{"id":"https://openalex.org/W4388562349","doi":"https://doi.org/10.1109/icstcc59206.2023.10308517","title":"Optimizing Precision in Cellular Clocks Through Self-Regulated Accumulation Of Molecules","display_name":"Optimizing Precision in Cellular Clocks Through Self-Regulated Accumulation Of Molecules","publication_year":2023,"publication_date":"2023-10-11","ids":{"openalex":"https://openalex.org/W4388562349","doi":"https://doi.org/10.1109/icstcc59206.2023.10308517"},"language":"en","primary_location":{"id":"doi:10.1109/icstcc59206.2023.10308517","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icstcc59206.2023.10308517","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 27th International Conference on System Theory, Control and Computing (ICSTCC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065187255","display_name":"Sayeh Rezaee","orcid":"https://orcid.org/0000-0003-2826-4756"},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sayeh Rezaee","raw_affiliation_strings":["University of Delaware,Department of Electrical and Computer Engineering,Newark,DE,USA","Department of Electrical and Computer Engineering, University of Delaware, Newark, DE, USA"],"affiliations":[{"raw_affiliation_string":"University of Delaware,Department of Electrical and Computer Engineering,Newark,DE,USA","institution_ids":["https://openalex.org/I86501945"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Delaware, Newark, DE, USA","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033750396","display_name":"C\u00e9sar Nieto","orcid":"https://orcid.org/0000-0001-6504-4619"},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C\u00e9sar Nieto","raw_affiliation_strings":["University of Delaware,Department of Electrical and Computer Engineering,Newark,DE,USA","Department of Electrical and Computer Engineering, University of Delaware, Newark, DE, USA"],"affiliations":[{"raw_affiliation_string":"University of Delaware,Department of Electrical and Computer Engineering,Newark,DE,USA","institution_ids":["https://openalex.org/I86501945"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Delaware, Newark, DE, USA","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022267407","display_name":"Abhyudai Singh","orcid":"https://orcid.org/0000-0002-1451-2838"},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhyudai Singh","raw_affiliation_strings":["University of Delaware,Biomedical Engineering, Mathematical Sciences, Center of Bioinformatic and Computational Biology,Department of Electrical and Computer Engineering,Newark,DE,USA","Department of Electrical and Computer Engineering, Biomedical Engineering, Mathematical Sciences, Center of Bioinformatic and Computational Biology, University of Delaware, Newark, DE, USA"],"affiliations":[{"raw_affiliation_string":"University of Delaware,Biomedical Engineering, Mathematical Sciences, Center of Bioinformatic and Computational Biology,Department of Electrical and Computer Engineering,Newark,DE,USA","institution_ids":["https://openalex.org/I86501945"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Biomedical Engineering, Mathematical Sciences, Center of Bioinformatic and Computational Biology, University of Delaware, Newark, DE, USA","institution_ids":["https://openalex.org/I86501945"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5065187255"],"corresponding_institution_ids":["https://openalex.org/I86501945"],"apc_list":null,"apc_paid":null,"fwci":0.7962,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.74086879,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"505","last_page":"510"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.6958580017089844},{"id":"https://openalex.org/keywords/negative-feedback","display_name":"Negative feedback","score":0.6520683169364929},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.6162986755371094},{"id":"https://openalex.org/keywords/degradation","display_name":"Degradation (telecommunications)","score":0.5963619947433472},{"id":"https://openalex.org/keywords/noise","display_name":"Noise (video)","score":0.5771430134773254},{"id":"https://openalex.org/keywords/positive-feedback","display_name":"Positive feedback","score":0.4994778633117676},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.4990413188934326},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.466139018535614},{"id":"https://openalex.org/keywords/production","display_name":"Production (economics)","score":0.44075438380241394},{"id":"https://openalex.org/keywords/value","display_name":"Value (mathematics)","score":0.42231130599975586},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.40609675645828247},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3572302460670471},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.25768136978149414},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.23661646246910095},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.2107410728931427},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.14666837453842163},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.13210716843605042},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.106578528881073},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.09173086285591125}],"concepts":[{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.6958580017089844},{"id":"https://openalex.org/C93586867","wikidata":"https://www.wikidata.org/wiki/Q62527","display_name":"Negative feedback","level":3,"score":0.6520683169364929},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.6162986755371094},{"id":"https://openalex.org/C2779679103","wikidata":"https://www.wikidata.org/wiki/Q5251805","display_name":"Degradation (telecommunications)","level":2,"score":0.5963619947433472},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.5771430134773254},{"id":"https://openalex.org/C48207687","wikidata":"https://www.wikidata.org/wiki/Q918004","display_name":"Positive feedback","level":2,"score":0.4994778633117676},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.4990413188934326},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.466139018535614},{"id":"https://openalex.org/C2778348673","wikidata":"https://www.wikidata.org/wiki/Q739302","display_name":"Production (economics)","level":2,"score":0.44075438380241394},{"id":"https://openalex.org/C2776291640","wikidata":"https://www.wikidata.org/wiki/Q2912517","display_name":"Value (mathematics)","level":2,"score":0.42231130599975586},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.40609675645828247},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3572302460670471},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.25768136978149414},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.23661646246910095},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.2107410728931427},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.14666837453842163},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13210716843605042},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.106578528881073},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.09173086285591125},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/icstcc59206.2023.10308517","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icstcc59206.2023.10308517","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 27th International Conference on System Theory, Control and Computing (ICSTCC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.75}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1499965417","https://openalex.org/W2007995850","https://openalex.org/W2032446791","https://openalex.org/W2042321087","https://openalex.org/W2052154287","https://openalex.org/W2078119846","https://openalex.org/W2087004443","https://openalex.org/W2093470850","https://openalex.org/W2096705138","https://openalex.org/W2108141605","https://openalex.org/W2111979970","https://openalex.org/W2128738030","https://openalex.org/W2137922575","https://openalex.org/W2147556100","https://openalex.org/W2155202381","https://openalex.org/W2158880200","https://openalex.org/W2194184864","https://openalex.org/W2204043954","https://openalex.org/W2292105009","https://openalex.org/W2300489152","https://openalex.org/W2505895487","https://openalex.org/W2569268737","https://openalex.org/W2748084525","https://openalex.org/W2783935061","https://openalex.org/W2914225492","https://openalex.org/W2951525168","https://openalex.org/W2964315080","https://openalex.org/W2979663327","https://openalex.org/W3026696099","https://openalex.org/W3033457568","https://openalex.org/W3083890889","https://openalex.org/W3101361690","https://openalex.org/W3101406762","https://openalex.org/W3109940323","https://openalex.org/W3172596968","https://openalex.org/W3184214471","https://openalex.org/W3184584171","https://openalex.org/W3194420991","https://openalex.org/W3195194102","https://openalex.org/W4221019942","https://openalex.org/W4225574646","https://openalex.org/W4226075239","https://openalex.org/W4289829011","https://openalex.org/W4294691776","https://openalex.org/W4315472009","https://openalex.org/W4377989995","https://openalex.org/W6852928137"],"related_works":["https://openalex.org/W2789936093","https://openalex.org/W1603824164","https://openalex.org/W1998677285","https://openalex.org/W2771707358","https://openalex.org/W4230360037","https://openalex.org/W2897954926","https://openalex.org/W2106469366","https://openalex.org/W2899244556","https://openalex.org/W2051497876","https://openalex.org/W4250776960"],"abstract_inverted_index":{"The":[0],"timing":[1,67,189],"of":[2,14,25,44,87,114,117,139,188,195],"cellular":[3],"events":[4],"is":[5,80,155],"often":[6],"determined":[7],"by":[8,49,166],"the":[9,12,29,37,45,62,81,85,96,99,107,115,125,132,137,178,185],"instant":[10],"when":[11],"level":[13,48],"a":[15,19,42,51,70,111,151,167,171],"chemical":[16],"species":[17,47,100,201],"crosses":[18],"threshold":[20],"from":[21],"an":[22,160],"initial":[23,161],"value":[24],"zero.":[26],"To":[27],"attenuate":[28],"inherent":[30],"random":[31],"fluctuations":[32],"in":[33,84,175,197],"this":[34,56,92,182],"first-passage":[35,73],"time,":[36],"production":[38,133],"rate":[39,134],"can":[40],"be":[41,110,203],"function":[43,113],"current":[46],"implementing":[50],"feedback":[52,108,142,163,173],"or":[53],"self-regulation.":[54],"In":[55,180],"study,":[57],"we":[58,94,105],"aim":[59],"to":[60,109,170,177,205],"identify":[61],"self-regulation":[63,153,196],"strategy":[64,83,127,158],"that":[65,78,124,150],"minimizes":[66],"noise":[68,190],"around":[69],"specified":[71],"mean":[72],"time.":[74],"Previous":[75],"results":[76],"showed":[77],"no-feedback":[79],"optimal":[82,126],"absence":[86],"molecule":[88],"degradation.":[89,103,206],"Based":[90],"on":[91],"result,":[93],"study":[95],"case":[97],"where":[98,199],"may":[101,202],"undergo":[102],"First,":[104],"set":[106],"linear":[112],"number":[116,138],"molecules.":[118,140],"We":[119],"derive":[120],"analytical":[121],"formulas":[122],"concluding":[123],"involves":[128,159],"positive":[129,162],"feedback,":[130],"whereby":[131],"increases":[135],"with":[136],"When":[141],"constraints":[143],"are":[144],"removed,":[145],"our":[146],"numerical":[147],"methods":[148],"suggest":[149],"mixed":[152],"scheme":[154,174],"optimal.":[156],"This":[157],"phase,":[164],"followed":[165],"sharp":[168],"transition":[169],"negative":[172],"proximity":[176],"threshold.":[179],"summary,":[181],"research":[183],"quantifies":[184],"fundamental":[186],"limits":[187],"reduction,":[191],"considering":[192],"different":[193],"strategies":[194],"situations":[198],"time-keeping":[200],"subjected":[204]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
