{"id":"https://openalex.org/W1976943127","doi":"https://doi.org/10.1109/iembs.2011.6090883","title":"Anticancer effectiveness of polymeric drug nanocarriers on colorectal cancer cells","display_name":"Anticancer effectiveness of polymeric drug nanocarriers on colorectal cancer cells","publication_year":2011,"publication_date":"2011-08-01","ids":{"openalex":"https://openalex.org/W1976943127","doi":"https://doi.org/10.1109/iembs.2011.6090883","mag":"1976943127","pmid":"https://pubmed.ncbi.nlm.nih.gov/22255032"},"language":"en","primary_location":{"id":"doi:10.1109/iembs.2011.6090883","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.2011.6090883","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001443386","display_name":"Jie\u2010Sheng Wang","orcid":"https://orcid.org/0000-0002-8853-1927"},"institutions":[{"id":"https://openalex.org/I11957088","display_name":"Michigan Technological University","ror":"https://ror.org/0036rpn28","country_code":"US","type":"education","lineage":["https://openalex.org/I11957088"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jiesheng Wang","raw_affiliation_strings":["Department of Chemical Engineering, Michigan Technological University, Houghton, MI 49931, USA"],"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Michigan Technological University, Houghton, MI 49931, USA","institution_ids":["https://openalex.org/I11957088"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028823583","display_name":"Ching\u2010An Peng","orcid":"https://orcid.org/0000-0003-0389-7311"},"institutions":[{"id":"https://openalex.org/I11957088","display_name":"Michigan Technological University","ror":"https://ror.org/0036rpn28","country_code":"US","type":"education","lineage":["https://openalex.org/I11957088"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ching-An Peng","raw_affiliation_strings":["Department of Chemical Engineering, Michigan Technological University, Houghton, MI, USA","Department of Chemical Engineering, Michigan Technological University, Houghton, MI 49931, USA"],"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Michigan Technological University, Houghton, MI, USA","institution_ids":["https://openalex.org/I11957088"]},{"raw_affiliation_string":"Department of Chemical Engineering, Michigan Technological University, Houghton, MI 49931, USA","institution_ids":["https://openalex.org/I11957088"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001443386"],"corresponding_institution_ids":["https://openalex.org/I11957088"],"apc_list":null,"apc_paid":null,"fwci":0.1693,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.56954436,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"79","issue":null,"first_page":"3249","last_page":"3252"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanocarriers","display_name":"Nanocarriers","score":0.9011176824569702},{"id":"https://openalex.org/keywords/prodrug","display_name":"Prodrug","score":0.83805251121521},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.604684591293335},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.5265023112297058},{"id":"https://openalex.org/keywords/micelle","display_name":"Micelle","score":0.4433504641056061},{"id":"https://openalex.org/keywords/chitosan","display_name":"Chitosan","score":0.4132179021835327},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.327606737613678},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2844344973564148},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"Drug delivery","score":0.28219157457351685},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.14315012097358704},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.0900769829750061},{"id":"https://openalex.org/keywords/aqueous-solution","display_name":"Aqueous solution","score":0.05989259481430054}],"concepts":[{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.9011176824569702},{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.83805251121521},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.604684591293335},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5265023112297058},{"id":"https://openalex.org/C11268172","wikidata":"https://www.wikidata.org/wiki/Q421110","display_name":"Micelle","level":3,"score":0.4433504641056061},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.4132179021835327},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.327606737613678},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2844344973564148},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.28219157457351685},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.14315012097358704},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0900769829750061},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.05989259481430054},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/iembs.2011.6090883","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.2011.6090883","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:22255032","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22255032","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:digitalcommons.mtu.edu:michigantech-p-29927","is_oa":false,"landing_page_url":"https://digitalcommons.mtu.edu/michigantech-p/10625","pdf_url":null,"source":{"id":"https://openalex.org/S4377196391","display_name":"Digital Commons - Michigan Tech (Michigan Technological University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I11957088","host_organization_name":"Michigan Technological University","host_organization_lineage":["https://openalex.org/I11957088"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Michigan Tech Publications, Part 1","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.47999998927116394}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1966538775","https://openalex.org/W1978779682","https://openalex.org/W2023056517","https://openalex.org/W2039639998","https://openalex.org/W2044917441","https://openalex.org/W2074075725","https://openalex.org/W2082641947","https://openalex.org/W2102616280","https://openalex.org/W2115957530","https://openalex.org/W2155635155","https://openalex.org/W2417368681","https://openalex.org/W6656382457","https://openalex.org/W6716899063"],"related_works":["https://openalex.org/W4366721369","https://openalex.org/W3126369458","https://openalex.org/W2895282589","https://openalex.org/W4386456777","https://openalex.org/W2611180281","https://openalex.org/W4311202961","https://openalex.org/W4387534949","https://openalex.org/W4306391223","https://openalex.org/W2902445771","https://openalex.org/W3032807122"],"abstract_inverted_index":{"Doxifluridine,":[0],"a":[1],"prodrug":[2,54,150],"of":[3,15,80,90,103,115,154],"5-fluorouracil":[4,59],"(5-FU),":[5],"was":[6,23,37,56,83,108],"used":[7],"as":[8],"the":[9,50,87,91,104],"initiator":[10],"directly":[11],"in":[12,68,86],"ring-opening":[13],"polymerization":[14],"\u03b5-caprolactone":[16],"to":[17,29,135],"form":[18],"hydrophobic":[19,88],"doxifluridine-poly(\u03b5-caprolactone)":[20],"(doxifluridine-PCL)":[21],"that":[22],"further":[24,84],"grafted":[25],"with":[26,49,97,127,142,147],"hydrophilic":[27],"chitosan":[28],"synthsize":[30],"amphiphilic":[31,35],"doxifluridine-PCL-chitosan":[32,148],"copolymer.":[33],"This":[34],"copolymer":[36],"self-assembled":[38],"into":[39,58],"micellar":[40],"nanoparticles.":[41],"After":[42],"HT-29":[43,98,124],"colon":[44],"cancer":[45],"cells":[46,125,140,156],"were":[47,130,145,157],"treated":[48,96],"polymeric":[51,92,105,149],"drug":[52,72,93,106],"nanocarrier,":[53],"doxifluridine":[55],"converted":[57],"by":[60,111,132],"endogenous":[61],"thymidine":[62],"phosphorylase":[63],"(TP)":[64],"and":[65,95,122],"thereby":[66],"resulting":[67],"cell":[69],"death.":[70],"Chemotherapy":[71],"7-ethyl-10-hydroxy-camptothecin":[73],"(SN-38),":[74],"an":[75],"active":[76],"water":[77],"insoluble":[78],"metabolite":[79],"irinoetcan":[81],"hydrochloride,":[82],"encapsulated":[85],"core":[89],"nanocarriers":[94,107],"cells.":[99,138],"The":[100,152],"anticancer":[101,113],"effectiveness":[102],"extensively":[109],"enhanced":[110],"synergistic":[112],"activity":[114],"slowly":[116],"released":[117],"cytotoxic":[118],"drugs":[119],"(i.e.,":[120],"5-FU":[121],"SN-38).":[123],"transfected":[126],"TP-encoding":[128],"plasmids":[129],"selected":[131],"antibiotic":[133],"G418":[134],"obtain":[136],"HT-29/TP":[137,155],"These":[139],"overexpressed":[141],"TP":[143],"enzyme":[144],"challenged":[146],"micelles.":[151],"viability":[153],"dropped":[158],"significantly":[159],"after":[160],"72-h":[161],"treatment.":[162]},"counts_by_year":[{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-03-10T16:38:18.471706","created_date":"2025-10-10T00:00:00"}