{"id":"https://openalex.org/W2047765047","doi":"https://doi.org/10.1109/iembs.2011.6089925","title":"Endothelial cell culture model of carotid artery atherosclerosis","display_name":"Endothelial cell culture model of carotid artery atherosclerosis","publication_year":2011,"publication_date":"2011-08-01","ids":{"openalex":"https://openalex.org/W2047765047","doi":"https://doi.org/10.1109/iembs.2011.6089925","mag":"2047765047","pmid":"https://pubmed.ncbi.nlm.nih.gov/22254281"},"language":"en","primary_location":{"id":"doi:10.1109/iembs.2011.6089925","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.2011.6089925","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035554590","display_name":"Rosendo Estrada","orcid":null},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rosendo Estrada","raw_affiliation_strings":["Department of Bioengineering, Speed School of Engineering, University of Louisville, Louisville, KY, USA. r0estr01@louisville.edu","Department of Bioengineering, Speed School of Engineering, University of Louisville, Louisville, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Speed School of Engineering, University of Louisville, Louisville, KY, USA. r0estr01@louisville.edu","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Department of Bioengineering, Speed School of Engineering, University of Louisville, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069633988","display_name":"Guruprasad A. Giridharan","orcid":"https://orcid.org/0000-0003-3263-9354"},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guruprasad Giridharan","raw_affiliation_strings":["Department of Bioengineering, Speed School of Engineering, University of Louisville, Louisville, KY, USA","Department of Bioengineering, Speed School of Engineering, University of Louisville, Louisville, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Speed School of Engineering, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Department of Bioengineering, Speed School of Engineering, University of Louisville, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013428111","display_name":"Sumanth D. Prabhu","orcid":"https://orcid.org/0000-0002-7247-7241"},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sumanth D. Prabhu","raw_affiliation_strings":["Institute of Molecular Cardiology, Department of Medicine, Louisville VAMC, University of Louisville, Louisville, KY, USA","Institute of Molecular Cardiology, Department of Medicine, University of Louisville, and Louisville VAMC, Louisville, KY 40202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Cardiology, Department of Medicine, Louisville VAMC, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Institute of Molecular Cardiology, Department of Medicine, University of Louisville, and Louisville VAMC, Louisville, KY 40202","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056107094","display_name":"Palaniappan Sethu","orcid":"https://orcid.org/0000-0002-5794-2037"},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Palaniappan Sethu","raw_affiliation_strings":["Department of Bioengineering, Speed School of Engineering, University of Louisville, Louisville, KY, USA","Department of Bioengineering, Speed School of Engineering, University of Louisville, Louisville, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Speed School of Engineering, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Department of Bioengineering, Speed School of Engineering, University of Louisville, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4985,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.64446295,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"262","issue":null,"first_page":"186","last_page":"189"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9901000261306763,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carotid-arteries","display_name":"Carotid arteries","score":0.5242776274681091},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.488443523645401},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.41980379819869995},{"id":"https://openalex.org/keywords/endothelial-stem-cell","display_name":"Endothelial stem cell","score":0.4161669611930847},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3615829348564148},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15288370847702026}],"concepts":[{"id":"https://openalex.org/C2987047532","wikidata":"https://www.wikidata.org/wiki/Q214275","display_name":"Carotid arteries","level":2,"score":0.5242776274681091},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.488443523645401},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41980379819869995},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.4161669611930847},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3615829348564148},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15288370847702026},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002340","descriptor_name":"Carotid Artery Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002340","descriptor_name":"Carotid Artery Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002340","descriptor_name":"Carotid Artery Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D033081","descriptor_name":"Shear Strength","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D033081","descriptor_name":"Shear Strength","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D033081","descriptor_name":"Shear Strength","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/iembs.2011.6089925","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.2011.6089925","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:22254281","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22254281","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1949173079","https://openalex.org/W1971716003","https://openalex.org/W1974747480","https://openalex.org/W1983515748","https://openalex.org/W1990011355","https://openalex.org/W2002154995","https://openalex.org/W2014171174","https://openalex.org/W2014762435","https://openalex.org/W2061409920","https://openalex.org/W2063665585","https://openalex.org/W2069568986","https://openalex.org/W2081563225","https://openalex.org/W2108230556","https://openalex.org/W2111187630","https://openalex.org/W2114308816","https://openalex.org/W2121700889","https://openalex.org/W2158201763","https://openalex.org/W2171686436","https://openalex.org/W2318363094","https://openalex.org/W2409629223","https://openalex.org/W6714677428"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W3183948672","https://openalex.org/W3173606202","https://openalex.org/W3110381201","https://openalex.org/W2948807893","https://openalex.org/W2935909890","https://openalex.org/W2778153218","https://openalex.org/W2758277628","https://openalex.org/W2748952813","https://openalex.org/W1531601525"],"abstract_inverted_index":{"Atherosclerotic":[0],"lesions":[1],"form":[2,47],"non-randomly":[3],"at":[4],"locations":[5],"in":[6,33,45,86,133,173,189,193,198],"bends":[7],"and":[8,20,53,59,68,80,100,123,138,175,184,192],"bifurcations":[9],"where":[10],"the":[11,46,66,72,75,153,194],"local":[12,76],"flow":[13,78,131,140],"can":[14],"be":[15],"classified":[16],"as":[17],"'disturbed":[18],"flow'":[19],"is":[21,158],"associated":[22,127,151],"with":[23,128,152],"low":[24],"shear":[25,54,81,94,124,185],"stress":[26,55,82,95,125,186],"oscillatory":[27],"or":[28],"reciprocating":[29],"flow.":[30],"Endothelial":[31,111],"cells":[32],"vivo":[34],"are":[35,83],"constantly":[36],"exposed":[37],"to":[38,42,56,116],"mechanical":[39,149],"stimulation":[40],"due":[41],"hemodynamic":[43],"loading":[44,70,187],"of":[48,89,120,136],"pulsatile":[49],"pressure,":[50,121,182],"cyclic":[51],"stretch":[52,183],"maintain":[57],"phenotype":[58],"control":[60],"function.":[61],"In":[62,178],"conditions":[63,169],"like":[64],"atherosclerosis,":[65],"pressure":[67,99],"strain":[69,101,122],"remains":[71],"same":[73],"whereas":[74],"fluid":[77],"behavior":[79],"altered.":[84],"Common":[85],"vitro":[87],"models":[88],"atherosclerosis":[90,142],"focus":[91],"primarily":[92],"on":[93],"without":[96],"accounting":[97],"for":[98,163],"loading.":[102],"To":[103],"overcome":[104],"this":[105],"limitation,":[106],"we":[107,180],"used":[108],"our":[109],"microfluidic":[110],"Cell":[112],"Culture":[113],"Model":[114],"(ECCM)":[115],"achieve":[117],"accurate":[118],"replication":[119],"waveforms":[126],"both":[129,168],"normal":[130],"seen":[132,141,188],"straight":[134,190],"sections":[135,191],"arteries":[137],"disturbed":[139],"lesion":[143],"susceptible":[144],"regions.":[145],"We":[146],"specifically":[147],"recreated":[148,181],"stresses":[150],"proximal":[154,195],"internal":[155,196],"carotid":[156,197],"which":[157],"a":[159,199],"major":[160],"risk":[161],"factor":[162],"stroke.":[164],"Cells":[165],"cultured":[166],"using":[167],"show":[170],"distinct":[171],"differences":[172],"alignment":[174],"cytoskeletal":[176],"organization.":[177],"summary":[179],"cell":[200],"culture":[201],"compatible":[202],"platform.":[203]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}