{"id":"https://openalex.org/W1972070534","doi":"https://doi.org/10.1109/iembs.2011.6091886","title":"Monolithically integrated Mach-Zehnder biosensors for real-time label-free monitoring of biomolecular reactions","display_name":"Monolithically integrated Mach-Zehnder biosensors for real-time label-free monitoring of biomolecular reactions","publication_year":2011,"publication_date":"2011-08-01","ids":{"openalex":"https://openalex.org/W1972070534","doi":"https://doi.org/10.1109/iembs.2011.6091886","mag":"1972070534","pmid":"https://pubmed.ncbi.nlm.nih.gov/22256111"},"language":"en","primary_location":{"id":"doi:10.1109/iembs.2011.6091886","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.2011.6091886","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045370741","display_name":"Eleni Makarona","orcid":"https://orcid.org/0000-0002-5115-5518"},"institutions":[{"id":"https://openalex.org/I203474044","display_name":"National Centre of Scientific Research \"Demokritos\"","ror":"https://ror.org/038jp4m40","country_code":"GR","type":"facility","lineage":["https://openalex.org/I203474044"]},{"id":"https://openalex.org/I4210119392","display_name":"Institute of Microelectronics","ror":"https://ror.org/02s6gs133","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210119392"]}],"countries":["CN","GR"],"is_corresponding":false,"raw_author_name":"E. Makarona","raw_affiliation_strings":["Microelectronics Institute NCSR Demokritos, Aghia Paraskevi 15310, Athens, Greece","Microelectronics Institute N.C.S.R \u201cDemokritos\u201d, Aghia Paraskevi 15310, Athens Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microelectronics Institute NCSR Demokritos, Aghia Paraskevi 15310, Athens, Greece","institution_ids":["https://openalex.org/I4210119392","https://openalex.org/I203474044"]},{"raw_affiliation_string":"Microelectronics Institute N.C.S.R \u201cDemokritos\u201d, Aghia Paraskevi 15310, Athens Greece","institution_ids":["https://openalex.org/I203474044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052477231","display_name":"Panagiota Petrou","orcid":"https://orcid.org/0000-0001-9125-3625"},"institutions":[{"id":"https://openalex.org/I203474044","display_name":"National Centre of Scientific Research \"Demokritos\"","ror":"https://ror.org/038jp4m40","country_code":"GR","type":"facility","lineage":["https://openalex.org/I203474044"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"P. S. Petrou","raw_affiliation_strings":["Immunoassay/Immunosensors Laboratory, Institute of Radioisotopes and Radiodiagnostic Products, Greece","Immunoassay/Immunosensors Lab, Institute of Radioisotopes and Radiodiagnostic Products, N.C.S.R \u201cDemokritos\u201d, Aghia Paraskevi 15310, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunoassay/Immunosensors Laboratory, Institute of Radioisotopes and Radiodiagnostic Products, Greece","institution_ids":["https://openalex.org/I203474044"]},{"raw_affiliation_string":"Immunoassay/Immunosensors Lab, Institute of Radioisotopes and Radiodiagnostic Products, N.C.S.R \u201cDemokritos\u201d, Aghia Paraskevi 15310, Greece","institution_ids":["https://openalex.org/I203474044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072547077","display_name":"Athanasia Bourkoula","orcid":null},"institutions":[{"id":"https://openalex.org/I203474044","display_name":"National Centre of Scientific Research \"Demokritos\"","ror":"https://ror.org/038jp4m40","country_code":"GR","type":"facility","lineage":["https://openalex.org/I203474044"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"A. Bourkoula","raw_affiliation_strings":["Immunoassay/Immunosensors Laboratory, Institute of Radioisotopes and Radiodiagnostic Products, Greece","Immunoassay/Immunosensors Lab, Institute of Radioisotopes and Radiodiagnostic Products, N.C.S.R \u201cDemokritos\u201d, Aghia Paraskevi 15310, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunoassay/Immunosensors Laboratory, Institute of Radioisotopes and Radiodiagnostic Products, Greece","institution_ids":["https://openalex.org/I203474044"]},{"raw_affiliation_string":"Immunoassay/Immunosensors Lab, Institute of Radioisotopes and Radiodiagnostic Products, N.C.S.R \u201cDemokritos\u201d, Aghia Paraskevi 15310, Greece","institution_ids":["https://openalex.org/I203474044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050391168","display_name":"A. Botsialas","orcid":null},"institutions":[{"id":"https://openalex.org/I203474044","display_name":"National Centre of Scientific Research \"Demokritos\"","ror":"https://ror.org/038jp4m40","country_code":"GR","type":"facility","lineage":["https://openalex.org/I203474044"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"A. Botsialas","raw_affiliation_strings":["Microelectronics Institute N. C. S. R Demokritos, Athens, Greece","Microelectronics Institute N.C.S.R \u201cDemokritos\u201d, Aghia Paraskevi 15310, Athens Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microelectronics Institute N. C. S. R Demokritos, Athens, Greece","institution_ids":["https://openalex.org/I203474044"]},{"raw_affiliation_string":"Microelectronics Institute N.C.S.R \u201cDemokritos\u201d, Aghia Paraskevi 15310, Athens Greece","institution_ids":["https://openalex.org/I203474044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063881999","display_name":"\u039c\u03b1\u03c1\u03af\u03b1 \u039a\u03b9\u03c4\u03c3\u03b1\u03c1\u03ac","orcid":"https://orcid.org/0000-0002-9614-306X"},"institutions":[{"id":"https://openalex.org/I203474044","display_name":"National Centre of Scientific Research \"Demokritos\"","ror":"https://ror.org/038jp4m40","country_code":"GR","type":"facility","lineage":["https://openalex.org/I203474044"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"M. Kitsara","raw_affiliation_strings":["Microelectronics Institute N. C. S. R Demokritos, Athens, Greece","Microelectronics Institute N.C.S.R \u201cDemokritos\u201d, Aghia Paraskevi 15310, Athens Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microelectronics Institute N. C. S. R Demokritos, Athens, Greece","institution_ids":["https://openalex.org/I203474044"]},{"raw_affiliation_string":"Microelectronics Institute N.C.S.R \u201cDemokritos\u201d, Aghia Paraskevi 15310, Athens Greece","institution_ids":["https://openalex.org/I203474044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031069528","display_name":"Sotirios Kakabakos","orcid":"https://orcid.org/0000-0002-0043-3119"},"institutions":[{"id":"https://openalex.org/I203474044","display_name":"National Centre of Scientific Research \"Demokritos\"","ror":"https://ror.org/038jp4m40","country_code":"GR","type":"facility","lineage":["https://openalex.org/I203474044"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"S. E. Kakabakos","raw_affiliation_strings":["Immunoassay/Immunosensors Laboratory, Institute of Radioisotopes and Radiodiagnostic Products, Greece","Immunoassay/Immunosensors Lab, Institute of Radioisotopes and Radiodiagnostic Products, N.C.S.R \u201cDemokritos\u201d, Aghia Paraskevi 15310, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunoassay/Immunosensors Laboratory, Institute of Radioisotopes and Radiodiagnostic Products, Greece","institution_ids":["https://openalex.org/I203474044"]},{"raw_affiliation_string":"Immunoassay/Immunosensors Lab, Institute of Radioisotopes and Radiodiagnostic Products, N.C.S.R \u201cDemokritos\u201d, Aghia Paraskevi 15310, Greece","institution_ids":["https://openalex.org/I203474044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054842494","display_name":"Remco Stoffer","orcid":null},"institutions":[{"id":"https://openalex.org/I4210098541","display_name":"PhoeniX Software (Netherlands)","ror":"https://ror.org/00epmfe95","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210098541"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"R. Stoffer","raw_affiliation_strings":["PhoeniX BV, Enschede, Netherlands","PhoeniX BV, Hengelosestraat, 705 7521 PA Enschede, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhoeniX BV, Enschede, Netherlands","institution_ids":["https://openalex.org/I4210098541"]},{"raw_affiliation_string":"PhoeniX BV, Hengelosestraat, 705 7521 PA Enschede, The Netherlands","institution_ids":["https://openalex.org/I4210098541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083075685","display_name":"G. Jobst","orcid":"https://orcid.org/0000-0001-9814-6267"},"institutions":[{"id":"https://openalex.org/I4210098044","display_name":"Jobst Technologies (Germany)","ror":"https://ror.org/00x2xws80","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210098044"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G. Jobst","raw_affiliation_strings":["Jobst Technologies GmbH, Freiburg im Breisgau, Germany","Jobst Technologies GmbH, Engesserstrasse 4b, D-79108 Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jobst Technologies GmbH, Freiburg im Breisgau, Germany","institution_ids":["https://openalex.org/I4210098044"]},{"raw_affiliation_string":"Jobst Technologies GmbH, Engesserstrasse 4b, D-79108 Freiburg, Germany","institution_ids":["https://openalex.org/I4210098044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019791297","display_name":"George Nounesis","orcid":"https://orcid.org/0000-0002-0846-1384"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Nounesis","raw_affiliation_strings":["BioGenomica SA, Chalandri, Greece","BioGenomica SA, G-15232, Chalandri, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioGenomica SA, Chalandri, Greece","institution_ids":[]},{"raw_affiliation_string":"BioGenomica SA, G-15232, Chalandri, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047753564","display_name":"I. Raptis","orcid":"https://orcid.org/0000-0002-7029-0715"},"institutions":[{"id":"https://openalex.org/I203474044","display_name":"National Centre of Scientific Research \"Demokritos\"","ror":"https://ror.org/038jp4m40","country_code":"GR","type":"facility","lineage":["https://openalex.org/I203474044"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"I. Raptis","raw_affiliation_strings":["Microelectronics Institute N. C. S. R Demokritos, Athens, Greece","Microelectronics Institute N.C.S.R \u201cDemokritos\u201d, Aghia Paraskevi 15310, Athens Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microelectronics Institute N. C. S. R Demokritos, Athens, Greece","institution_ids":["https://openalex.org/I203474044"]},{"raw_affiliation_string":"Microelectronics Institute N.C.S.R \u201cDemokritos\u201d, Aghia Paraskevi 15310, Athens Greece","institution_ids":["https://openalex.org/I203474044"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031078155","display_name":"\u039a. \u039c\u03b9\u03c3\u03b9\u03ac\u03ba\u03bf\u03c2","orcid":null},"institutions":[{"id":"https://openalex.org/I203474044","display_name":"National Centre of Scientific Research \"Demokritos\"","ror":"https://ror.org/038jp4m40","country_code":"GR","type":"facility","lineage":["https://openalex.org/I203474044"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"K. Misiakos","raw_affiliation_strings":["Microelectronics Institute N. C. S. R Demokritos, Athens, Greece","Microelectronics Institute N.C.S.R \u201cDemokritos\u201d, Aghia Paraskevi 15310, Athens Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microelectronics Institute N. C. S. R Demokritos, Athens, Greece","institution_ids":["https://openalex.org/I203474044"]},{"raw_affiliation_string":"Microelectronics Institute N.C.S.R \u201cDemokritos\u201d, Aghia Paraskevi 15310, Athens Greece","institution_ids":["https://openalex.org/I203474044"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":11,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8109,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.74752435,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"2011","issue":null,"first_page":"7654","last_page":"7657"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10299","display_name":"Photonic and Optical Devices","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10299","display_name":"Photonic and Optical Devices","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12224","display_name":"Nanofabrication and Lithography Techniques","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biosensor","display_name":"Biosensor","score":0.7239026427268982},{"id":"https://openalex.org/keywords/detection-limit","display_name":"Detection limit","score":0.6953574419021606},{"id":"https://openalex.org/keywords/streptavidin","display_name":"Streptavidin","score":0.6894187331199646},{"id":"https://openalex.org/keywords/interferometry","display_name":"Interferometry","score":0.6337645053863525},{"id":"https://openalex.org/keywords/astronomical-interferometer","display_name":"Astronomical interferometer","score":0.6173477172851562},{"id":"https://openalex.org/keywords/mach\u2013zehnder-interferometer","display_name":"Mach\u2013Zehnder interferometer","score":0.5934100151062012},{"id":"https://openalex.org/keywords/biomolecule","display_name":"Biomolecule","score":0.530541718006134},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.5035251975059509},{"id":"https://openalex.org/keywords/dynamic-range","display_name":"Dynamic range","score":0.45514753460884094},{"id":"https://openalex.org/keywords/refractive-index","display_name":"Refractive index","score":0.43743598461151123},{"id":"https://openalex.org/keywords/bioanalysis","display_name":"Bioanalysis","score":0.4366738796234131},{"id":"https://openalex.org/keywords/wafer","display_name":"Wafer","score":0.4173700511455536},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.3964284360408783},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.3538777232170105},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.35003745555877686},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3249659538269043},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.23617443442344666},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.23238450288772583},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.2182387113571167},{"id":"https://openalex.org/keywords/biotin","display_name":"Biotin","score":0.11987128853797913}],"concepts":[{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.7239026427268982},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.6953574419021606},{"id":"https://openalex.org/C2776190903","wikidata":"https://www.wikidata.org/wiki/Q421817","display_name":"Streptavidin","level":3,"score":0.6894187331199646},{"id":"https://openalex.org/C166689943","wikidata":"https://www.wikidata.org/wiki/Q850283","display_name":"Interferometry","level":2,"score":0.6337645053863525},{"id":"https://openalex.org/C23576306","wikidata":"https://www.wikidata.org/wiki/Q17004698","display_name":"Astronomical interferometer","level":3,"score":0.6173477172851562},{"id":"https://openalex.org/C12296473","wikidata":"https://www.wikidata.org/wiki/Q621727","display_name":"Mach\u2013Zehnder interferometer","level":3,"score":0.5934100151062012},{"id":"https://openalex.org/C49853544","wikidata":"https://www.wikidata.org/wiki/Q206229","display_name":"Biomolecule","level":2,"score":0.530541718006134},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5035251975059509},{"id":"https://openalex.org/C87133666","wikidata":"https://www.wikidata.org/wiki/Q1161699","display_name":"Dynamic range","level":2,"score":0.45514753460884094},{"id":"https://openalex.org/C42067758","wikidata":"https://www.wikidata.org/wiki/Q174102","display_name":"Refractive index","level":2,"score":0.43743598461151123},{"id":"https://openalex.org/C137535248","wikidata":"https://www.wikidata.org/wiki/Q4914691","display_name":"Bioanalysis","level":2,"score":0.4366738796234131},{"id":"https://openalex.org/C160671074","wikidata":"https://www.wikidata.org/wiki/Q267131","display_name":"Wafer","level":2,"score":0.4173700511455536},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.3964284360408783},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3538777232170105},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35003745555877686},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3249659538269043},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.23617443442344666},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.23238450288772583},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2182387113571167},{"id":"https://openalex.org/C2778204606","wikidata":"https://www.wikidata.org/wiki/Q181354","display_name":"Biotin","level":2,"score":0.11987128853797913},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001669","descriptor_name":"Biochemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001669","descriptor_name":"Biochemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001669","descriptor_name":"Biochemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012710","descriptor_name":"Serum Albumin, Bovine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012710","descriptor_name":"Serum Albumin, Bovine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012710","descriptor_name":"Serum Albumin, Bovine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D017430","descriptor_name":"Prostate-Specific Antigen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017430","descriptor_name":"Prostate-Specific Antigen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017430","descriptor_name":"Prostate-Specific Antigen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019921","descriptor_name":"Biotinylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019921","descriptor_name":"Biotinylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019921","descriptor_name":"Biotinylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/iembs.2011.6091886","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.2011.6091886","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:22256111","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22256111","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6200000047683716,"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1969416450","https://openalex.org/W1987289293","https://openalex.org/W2030978106","https://openalex.org/W2033613851","https://openalex.org/W2052089838","https://openalex.org/W2056127911","https://openalex.org/W2075377787","https://openalex.org/W2080078864","https://openalex.org/W2085114931","https://openalex.org/W2143558278","https://openalex.org/W2840707413"],"related_works":["https://openalex.org/W2021553614","https://openalex.org/W1966090971","https://openalex.org/W2125854550","https://openalex.org/W1980848863","https://openalex.org/W1479860288","https://openalex.org/W2021828270","https://openalex.org/W1973278743","https://openalex.org/W2112368854","https://openalex.org/W4321137619","https://openalex.org/W2588851067"],"abstract_inverted_index":{"Arrays":[0],"of":[1,19,49,64,69,82,93,108],"monolithically":[2],"integrated":[3],"Mach-Zehnder":[4,41],"interferometers":[5],"were":[6,26,129],"fabricated":[7],"by":[8,54],"standard":[9],"silicon":[10],"technology":[11],"and":[12,31],"applied":[13],"to":[14],"the":[15,50,56,65,94,106,126],"label-free":[16],"real-time":[17],"monitoring":[18,55],"biomolecular":[20],"interactions.":[21],"Chips":[22],"accommodating":[23],"10":[24],"MZIs":[25],"functionalized":[27],"with":[28,119],"recognition":[29],"biomolecules":[30],"encapsulated":[32],"in":[33,67,113],"wafer":[34],"scale.":[35],"Detection":[36,123],"is":[37],"based":[38],"on":[39],"Frequency-Resolved":[40],"Interferometry,":[42],"a":[43],"new":[44],"concept":[45],"that":[46],"takes":[47],"advantage":[48],"broad-band":[51],"input":[52,60],"spectrum":[53],"changes":[57,72],"for":[58],"every":[59],"frequency.":[61],"The":[62,90],"sensitivity":[63],"device":[66,95],"terms":[68],"refractive":[70],"index":[71],"(\u0394n)":[73],"was":[74,88],"calculated":[75],"using":[76,116],"isopropanol/water":[77],"solutions.":[78],"A":[79],"detection":[80,107],"limit":[81],"\u0394n":[83],"=":[84],"4":[85],"\u00d7":[86],"10(-6)":[87],"calculated.":[89],"bioanalytical":[91],"capabilities":[92],"there":[96],"demonstrated":[97],"through":[98],"model":[99],"binding":[100],"assays":[101],"(biotin/streptavidin)":[102],"as":[103,105],"well":[104],"total":[109],"prostate":[110],"specific":[111],"antigen":[112],"serum":[114],"samples":[115],"devices":[117],"coated":[118],"antigen-specific":[120],"monoclonal":[121],"antibody.":[122],"limits":[124],"at":[125],"pM":[127],"range":[128],"determined.":[130]},"counts_by_year":[{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}