multiple":[134],"biomarker":[135],"expressions":[136],"patients.":[139]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}