{"id":"https://openalex.org/W2047472639","doi":"https://doi.org/10.1109/iembs.2011.6090769","title":"Investigation of parameters highlighting drug induced small changes of the T-wave's morphology for drug safety studies","display_name":"Investigation of parameters highlighting drug induced small changes of the T-wave's morphology for drug safety studies","publication_year":2011,"publication_date":"2011-08-01","ids":{"openalex":"https://openalex.org/W2047472639","doi":"https://doi.org/10.1109/iembs.2011.6090769","mag":"2047472639","pmid":"https://pubmed.ncbi.nlm.nih.gov/22255166"},"language":"en","primary_location":{"id":"doi:10.1109/iembs.2011.6090769","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.2011.6090769","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067188726","display_name":"T. Baas","orcid":null},"institutions":[{"id":"https://openalex.org/I102335020","display_name":"Karlsruhe Institute of Technology","ror":"https://ror.org/04t3en479","country_code":"DE","type":"education","lineage":["https://openalex.org/I102335020","https://openalex.org/I1305996414"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"T. Baas","raw_affiliation_strings":["Karlsruhe Institute of Technology, Institute of Biomedical Engineering, 76131 Karlsruhe, Germany.Tobias.baas@kit.edu","Karlsruhe Institute of Technology, Institute of Biomedical Engineering, 76131 Karlsruhe, Germany"],"affiliations":[{"raw_affiliation_string":"Karlsruhe Institute of Technology, Institute of Biomedical Engineering, 76131 Karlsruhe, Germany.Tobias.baas@kit.edu","institution_ids":["https://openalex.org/I102335020"]},{"raw_affiliation_string":"Karlsruhe Institute of Technology, Institute of Biomedical Engineering, 76131 Karlsruhe, Germany","institution_ids":["https://openalex.org/I102335020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081927318","display_name":"Kerstin Gr\u00e4fe","orcid":null},"institutions":[{"id":"https://openalex.org/I102335020","display_name":"Karlsruhe Institute of Technology","ror":"https://ror.org/04t3en479","country_code":"DE","type":"education","lineage":["https://openalex.org/I102335020","https://openalex.org/I1305996414"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. Grafe","raw_affiliation_strings":["Institute of Biomedical Engineering, Karlsruhe Institute of Technology, Karlsruhe, Germany","Karlsruhe Institute of Technology, Institute of Biomedical Engineering, 76131 Karlsruhe, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Engineering, Karlsruhe Institute of Technology, Karlsruhe, Germany","institution_ids":["https://openalex.org/I102335020"]},{"raw_affiliation_string":"Karlsruhe Institute of Technology, Institute of Biomedical Engineering, 76131 Karlsruhe, Germany","institution_ids":["https://openalex.org/I102335020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110660807","display_name":"Antoun Khawaja","orcid":null},"institutions":[{"id":"https://openalex.org/I4210149021","display_name":"CS Diagnostics","ror":"https://ror.org/04dqgsa85","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210149021"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Khawaja","raw_affiliation_strings":["Medical Diagnostics, Biosigna, Munich, Germany","Biosigna, Medical Diagnostics, 80337 Munich, Germany"],"affiliations":[{"raw_affiliation_string":"Medical Diagnostics, Biosigna, Munich, Germany","institution_ids":["https://openalex.org/I4210149021"]},{"raw_affiliation_string":"Biosigna, Medical Diagnostics, 80337 Munich, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109145660","display_name":"Olaf D\u00f6ssel","orcid":null},"institutions":[{"id":"https://openalex.org/I102335020","display_name":"Karlsruhe Institute of Technology","ror":"https://ror.org/04t3en479","country_code":"DE","type":"education","lineage":["https://openalex.org/I102335020","https://openalex.org/I1305996414"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"O. Dossel","raw_affiliation_strings":["Institute of Biomedical Engineering, Karlsruhe Institute of Technology, Karlsruhe, Germany","Karlsruhe Institute of Technology, Institute of Biomedical Engineering, 76131 Karlsruhe, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Engineering, Karlsruhe Institute of Technology, Karlsruhe, Germany","institution_ids":["https://openalex.org/I102335020"]},{"raw_affiliation_string":"Karlsruhe Institute of Technology, Institute of Biomedical Engineering, 76131 Karlsruhe, Germany","institution_ids":["https://openalex.org/I102335020"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5067188726"],"corresponding_institution_ids":["https://openalex.org/I102335020"],"apc_list":null,"apc_paid":null,"fwci":0.5765,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.72196518,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"37","issue":null,"first_page":"3796","last_page":"3799"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11021","display_name":"ECG Monitoring and Analysis","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.977400004863739,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/qt-interval","display_name":"QT interval","score":0.8888390064239502},{"id":"https://openalex.org/keywords/moxifloxacin","display_name":"Moxifloxacin","score":0.7767512798309326},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.7186784744262695},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.5796355605125427},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5786309242248535},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.5687236785888672},{"id":"https://openalex.org/keywords/electrocardiography","display_name":"Electrocardiography","score":0.5132129192352295},{"id":"https://openalex.org/keywords/prolongation","display_name":"Prolongation","score":0.4555048942565918},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.34785962104797363},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.33316224813461304},{"id":"https://openalex.org/keywords/antibiotics","display_name":"Antibiotics","score":0.0891522765159607}],"concepts":[{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.8888390064239502},{"id":"https://openalex.org/C2778836808","wikidata":"https://www.wikidata.org/wiki/Q424940","display_name":"Moxifloxacin","level":3,"score":0.7767512798309326},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7186784744262695},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5796355605125427},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5786309242248535},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5687236785888672},{"id":"https://openalex.org/C2780040984","wikidata":"https://www.wikidata.org/wiki/Q79785","display_name":"Electrocardiography","level":2,"score":0.5132129192352295},{"id":"https://openalex.org/C2777672339","wikidata":"https://www.wikidata.org/wiki/Q7249641","display_name":"Prolongation","level":2,"score":0.4555048942565918},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.34785962104797363},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33316224813461304},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0891522765159607},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000077266","descriptor_name":"Moxifloxacin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077266","descriptor_name":"Moxifloxacin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077266","descriptor_name":"Moxifloxacin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001372","descriptor_name":"Aza Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001372","descriptor_name":"Aza Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001372","descriptor_name":"Aza Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014486","descriptor_name":"United States Food and Drug Administration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014486","descriptor_name":"United States Food and Drug Administration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014486","descriptor_name":"United States Food and Drug Administration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016171","descriptor_name":"Torsades de Pointes","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D016171","descriptor_name":"Torsades de Pointes","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D016171","descriptor_name":"Torsades de Pointes","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017180","descriptor_name":"Tachycardia, Ventricular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017180","descriptor_name":"Tachycardia, Ventricular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017180","descriptor_name":"Tachycardia, Ventricular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D024841","descriptor_name":"Fluoroquinolones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024841","descriptor_name":"Fluoroquinolones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024841","descriptor_name":"Fluoroquinolones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/iembs.2011.6090769","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.2011.6090769","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:22255166","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22255166","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7400000095367432}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1761937902","https://openalex.org/W1847757863","https://openalex.org/W2063877208","https://openalex.org/W2135299895","https://openalex.org/W2136233069","https://openalex.org/W4249981013","https://openalex.org/W6637812453","https://openalex.org/W6680330816"],"related_works":["https://openalex.org/W2075818984","https://openalex.org/W2107285766","https://openalex.org/W2063119282","https://openalex.org/W1510771325","https://openalex.org/W2059530273","https://openalex.org/W2297534580","https://openalex.org/W2883086396","https://openalex.org/W1984220118","https://openalex.org/W3094909023","https://openalex.org/W2392953740"],"abstract_inverted_index":{"In":[0,76],"guideline":[1],"E14,":[2],"the":[3,16,19,26,38,41,71,74,92],"American":[4],"Food":[5],"and":[6,56,88],"Drug":[7],"Administration":[8],"(FDA)":[9],"requests":[10],"for":[11,53],"clinical":[12],"studies":[13],"to":[14,109],"investigate":[15],"prolongation":[17],"of":[18,25,40,51,73,119],"heart":[20],"rate":[21],"corrected":[22],"QT-interval":[23],"(QTc)":[24],"ECG.":[27],"As":[28],"drug":[29],"induced":[30],"QT-prolongation":[31],"can":[32],"be":[33],"caused":[34],"by":[35],"changes":[36,63],"in":[37],"repolarisation":[39,62],"ventricles,":[42],"it":[43],"is":[44,99],"so":[45],"far":[46],"a":[47,77,113],"thorough":[48],"ECG":[49],"biomarker":[50],"risk":[52],"ventricular":[54],"tachyarrhythmias":[55],"Torsade":[57],"de":[58],"Pointes":[59],"(TdP).":[60],"Ventricular":[61],"not":[64],"only":[65],"change":[66],"QT":[67],"but":[68],"also":[69],"influence":[70],"morphology":[72,94],"T-wave.":[75],"(400":[78],"mg":[79,115],"single":[80,117],"dose)":[81],"Moxifloxacin":[82,98],"positive":[83],"control":[84],"study":[85],"both,":[86],"QTc":[87],"several":[89],"descriptors":[90,104],"describing":[91],"T-wave":[93],"have":[95],"been":[96],"measured.":[97],"changing":[100],"two":[101],"shape":[102],"dependent":[103],"significantly":[105],"(P<0.05)":[106],"about":[107],"3":[108],"4":[110],"hours":[111],"after":[112],"400":[114],"oral":[116],"dose":[118],"Moxifloxacin.":[120]},"counts_by_year":[{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}
