{"id":"https://openalex.org/W1995532429","doi":"https://doi.org/10.1109/iembs.2011.6091911","title":"Motor neuron morphology estimation for its classification in the Drosophila brain","display_name":"Motor neuron morphology estimation for its classification in the Drosophila brain","publication_year":2011,"publication_date":"2011-08-01","ids":{"openalex":"https://openalex.org/W1995532429","doi":"https://doi.org/10.1109/iembs.2011.6091911","mag":"1995532429","pmid":"https://pubmed.ncbi.nlm.nih.gov/22256136"},"language":"en","primary_location":{"id":"doi:10.1109/iembs.2011.6091911","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.2011.6091911","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014714918","display_name":"Gavriil Tsechpenakis","orcid":"https://orcid.org/0000-0002-8864-3435"},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Tsechpenakis","raw_affiliation_strings":["Department of Computer and Information Science, Indiana University-Purdue University Indianapolis, USA. gavriil@cs.iupui.edu","Department of Computer and Information Science, Indiana University Purdue University Indianapolis,#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer and Information Science, Indiana University-Purdue University Indianapolis, USA. gavriil@cs.iupui.edu","institution_ids":["https://openalex.org/I55769427"]},{"raw_affiliation_string":"Department of Computer and Information Science, Indiana University Purdue University Indianapolis,#TAB#","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055328134","display_name":"Ruwan Egoda Gamage","orcid":null},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. E. Gamage","raw_affiliation_strings":["Department of Computer and Information Science, Indiana University-Purdue University Indianapolis, USA","Department of Computer and Information Science, Indiana University Purdue University Indianapolis,#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer and Information Science, Indiana University-Purdue University Indianapolis, USA","institution_ids":["https://openalex.org/I55769427"]},{"raw_affiliation_string":"Department of Computer and Information Science, Indiana University Purdue University Indianapolis,#TAB#","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049208889","display_name":"Michael D. Kim","orcid":"https://orcid.org/0000-0003-2103-6603"},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. D. Kim","raw_affiliation_strings":["Department of Molecular and Cellular Pharmacology, School of Medicine, University of Miami Miller, USA","Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Pharmacology, School of Medicine, University of Miami Miller, USA","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine;","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102901263","display_name":"Akira Chiba","orcid":"https://orcid.org/0000-0003-4809-2402"},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Chiba","raw_affiliation_strings":["Biology Department, University of Miami, USA","Biology Department, University of Miami"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, University of Miami, USA","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Biology Department, University of Miami","institution_ids":["https://openalex.org/I145608581"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.04425827,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"17","issue":null,"first_page":"7755","last_page":"7758"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12417","display_name":"Morphological variations and asymmetry","score":0.9790999889373779,"subfield":{"id":"https://openalex.org/subfields/2608","display_name":"Geometry and Topology"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.9710999727249146,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/soma","display_name":"Soma","score":0.7623990178108215},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.6807509660720825},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6313612461090088},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.6053676009178162},{"id":"https://openalex.org/keywords/neurophysiology","display_name":"Neurophysiology","score":0.5311219692230225},{"id":"https://openalex.org/keywords/axon","display_name":"Axon","score":0.4855796694755554},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4813185930252075},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4172951579093933},{"id":"https://openalex.org/keywords/biological-neural-network","display_name":"Biological neural network","score":0.41568875312805176},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.4101606607437134},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3367748260498047}],"concepts":[{"id":"https://openalex.org/C2779617337","wikidata":"https://www.wikidata.org/wiki/Q842429","display_name":"Soma","level":2,"score":0.7623990178108215},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.6807509660720825},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6313612461090088},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6053676009178162},{"id":"https://openalex.org/C152478114","wikidata":"https://www.wikidata.org/wiki/Q660910","display_name":"Neurophysiology","level":2,"score":0.5311219692230225},{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.4855796694755554},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4813185930252075},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4172951579093933},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.41568875312805176},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.4101606607437134},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3367748260498047}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012996","descriptor_name":"Solutions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012996","descriptor_name":"Solutions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012996","descriptor_name":"Solutions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/iembs.2011.6091911","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.2011.6091911","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:22256136","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22256136","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Life in Land","score":0.5600000023841858,"id":"https://metadata.un.org/sdg/15"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1892652257","https://openalex.org/W2005763203","https://openalex.org/W2006229889","https://openalex.org/W2006805865","https://openalex.org/W2015832139","https://openalex.org/W2038952578","https://openalex.org/W2086052791","https://openalex.org/W2091766579","https://openalex.org/W2118802082","https://openalex.org/W2125821389","https://openalex.org/W2131326854","https://openalex.org/W2147276933","https://openalex.org/W2153562369","https://openalex.org/W2164598857","https://openalex.org/W6678200344"],"related_works":["https://openalex.org/W2127637679","https://openalex.org/W2059256607","https://openalex.org/W1576420526","https://openalex.org/W1998420627","https://openalex.org/W4250471973","https://openalex.org/W1967315726","https://openalex.org/W2018619633","https://openalex.org/W2060810169","https://openalex.org/W2021271933","https://openalex.org/W2828684081"],"abstract_inverted_index":{"Type-specific":[0],"dendritic":[1,31],"arborization":[2],"patterns":[3],"dictate":[4],"synaptic":[5,43],"connectivity":[6,44],"and":[7,19,65,87,98,130],"are":[8],"fundamental":[9],"determinants":[10],"of":[11,22,33,42,52,83,104,127,139],"neuronal":[12],"function.":[13],"We":[14,100],"exploit":[15],"the":[16,23,29,80,84,88,95,102,110,132,140],"morphological":[17],"stereotypy":[18],"relative":[20],"simplicity":[21],"Drosophila":[24,53],"nervous":[25],"system":[26],"to":[27,38,56],"model":[28],"diverse":[30],"morphologies":[32],"individual":[34],"motor":[35,47],"neurons":[36],"(MNs)":[37],"understand":[39],"underlying":[40],"principles":[41],"in":[45,70],"a":[46,124],"circuit.":[48],"The":[49],"genetic":[50],"tractability":[51],"allows":[54],"us":[55],"label":[57],"single":[58],"MNs":[59,69],"with":[60,72],"green":[61],"fluorescent":[62],"protein":[63],"(GFP)":[64],"serially":[66],"reconstruct":[67],"identifiable":[68],"3D":[71,125],"confocal":[73],"microscopy.":[74],"Our":[75],"computational":[76],"approach":[77],"aims":[78],"at":[79],"robust":[81],"segmentation":[82,141],"MN":[85],"volumes":[86],"simultaneous":[89],"partitioning":[90],"into":[91],"their":[92],"compartments,":[93],"namely":[94],"soma,":[96],"axon":[97],"dendrites.":[99],"use":[101,123],"idea":[103],"co-segmentation,":[105],"where":[106],"every":[107],"image":[108],"along":[109],"z-axis":[111],"(depth)":[112],"is":[113],"clustered":[114],"using":[115],"information":[116],"from":[117],"'neighboring'":[118],"depths.":[119],"As":[120],"appearance":[121],"we":[122,134],"extension":[126],"Haar":[128],"features":[129],"for":[131],"shape":[133],"define":[135],"an":[136],"implicit":[137],"representation":[138],"domain.":[142]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}