{"id":"https://openalex.org/W2070956471","doi":"https://doi.org/10.1109/iembs.2011.6090904","title":"Dynamic nonlinear modeling of interactions between neuronal ensembles using principal dynamic modes","display_name":"Dynamic nonlinear modeling of interactions between neuronal ensembles using principal dynamic modes","publication_year":2011,"publication_date":"2011-08-01","ids":{"openalex":"https://openalex.org/W2070956471","doi":"https://doi.org/10.1109/iembs.2011.6090904","mag":"2070956471","pmid":"https://pubmed.ncbi.nlm.nih.gov/22255053"},"language":"en","primary_location":{"id":"doi:10.1109/iembs.2011.6090904","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.2011.6090904","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036646017","display_name":"Vasilis Z. Marmarelis","orcid":"https://orcid.org/0000-0003-1457-813X"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. Z. Marmarelis","raw_affiliation_strings":["Department of Biomedical Engineering and the Biomedical Simulations Resource, University of Southern California, Los Angeles, CA 90089, USA. vzm@usc.edu","Department of Biomedical Engineering and the Biomedical Simulations Resource (BMSR), University of Southern California, Los Angeles, CA, 90089, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and the Biomedical Simulations Resource, University of Southern California, Los Angeles, CA 90089, USA. vzm@usc.edu","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Biomedical Engineering and the Biomedical Simulations Resource (BMSR), University of Southern California, Los Angeles, CA, 90089, USA,","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101423737","display_name":"Dongkyu Shin","orcid":"https://orcid.org/0000-0003-4939-4023"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. C. Shin","raw_affiliation_strings":["Department of Biomedical Engineering and the Biomedical Simulations Resource (BMSR), University of Southern California, Los Angeles, CA, USA","Department of Biomedical Engineering and the Biomedical Simulations Resource (BMSR), University of Southern California, Los Angeles, CA, 90089, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and the Biomedical Simulations Resource (BMSR), University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Biomedical Engineering and the Biomedical Simulations Resource (BMSR), University of Southern California, Los Angeles, CA, 90089, USA,","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070732235","display_name":"Dong Song","orcid":"https://orcid.org/0000-0002-6179-1120"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Song","raw_affiliation_strings":["Department of Biomedical Engineering, the Biomedical Simulations Resource and the Center of Neural Engineering, University of Southern California, Los Angeles, CA, USA","Department of Biomedical Engineering, the Biomedical Simulations Resource and the Center for Neural Engineering, University of Southern California, Los Angeles, CA 90089 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, the Biomedical Simulations Resource and the Center of Neural Engineering, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Biomedical Engineering, the Biomedical Simulations Resource and the Center for Neural Engineering, University of Southern California, Los Angeles, CA 90089 USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014818977","display_name":"Robert E. Hampson","orcid":"https://orcid.org/0000-0002-8648-9462"},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. E. Hampson","raw_affiliation_strings":["Department of Physiology & Pharmacology, School of Medicine, Wake Forest University, Winston Salem, NC, USA","Department of Physiology and Pharmacology, Wake Forest University School of Medicine Winston\u2013Salem, NC 27157, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology & Pharmacology, School of Medicine, Wake Forest University, Winston Salem, NC, USA","institution_ids":["https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Physiology and Pharmacology, Wake Forest University School of Medicine Winston\u2013Salem, NC 27157, USA","institution_ids":["https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073769081","display_name":"Sam A. Deadwyler","orcid":null},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. A. Deadwyler","raw_affiliation_strings":["Department of Physiology & Pharmacology, School of Medicine, Wake Forest University, Winston Salem, NC, USA","Department of Physiology and Pharmacology, Wake Forest University School of Medicine Winston\u2013Salem, NC 27157, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology & Pharmacology, School of Medicine, Wake Forest University, Winston Salem, NC, USA","institution_ids":["https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Physiology and Pharmacology, Wake Forest University School of Medicine Winston\u2013Salem, NC 27157, USA","institution_ids":["https://openalex.org/I47251452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111911478","display_name":"Theodore W. Berger","orcid":null},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. W. Berger","raw_affiliation_strings":["Department of Biomedical Engineering, the Biomedical Simulations Resource and the Center of Neural Engineering, University of Southern California, Los Angeles, CA, USA","Department of Biomedical Engineering, the Biomedical Simulations Resource and the Center for Neural Engineering, University of Southern California, Los Angeles, CA 90089 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, the Biomedical Simulations Resource and the Center of Neural Engineering, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Biomedical Engineering, the Biomedical Simulations Resource and the Center for Neural Engineering, University of Southern California, Los Angeles, CA 90089 USA","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":"3334","last_page":"3337"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9930999875068665,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9807999730110168,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.6721429824829102},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6191479563713074},{"id":"https://openalex.org/keywords/nonlinear-dynamical-systems","display_name":"Nonlinear dynamical systems","score":0.569876492023468},{"id":"https://openalex.org/keywords/principal","display_name":"Principal (computer security)","score":0.5207141041755676},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3609229624271393},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.35979968309402466},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.3211345672607422},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.30987924337387085},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.19943737983703613},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.07283291220664978},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.062322020530700684}],"concepts":[{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.6721429824829102},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6191479563713074},{"id":"https://openalex.org/C2983030100","wikidata":"https://www.wikidata.org/wiki/Q638328","display_name":"Nonlinear dynamical systems","level":3,"score":0.569876492023468},{"id":"https://openalex.org/C144559511","wikidata":"https://www.wikidata.org/wiki/Q2986279","display_name":"Principal (computer security)","level":2,"score":0.5207141041755676},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3609229624271393},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.35979968309402466},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.3211345672607422},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.30987924337387085},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.19943737983703613},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07283291220664978},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.062322020530700684},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011323","descriptor_name":"Primates","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011323","descriptor_name":"Primates","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011323","descriptor_name":"Primates","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013647","descriptor_name":"Task Performance and Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013647","descriptor_name":"Task Performance and Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013647","descriptor_name":"Task Performance and Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/iembs.2011.6090904","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.2011.6090904","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:22255053","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22255053","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1103029161","display_name":null,"funder_award_id":"R01 DA026487","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G2015879519","display_name":null,"funder_award_id":"P41-EB001978","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G7085300469","display_name":null,"funder_award_id":"R01 DA023573","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G902326085","display_name":null,"funder_award_id":"R01 DA008549","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1482184480","https://openalex.org/W2014237562","https://openalex.org/W2089623021","https://openalex.org/W2089831095","https://openalex.org/W2126927871","https://openalex.org/W2147512414","https://openalex.org/W2163306439","https://openalex.org/W2499601348"],"related_works":["https://openalex.org/W236190221","https://openalex.org/W2379779959","https://openalex.org/W2333822231","https://openalex.org/W1966008566","https://openalex.org/W2079574545","https://openalex.org/W3127651486","https://openalex.org/W2921182178","https://openalex.org/W4247979471","https://openalex.org/W2159708048","https://openalex.org/W2118964038"],"abstract_inverted_index":{"We":[0],"present":[1],"a":[2,133,143,147],"novel":[3],"methodology":[4,189],"for":[5,92],"modeling":[6],"the":[7,14,33,36,41,54,71,93,96,102,107,110,139,161,168,193,196],"interactions":[8,42],"between":[9,43],"neuronal":[10,44],"ensembles":[11],"that":[12,116,187],"utilizes":[13],"concept":[15],"of":[16,35,40,47,63,95,101,109,112,126,135,142,177,195,202],"Principal":[17],"Dynamic":[18],"Modes":[19],"(PDM)":[20],"and":[21,76,79,124,163],"their":[22],"associated":[23],"nonlinear":[24],"functions":[25],"(ANF).":[26],"This":[27],"new":[28],"approach":[29],"seeks":[30],"to":[31,57,118,132],"reduce":[32,192],"complexity":[34,194],"multi-input/multi-output":[37],"(MIMO)":[38],"model":[39,198],"ensembles--an":[45],"issue":[46],"critical":[48],"practical":[49],"importance":[50],"in":[51],"scaling":[52],"up":[53],"MIMO":[55,97,197],"models":[56],"incorporate":[58],"hundreds":[59],"(or":[60],"even":[61],"thousands)":[62],"input-output":[64],"neurons.":[65],"Global":[66],"PDMs":[67,86,103],"were":[68,158],"extracted":[69],"from":[70,106,155,164],"data":[72,136],"using":[73],"estimated":[74,105],"first-order":[75],"second-order":[77],"kernels":[78],"singular":[80],"value":[81],"decomposition":[82],"(SVD).":[83],"These":[84],"global":[85],"represent":[87],"an":[88],"efficient":[89],"\"coordinate":[90],"system\"":[91],"representation":[94],"model.":[98],"The":[99,184],"ANFs":[100],"are":[104],"histograms":[108],"combinations":[111],"PDM":[113],"output":[114,119],"values":[115],"lead":[117],"spikes.":[120],"For":[121],"initial":[122],"testing":[123],"validation":[125],"this":[127,188],"approach,":[128],"we":[129],"applied":[130],"it":[131],"set":[134],"collected":[137],"at":[138],"pre-frontal":[140],"cortex":[141],"non-human":[144],"primate":[145],"during":[146],"behavioral":[148],"task":[149],"(Delayed":[150],"Match-to-Sample).":[151],"Recorded":[152],"spike":[153],"trains":[154],"Layer-2":[156],"neurons":[157,166],"viewed":[159],"as":[160,167],"\"inputs\"":[162],"Layer-5":[165],"outputs.":[169],"Model":[170],"prediction":[171],"performance":[172],"was":[173],"evaluated":[174],"by":[175],"means":[176],"computed":[178],"Receiver":[179],"Operating":[180],"Characteristic":[181],"(ROC)":[182],"curves.":[183],"results":[185],"indicate":[186],"may":[190],"greatly":[191],"without":[199],"significant":[200],"degradation":[201],"performance.":[203]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}