{"id":"https://openalex.org/W2896786131","doi":"https://doi.org/10.1109/ijcnn.2018.8489054","title":"Modeling Gene Transcriptional Regulation by Means of Hyperplanes Genetic Clustering","display_name":"Modeling Gene Transcriptional Regulation by Means of Hyperplanes Genetic Clustering","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2896786131","doi":"https://doi.org/10.1109/ijcnn.2018.8489054","mag":"2896786131"},"language":"en","primary_location":{"id":"doi:10.1109/ijcnn.2018.8489054","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ijcnn.2018.8489054","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 International Joint Conference on Neural Networks (IJCNN)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11311/1068380","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029627909","display_name":"Fabrizio Frasca","orcid":"https://orcid.org/0000-0002-5165-1394"},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Fabrizio Frasca","raw_affiliation_strings":["Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Piazza L. Da Vinci, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Piazza L. Da Vinci, Milan, Italy","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003932703","display_name":"Matteo Matteucci","orcid":"https://orcid.org/0000-0002-8306-6739"},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matteo Matteucci","raw_affiliation_strings":["Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Piazza L. Da Vinci, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Piazza L. Da Vinci, Milan, Italy","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085346183","display_name":"Marco Masseroli","orcid":"https://orcid.org/0000-0003-2574-1174"},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Masseroli","raw_affiliation_strings":["Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Piazza L. Da Vinci, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Piazza L. Da Vinci, Milan, Italy","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007690571","display_name":"Marco J. Morelli","orcid":"https://orcid.org/0000-0003-1862-667X"},"institutions":[{"id":"https://openalex.org/I30771326","display_name":"Italian Institute of Technology","ror":"https://ror.org/042t93s57","country_code":"IT","type":"facility","lineage":["https://openalex.org/I30771326"]},{"id":"https://openalex.org/I4210151238","display_name":"Center for Genomic Science","ror":"https://ror.org/04xbkmk86","country_code":"IT","type":"facility","lineage":["https://openalex.org/I30771326","https://openalex.org/I4210151238"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Morelli","raw_affiliation_strings":["Center for Genomic Science of IIT@SEMM, Istituto Italiano di Tecnologia (IIT), Milan, Italy"],"affiliations":[{"raw_affiliation_string":"Center for Genomic Science of IIT@SEMM, Istituto Italiano di Tecnologia (IIT), Milan, Italy","institution_ids":["https://openalex.org/I4210151238","https://openalex.org/I30771326"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5029627909"],"corresponding_institution_ids":["https://openalex.org/I93860229"],"apc_list":null,"apc_paid":null,"fwci":0.1838,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.53357441,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"7 p","issue":null,"first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.992900013923645,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.987500011920929,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.6982428431510925},{"id":"https://openalex.org/keywords/hyperplane","display_name":"Hyperplane","score":0.6402477622032166},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5693230628967285},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5012085437774658},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.463545024394989},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.35851556062698364},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3098037838935852},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.28859102725982666},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.15628647804260254},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.07952567934989929}],"concepts":[{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.6982428431510925},{"id":"https://openalex.org/C68693459","wikidata":"https://www.wikidata.org/wiki/Q657586","display_name":"Hyperplane","level":2,"score":0.6402477622032166},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5693230628967285},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5012085437774658},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.463545024394989},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35851556062698364},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3098037838935852},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.28859102725982666},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.15628647804260254},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.07952567934989929}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/ijcnn.2018.8489054","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ijcnn.2018.8489054","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 International Joint Conference on Neural Networks (IJCNN)","raw_type":"proceedings-article"},{"id":"pmh:oai:re.public.polimi.it:11311/1068380","is_oa":true,"landing_page_url":"http://hdl.handle.net/11311/1068380","pdf_url":null,"source":{"id":"https://openalex.org/S4306400312","display_name":"Virtual Community of Pathological Anatomy (University of Castilla La Mancha)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I79189158","host_organization_name":"University of Castilla-La Mancha","host_organization_lineage":["https://openalex.org/I79189158"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":{"id":"pmh:oai:re.public.polimi.it:11311/1068380","is_oa":true,"landing_page_url":"http://hdl.handle.net/11311/1068380","pdf_url":null,"source":{"id":"https://openalex.org/S4306400312","display_name":"Virtual Community of Pathological Anatomy (University of Castilla La Mancha)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I79189158","host_organization_name":"University of Castilla-La Mancha","host_organization_lineage":["https://openalex.org/I79189158"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1848866248","https://openalex.org/W1963553964","https://openalex.org/W1969573621","https://openalex.org/W2001318439","https://openalex.org/W2013171083","https://openalex.org/W2059577313","https://openalex.org/W2089689396","https://openalex.org/W2098412979","https://openalex.org/W2100974717","https://openalex.org/W2105924780","https://openalex.org/W2112027492","https://openalex.org/W2113604695","https://openalex.org/W2115028540","https://openalex.org/W2122825543","https://openalex.org/W2127081697","https://openalex.org/W2147524392","https://openalex.org/W2159164310","https://openalex.org/W2161827767","https://openalex.org/W2164116506","https://openalex.org/W2259938310"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2369655046","https://openalex.org/W2019467317","https://openalex.org/W1585519779","https://openalex.org/W1965515989","https://openalex.org/W2088737283","https://openalex.org/W1999587863","https://openalex.org/W1929902734","https://openalex.org/W3104474499","https://openalex.org/W4376167435"],"abstract_inverted_index":{"In":[0,121],"the":[1,18,25,42,49,80,97,126,153,165,172,181,185,212,218,223],"wide":[2],"context":[3],"of":[4,28,45,51,84,94,113,133,152,156,160,200,217],"biological":[5,107,215],"processes":[6],"regulating":[7],"gene":[8,205],"expression,":[9],"transcriptional":[10],"regulation":[11],"driven":[12],"by":[13,184],"epigenetic":[14,66,85,118,134,174,197],"activity":[15,67],"is":[16,35,77,87],"among":[17],"most":[19],"effective":[20],"and":[21,31,48,115,138,171,214,222],"intriguing":[22],"ones.":[23],"Understanding":[24],"complex":[26],"language":[27],"histone":[29],"modifications":[30],"transcription":[32],"factor":[33],"bindings":[34],"an":[36,71,100,161],"appealing":[37],"yet":[38],"hard":[39,88],"task,":[40,146],"given":[41],"large":[43],"number":[44],"involved":[46],"features":[47,86,198],"specificity":[50],"their":[52,75,169],"combinatorial":[53],"behavior":[54],"across":[55],"genes.":[56],"Genome-wide":[57],"regression":[58],"models":[59],"for":[60],"predicting":[61,204],"mRNA":[62],"abundance":[63],"quantifications":[64],"from":[65,190],"are":[68,199],"interesting":[69],"in":[70,203],"exploratory":[72],"framework,":[73],"but":[74,193],"effectiveness":[76],"limited":[78],"as":[79,130],"relative":[81],"predictive":[82],"power":[83],"to":[89,109,143],"discern":[90],"at":[91,148],"such":[92],"level":[93],"resolution.":[95],"On":[96],"other":[98],"hand,":[99],"investigative":[101],"analysis":[102],"cannot":[103],"rely":[104],"on":[105,164],"prior":[106],"knowledge":[108],"perform":[110],"sensible":[111],"grouping":[112],"genes":[114,159],"locally":[116],"study":[117],"regulative":[119],"processes.":[120],"this":[122,145],"context,":[123],"we":[124],"shaped":[125],"\u201cgene":[127],"stratification":[128],"problem\u201d":[129],"a":[131,140],"form":[132],"feature-based":[135],"hyperplanes":[136,182],"clustering,":[137],"proposed":[139,219],"genetic":[141],"algorithm":[142],"approach":[144],"aiming":[147],"performing":[149],"datadriven":[150],"partitioning":[151],"whole":[154],"set":[155],"protein":[157],"coding":[158],"organism":[162],"based":[163],"characteristic":[166],"relation":[167],"between":[168],"expression":[170,206],"associated":[173],"activity.":[175],"We":[176],"observed":[177],"how,":[178],"not":[179],"only":[180],"described":[183],"resulting":[186],"partitions":[187],"significantly":[188],"differ":[189],"each":[191,208],"other,":[192],"also":[194],"how":[195],"different":[196],"diverse":[201],"importance":[202],"within":[207],"partition.":[209],"This":[210],"demonstrates":[211],"validity":[213],"interest":[216],"computational":[220],"method":[221],"obtained":[224],"results.":[225]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}