{"id":"https://openalex.org/W2927224158","doi":"https://doi.org/10.1109/ieeeconf51394.2020.9443372","title":"Hieroglyph: Hierarchical Glia Graph Skeletonization and Matching","display_name":"Hieroglyph: Hierarchical Glia Graph Skeletonization and Matching","publication_year":2020,"publication_date":"2020-11-01","ids":{"openalex":"https://openalex.org/W2927224158","doi":"https://doi.org/10.1109/ieeeconf51394.2020.9443372","mag":"2927224158"},"language":"en","primary_location":{"id":"doi:10.1109/ieeeconf51394.2020.9443372","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ieeeconf51394.2020.9443372","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 54th Asilomar Conference on Signals, Systems, and Computers","raw_type":"proceedings-article"},"type":"preprint","indexed_in":["arxiv","crossref","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/1903.12210","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016699319","display_name":"Tiffany Ly","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tiffany T. Ly","raw_affiliation_strings":["Department of Electrical & Computer Engineering, C.L. Brown","C.L. Brown,Department of Electrical & Computer Engineering"],"affiliations":[{"raw_affiliation_string":"Department of Electrical & Computer Engineering, C.L. Brown","institution_ids":[]},{"raw_affiliation_string":"C.L. Brown,Department of Electrical & Computer Engineering","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001406804","display_name":"Tamal Batabyal","orcid":"https://orcid.org/0000-0001-6809-4144"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tamal Batabyal","raw_affiliation_strings":["Department of Electrical & Computer Engineering, C.L. Brown","C.L. Brown,Department of Electrical & Computer Engineering"],"affiliations":[{"raw_affiliation_string":"Department of Electrical & Computer Engineering, C.L. Brown","institution_ids":[]},{"raw_affiliation_string":"C.L. Brown,Department of Electrical & Computer Engineering","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012917190","display_name":"Jeremy Thompson","orcid":"https://orcid.org/0000-0001-9937-1888"},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy Thompson","raw_affiliation_strings":["Department of Neuroscience, Center for Brain Immunology and Glia, University of Virginia Charlottesville, Virginia, USA","University of Virginia Charlottesville,Center for Brain Immunology and Glia,Department of Neuroscience,Virginia,USA"],"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Center for Brain Immunology and Glia, University of Virginia Charlottesville, Virginia, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"University of Virginia Charlottesville,Center for Brain Immunology and Glia,Department of Neuroscience,Virginia,USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002993465","display_name":"Tajie H. Harris","orcid":"https://orcid.org/0000-0002-1355-2109"},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tajie Harris","raw_affiliation_strings":["Department of Neuroscience, Center for Brain Immunology and Glia, University of Virginia Charlottesville, Virginia, USA","University of Virginia Charlottesville,Center for Brain Immunology and Glia,Department of Neuroscience,Virginia,USA"],"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Center for Brain Immunology and Glia, University of Virginia Charlottesville, Virginia, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"University of Virginia Charlottesville,Center for Brain Immunology and Glia,Department of Neuroscience,Virginia,USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006764308","display_name":"Daniel S. Weller","orcid":"https://orcid.org/0000-0001-9818-7325"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel S. Weller","raw_affiliation_strings":["Department of Electrical & Computer Engineering, C.L. Brown","C.L. Brown,Department of Electrical & Computer Engineering"],"affiliations":[{"raw_affiliation_string":"Department of Electrical & Computer Engineering, C.L. Brown","institution_ids":[]},{"raw_affiliation_string":"C.L. Brown,Department of Electrical & Computer Engineering","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034452294","display_name":"Scott T. Acton","orcid":"https://orcid.org/0000-0003-3288-1255"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott T. Acton","raw_affiliation_strings":["Department of Electrical & Computer Engineering, C.L. Brown","C.L. Brown,Department of Electrical & Computer Engineering"],"affiliations":[{"raw_affiliation_string":"Department of Electrical & Computer Engineering, C.L. Brown","institution_ids":[]},{"raw_affiliation_string":"C.L. Brown,Department of Electrical & Computer Engineering","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5016699319"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0934,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.4521703,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"421","issue":null,"first_page":"251","last_page":"255"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9900000095367432,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9894999861717224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microglia","display_name":"Microglia","score":0.7665234804153442},{"id":"https://openalex.org/keywords/skeletonization","display_name":"Skeletonization","score":0.7581925392150879},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6343298554420471},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5285153388977051},{"id":"https://openalex.org/keywords/tracing","display_name":"Tracing","score":0.5204196572303772},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.48685210943222046},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.47809740900993347},{"id":"https://openalex.org/keywords/matching","display_name":"Matching (statistics)","score":0.4518470764160156},{"id":"https://openalex.org/keywords/skeleton","display_name":"Skeleton (computer programming)","score":0.44167396426200867},{"id":"https://openalex.org/keywords/3d-reconstruction","display_name":"3D reconstruction","score":0.41011175513267517},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.37954390048980713},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.3473704159259796},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2814370393753052},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.15701285004615784},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1264166235923767},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.09124216437339783}],"concepts":[{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.7665234804153442},{"id":"https://openalex.org/C23951316","wikidata":"https://www.wikidata.org/wiki/Q1984140","display_name":"Skeletonization","level":2,"score":0.7581925392150879},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6343298554420471},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5285153388977051},{"id":"https://openalex.org/C138673069","wikidata":"https://www.wikidata.org/wiki/Q322229","display_name":"Tracing","level":2,"score":0.5204196572303772},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.48685210943222046},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.47809740900993347},{"id":"https://openalex.org/C165064840","wikidata":"https://www.wikidata.org/wiki/Q1321061","display_name":"Matching (statistics)","level":2,"score":0.4518470764160156},{"id":"https://openalex.org/C18969341","wikidata":"https://www.wikidata.org/wiki/Q1169129","display_name":"Skeleton (computer programming)","level":2,"score":0.44167396426200867},{"id":"https://openalex.org/C109950114","wikidata":"https://www.wikidata.org/wiki/Q4464732","display_name":"3D reconstruction","level":2,"score":0.41011175513267517},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.37954390048980713},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.3473704159259796},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2814370393753052},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15701285004615784},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1264166235923767},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.09124216437339783},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1109/ieeeconf51394.2020.9443372","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ieeeconf51394.2020.9443372","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 54th Asilomar Conference on Signals, Systems, and Computers","raw_type":"proceedings-article"},{"id":"pmh:oai:arXiv.org:1903.12210","is_oa":true,"landing_page_url":"http://arxiv.org/abs/1903.12210","pdf_url":"https://arxiv.org/pdf/1903.12210","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"mag:2927224158","is_oa":true,"landing_page_url":"https://arxiv.org/pdf/1903.12210","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"arXiv (Cornell University)","raw_type":null},{"id":"doi:10.48550/arxiv.1903.12210","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.1903.12210","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:1903.12210","is_oa":true,"landing_page_url":"http://arxiv.org/abs/1903.12210","pdf_url":"https://arxiv.org/pdf/1903.12210","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2927224158.pdf","grobid_xml":"https://content.openalex.org/works/W2927224158.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1964041350","https://openalex.org/W1983383587","https://openalex.org/W1994909588","https://openalex.org/W2048733914","https://openalex.org/W2061628168","https://openalex.org/W2066943555","https://openalex.org/W2094660330","https://openalex.org/W2094831055","https://openalex.org/W2096320880","https://openalex.org/W2104135721","https://openalex.org/W2104827963","https://openalex.org/W2122828560","https://openalex.org/W2125281412","https://openalex.org/W2151003930","https://openalex.org/W2153406260","https://openalex.org/W2153965609","https://openalex.org/W2169528473","https://openalex.org/W2527645962","https://openalex.org/W2590925679","https://openalex.org/W2778796229","https://openalex.org/W2797384836","https://openalex.org/W2806300791","https://openalex.org/W2963223931","https://openalex.org/W3098652539","https://openalex.org/W6679367408","https://openalex.org/W6807802501"],"related_works":["https://openalex.org/W2949475904","https://openalex.org/W2945956161","https://openalex.org/W2766931013","https://openalex.org/W2061628168","https://openalex.org/W2951894589","https://openalex.org/W2870567125","https://openalex.org/W2950922002","https://openalex.org/W2942187625","https://openalex.org/W2968844558","https://openalex.org/W2977008057","https://openalex.org/W3102110817","https://openalex.org/W2092859932","https://openalex.org/W2526279161","https://openalex.org/W2594357166","https://openalex.org/W3035659966","https://openalex.org/W1483454499","https://openalex.org/W1966930384","https://openalex.org/W2093230218","https://openalex.org/W2112740595","https://openalex.org/W2139833624"],"abstract_inverted_index":{"Automatic":[0],"3D":[1,66,74,108,119],"reconstruction":[2,28,68,91,123],"of":[3,15,36,45,86,97,103,107,110,124,130],"glia":[4,26,71,125],"morphology":[5,50],"is":[6],"a":[7,62,79,118,128],"powerful":[8],"tool":[9],"necessary":[10],"for":[11,42,70,127],"investigating":[12],"the":[13,21,37,43,46,52,87,95,98],"role":[14],"microglia":[16,47],"in":[17,20,51,100,137],"neurological":[18],"disorders":[19],"central":[22],"nervous":[23],"system.":[24],"Current":[25],"skeleton":[27,67,90],"techniques":[29],"fail":[30],"to":[31,84],"capture":[32],"an":[33],"accurate":[34],"tracing":[35],"processes":[38],"over":[39],"time,":[40],"useful":[41,126],"study":[44],"motility":[48],"and":[49,56,93,121,140],"brain":[53,138],"during":[54],"healthy":[55],"diseased":[57],"states.":[58],"We":[59],"propose":[60],"Hieroglyph,":[61],"fully":[63],"automatic":[64,89],"temporal":[65],"algorithm":[69],"imaged":[72],"via":[73],"multiphoton":[75],"microscopy.":[76],"Hieroglyph":[77],"yielded":[78],"21%":[80],"performance":[81],"increase":[82],"compared":[83],"state":[85,96],"art":[88,99],"methods":[92],"outperforms":[94],"different":[101],"measures":[102],"consistency":[104],"on":[105],"datasets":[106],"images":[109],"microglia.":[111],"The":[112],"results":[113],"from":[114],"this":[115],"method":[116],"provide":[117],"graph":[120],"digital":[122],"myriad":[129],"morphological":[131],"analyses":[132],"that":[133],"could":[134],"impact":[135],"studies":[136],"immunology":[139],"disease.":[141]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-04-09T08:11:56.329763","created_date":"2025-10-10T00:00:00"}