{"id":"https://openalex.org/W1964565477","doi":"https://doi.org/10.1109/iembs.2011.6091799","title":"Diagnostic biomarkers for Alzheimer's disease using dynamic nonlinear models based on principal dynamic modes","display_name":"Diagnostic biomarkers for Alzheimer's disease using dynamic nonlinear models based on principal dynamic modes","publication_year":2011,"publication_date":"2011-08-01","ids":{"openalex":"https://openalex.org/W1964565477","doi":"https://doi.org/10.1109/iembs.2011.6091799","mag":"1964565477","pmid":"https://pubmed.ncbi.nlm.nih.gov/22255979"},"language":"en","primary_location":{"id":"doi:10.1109/iembs.2011.6091799","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.2011.6091799","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036646017","display_name":"Vasilis Z. Marmarelis","orcid":"https://orcid.org/0000-0003-1457-813X"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"V. Z. Marmarelis","raw_affiliation_strings":["Department of Biomedical Engineering and the Biomedical Simulations Resource, University of Southern California, Los Angeles, CA 90089, USA. vzm@usc.edu","Department of Biomedical Engineering and the Biomedical Simulations Resource (BMSR) at the University of Southern California, Los Angeles, CA 90089 USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and the Biomedical Simulations Resource, University of Southern California, Los Angeles, CA 90089, USA. vzm@usc.edu","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Biomedical Engineering and the Biomedical Simulations Resource (BMSR) at the University of Southern California, Los Angeles, CA 90089 USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101423737","display_name":"Dongkyu Shin","orcid":"https://orcid.org/0000-0003-4939-4023"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. C. Shin","raw_affiliation_strings":["Department of Biomedical Engineering and the Biomedical Simulations Resource (BMSR), University of Southern California, Los Angeles, CA, USA","Department of Biomedical Engineering and the Biomedical Simulations Resource (BMSR) at the University of Southern California, Los Angeles, CA 90089 USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and the Biomedical Simulations Resource (BMSR), University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Biomedical Engineering and the Biomedical Simulations Resource (BMSR) at the University of Southern California, Los Angeles, CA 90089 USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029617270","display_name":"Ramon Diaz\u2010Arrastia","orcid":"https://orcid.org/0000-0001-6051-3594"},"institutions":[{"id":"https://openalex.org/I4210145855","display_name":"Institute for Exercise and Environmental Medicine","ror":"https://ror.org/03gqc7y13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800861319","https://openalex.org/I4210145855","https://openalex.org/I4210163017","https://openalex.org/I867280407","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"education","lineage":["https://openalex.org/I867280407"]},{"id":"https://openalex.org/I2800861319","display_name":"Texas Health Dallas","ror":"https://ror.org/05k07p323","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800861319","https://openalex.org/I4210163017","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I4210096815","display_name":"Southwestern Medical Center","ror":"https://ror.org/00t9vx427","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210096815"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Diaz-Arrastia","raw_affiliation_strings":["Institute for Exercise and Environmental Medicine at the Presbyterian Hospital of Dallas, University of Texas Southwestern Medical Center, Dallas, TX, USA","Institute for Exercise and Environmental Medicine at the Presbyterian Hospital of Dallas, University of Texas Southwestern Medical Center, 7232 Greenville Avenue, Dallas, TX 75231, USA"],"affiliations":[{"raw_affiliation_string":"Institute for Exercise and Environmental Medicine at the Presbyterian Hospital of Dallas, University of Texas Southwestern Medical Center, Dallas, TX, USA","institution_ids":["https://openalex.org/I2800861319","https://openalex.org/I867280407","https://openalex.org/I4210145855","https://openalex.org/I4210096815"]},{"raw_affiliation_string":"Institute for Exercise and Environmental Medicine at the Presbyterian Hospital of Dallas, University of Texas Southwestern Medical Center, 7232 Greenville Avenue, Dallas, TX 75231, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089256867","display_name":"R. Zhang","orcid":"https://orcid.org/0009-0001-8853-5813"},"institutions":[{"id":"https://openalex.org/I4210096815","display_name":"Southwestern Medical Center","ror":"https://ror.org/00t9vx427","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210096815"]},{"id":"https://openalex.org/I4210145855","display_name":"Institute for Exercise and Environmental Medicine","ror":"https://ror.org/03gqc7y13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800861319","https://openalex.org/I4210145855","https://openalex.org/I4210163017","https://openalex.org/I867280407","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"education","lineage":["https://openalex.org/I867280407"]},{"id":"https://openalex.org/I2800861319","display_name":"Texas Health Dallas","ror":"https://ror.org/05k07p323","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800861319","https://openalex.org/I4210163017","https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Zhang","raw_affiliation_strings":["Institute for Exercise and Environmental Medicine at the Presbyterian Hospital of Dallas, University of Texas Southwestern Medical Center, Dallas, TX, USA","Institute for Exercise and Environmental Medicine at the Presbyterian Hospital of Dallas, University of Texas Southwestern Medical Center, 7232 Greenville Avenue, Dallas, TX 75231, USA"],"affiliations":[{"raw_affiliation_string":"Institute for Exercise and Environmental Medicine at the Presbyterian Hospital of Dallas, University of Texas Southwestern Medical Center, Dallas, TX, USA","institution_ids":["https://openalex.org/I2800861319","https://openalex.org/I867280407","https://openalex.org/I4210145855","https://openalex.org/I4210096815"]},{"raw_affiliation_string":"Institute for Exercise and Environmental Medicine at the Presbyterian Hospital of Dallas, University of Texas Southwestern Medical Center, 7232 Greenville Avenue, Dallas, TX 75231, USA","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5036646017"],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.084909,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"85","issue":null,"first_page":"7119","last_page":"7122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9606000185012817,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9129999876022339,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5752469301223755},{"id":"https://openalex.org/keywords/principal","display_name":"Principal (computer security)","score":0.5716136693954468},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.5576540231704712},{"id":"https://openalex.org/keywords/nonlinear-dynamical-systems","display_name":"Nonlinear dynamical systems","score":0.4982733726501465},{"id":"https://openalex.org/keywords/principal-component-analysis","display_name":"Principal component analysis","score":0.4157904386520386},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.34047064185142517},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.12325674295425415}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5752469301223755},{"id":"https://openalex.org/C144559511","wikidata":"https://www.wikidata.org/wiki/Q2986279","display_name":"Principal (computer security)","level":2,"score":0.5716136693954468},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.5576540231704712},{"id":"https://openalex.org/C2983030100","wikidata":"https://www.wikidata.org/wiki/Q638328","display_name":"Nonlinear dynamical systems","level":3,"score":0.4982733726501465},{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.4157904386520386},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.34047064185142517},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.12325674295425415},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/iembs.2011.6091799","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.2011.6091799","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:22255979","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22255979","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7900000214576721,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W587742752","https://openalex.org/W1535883728","https://openalex.org/W2095800632","https://openalex.org/W2101077152","https://openalex.org/W2115271383","https://openalex.org/W2131174847","https://openalex.org/W2148577539","https://openalex.org/W2153579287","https://openalex.org/W2499601348","https://openalex.org/W6674753078"],"related_works":["https://openalex.org/W1975632186","https://openalex.org/W3027745756","https://openalex.org/W3205213561","https://openalex.org/W1966008566","https://openalex.org/W2079574545","https://openalex.org/W3127651486","https://openalex.org/W2921182178","https://openalex.org/W4247979471","https://openalex.org/W2159708048","https://openalex.org/W2118964038"],"abstract_inverted_index":{"Sensitive":[0],"and":[1,29,41,54],"robust":[2],"diagnostic":[3],"biomarkers":[4],"for":[5,59,87],"Alzheimer's":[6],"disease":[7],"(AD)":[8],"were":[9,47],"sought":[10],"using":[11],"dynamic":[12],"nonlinear":[13],"models":[14,46],"of":[15,23,65,78,83],"the":[16,63,66,81,84],"causal":[17],"interrelationships":[18],"among":[19],"time-series":[20],"(beat-to-beat)":[21],"data":[22],"arterial":[24],"blood":[25,31],"pressure,":[26],"end-tidal":[27],"CO(2)":[28,68],"cerebral":[30],"flow":[32],"velocity":[33],"collected":[34],"in":[35,62],"human":[36],"subjects":[37,79],"(4":[38],"AD":[39,60,89],"patients":[40],"4":[42],"control":[43],"subjects).":[44],"These":[45],"based":[48],"on":[49],"Principal":[50],"Dynamic":[51],"Modes":[52],"(PDM)":[53],"yielded":[55],"a":[56],"reliable":[57],"biomarker":[58,86],"diagnosis":[61],"form":[64],"\"Effective":[67],"Reactivity":[69],"Index\"":[70],"(ECRI).":[71],"The":[72],"results":[73],"from":[74],"this":[75],"initial":[76],"set":[77],"corroborated":[80],"efficacy":[82],"ECRI":[85],"accurate":[88],"diagnosis.":[90]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}