{"id":"https://openalex.org/W2078744127","doi":"https://doi.org/10.1109/iembs.2011.6090672","title":"A multiscale bidirectional coupling framework","display_name":"A multiscale bidirectional coupling framework","publication_year":2011,"publication_date":"2011-08-01","ids":{"openalex":"https://openalex.org/W2078744127","doi":"https://doi.org/10.1109/iembs.2011.6090672","mag":"2078744127","pmid":"https://pubmed.ncbi.nlm.nih.gov/22254828"},"language":"en","primary_location":{"id":"doi:10.1109/iembs.2011.6090672","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.2011.6090672","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064036055","display_name":"Senthil Kabilan","orcid":null},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"S. Kabilan","raw_affiliation_strings":["Biological Monitoring and Modeling, Pacific Northwest National Laboratory, Richland, WA, USA","Biological Monitoring and Modeling, Pacific Northwest National Laboratory, Richland, WA"],"affiliations":[{"raw_affiliation_string":"Biological Monitoring and Modeling, Pacific Northwest National Laboratory, Richland, WA, USA","institution_ids":["https://openalex.org/I142606810"]},{"raw_affiliation_string":"Biological Monitoring and Modeling, Pacific Northwest National Laboratory, Richland, WA","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022743648","display_name":"Andrew P. Kuprat","orcid":"https://orcid.org/0000-0003-4159-918X"},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. P. Kuprat","raw_affiliation_strings":["Biological Monitoring and Modeling, Pacific Northwest National Laboratory, Richland, WA, USA","Biological Monitoring and Modeling, Pacific Northwest National Laboratory, Richland, WA"],"affiliations":[{"raw_affiliation_string":"Biological Monitoring and Modeling, Pacific Northwest National Laboratory, Richland, WA, USA","institution_ids":["https://openalex.org/I142606810"]},{"raw_affiliation_string":"Biological Monitoring and Modeling, Pacific Northwest National Laboratory, Richland, WA","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110315032","display_name":"M. P. Hlastala","orcid":null},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. P. Hlastala","raw_affiliation_strings":["Department of Bioengineering, University of Washington, Seattle, WA, USA","Department of Bioengineering, University of Washington, Seattle, WA,"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Bioengineering, University of Washington, Seattle, WA,","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063226007","display_name":"Richard Corley","orcid":"https://orcid.org/0000-0003-2877-9194"},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. A. Corley","raw_affiliation_strings":["Biological Monitoring and Modeling, Pacific Northwest National Laboratory, Richland, WA, USA","Biological Monitoring and Modeling, Pacific Northwest National Laboratory, Richland, WA"],"affiliations":[{"raw_affiliation_string":"Biological Monitoring and Modeling, Pacific Northwest National Laboratory, Richland, WA, USA","institution_ids":["https://openalex.org/I142606810"]},{"raw_affiliation_string":"Biological Monitoring and Modeling, Pacific Northwest National Laboratory, Richland, WA","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113704773","display_name":"Daniel R. Einstein","orcid":null},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. R. Einstein","raw_affiliation_strings":["Biological Monitoring and Modeling, Pacific Northwest National Laboratory, Richland, WA, USA","Biological Monitoring and Modeling, Pacific Northwest National Laboratory, Richland, WA"],"affiliations":[{"raw_affiliation_string":"Biological Monitoring and Modeling, Pacific Northwest National Laboratory, Richland, WA, USA","institution_ids":["https://openalex.org/I142606810"]},{"raw_affiliation_string":"Biological Monitoring and Modeling, Pacific Northwest National Laboratory, Richland, WA","institution_ids":["https://openalex.org/I142606810"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5064036055"],"corresponding_institution_ids":["https://openalex.org/I142606810"],"apc_list":null,"apc_paid":null,"fwci":0.3445,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.63520479,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"67","issue":null,"first_page":"2414","last_page":"2417"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11751","display_name":"Lattice Boltzmann Simulation Studies","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/2206","display_name":"Computational Mechanics"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11751","display_name":"Lattice Boltzmann Simulation Studies","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/2206","display_name":"Computational Mechanics"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.9886999726295471,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12063","display_name":"Heat and Mass Transfer in Porous Media","score":0.980400025844574,"subfield":{"id":"https://openalex.org/subfields/2206","display_name":"Computational Mechanics"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-fluid-dynamics","display_name":"Computational fluid dynamics","score":0.7629871368408203},{"id":"https://openalex.org/keywords/ode","display_name":"Ode","score":0.6587264537811279},{"id":"https://openalex.org/keywords/coupling","display_name":"Coupling (piping)","score":0.6058619022369385},{"id":"https://openalex.org/keywords/finite-volume-method","display_name":"Finite volume method","score":0.5953473448753357},{"id":"https://openalex.org/keywords/krylov-subspace","display_name":"Krylov subspace","score":0.5931451320648193},{"id":"https://openalex.org/keywords/mechanics","display_name":"Mechanics","score":0.5354357957839966},{"id":"https://openalex.org/keywords/computational-model","display_name":"Computational model","score":0.523046612739563},{"id":"https://openalex.org/keywords/finite-element-method","display_name":"Finite element method","score":0.5079360604286194},{"id":"https://openalex.org/keywords/flow","display_name":"Flow (mathematics)","score":0.49057430028915405},{"id":"https://openalex.org/keywords/computation","display_name":"Computation","score":0.4603351056575775},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.40265634655952454},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.40061402320861816},{"id":"https://openalex.org/keywords/applied-mathematics","display_name":"Applied mathematics","score":0.3858622610569},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3219309449195862},{"id":"https://openalex.org/keywords/iterative-method","display_name":"Iterative method","score":0.30281996726989746},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.2773907780647278},{"id":"https://openalex.org/keywords/simulation","display_name":"Simulation","score":0.2646203339099884},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.23556524515151978},{"id":"https://openalex.org/keywords/mechanical-engineering","display_name":"Mechanical engineering","score":0.1733272671699524},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.16680654883384705},{"id":"https://openalex.org/keywords/thermodynamics","display_name":"Thermodynamics","score":0.08738058805465698}],"concepts":[{"id":"https://openalex.org/C1633027","wikidata":"https://www.wikidata.org/wiki/Q815820","display_name":"Computational fluid dynamics","level":2,"score":0.7629871368408203},{"id":"https://openalex.org/C34862557","wikidata":"https://www.wikidata.org/wiki/Q178985","display_name":"Ode","level":2,"score":0.6587264537811279},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.6058619022369385},{"id":"https://openalex.org/C50478463","wikidata":"https://www.wikidata.org/wiki/Q1401936","display_name":"Finite volume method","level":2,"score":0.5953473448753357},{"id":"https://openalex.org/C147060835","wikidata":"https://www.wikidata.org/wiki/Q1757151","display_name":"Krylov subspace","level":3,"score":0.5931451320648193},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.5354357957839966},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.523046612739563},{"id":"https://openalex.org/C135628077","wikidata":"https://www.wikidata.org/wiki/Q220184","display_name":"Finite element method","level":2,"score":0.5079360604286194},{"id":"https://openalex.org/C38349280","wikidata":"https://www.wikidata.org/wiki/Q1434290","display_name":"Flow (mathematics)","level":2,"score":0.49057430028915405},{"id":"https://openalex.org/C45374587","wikidata":"https://www.wikidata.org/wiki/Q12525525","display_name":"Computation","level":2,"score":0.4603351056575775},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.40265634655952454},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.40061402320861816},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.3858622610569},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3219309449195862},{"id":"https://openalex.org/C159694833","wikidata":"https://www.wikidata.org/wiki/Q2321565","display_name":"Iterative method","level":2,"score":0.30281996726989746},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2773907780647278},{"id":"https://openalex.org/C44154836","wikidata":"https://www.wikidata.org/wiki/Q45045","display_name":"Simulation","level":1,"score":0.2646203339099884},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.23556524515151978},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.1733272671699524},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.16680654883384705},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.08738058805465698}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012123","descriptor_name":"Pulmonary Ventilation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012123","descriptor_name":"Pulmonary Ventilation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012123","descriptor_name":"Pulmonary Ventilation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/iembs.2011.6090672","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.2011.6090672","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:22254828","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22254828","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W2031942060","https://openalex.org/W2061573370","https://openalex.org/W2065340330","https://openalex.org/W2092455907","https://openalex.org/W2097995500","https://openalex.org/W2140966322","https://openalex.org/W2141189968","https://openalex.org/W2341939190","https://openalex.org/W4253621355"],"related_works":["https://openalex.org/W2371448224","https://openalex.org/W3134495997","https://openalex.org/W2363680170","https://openalex.org/W2376428685","https://openalex.org/W4256082577","https://openalex.org/W625783435","https://openalex.org/W2119553411","https://openalex.org/W1993980131","https://openalex.org/W2116573255","https://openalex.org/W2575167716"],"abstract_inverted_index":{"The":[0,101,151],"lung":[1,76,86],"is":[2,18,181],"geometrically":[3],"articulated":[4],"across":[5],"multiple":[6],"scales":[7,26],"from":[8,104],"the":[9,12,67,81,85,98,105,131,158,172,175,178,196],"trachea":[10],"to":[11,19,27,110,164,169],"alveoli.":[13],"A":[14],"major":[15],"computational":[16,51],"challenge":[17],"tightly":[20],"link":[21],"ODEs":[22],"that":[23,124],"describe":[24],"lower":[25,62],"3D":[28,56,113],"finite":[29,32],"element":[30],"or":[31,128],"volume":[33],"models":[34,58,87,107,115,146,160],"of":[35,61,171,177],"airway":[36],"mechanics":[37],"using":[38],"iterative":[39],"communication":[40],"between":[41,142],"scales.":[42],"In":[43],"this":[44],"study,":[45],"we":[46],"developed":[47],"a":[48,70,94,139],"novel":[49],"multiscale":[50],"framework":[52],"for":[53,157],"bidirectionally":[54],"coupling":[55,68,180],"CFD":[57,114],"and":[59,72,93,119,144],"systems":[60],"order":[63],"ODEs.":[64],"To":[65],"validate":[66],"framework,":[69],"four":[71],"eight":[73],"generation":[74],"Weibel":[75],"model":[77],"was":[78,130,147],"constructed.":[79],"For":[80],"coupled":[82,106,145,159],"CFD-ODE":[83],"simulations,":[84],"were":[88,108],"truncated":[89,99],"at":[90,116,125,138,154,195],"different":[91],"generations":[92],"RL":[95],"circuit":[96],"represented":[97],"portion.":[100],"flow":[102,152],"characteristics":[103,153],"compared":[109],"untruncated":[111],"full":[112,187],"peak":[117,120],"inhalation":[118],"exhalation.":[121],"Results":[122],"showed":[123,161],"no":[126],"time":[127],"simulation":[129],"difference":[132],"in":[133],"mass":[134],"flux":[135],"and/or":[136],"pressure":[137,193],"given":[140],"location":[141],"uncoupled":[143,165,186],"greater":[148,184],"than":[149,185],"2.43%.":[150],"prime":[155],"locations":[156],"good":[162],"agreement":[163],"models.":[166],"Remarkably,":[167],"due":[168],"reuse":[170],"Krylov":[173],"subspace,":[174],"cost":[176],"ODE":[179],"not":[182],"much":[183],"3D-CFD":[188],"computations":[189],"with":[190],"simple":[191],"prescribed":[192],"values":[194],"outlets.":[197]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}
