{"id":"https://openalex.org/W2113648797","doi":"https://doi.org/10.1109/iembs.2011.6091821","title":"Effect of therapeutic ultrasound on acoustically sensitive microcapsules","display_name":"Effect of therapeutic ultrasound on acoustically sensitive microcapsules","publication_year":2011,"publication_date":"2011-08-01","ids":{"openalex":"https://openalex.org/W2113648797","doi":"https://doi.org/10.1109/iembs.2011.6091821","mag":"2113648797","pmid":"https://pubmed.ncbi.nlm.nih.gov/22256001"},"language":"en","primary_location":{"id":"doi:10.1109/iembs.2011.6091821","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.2011.6091821","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008765755","display_name":"S. Thirumalai","orcid":null},"institutions":[{"id":"https://openalex.org/I4210106389","display_name":"Physical Devices (United States)","ror":"https://ror.org/01nsm8h24","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106389"]},{"id":"https://openalex.org/I4210143726","display_name":"Advanced Materials and Devices (United States)","ror":"https://ror.org/04ntc3565","country_code":"US","type":"company","lineage":["https://openalex.org/I4210143726"]},{"id":"https://openalex.org/I51504820","display_name":"San Jose State University","ror":"https://ror.org/04qyvz380","country_code":"US","type":"education","lineage":["https://openalex.org/I51504820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Thirumalai","raw_affiliation_strings":["Biomedical Devices, SJSU","Biomedical Devices at SJSU"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Devices, SJSU","institution_ids":["https://openalex.org/I4210143726","https://openalex.org/I4210106389"]},{"raw_affiliation_string":"Biomedical Devices at SJSU","institution_ids":["https://openalex.org/I51504820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023971671","display_name":"Maryam Mobed-Miremadi","orcid":"https://orcid.org/0000-0002-8671-6805"},"institutions":[{"id":"https://openalex.org/I4210133661","display_name":"La Jolla Bioengineering Institute","ror":"https://ror.org/03sgbh608","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210133661"]},{"id":"https://openalex.org/I51504820","display_name":"San Jose State University","ror":"https://ror.org/04qyvz380","country_code":"US","type":"education","lineage":["https://openalex.org/I51504820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maryam Mobed-Miremadi","raw_affiliation_strings":["Bioengineering, SJSU, USA","Bioengineering, SJSU"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioengineering, SJSU, USA","institution_ids":["https://openalex.org/I4210133661"]},{"raw_affiliation_string":"Bioengineering, SJSU","institution_ids":["https://openalex.org/I51504820"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055140124","display_name":"Mallika Sridhar\u2010Keralapura","orcid":null},"institutions":[{"id":"https://openalex.org/I4210116219","display_name":"Engineering Systems (United States)","ror":"https://ror.org/02qg60849","country_code":"US","type":"company","lineage":["https://openalex.org/I4210116219"]},{"id":"https://openalex.org/I51504820","display_name":"San Jose State University","ror":"https://ror.org/04qyvz380","country_code":"US","type":"education","lineage":["https://openalex.org/I51504820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Sridhar-Keralapura","raw_affiliation_strings":["Faculty in the Electrical Engineering Department, Biomedical Systems Lab, SJSU, USA","Electrical Engineering department, SJSU"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty in the Electrical Engineering Department, Biomedical Systems Lab, SJSU, USA","institution_ids":["https://openalex.org/I4210116219"]},{"raw_affiliation_string":"Electrical Engineering department, SJSU","institution_ids":["https://openalex.org/I51504820"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":null,"first_page":"7207","last_page":"7210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/therapeutic-ultrasound","display_name":"Therapeutic ultrasound","score":0.8367762565612793},{"id":"https://openalex.org/keywords/ultrasound","display_name":"Ultrasound","score":0.831733226776123},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.60065096616745},{"id":"https://openalex.org/keywords/ultrasound-imaging","display_name":"Ultrasound imaging","score":0.5864902138710022},{"id":"https://openalex.org/keywords/payload","display_name":"Payload (computing)","score":0.5231695771217346},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"Drug delivery","score":0.47316795587539673},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.45643579959869385},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3231341242790222},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.24707528948783875},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2453865110874176},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.2235836386680603}],"concepts":[{"id":"https://openalex.org/C2779727089","wikidata":"https://www.wikidata.org/wiki/Q564875","display_name":"Therapeutic ultrasound","level":3,"score":0.8367762565612793},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.831733226776123},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.60065096616745},{"id":"https://openalex.org/C2986892559","wikidata":"https://www.wikidata.org/wiki/Q234904","display_name":"Ultrasound imaging","level":3,"score":0.5864902138710022},{"id":"https://openalex.org/C134066672","wikidata":"https://www.wikidata.org/wiki/Q1424639","display_name":"Payload (computing)","level":3,"score":0.5231695771217346},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.47316795587539673},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.45643579959869385},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3231341242790222},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.24707528948783875},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2453865110874176},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2235836386680603},{"id":"https://openalex.org/C158379750","wikidata":"https://www.wikidata.org/wiki/Q214111","display_name":"Network packet","level":2,"score":0.0},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000162","descriptor_name":"Acoustics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000162","descriptor_name":"Acoustics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000162","descriptor_name":"Acoustics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000464","descriptor_name":"Alginates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000464","descriptor_name":"Alginates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000464","descriptor_name":"Alginates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002214","descriptor_name":"Capsules","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002214","descriptor_name":"Capsules","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002214","descriptor_name":"Capsules","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006603","descriptor_name":"Hexuronic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006603","descriptor_name":"Hexuronic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006603","descriptor_name":"Hexuronic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014159","descriptor_name":"Transducers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014159","descriptor_name":"Transducers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014159","descriptor_name":"Transducers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014464","descriptor_name":"Ultrasonic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014464","descriptor_name":"Ultrasonic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014464","descriptor_name":"Ultrasonic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020723","descriptor_name":"Glucuronic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020723","descriptor_name":"Glucuronic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020723","descriptor_name":"Glucuronic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055095","descriptor_name":"Optics and Photonics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055095","descriptor_name":"Optics and Photonics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055095","descriptor_name":"Optics and Photonics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055119","descriptor_name":"Elastic Modulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055119","descriptor_name":"Elastic Modulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055119","descriptor_name":"Elastic Modulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/iembs.2011.6091821","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.2011.6091821","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:22256001","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22256001","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:scholarcommons.scu.edu:bio_eng-1050","is_oa":false,"landing_page_url":"https://scholarcommons.scu.edu/bio_eng/51","pdf_url":null,"source":{"id":"https://openalex.org/S4377196452","display_name":"Scholar Commons (Santa Clara University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I16269868","host_organization_name":"Santa Clara University","host_organization_lineage":["https://openalex.org/I16269868"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioengineering","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8100000023841858,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320316409","display_name":"San Jos\u00e9 State University","ror":"https://ror.org/04qyvz380"},{"id":"https://openalex.org/F4320326972","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W207673420","https://openalex.org/W1973189310","https://openalex.org/W1992506113","https://openalex.org/W2022282748","https://openalex.org/W2032773633","https://openalex.org/W2036898521","https://openalex.org/W2087898189","https://openalex.org/W2092029860","https://openalex.org/W2098946064","https://openalex.org/W2106430423","https://openalex.org/W2123285370","https://openalex.org/W2334241839","https://openalex.org/W2400023560"],"related_works":["https://openalex.org/W2130793660","https://openalex.org/W2187196170","https://openalex.org/W2133397304","https://openalex.org/W2401590517","https://openalex.org/W163999654","https://openalex.org/W3151629841","https://openalex.org/W2312679656","https://openalex.org/W2610150565","https://openalex.org/W2114471609","https://openalex.org/W2187023372"],"abstract_inverted_index":{"In":[0,29],"the":[1,70,122],"area":[2],"of":[3,81],"therapeutic":[4,46,82],"ultrasound":[5,18,47,83,133],"activated":[6,44,134],"drug":[7],"delivery,":[8],"difficulties":[9],"exist":[10],"in":[11,141],"designing":[12],"a":[13,35,90,95],"carrier":[14],"that":[15,41],"responds":[16],"to":[17],"for":[19,48,62,69,103,131],"triggering":[20],"and":[21,51,65,78,101,105,111,136,143],"imaging":[22,137],"but":[23],"also":[24,115],"provides":[25],"adequate":[26],"treatment":[27],"potential.":[28],"this":[30],"paper,":[31],"we":[32,73],"report":[33],"on":[34,84,94,120],"novel":[36],"acoustically":[37],"sensitive":[38],"microcapsule":[39],"reservoir":[40],"can":[42,52],"be":[43,53],"with":[45,108],"payload":[49],"release":[50,135],"potentially":[54],"tracked":[55],"using":[56,89],"imaging.":[57],"It":[58],"is":[59,66],"being":[60,139],"designed":[61],"increased":[63],"longevity":[64],"not":[67],"planned":[68],"circulation.":[71],"Here,":[72],"describe":[74],"its":[75],"unique":[76],"formulation":[77],"demonstrate":[79],"effects":[80],"it":[85],"at":[86],"1":[87],"MHz":[88],"combined":[91],"optical-acoustic":[92],"setup":[93],"microscope.":[96],"We":[97,114],"see":[98],"membrane":[99],"bulging":[100],"damage":[102],"small":[104],"large":[106],"capsules":[107],"both":[109],"continuous":[110],"pulsed":[112],"ultrasound.":[113],"show":[116,129],"some":[117],"preliminary":[118],"work":[119],"understanding":[121],"mechanism":[123],"behind":[124],"these":[125],"effects.":[126],"The":[127],"reservoirs":[128],"potential":[130],"future":[132],"while":[138],"patent":[140],"form":[142],"function":[144],"over":[145],"several":[146],"weeks.":[147]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}