{"id":"https://openalex.org/W3216936383","doi":"https://doi.org/10.1109/icstcc52150.2021.9607196","title":"Global Sensitivity Analysis for the input parameters of a Perfusion Bioreactor System in Tissue Engineering","display_name":"Global Sensitivity Analysis for the input parameters of a Perfusion Bioreactor System in Tissue Engineering","publication_year":2021,"publication_date":"2021-10-20","ids":{"openalex":"https://openalex.org/W3216936383","doi":"https://doi.org/10.1109/icstcc52150.2021.9607196","mag":"3216936383"},"language":"en","primary_location":{"id":"doi:10.1109/icstcc52150.2021.9607196","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icstcc52150.2021.9607196","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 25th International Conference on System Theory, Control and Computing (ICSTCC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070756192","display_name":"Ioana Na\u015fcu","orcid":"https://orcid.org/0000-0002-9209-6083"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]},{"id":"https://openalex.org/I158333966","display_name":"Technical University of Cluj-Napoca","ror":"https://ror.org/03r8nwp71","country_code":"RO","type":"education","lineage":["https://openalex.org/I158333966"]}],"countries":["CN","RO"],"is_corresponding":true,"raw_author_name":"Ioana Nascu","raw_affiliation_strings":["Key Laboratory of Advanced Control and optimization for Chemical Processes, ECUST, Shanghai, China","Technical University of Cluj Napoca, Cluj-Napoca"],"affiliations":[{"raw_affiliation_string":"Key Laboratory of Advanced Control and optimization for Chemical Processes, ECUST, Shanghai, China","institution_ids":["https://openalex.org/I143593769"]},{"raw_affiliation_string":"Technical University of Cluj Napoca, Cluj-Napoca","institution_ids":["https://openalex.org/I158333966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100357748","display_name":"Tao Chen","orcid":"https://orcid.org/0000-0002-3941-1603"},"institutions":[{"id":"https://openalex.org/I28290843","display_name":"University of Surrey","ror":"https://ror.org/00ks66431","country_code":"GB","type":"education","lineage":["https://openalex.org/I28290843"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tao Chen","raw_affiliation_strings":["University of Surrey, Guildford, United Kingdom"],"affiliations":[{"raw_affiliation_string":"University of Surrey, Guildford, United Kingdom","institution_ids":["https://openalex.org/I28290843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048267931","display_name":"Wenli Du","orcid":"https://orcid.org/0000-0002-2676-6341"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]},{"id":"https://openalex.org/I1327237609","display_name":"Ministry of Education of the People's Republic of China","ror":"https://ror.org/01mv9t934","country_code":"CN","type":"funder","lineage":["https://openalex.org/I1327237609","https://openalex.org/I4210127390"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenli Du","raw_affiliation_strings":["Key Laboratory of Advanced Control and Optimization for Chemical Processes, Ministry of Education, ECUST, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Key Laboratory of Advanced Control and Optimization for Chemical Processes, Ministry of Education, ECUST, Shanghai, China","institution_ids":["https://openalex.org/I1327237609","https://openalex.org/I143593769"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113080223","display_name":"Ioan Na\u0219cu","orcid":null},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]},{"id":"https://openalex.org/I158333966","display_name":"Technical University of Cluj-Napoca","ror":"https://ror.org/03r8nwp71","country_code":"RO","type":"education","lineage":["https://openalex.org/I158333966"]}],"countries":["CN","RO"],"is_corresponding":false,"raw_author_name":"Ioan Nascu","raw_affiliation_strings":["Key Laboratory of Advanced Control and optimization for Chemical Processes, ECUST, Shanghai, China","Technical University of Cluj Napoca, Cluj-Napoca"],"affiliations":[{"raw_affiliation_string":"Key Laboratory of Advanced Control and optimization for Chemical Processes, ECUST, Shanghai, China","institution_ids":["https://openalex.org/I143593769"]},{"raw_affiliation_string":"Technical University of Cluj Napoca, Cluj-Napoca","institution_ids":["https://openalex.org/I158333966"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5070756192"],"corresponding_institution_ids":["https://openalex.org/I143593769","https://openalex.org/I158333966"],"apc_list":null,"apc_paid":null,"fwci":0.0861,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.62264151,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"5","issue":null,"first_page":"172","last_page":"177"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10928","display_name":"Probabilistic and Robust Engineering Design","score":0.987500011920929,"subfield":{"id":"https://openalex.org/subfields/1804","display_name":"Statistics, Probability and Uncertainty"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10928","display_name":"Probabilistic and Robust Engineering Design","score":0.987500011920929,"subfield":{"id":"https://openalex.org/subfields/1804","display_name":"Statistics, Probability and Uncertainty"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10791","display_name":"Advanced Control Systems Optimization","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.9311000108718872,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.7194586992263794},{"id":"https://openalex.org/keywords/bioreactor","display_name":"Bioreactor","score":0.6964990496635437},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.5241611003875732},{"id":"https://openalex.org/keywords/perfusion","display_name":"Perfusion","score":0.47407618165016174},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.37727850675582886},{"id":"https://openalex.org/keywords/process-engineering","display_name":"Process engineering","score":0.3656398355960846},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.23525884747505188},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.17929649353027344},{"id":"https://openalex.org/keywords/electronic-engineering","display_name":"Electronic engineering","score":0.11334019899368286},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.08856534957885742},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.08609572052955627}],"concepts":[{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.7194586992263794},{"id":"https://openalex.org/C168170006","wikidata":"https://www.wikidata.org/wiki/Q864699","display_name":"Bioreactor","level":2,"score":0.6964990496635437},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5241611003875732},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.47407618165016174},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.37727850675582886},{"id":"https://openalex.org/C21880701","wikidata":"https://www.wikidata.org/wiki/Q2144042","display_name":"Process engineering","level":1,"score":0.3656398355960846},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.23525884747505188},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.17929649353027344},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.11334019899368286},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.08856534957885742},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08609572052955627},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/icstcc52150.2021.9607196","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icstcc52150.2021.9607196","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 25th International Conference on System Theory, Control and Computing (ICSTCC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W79383899","https://openalex.org/W601171635","https://openalex.org/W1966293504","https://openalex.org/W1981532661","https://openalex.org/W1988540551","https://openalex.org/W2023361095","https://openalex.org/W2033747672","https://openalex.org/W2060833676","https://openalex.org/W2062702534","https://openalex.org/W2064904731","https://openalex.org/W2079604837","https://openalex.org/W2086269269","https://openalex.org/W2100845629","https://openalex.org/W2101589741","https://openalex.org/W2130653190","https://openalex.org/W2169658509","https://openalex.org/W2902298837","https://openalex.org/W2962615133","https://openalex.org/W3011730451","https://openalex.org/W4230884859","https://openalex.org/W4247463565"],"related_works":["https://openalex.org/W2082762559","https://openalex.org/W2750811721","https://openalex.org/W38760852","https://openalex.org/W2376673900","https://openalex.org/W2040528063","https://openalex.org/W1982796632","https://openalex.org/W2118108729","https://openalex.org/W2002535120","https://openalex.org/W3010971161","https://openalex.org/W1976370882"],"abstract_inverted_index":{"This":[0,23],"paper":[1],"uses":[2],"the":[3,26,29,44,51,86,105,109,125,147,150,154],"method":[4,24],"of":[5,18,28,32,53,108,124,132,149],"high-dimensional":[6],"model":[7,35,59,68,151],"representation":[8],"(HDMR)":[9],"to":[10,136,165],"present":[11],"a":[12,19,33,37,54,65,74,99,121],"global":[13,137],"sensitivity":[14,138],"analysis":[15,27,123,141],"and":[16,71,94,139],"simulations":[17],"perfusion":[20,55,75,110],"bioreactor":[21,56,111],"operation.":[22],"enables":[25],"input\u2013output":[30],"relationships":[31],"complex":[34,126],"containing":[36],"high":[38],"dimensional":[39],"input":[40],"space":[41],"focusing":[42],"on":[43,153],"parameters":[45],"that":[46,84],"could":[47],"be":[48],"used":[49,60],"in":[50,61,98],"control":[52,167],"process.":[57],"The":[58],"this":[62],"work":[63],"is":[64,78,144,158],"comprehensive":[66],"mathematical":[67,134],"for":[69,73],"diffusion":[70],"convection":[72],"bioreactor,":[76],"which":[77],"combined":[79],"with":[80],"cell":[81,95],"growth":[82],"kinetics":[83],"describes":[85],"spatio-temporal":[87],"glucose":[88],"concentration,":[89,91],"oxygen":[90],"lactate":[92],"concentration":[93],"density":[96],"evolution":[97],"3D":[100],"polymeric":[101],"scaffold.":[102],"To":[103],"investigate":[104],"important":[106,160],"features":[107],"process":[112],"as":[113,115],"well":[114],"possible":[116],"factors":[117],"underlying":[118],"qualitative":[119],"discrepancies":[120],"quantitative":[122],"kinetic":[127],"mechanisms":[128],"using":[129],"recent":[130],"development":[131],"advanced":[133],"approaches":[135],"uncertainty":[140],"through":[142],"HDMR":[143],"used.":[145],"Assessing":[146],"effect":[148],"inputs":[152],"model\u2019s":[155],"predicted":[156],"outputs":[157],"an":[159],"step":[161],"especially":[162],"when":[163],"trying":[164],"develop":[166],"strategies":[168]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}