{"id":"https://openalex.org/W1610138014","doi":"https://doi.org/10.1109/ijcnn.2015.7280410","title":"New insights into the landscape relationships of host response to bacterial pathogens","display_name":"New insights into the landscape relationships of host response to bacterial pathogens","publication_year":2015,"publication_date":"2015-07-01","ids":{"openalex":"https://openalex.org/W1610138014","doi":"https://doi.org/10.1109/ijcnn.2015.7280410","mag":"1610138014"},"language":"en","primary_location":{"id":"doi:10.1109/ijcnn.2015.7280410","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ijcnn.2015.7280410","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 International Joint Conference on Neural Networks (IJCNN)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072518075","display_name":"Xiaoyao Yin","orcid":"https://orcid.org/0000-0002-8207-2512"},"institutions":[{"id":"https://openalex.org/I170215575","display_name":"National University of Defense Technology","ror":"https://ror.org/05d2yfz11","country_code":"CN","type":"education","lineage":["https://openalex.org/I170215575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyao Yin","raw_affiliation_strings":["Department of Chemistry and Biology, National University of Defence Technology, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biology, National University of Defence Technology, Changsha, China","institution_ids":["https://openalex.org/I170215575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100611077","display_name":"Lu Han","orcid":"https://orcid.org/0000-0002-9842-2636"},"institutions":[{"id":"https://openalex.org/I4210132047","display_name":"Beijing Radiation Center","ror":"https://ror.org/030t7nd77","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210132047"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Han","raw_affiliation_strings":["Department of Biotechnology Beijing, Institute of Radiation Medicine, Beijing, China","Department of Biotechnology, Beijing Institute of Radiation Medicine, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology Beijing, Institute of Radiation Medicine, Beijing, China","institution_ids":["https://openalex.org/I4210132047"]},{"raw_affiliation_string":"Department of Biotechnology, Beijing Institute of Radiation Medicine, China","institution_ids":["https://openalex.org/I4210132047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018758426","display_name":"Hui Bai","orcid":"https://orcid.org/0000-0002-9013-7873"},"institutions":[{"id":"https://openalex.org/I4210132047","display_name":"Beijing Radiation Center","ror":"https://ror.org/030t7nd77","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210132047"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Bai","raw_affiliation_strings":["Department of Biotechnology Beijing, Institute of Radiation Medicine, Beijing, China","Department of Biotechnology, Beijing Institute of Radiation Medicine, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology Beijing, Institute of Radiation Medicine, Beijing, China","institution_ids":["https://openalex.org/I4210132047"]},{"raw_affiliation_string":"Department of Biotechnology, Beijing Institute of Radiation Medicine, China","institution_ids":["https://openalex.org/I4210132047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045958734","display_name":"Xiaochen Bo","orcid":"https://orcid.org/0000-0003-1911-7922"},"institutions":[{"id":"https://openalex.org/I4210132047","display_name":"Beijing Radiation Center","ror":"https://ror.org/030t7nd77","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210132047"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaochen Bo","raw_affiliation_strings":["Department of Biotechnology Beijing, Institute of Radiation Medicine, Beijing, China","Department of Biotechnology, Beijing Institute of Radiation Medicine, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology Beijing, Institute of Radiation Medicine, Beijing, China","institution_ids":["https://openalex.org/I4210132047"]},{"raw_affiliation_string":"Department of Biotechnology, Beijing Institute of Radiation Medicine, China","institution_ids":["https://openalex.org/I4210132047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101528042","display_name":"Yun Bai","orcid":"https://orcid.org/0000-0002-9026-7926"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yun Bai","raw_affiliation_strings":["Key lab of complex aviation system simulation, Beijing, China","Key lab of complex aviation system simulation, No.8 of 9236 mailbox, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key lab of complex aviation system simulation, Beijing, China","institution_ids":[]},{"raw_affiliation_string":"Key lab of complex aviation system simulation, No.8 of 9236 mailbox, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060974542","display_name":"Cong Niu","orcid":"https://orcid.org/0000-0001-6312-8907"},"institutions":[{"id":"https://openalex.org/I162608824","display_name":"University of Sussex","ror":"https://ror.org/00ayhx656","country_code":"GB","type":"education","lineage":["https://openalex.org/I162608824"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Cong Niu","raw_affiliation_strings":["University of Sussex Sussex House Brighton, United Kingdom","University of Sussex, Sussex House, Brighton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Sussex Sussex House Brighton, United Kingdom","institution_ids":["https://openalex.org/I162608824"]},{"raw_affiliation_string":"University of Sussex, Sussex House, Brighton, United Kingdom","institution_ids":["https://openalex.org/I162608824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103181621","display_name":"Naiyang Guan","orcid":null},"institutions":[{"id":"https://openalex.org/I170215575","display_name":"National University of Defense Technology","ror":"https://ror.org/05d2yfz11","country_code":"CN","type":"education","lineage":["https://openalex.org/I170215575"]},{"id":"https://openalex.org/I96415178","display_name":"University of Defence","ror":"https://ror.org/04arkmn57","country_code":"CZ","type":"education","lineage":["https://openalex.org/I96415178"]}],"countries":["CN","CZ"],"is_corresponding":false,"raw_author_name":"Naiyang Guan","raw_affiliation_strings":["Science and technology on Parallel, National University of Defence Technology, Changsha, China","Science and technology on Parallel and Distributed Processing Laboratory, National University of Defence Technology, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Science and technology on Parallel, National University of Defence Technology, Changsha, China","institution_ids":["https://openalex.org/I170215575"]},{"raw_affiliation_string":"Science and technology on Parallel and Distributed Processing Laboratory, National University of Defence Technology, Changsha, China","institution_ids":["https://openalex.org/I96415178"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061811574","display_name":"Zhigang Luo","orcid":"https://orcid.org/0000-0002-7552-201X"},"institutions":[{"id":"https://openalex.org/I170215575","display_name":"National University of Defense Technology","ror":"https://ror.org/05d2yfz11","country_code":"CN","type":"education","lineage":["https://openalex.org/I170215575"]},{"id":"https://openalex.org/I96415178","display_name":"University of Defence","ror":"https://ror.org/04arkmn57","country_code":"CZ","type":"education","lineage":["https://openalex.org/I96415178"]}],"countries":["CN","CZ"],"is_corresponding":false,"raw_author_name":"Zhigang Luo","raw_affiliation_strings":["Science and technology on Parallel, National University of Defence Technology, Changsha, China","Science and technology on Parallel and Distributed Processing Laboratory, National University of Defence Technology, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Science and technology on Parallel, National University of Defence Technology, Changsha, China","institution_ids":["https://openalex.org/I170215575"]},{"raw_affiliation_string":"Science and technology on Parallel and Distributed Processing Laboratory, National University of Defence Technology, Changsha, China","institution_ids":["https://openalex.org/I96415178"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02511028,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":null,"first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9919999837875366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7440137267112732},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6145959496498108},{"id":"https://openalex.org/keywords/host","display_name":"Host (biology)","score":0.5691516995429993},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5081675052642822},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4324057996273041},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.42507120966911316},{"id":"https://openalex.org/keywords/pathogen","display_name":"Pathogen","score":0.4185151755809784},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.32772862911224365},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.11164700984954834}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7440137267112732},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6145959496498108},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.5691516995429993},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5081675052642822},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4324057996273041},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.42507120966911316},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.4185151755809784},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.32772862911224365},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11164700984954834},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/ijcnn.2015.7280410","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ijcnn.2015.7280410","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 International Joint Conference on Neural Networks (IJCNN)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.7200000286102295}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1551748455","https://openalex.org/W1559370438","https://openalex.org/W1990409230","https://openalex.org/W2002551740","https://openalex.org/W2026028158","https://openalex.org/W2056153476","https://openalex.org/W2094791588","https://openalex.org/W2106794374","https://openalex.org/W2113002397","https://openalex.org/W2123679324","https://openalex.org/W2130410032","https://openalex.org/W2145686583","https://openalex.org/W2165232124","https://openalex.org/W6633292003"],"related_works":["https://openalex.org/W2157598224","https://openalex.org/W2478842321","https://openalex.org/W2117112636","https://openalex.org/W2091398531","https://openalex.org/W2343234619","https://openalex.org/W3173815060","https://openalex.org/W4393700755","https://openalex.org/W2227774892","https://openalex.org/W4393655603","https://openalex.org/W4286497165"],"abstract_inverted_index":{"Modern":[0],"understanding":[1,195],"of":[2,11,17,38,58,75,82,105,143,160,194],"microbiology":[3],"largely":[4],"lays":[5],"foundation":[6],"in":[7],"the":[8,14,35,44,67,161,179],"biological":[9],"characterization":[10,175],"microorganisms.":[12],"However,":[13],"landscape":[15],"relationships":[16],"host":[18,59,106],"transcriptional":[19],"response":[20,108],"(HTR)":[21],"to":[22,43,109,181],"different":[23,49,86],"bacterial":[24,52,73,110,128,149,187],"pathogens":[25],"have":[26],"not":[27],"yet":[28],"been":[29],"systematically":[30],"explored.":[31],"Here,":[32],"we":[33],"established":[34],"first":[36,180],"generation":[37],"HTR":[39,45],"network":[40,68],"(HTRN)":[41],"according":[42],"similarities":[46],"among":[47],"21":[48],"human":[50,156],"pathogenic":[51],"species":[53],"by":[54,126,165],"integrating":[55],"258":[56],"pairs":[57],"cellular":[60],"gene":[61,96,115],"expression":[62,97],"profiles":[63],"upon":[64,186],"infections.":[65],"Further,":[66],"was":[69],"dissected":[70],"into":[71],"five":[72],"communities":[74,87],"more":[76],"consensus":[77],"internal":[78],"HTR.":[79],"Interestingly,":[80],"analysis":[81,177],"signature":[83],"genes":[84],"across":[85],"revealed":[88],"that":[89,112,168],"distinct":[90],"community":[91,127,131,184],"signatures":[92,132],"(CS)":[93],"present":[94],"differential":[95,183],"patterns.":[98],"Functional":[99],"annotation":[100],"suggested":[101,191],"a":[102],"common":[103,152],"feature":[104,182],"cell":[107],"infections":[111,150,189],"specific":[113,154],"functional":[114,138],"clusters":[116],"(BPs":[117],"and/or":[118],"signaling":[119],"pathways)":[120],"were":[121,140,163,178],"preferentially":[122],"elicited":[123],"or":[124],"subverted":[125],"pathogens.":[129],"Notably,":[130],"(especially":[133],"key":[134],"associators":[135],"participating":[136],"dissimilar":[137],"profiles)":[139],"highly":[141],"enriched":[142],"GWAS":[144],"disease-related":[145],"genes,":[146],"which":[147],"associated":[148],"with":[151],"and":[153,176,190,198],"non-infectious":[155],"disease(s).":[157],"About":[158],"40%":[159],"associations":[162,197],"confirmed":[164],"literature":[166],"investigation":[167],"further":[169],"indicated":[170],"possible/potential":[171],"association":[172],"directionality.":[173],"Our":[174],"HTRs":[185],"pathogen":[188],"new":[192],"perspective":[193],"infection-disease":[196],"underlying":[199],"pathogenesis.":[200]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
