{"id":"https://openalex.org/W2003681838","doi":"https://doi.org/10.1109/iembs.2011.6090245","title":"Responses of starburst amacrine cells to prosthetic stimulation of the retina","display_name":"Responses of starburst amacrine cells to prosthetic stimulation of the retina","publication_year":2011,"publication_date":"2011-08-01","ids":{"openalex":"https://openalex.org/W2003681838","doi":"https://doi.org/10.1109/iembs.2011.6090245","mag":"2003681838","pmid":"https://pubmed.ncbi.nlm.nih.gov/22254494"},"language":"en","primary_location":{"id":"doi:10.1109/iembs.2011.6090245","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.2011.6090245","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065277088","display_name":"David Tsai","orcid":"https://orcid.org/0000-0002-5931-1861"},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"D. Tsai","raw_affiliation_strings":["Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia","Graduate School of Biomedical Engineering, University of New South Wales, Sydney Australia"],"affiliations":[{"raw_affiliation_string":"Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"Graduate School of Biomedical Engineering, University of New South Wales, Sydney Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027549089","display_name":"John W. Morley","orcid":"https://orcid.org/0000-0001-9246-853X"},"institutions":[{"id":"https://openalex.org/I63525965","display_name":"Western Sydney University","ror":"https://ror.org/03t52dk35","country_code":"AU","type":"education","lineage":["https://openalex.org/I63525965"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"J. W. Morley","raw_affiliation_strings":["School of Medicine, University of Western Sydney, Penrith, Australia"],"affiliations":[{"raw_affiliation_string":"School of Medicine, University of Western Sydney, Penrith, Australia","institution_ids":["https://openalex.org/I63525965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027574689","display_name":"Gregg J. Suaning","orcid":"https://orcid.org/0000-0003-1918-3313"},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"G. J. Suaning","raw_affiliation_strings":["Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia","Graduate School of Biomedical Engineering, University of New South Wales, Sydney Australia"],"affiliations":[{"raw_affiliation_string":"Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"Graduate School of Biomedical Engineering, University of New South Wales, Sydney Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060602596","display_name":"Nigel H. Lovell","orcid":"https://orcid.org/0000-0003-1637-1079"},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"N. H. Lovell","raw_affiliation_strings":["Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia","Graduate School of Biomedical Engineering, University of New South Wales, Sydney Australia"],"affiliations":[{"raw_affiliation_string":"Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"Graduate School of Biomedical Engineering, University of New South Wales, Sydney Australia","institution_ids":["https://openalex.org/I31746571"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5065277088"],"corresponding_institution_ids":["https://openalex.org/I31746571"],"apc_list":null,"apc_paid":null,"fwci":0.2329,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.46695185,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"22","issue":null,"first_page":"1053","last_page":"1056"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retina","display_name":"Retina","score":0.868630051612854},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.7176503539085388},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.7147696018218994},{"id":"https://openalex.org/keywords/stimulus","display_name":"Stimulus (psychology)","score":0.691910982131958},{"id":"https://openalex.org/keywords/amacrine-cell","display_name":"Amacrine cell","score":0.6487778425216675},{"id":"https://openalex.org/keywords/retinal","display_name":"Retinal","score":0.6144995093345642},{"id":"https://openalex.org/keywords/retinal-implant","display_name":"Retinal implant","score":0.5921221971511841},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.500859260559082},{"id":"https://openalex.org/keywords/visual-prosthesis","display_name":"Visual prosthesis","score":0.4881938099861145},{"id":"https://openalex.org/keywords/retinal-waves","display_name":"Retinal waves","score":0.4310178756713867},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.4198591113090515},{"id":"https://openalex.org/keywords/intrinsically-photosensitive-retinal-ganglion-cells","display_name":"Intrinsically photosensitive retinal ganglion cells","score":0.4165947437286377},{"id":"https://openalex.org/keywords/retinal-ganglion-cell","display_name":"Retinal ganglion cell","score":0.2875937223434448},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.18037691712379456}],"concepts":[{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.868630051612854},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.7176503539085388},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7147696018218994},{"id":"https://openalex.org/C2779918689","wikidata":"https://www.wikidata.org/wiki/Q3771842","display_name":"Stimulus (psychology)","level":2,"score":0.691910982131958},{"id":"https://openalex.org/C2778658801","wikidata":"https://www.wikidata.org/wiki/Q452595","display_name":"Amacrine cell","level":3,"score":0.6487778425216675},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.6144995093345642},{"id":"https://openalex.org/C158383150","wikidata":"https://www.wikidata.org/wiki/Q3149439","display_name":"Retinal implant","level":3,"score":0.5921221971511841},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.500859260559082},{"id":"https://openalex.org/C2778560042","wikidata":"https://www.wikidata.org/wiki/Q540043","display_name":"Visual prosthesis","level":3,"score":0.4881938099861145},{"id":"https://openalex.org/C133529732","wikidata":"https://www.wikidata.org/wiki/Q7316772","display_name":"Retinal waves","level":5,"score":0.4310178756713867},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4198591113090515},{"id":"https://openalex.org/C38137364","wikidata":"https://www.wikidata.org/wiki/Q934475","display_name":"Intrinsically photosensitive retinal ganglion cells","level":4,"score":0.4165947437286377},{"id":"https://openalex.org/C2777624874","wikidata":"https://www.wikidata.org/wiki/Q927337","display_name":"Retinal ganglion cell","level":3,"score":0.2875937223434448},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.18037691712379456},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009475","descriptor_name":"Neurons, Afferent","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009475","descriptor_name":"Neurons, Afferent","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009475","descriptor_name":"Neurons, Afferent","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025042","descriptor_name":"Amacrine Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D025042","descriptor_name":"Amacrine Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D025042","descriptor_name":"Amacrine Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D057488","descriptor_name":"Visual Prosthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057488","descriptor_name":"Visual Prosthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057488","descriptor_name":"Visual Prosthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/iembs.2011.6090245","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.2011.6090245","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:22254494","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22254494","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5400000214576721,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W167412706","https://openalex.org/W1127525477","https://openalex.org/W1619467612","https://openalex.org/W1865596632","https://openalex.org/W1967165001","https://openalex.org/W1973759950","https://openalex.org/W1979353221","https://openalex.org/W1990779469","https://openalex.org/W2040794896","https://openalex.org/W2051923857","https://openalex.org/W2058989589","https://openalex.org/W2063640158","https://openalex.org/W2102165670","https://openalex.org/W2135120979","https://openalex.org/W2136322758","https://openalex.org/W2147498251","https://openalex.org/W2159659012","https://openalex.org/W6627261209"],"related_works":["https://openalex.org/W1983632939","https://openalex.org/W1976393632","https://openalex.org/W3208576149","https://openalex.org/W4377023576","https://openalex.org/W2111530177","https://openalex.org/W4200286249","https://openalex.org/W2011931446","https://openalex.org/W2126794440","https://openalex.org/W4282028652","https://openalex.org/W1484981637"],"abstract_inverted_index":{"Recent":[0],"advances":[1],"in":[2,60,93,123,131],"the":[3,22,25,34,37,53,55,69,76,79,94,105,116,124,132,138,142,153,168,179,185,199],"design":[4],"and":[5],"development":[6],"of":[7,30,36,48,71,78,96,141,165,175,195],"retinal":[8,38,64],"implants":[9],"have":[10,32,87],"made":[11],"these":[12,85,196],"devices":[13],"a":[14,28,46,110,173],"promising":[15],"therapeutic":[16],"strategy":[17],"for":[18,161],"restoring":[19],"sight":[20],"to":[21,42,52,121,152,163],"blind.":[23],"Over":[24],"last":[26],"decade":[27],"plethora":[29],"studies":[31],"investigated":[33,137],"responses":[35,77,140,181],"ganglion":[39],"cells":[40,57,81,86,108,150,197],"(RGCs)":[41],"electrical":[43,200],"stimulation":[44],"under":[45],"variety":[47],"stimulus":[49,176],"configurations.":[50],"Similar":[51],"RGCs,":[54],"amacrine":[56,80,107,113],"also":[58],"survive":[59],"large":[61],"numbers":[62],"following":[63,144],"neural":[65],"degeneration.":[66],"However,":[67],"with":[68,155,167],"exception":[70],"two":[72],"previous":[73],"reports,":[74],"where":[75],"were":[82],"measured":[83],"indirectly,":[84],"thus":[88],"far":[89],"received":[90],"little":[91],"attention":[92],"context":[95],"prosthetic":[97],"stimulation.":[98,148],"In":[99],"this":[100],"study":[101],"we":[102,136],"focused":[103],"on":[104],"starburst":[106],"(SACs),":[109],"particularly":[111],"well-characterized":[112],"cell":[114],"among":[115],"approximately":[117],"two-dozen":[118],"types":[119],"known":[120],"exist":[122],"retina.":[125],"Using":[126],"whole-cell":[127],"patch":[128],"clamp":[129],"recordings":[130],"whole-mount":[133],"rabbit":[134],"retina,":[135],"temporal":[139],"SACs":[143],"subretinal":[145],"biphasic":[146],"pulse":[147],"These":[149],"responded":[151],"stimuli":[154],"oscillatory":[156],"membrane":[157],"potentials":[158],"that":[159],"lasted":[160],"tens":[162],"hundreds":[164],"milliseconds,":[166],"response":[169],"amplitude":[170],"increasing":[171],"as":[172],"function":[174],"strength.":[177],"Furthermore,":[178],"SAC":[180],"originated":[182],"primarily":[183],"from":[184],"presynaptic":[186],"inputs":[187],"they":[188],"receive,":[189],"rather":[190],"than":[191],"through":[192],"direct":[193],"activation":[194],"by":[198],"stimuli.":[201]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}