{"id":"https://openalex.org/W2027606895","doi":"https://doi.org/10.1109/iembs.2011.6090207","title":"Estimating parameters in genetic regulatory networks with SUM logic","display_name":"Estimating parameters in genetic regulatory networks with SUM logic","publication_year":2011,"publication_date":"2011-08-01","ids":{"openalex":"https://openalex.org/W2027606895","doi":"https://doi.org/10.1109/iembs.2011.6090207","mag":"2027606895","pmid":"https://pubmed.ncbi.nlm.nih.gov/22254572"},"language":"en","primary_location":{"id":"doi:10.1109/iembs.2011.6090207","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.2011.6090207","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100518718","display_name":"Li\u2010Ping Tian","orcid":null},"institutions":[{"id":"https://openalex.org/I176432857","display_name":"Beijing Wuzi University","ror":"https://ror.org/00bd1d647","country_code":"CN","type":"education","lineage":["https://openalex.org/I176432857"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li-Ping Tian","raw_affiliation_strings":["School of Information, Beijing Wuzi University, Beijing, PR China. bmitian@163.com","School of Information, Beijing Wuzi University, Beijing, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information, Beijing Wuzi University, Beijing, PR China. bmitian@163.com","institution_ids":["https://openalex.org/I176432857"]},{"raw_affiliation_string":"School of Information, Beijing Wuzi University, Beijing, P.R. China","institution_ids":["https://openalex.org/I176432857"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100746337","display_name":"Lizhi Liu","orcid":"https://orcid.org/0000-0002-4612-512X"},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Lizhi Liu","raw_affiliation_strings":["Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, SAS, Canada","Department of Mechanical Engineering and in the University of Saskatchewan, Saskatoon, SK S7N 5A9, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, SAS, Canada","institution_ids":["https://openalex.org/I32625721"]},{"raw_affiliation_string":"Department of Mechanical Engineering and in the University of Saskatchewan, Saskatoon, SK S7N 5A9, Canada","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091157395","display_name":"Fang\u2010Xiang Wu","orcid":"https://orcid.org/0000-0002-4593-9332"},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Fang-Xiang Wu","raw_affiliation_strings":["Department of Mechanical Engineering and Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SAS, Canada","Department of Mechanical Engineering and Division of Biomedical Engineering in the University of Saskatchewan, Saskatoon, SK S7N 5A9, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering and Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SAS, Canada","institution_ids":["https://openalex.org/I32625721"]},{"raw_affiliation_string":"Department of Mechanical Engineering and Division of Biomedical Engineering in the University of Saskatchewan, Saskatoon, SK S7N 5A9, Canada","institution_ids":["https://openalex.org/I32625721"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9941,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.77486206,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"403","issue":null,"first_page":"1371","last_page":"1374"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.991100013256073,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9879999756813049,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.6884852051734924},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.6298015117645264},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6041489839553833},{"id":"https://openalex.org/keywords/genetic-network","display_name":"Genetic network","score":0.5910238027572632},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.5730279684066772},{"id":"https://openalex.org/keywords/genetic-algorithm","display_name":"Genetic algorithm","score":0.5128533840179443},{"id":"https://openalex.org/keywords/stability","display_name":"Stability (learning theory)","score":0.4913443624973297},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.4383791983127594},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.32797005772590637},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.26974034309387207},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.24389716982841492},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.23578444123268127},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.17473652958869934},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.1629050076007843},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.16042625904083252}],"concepts":[{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.6884852051734924},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.6298015117645264},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6041489839553833},{"id":"https://openalex.org/C2986044853","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Genetic network","level":3,"score":0.5910238027572632},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.5730279684066772},{"id":"https://openalex.org/C8880873","wikidata":"https://www.wikidata.org/wiki/Q187787","display_name":"Genetic algorithm","level":2,"score":0.5128533840179443},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.4913443624973297},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4383791983127594},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.32797005772590637},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.26974034309387207},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.24389716982841492},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23578444123268127},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17473652958869934},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.1629050076007843},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16042625904083252},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/iembs.2011.6090207","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.2011.6090207","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:22254572","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22254572","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1481919380","https://openalex.org/W1604790719","https://openalex.org/W1645305843","https://openalex.org/W1990853262","https://openalex.org/W1993904195","https://openalex.org/W2004608252","https://openalex.org/W2008107402","https://openalex.org/W2046871615","https://openalex.org/W2053126761","https://openalex.org/W2067203347","https://openalex.org/W2069986908","https://openalex.org/W2074006029","https://openalex.org/W2081999679","https://openalex.org/W2082982706","https://openalex.org/W2085811977","https://openalex.org/W2096159618","https://openalex.org/W2104123948","https://openalex.org/W2120510384","https://openalex.org/W2125210796","https://openalex.org/W2125631472","https://openalex.org/W2134759932","https://openalex.org/W2140497888","https://openalex.org/W2145033008","https://openalex.org/W2145644212","https://openalex.org/W2611370172","https://openalex.org/W4213007956","https://openalex.org/W6628887588","https://openalex.org/W6671346601","https://openalex.org/W6674521087"],"related_works":["https://openalex.org/W2950199998","https://openalex.org/W2761509462","https://openalex.org/W2560421304","https://openalex.org/W2016470694","https://openalex.org/W1973932849","https://openalex.org/W2951387065","https://openalex.org/W4385727351","https://openalex.org/W4306798985","https://openalex.org/W2937980818","https://openalex.org/W1530164014"],"abstract_inverted_index":{"Many":[0],"methods":[1],"for":[2,81,102],"inferring":[3],"genetic":[4,22,33,45,63,85,96,151],"regulatory":[5,23,34,46,64,86,90,97,100,152],"networks":[6,12,47,65,87,153],"have":[7],"been":[8,49,70],"proposed.":[9],"However":[10],"inferred":[11],"can":[13,146],"hardly":[14],"be":[15],"used":[16,133],"to":[17,31],"analyze":[18],"the":[19,42,124,127,143],"dynamics":[20],"of":[21,40,44,53,62,95,109],"networks.":[24,35],"Recently":[25],"nonlinear":[26,59,67,115],"differential":[27],"equations":[28],"are":[29,114],"proposed":[30,125,144],"model":[32,68],"Based":[36],"on":[37],"this":[38,75,93],"kind":[39,94],"model,":[41,60],"stability":[43],"has":[48,69],"intensively":[50],"investigated.":[51],"Because":[52],"difficulty":[54],"in":[55,58,84,116,119,150],"estimating":[56,82],"parameters":[57,83,117,149],"inference":[61],"with":[66,88,154],"paid":[71],"little":[72],"attention.":[73],"In":[74,92],"paper,":[76],"we":[77],"present":[78],"a":[79,99,106],"method":[80,145],"SUM":[89,155],"logic.":[91,156],"networks,":[98],"function":[101],"each":[103],"gene":[104,128],"is":[105,132],"linear":[107],"combination":[108],"Hill":[110],"form":[111],"functions,":[112],"which":[113],"and":[118],"system":[120],"states.":[121],"To":[122],"investigate":[123],"method,":[126],"toggle":[129],"switch":[130],"network":[131],"as":[134],"an":[135],"illustrative":[136],"example.":[137],"The":[138],"simulation":[139],"results":[140],"show":[141],"that":[142],"accurately":[147],"estimates":[148]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}