{"id":"https://openalex.org/W2059143453","doi":"https://doi.org/10.1109/iembs.2011.6089923","title":"Mechanical forces mediate localized topological change in epithelia","display_name":"Mechanical forces mediate localized topological change in epithelia","publication_year":2011,"publication_date":"2011-08-01","ids":{"openalex":"https://openalex.org/W2059143453","doi":"https://doi.org/10.1109/iembs.2011.6089923","mag":"2059143453","pmid":"https://pubmed.ncbi.nlm.nih.gov/22254279"},"language":"en","primary_location":{"id":"doi:10.1109/iembs.2011.6089923","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.2011.6089923","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101738988","display_name":"Yingzi Li","orcid":"https://orcid.org/0000-0001-7507-9751"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yingzi Li","raw_affiliation_strings":["Department of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China. yingzili@sjtu.edu.cn","Bioinformatics Program, Department of Bioengineering, University of Illinois, Chicago, Chicago, IL, USA","Department of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China. yingzili@sjtu.edu.cn","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Bioinformatics Program, Department of Bioengineering, University of Illinois, Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074736458","display_name":"Hammad Naveed","orcid":"https://orcid.org/0000-0002-1867-974X"},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hammad Naveed","raw_affiliation_strings":["Bioinformatics Program, Department of Bioengineering, University of Illinois, Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Program, Department of Bioengineering, University of Illinois, Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020089442","display_name":"S\u00ebma Kachalo","orcid":null},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sema Kachalo","raw_affiliation_strings":["Bioinformatics Program, Department of Bioengineering, University of Illinois, Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Program, Department of Bioengineering, University of Illinois, Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043622943","display_name":"Lisa X. Xu","orcid":"https://orcid.org/0000-0003-2873-3225"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lisa X. Xu","raw_affiliation_strings":["Department of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091558783","display_name":"Jie Liang","orcid":"https://orcid.org/0000-0002-2773-6427"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Jie Liang","raw_affiliation_strings":["Bioinformatics Program, Department of Bioengineering, University of Illinois, Chicago, Chicago, IL, USA","Shanghai Center of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Program, Department of Bioengineering, University of Illinois, Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Shanghai Center of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4111,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.60711968,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"2011","issue":null,"first_page":"178","last_page":"181"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.991599977016449,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/morphogenesis","display_name":"Morphogenesis","score":0.8126686811447144},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.6129845380783081},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.6111385822296143},{"id":"https://openalex.org/keywords/organogenesis","display_name":"Organogenesis","score":0.6079209446907043},{"id":"https://openalex.org/keywords/cell-growth","display_name":"Cell growth","score":0.5806386470794678},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.4477449059486389},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.41532444953918457},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1775738000869751},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.11215612292289734},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.086428701877594}],"concepts":[{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.8126686811447144},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6129845380783081},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.6111385822296143},{"id":"https://openalex.org/C30503417","wikidata":"https://www.wikidata.org/wiki/Q958938","display_name":"Organogenesis","level":3,"score":0.6079209446907043},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5806386470794678},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4477449059486389},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41532444953918457},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1775738000869751},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11215612292289734},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.086428701877594},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D048429","descriptor_name":"Cell Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048429","descriptor_name":"Cell Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048429","descriptor_name":"Cell Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049108","descriptor_name":"Cell Enlargement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049108","descriptor_name":"Cell Enlargement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049108","descriptor_name":"Cell Enlargement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/iembs.2011.6089923","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.2011.6089923","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:22254279","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22254279","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:europepmc.org:2716314","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3725274","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1018576370","display_name":null,"funder_award_id":"P50 GM086145","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1338833578","display_name":null,"funder_award_id":"R01 GM081682","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4863215970","display_name":null,"funder_award_id":"GM079804","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5184057102","display_name":null,"funder_award_id":"GM081682","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6738109223","display_name":null,"funder_award_id":"GM086145","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8009226502","display_name":null,"funder_award_id":"R01 GM079804","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320322799","display_name":"Higher Education Commission, Pakistan","ror":"https://ror.org/038y3sz68"},{"id":"https://openalex.org/F4320326275","display_name":"Higher Education Commision, Pakistan","ror":null},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1494873915","https://openalex.org/W1967744164","https://openalex.org/W1981477992","https://openalex.org/W2009687000","https://openalex.org/W2010567868","https://openalex.org/W2033266597","https://openalex.org/W2040248640","https://openalex.org/W2061220010","https://openalex.org/W2124586890","https://openalex.org/W4230406461"],"related_works":["https://openalex.org/W2060384681","https://openalex.org/W2301079679","https://openalex.org/W2143665979","https://openalex.org/W2083693850","https://openalex.org/W2361888356","https://openalex.org/W2320661246","https://openalex.org/W2354502831","https://openalex.org/W2351474733","https://openalex.org/W2382119638","https://openalex.org/W1981686547"],"abstract_inverted_index":{"Regulation":[0],"of":[1,19,22,24,30,37,46,82,120,142],"cell":[2,94,143,176],"growth":[3],"and":[4,14,90,96,99,178],"proliferation":[5,89,112,162],"has":[6],"a":[7,27,35,76],"fundamental":[8],"role":[9],"in":[10,34,131,157],"tissue":[11,97,179],"development,":[12],"organogenesis,":[13],"disease":[15],"progression.":[16],"Conserved":[17],"distribution":[18],"the":[20,60,118,129,139,167,174],"number":[21,141],"sides":[23,55],"cells":[25,48,52],"with":[26,80,149],"mean":[28],"value":[29],"six":[31],"was":[32],"found":[33],"variety":[36],"proliferating":[38,47,122],"epithelia.":[39,58],"Previous":[40],"studies":[41],"have":[42,53],"shown":[43],"that":[44,110,154],"clones":[45],"bounded":[49],"by":[50],"quiescent":[51],"fewer":[54],"than":[56],"normal":[57],"However,":[59],"mechanisms":[61],"for":[62],"mediating":[63],"such":[64],"localized":[65,160],"topological":[66,106,169],"change":[67,170],"remain":[68],"poorly":[69],"understood.":[70],"In":[71],"this":[72],"study,":[73],"we":[74],"use":[75],"two-dimensional":[77],"vertex":[78],"model":[79],"consideration":[81],"mechanical":[83,155],"forces":[84,91,156],"to":[85,104,116,133,159,165],"investigate":[86],"how":[87,100],"differential":[88,111,134,161],"can":[92,136],"influence":[93],"shape":[95,177],"morphogenesis,":[98],"they":[101],"may":[102],"lead":[103],"distorted":[105,168],"change.":[107],"We":[108,152],"find":[109],"alone":[113],"is":[114],"insufficient":[115],"affect":[117],"topology":[119],"boundary":[121],"cells.":[123],"Rather,":[124],"increased":[125],"surface":[126],"tension":[127],"on":[128],"boundary,":[130],"addition":[132,158],"proliferation,":[135],"significantly":[137,172],"decrease":[138],"average":[140],"sides.":[144],"Our":[145],"results":[146],"are":[147,163],"consistent":[148],"experimental":[150],"observations.":[151],"conclude":[153],"required":[164],"produce":[166],"which":[171],"impacts":[173],"overall":[175],"morphogenesis.":[180]},"counts_by_year":[{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}