{"id":"https://openalex.org/W2908173566","doi":"https://doi.org/10.1109/iecon.2018.8591092","title":"Controllability Analysis of Transcriptional Regulatory Networks for Saccharomyces Cerevisiae","display_name":"Controllability Analysis of Transcriptional Regulatory Networks for Saccharomyces Cerevisiae","publication_year":2018,"publication_date":"2018-10-01","ids":{"openalex":"https://openalex.org/W2908173566","doi":"https://doi.org/10.1109/iecon.2018.8591092","mag":"2908173566"},"language":"en","primary_location":{"id":"doi:10.1109/iecon.2018.8591092","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iecon.2018.8591092","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IECON 2018 - 44th Annual Conference of the IEEE Industrial Electronics Society","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082254990","display_name":"Suling Liu","orcid":"https://orcid.org/0000-0002-0475-0242"},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Suling Liu","raw_affiliation_strings":["School of Mathematics and Statistics, Henan University, Kaifeng, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mathematics and Statistics, Henan University, Kaifeng, China","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008425079","display_name":"Qiong Xu","orcid":"https://orcid.org/0000-0002-0575-1263"},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiong Xu","raw_affiliation_strings":["School of Mathematics and Statistics, Henan University, Kaifeng, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mathematics and Statistics, Henan University, Kaifeng, China","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100626541","display_name":"Aimin Chen","orcid":"https://orcid.org/0000-0003-3375-4426"},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Aimin Chen","raw_affiliation_strings":["School of Mathematics and Statistics, Institute of Applied Mathematics Henan University, Kaifeng, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mathematics and Statistics, Institute of Applied Mathematics Henan University, Kaifeng, China","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100462649","display_name":"Pei Wang","orcid":"https://orcid.org/0000-0002-8149-756X"},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pei Wang","raw_affiliation_strings":["School of Mathematics and Statistics, Institute of Applied Mathematics Henan University, Kaifeng, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mathematics and Statistics, Institute of Applied Mathematics Henan University, Kaifeng, China","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027725400","display_name":"Jinhu L\u00fc","orcid":"https://orcid.org/0000-0003-0275-8387"},"institutions":[{"id":"https://openalex.org/I82880672","display_name":"Beihang University","ror":"https://ror.org/00wk2mp56","country_code":"CN","type":"education","lineage":["https://openalex.org/I82880672"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinhu Lu","raw_affiliation_strings":["School of Automation Science and Electrical Engineering, Beihang University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Automation Science and Electrical Engineering, Beihang University, Beijing, China","institution_ids":["https://openalex.org/I82880672"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12988373,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"278","issue":null,"first_page":"6172","last_page":"6177"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9921000003814697,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/controllability","display_name":"Controllability","score":0.98175048828125},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.6919339895248413},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.5573872327804565},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5250687003135681},{"id":"https://openalex.org/keywords/complex-network","display_name":"Complex network","score":0.5026049613952637},{"id":"https://openalex.org/keywords/network-controllability","display_name":"Network controllability","score":0.46623843908309937},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.31300827860832214},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.28910017013549805},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2097162902355194},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12377089262008667},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10703682899475098},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.07799094915390015}],"concepts":[{"id":"https://openalex.org/C48209547","wikidata":"https://www.wikidata.org/wiki/Q1331104","display_name":"Controllability","level":2,"score":0.98175048828125},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.6919339895248413},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.5573872327804565},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5250687003135681},{"id":"https://openalex.org/C34947359","wikidata":"https://www.wikidata.org/wiki/Q665189","display_name":"Complex network","level":2,"score":0.5026049613952637},{"id":"https://openalex.org/C41982775","wikidata":"https://www.wikidata.org/wiki/Q7000977","display_name":"Network controllability","level":4,"score":0.46623843908309937},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.31300827860832214},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.28910017013549805},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2097162902355194},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12377089262008667},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10703682899475098},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.07799094915390015},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C117045392","wikidata":"https://www.wikidata.org/wiki/Q4899215","display_name":"Betweenness centrality","level":3,"score":0.0},{"id":"https://openalex.org/C53811970","wikidata":"https://www.wikidata.org/wiki/Q5062194","display_name":"Centrality","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/iecon.2018.8591092","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iecon.2018.8591092","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IECON 2018 - 44th Annual Conference of the IEEE Industrial Electronics Society","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1487127700","https://openalex.org/W1572996156","https://openalex.org/W1974372969","https://openalex.org/W1982821381","https://openalex.org/W1990032525","https://openalex.org/W1994368767","https://openalex.org/W2009660640","https://openalex.org/W2018587472","https://openalex.org/W2060038721","https://openalex.org/W2063716346","https://openalex.org/W2070672503","https://openalex.org/W2078008084","https://openalex.org/W2082019892","https://openalex.org/W2099325822","https://openalex.org/W2101420429","https://openalex.org/W2104488364","https://openalex.org/W2105813236","https://openalex.org/W2124655218","https://openalex.org/W2135951244","https://openalex.org/W2136656652","https://openalex.org/W2137683543","https://openalex.org/W2142460132","https://openalex.org/W2158893758","https://openalex.org/W2159581461","https://openalex.org/W2159715570","https://openalex.org/W2162735386","https://openalex.org/W2165011536","https://openalex.org/W2180749449","https://openalex.org/W2283907552","https://openalex.org/W2293216767","https://openalex.org/W2296217093","https://openalex.org/W2575034652","https://openalex.org/W2575421008","https://openalex.org/W2587812844","https://openalex.org/W2588148443","https://openalex.org/W2591778881","https://openalex.org/W2593940606","https://openalex.org/W2606241238","https://openalex.org/W2750877131","https://openalex.org/W2757799468","https://openalex.org/W2766650025","https://openalex.org/W2795130168","https://openalex.org/W2809308729","https://openalex.org/W2964110462","https://openalex.org/W3104043334","https://openalex.org/W4240896209","https://openalex.org/W4296180618","https://openalex.org/W6643661869"],"related_works":["https://openalex.org/W2594902070","https://openalex.org/W2508095019","https://openalex.org/W1982821381","https://openalex.org/W2895969319","https://openalex.org/W2765453580","https://openalex.org/W3013256330","https://openalex.org/W2229005201","https://openalex.org/W2560597738","https://openalex.org/W1972577981","https://openalex.org/W2756083531"],"abstract_inverted_index":{"Structural":[0],"controllability":[1,19,32,65,142,166],"of":[2,20,33,67,79,88,91,144,167,185,197],"complex":[3],"networks":[4,41,54,92,155,170],"has":[5],"been":[6,49],"a":[7],"research":[8],"focus":[9],"in":[10,187],"recent":[11],"years.":[12],"However,":[13,108],"few":[14],"works":[15],"considered":[16],"the":[17,64,74,85,99,109,119,131,135,140,147,164,168,182],"structural":[18,31,86,141,165],"biological":[21,26,198],"networks,":[22,69],"especially":[23],"for":[24,43],"dynamic":[25,38,53,110],"networks.":[27,80,199],"In":[28],"this":[29],"paper,":[30],"one":[34,123],"static":[35,120],"and":[36,58,122],"five":[37,52],"transcriptional":[39],"regulatory":[40],"(TRNs)":[42],"Saccharomyces":[44],"cerevisiae":[45],"(S.":[46],"cerevisiae)":[47],"have":[48],"investigated.":[50],"The":[51],"included":[55],"two":[56],"endogenous":[57,136],"three":[59],"exogenous":[60,132],"ones.":[61,137],"We":[62,96],"clarified":[63],"properties":[66,87,184],"these":[68],"as":[70,72,150,152],"well":[71,151],"explored":[73],"differences":[75],"among":[76],"different":[77,89],"types":[78,90],"Our":[81,179],"results":[82],"revealed":[83],"that":[84,98,163],"are":[93,101],"significantly":[94],"different.":[95],"found":[97],"TRNs":[100,111,133,186],"rather":[102],"difficult":[103],"to":[104,115,129],"be":[105,116,172],"fully":[106],"controlled.":[107],"were":[112],"relatively":[113,125],"easier":[114],"controlled":[117],"than":[118,134],"one,":[121],"needs":[124],"more":[126],"external":[127],"inputs":[128],"control":[130,183,196],"Based":[138],"on":[139,194],"analysis":[143],"subnetworks":[145],"with":[146],"same":[148],"sizes,":[149],"randomly":[153],"perturbed":[154],"by":[156,175],"preserving":[157],"degree":[158,177],"distributions,":[159],"we":[160],"further":[161],"illustrated":[162],"six":[169],"may":[171],"mainly":[173],"dominated":[174],"their":[176],"distributions.":[178],"investigations":[180],"clarify":[181],"S.":[188],"cerevisiae,":[189],"it":[190],"provides":[191],"some":[192],"insights":[193],"real-world":[195]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
