{"id":"https://openalex.org/W2004926375","doi":"https://doi.org/10.1109/iembs.2011.6091069","title":"The response of hepatocyte cell volume to hyperthermia and its role in oedema","display_name":"The response of hepatocyte cell volume to hyperthermia and its role in oedema","publication_year":2011,"publication_date":"2011-08-01","ids":{"openalex":"https://openalex.org/W2004926375","doi":"https://doi.org/10.1109/iembs.2011.6091069","mag":"2004926375","pmid":"https://pubmed.ncbi.nlm.nih.gov/22255292"},"language":"en","primary_location":{"id":"doi:10.1109/iembs.2011.6091069","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.2011.6091069","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072197244","display_name":"David O'Neill","orcid":"https://orcid.org/0000-0002-1609-7666"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210146410","display_name":"Science Oxford","ror":"https://ror.org/04j8yhy50","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210146410"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D. P. O'Neill","raw_affiliation_strings":["Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, UK. david.oneill@eng.ox.ac.uk","Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK, OX1 3PJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, UK. david.oneill@eng.ox.ac.uk","institution_ids":["https://openalex.org/I4210146410"]},{"raw_affiliation_string":"Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK, OX1 3PJ","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070636207","display_name":"Tingying Peng","orcid":"https://orcid.org/0000-0002-7881-1749"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"T. Peng","raw_affiliation_strings":["Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK","Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK, OX1 3PJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK, OX1 3PJ","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056716007","display_name":"Stephen J. Payne","orcid":"https://orcid.org/0000-0003-1156-2810"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. J. Payne","raw_affiliation_strings":["Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK","Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK, OX1 3PJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK, OX1 3PJ","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.04832022,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"46","issue":null,"first_page":"4305","last_page":"4308"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9811000227928162,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/volume","display_name":"Volume (thermodynamics)","score":0.6474201679229736},{"id":"https://openalex.org/keywords/diffusion","display_name":"Diffusion","score":0.6113450527191162},{"id":"https://openalex.org/keywords/hepatocyte","display_name":"Hepatocyte","score":0.5868743658065796},{"id":"https://openalex.org/keywords/mechanics","display_name":"Mechanics","score":0.48998990654945374},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.4727005958557129},{"id":"https://openalex.org/keywords/hyperthermia","display_name":"Hyperthermia","score":0.46511581540107727},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.4303521513938904},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.40063348412513733},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.37089627981185913},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3435589075088501},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3373981714248657},{"id":"https://openalex.org/keywords/thermodynamics","display_name":"Thermodynamics","score":0.22191563248634338},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.18777891993522644},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.17413580417633057},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.16799339652061462},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.1328011453151703}],"concepts":[{"id":"https://openalex.org/C20556612","wikidata":"https://www.wikidata.org/wiki/Q4469374","display_name":"Volume (thermodynamics)","level":2,"score":0.6474201679229736},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.6113450527191162},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.5868743658065796},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.48998990654945374},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4727005958557129},{"id":"https://openalex.org/C2779949491","wikidata":"https://www.wikidata.org/wiki/Q242165","display_name":"Hyperthermia","level":2,"score":0.46511581540107727},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4303521513938904},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.40063348412513733},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.37089627981185913},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3435589075088501},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3373981714248657},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.22191563248634338},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.18777891993522644},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17413580417633057},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16799339652061462},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1328011453151703},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004487","descriptor_name":"Edema","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004487","descriptor_name":"Edema","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004487","descriptor_name":"Edema","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005334","descriptor_name":"Fever","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005334","descriptor_name":"Fever","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005334","descriptor_name":"Fever","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048429","descriptor_name":"Cell Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048429","descriptor_name":"Cell Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048429","descriptor_name":"Cell Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1109/iembs.2011.6091069","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.2011.6091069","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:22255292","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22255292","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:ora.ox.ac.uk:uuid:b104a66c-ff76-46cc-bb77-ffba6db676cc","is_oa":false,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:b104a66c-ff76-46cc-bb77-ffba6db676cc","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symplectic Elements at Oxford","raw_type":"Journal article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7599999904632568,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1588087328","https://openalex.org/W1855112288","https://openalex.org/W1963855060","https://openalex.org/W1981450479","https://openalex.org/W1992896098","https://openalex.org/W2019013376","https://openalex.org/W2106151879","https://openalex.org/W4254402395","https://openalex.org/W6676048028"],"related_works":["https://openalex.org/W2412647768","https://openalex.org/W2071759860","https://openalex.org/W2107241099","https://openalex.org/W645160927","https://openalex.org/W2417036867","https://openalex.org/W2086358699","https://openalex.org/W2043809791","https://openalex.org/W2406020269","https://openalex.org/W3083804625","https://openalex.org/W2379226637"],"abstract_inverted_index":{"A":[0],"novel":[1],"mathematical":[2],"model":[3,22,56],"for":[4,24],"hepatocytes":[5],"and":[6,18,30],"surrounding":[7],"volume":[8],"is":[9],"presented":[10],"here;":[11],"in":[12,48,73],"addition":[13],"to":[14,65],"tracking":[15],"ion":[16],"transport":[17],"diffusion":[19,43],"the":[20,55,66],"new":[21],"allows":[23],"changing":[25],"cell":[26,49],"volume.":[27,50],"Using":[28],"temporally":[29],"spatially":[31],"varying":[32],"temperature":[33],"as":[34],"an":[35],"input,":[36],"this":[37],"paper":[38],"shows":[39],"how":[40],"differences":[41],"between":[42],"coefficients":[44],"directly":[45],"influence":[46],"increases":[47],"The":[51],"multiscale":[52],"nature":[53],"of":[54,70,76],"presents":[57],"a":[58],"possible":[59],"link":[60],"from":[61],"established":[62],"cellular":[63],"equations":[64],"observed":[67],"clinical":[68],"result":[69],"oedema":[71],"present":[72],"thermal":[74],"treatments":[75],"cancer.":[77]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
