{"id":"https://openalex.org/W4392943745","doi":"https://doi.org/10.1109/icst59744.2023.10460786","title":"Design and Fabrication of Microfluidic Chip for Temperature Control Applications in Biomedical","display_name":"Design and Fabrication of Microfluidic Chip for Temperature Control Applications in Biomedical","publication_year":2023,"publication_date":"2023-12-17","ids":{"openalex":"https://openalex.org/W4392943745","doi":"https://doi.org/10.1109/icst59744.2023.10460786"},"language":"en","primary_location":{"id":"doi:10.1109/icst59744.2023.10460786","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/icst59744.2023.10460786","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 16th International Conference on Sensing Technology (ICST)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109414323","display_name":"Andleeb Zahra","orcid":null},"institutions":[{"id":"https://openalex.org/I64189192","display_name":"International Institute of Information Technology, Hyderabad","ror":"https://ror.org/05f11g639","country_code":"IN","type":"education","lineage":["https://openalex.org/I64189192"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IN","IT"],"is_corresponding":true,"raw_author_name":"Andleeb Zahra","raw_affiliation_strings":["Sapienza University of Rome,DIET,Italy","CVEST, International Institute of Information Technology, Hyderabad, India","CCNSB, International Institute of Information Technology, Hyderabad, India","DIET, Sapienza University of Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Sapienza University of Rome,DIET,Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"CVEST, International Institute of Information Technology, Hyderabad, India","institution_ids":["https://openalex.org/I64189192"]},{"raw_affiliation_string":"CCNSB, International Institute of Information Technology, Hyderabad, India","institution_ids":["https://openalex.org/I64189192"]},{"raw_affiliation_string":"DIET, Sapienza University of Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041969796","display_name":"G. de Cesare","orcid":"https://orcid.org/0000-0002-9935-2975"},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giampiero de Cesare","raw_affiliation_strings":["Sapienza University of Rome,DIET,Italy","DIET, Sapienza University of Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Sapienza University of Rome,DIET,Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"DIET, Sapienza University of Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051139574","display_name":"D. Caputo","orcid":"https://orcid.org/0000-0002-3709-6662"},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Domenico Caputo","raw_affiliation_strings":["Sapienza University of Rome,DIET,Italy","DIET, Sapienza University of Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Sapienza University of Rome,DIET,Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"DIET, Sapienza University of Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060274993","display_name":"Nicola Lovecchio","orcid":"https://orcid.org/0000-0002-2571-2712"},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nicola Lovecchio","raw_affiliation_strings":["Sapienza University of Rome,DIET,Italy","DIET, Sapienza University of Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Sapienza University of Rome,DIET,Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"DIET, Sapienza University of Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064386690","display_name":"Prabhakar Bhimalapuram","orcid":"https://orcid.org/0000-0002-8302-1696"},"institutions":[{"id":"https://openalex.org/I64189192","display_name":"International Institute of Information Technology, Hyderabad","ror":"https://ror.org/05f11g639","country_code":"IN","type":"education","lineage":["https://openalex.org/I64189192"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Prabhakar Bhimalapuram","raw_affiliation_strings":["International Institute of Information Technology,CCNSB,Hyderabad,India","CCNSB, International Institute of Information Technology, Hyderabad, India"],"affiliations":[{"raw_affiliation_string":"International Institute of Information Technology,CCNSB,Hyderabad,India","institution_ids":["https://openalex.org/I64189192"]},{"raw_affiliation_string":"CCNSB, International Institute of Information Technology, Hyderabad, India","institution_ids":["https://openalex.org/I64189192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064516025","display_name":"Syed Azeemuddin","orcid":"https://orcid.org/0000-0002-5974-3584"},"institutions":[{"id":"https://openalex.org/I4210097016","display_name":"International Institute of Information Technology","ror":"https://ror.org/00qryer39","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210097016"]},{"id":"https://openalex.org/I64189192","display_name":"International Institute of Information Technology, Hyderabad","ror":"https://ror.org/05f11g639","country_code":"IN","type":"education","lineage":["https://openalex.org/I64189192"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Syed Azeemuddin","raw_affiliation_strings":["International Institute of Information Technology,CVEST,Hyderabad,India","CVEST, International Institute of Information Technology, Hyderabad, India"],"affiliations":[{"raw_affiliation_string":"International Institute of Information Technology,CVEST,Hyderabad,India","institution_ids":["https://openalex.org/I4210097016"]},{"raw_affiliation_string":"CVEST, International Institute of Information Technology, Hyderabad, India","institution_ids":["https://openalex.org/I64189192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060396811","display_name":"Zia Abbas","orcid":"https://orcid.org/0000-0002-3747-3640"},"institutions":[{"id":"https://openalex.org/I4210097016","display_name":"International Institute of Information Technology","ror":"https://ror.org/00qryer39","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210097016"]},{"id":"https://openalex.org/I64189192","display_name":"International Institute of Information Technology, Hyderabad","ror":"https://ror.org/05f11g639","country_code":"IN","type":"education","lineage":["https://openalex.org/I64189192"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Zia Abbas","raw_affiliation_strings":["International Institute of Information Technology,CVEST,Hyderabad,India","CVEST, International Institute of Information Technology, Hyderabad, India"],"affiliations":[{"raw_affiliation_string":"International Institute of Information Technology,CVEST,Hyderabad,India","institution_ids":["https://openalex.org/I4210097016"]},{"raw_affiliation_string":"CVEST, International Institute of Information Technology, Hyderabad, India","institution_ids":["https://openalex.org/I64189192"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5109414323"],"corresponding_institution_ids":["https://openalex.org/I64189192","https://openalex.org/I861853513"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1977449,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"740","issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.8349999785423279,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.8349999785423279,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10338","display_name":"Advanced Sensor and Energy Harvesting Materials","score":0.7556999921798706,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.7941072583198547},{"id":"https://openalex.org/keywords/fabrication","display_name":"Fabrication","score":0.7491757273674011},{"id":"https://openalex.org/keywords/temperature-control","display_name":"Temperature control","score":0.5694496035575867},{"id":"https://openalex.org/keywords/lab-on-a-chip","display_name":"Lab-on-a-chip","score":0.48727238178253174},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.4844188988208771},{"id":"https://openalex.org/keywords/chip","display_name":"Chip","score":0.4630221724510193},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4459786117076874},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3996446132659912},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.2944582402706146},{"id":"https://openalex.org/keywords/mechanical-engineering","display_name":"Mechanical engineering","score":0.2216799557209015},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.09417217969894409}],"concepts":[{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.7941072583198547},{"id":"https://openalex.org/C136525101","wikidata":"https://www.wikidata.org/wiki/Q5428139","display_name":"Fabrication","level":3,"score":0.7491757273674011},{"id":"https://openalex.org/C536315585","wikidata":"https://www.wikidata.org/wiki/Q7698332","display_name":"Temperature control","level":2,"score":0.5694496035575867},{"id":"https://openalex.org/C138942068","wikidata":"https://www.wikidata.org/wiki/Q633261","display_name":"Lab-on-a-chip","level":3,"score":0.48727238178253174},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4844188988208771},{"id":"https://openalex.org/C165005293","wikidata":"https://www.wikidata.org/wiki/Q1074500","display_name":"Chip","level":2,"score":0.4630221724510193},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4459786117076874},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3996446132659912},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.2944582402706146},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.2216799557209015},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.09417217969894409},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/icst59744.2023.10460786","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/icst59744.2023.10460786","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 16th International Conference on Sensing Technology (ICST)","raw_type":"proceedings-article"},{"id":"pmh:oai:iris.uniroma1.it:11573/1714387","is_oa":false,"landing_page_url":"https://hdl.handle.net/11573/1714387","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.49000000953674316,"id":"https://metadata.un.org/sdg/7","display_name":"Affordable and clean energy"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320325847","display_name":"Istituto Italiano di Tecnologia","ror":"https://ror.org/042t93s57"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W585951081","https://openalex.org/W1893747875","https://openalex.org/W1964683190","https://openalex.org/W1967241461","https://openalex.org/W1968048449","https://openalex.org/W1969984933","https://openalex.org/W2013117405","https://openalex.org/W2020678155","https://openalex.org/W2023885786","https://openalex.org/W2039989758","https://openalex.org/W2056584136","https://openalex.org/W2057417043","https://openalex.org/W2074305200","https://openalex.org/W2084301524","https://openalex.org/W2084778748","https://openalex.org/W2169593348","https://openalex.org/W2313945923","https://openalex.org/W2792466667","https://openalex.org/W3034505785","https://openalex.org/W6782110519","https://openalex.org/W6847027051"],"related_works":["https://openalex.org/W2082914599","https://openalex.org/W3103016203","https://openalex.org/W2756570351","https://openalex.org/W2106238498","https://openalex.org/W2021085378","https://openalex.org/W2136854845","https://openalex.org/W2733260917","https://openalex.org/W2375007538","https://openalex.org/W2387172946","https://openalex.org/W2569660137"],"abstract_inverted_index":{"This":[0],"paper":[1],"proposes":[2],"an":[3],"On-chip":[4],"microfluidic":[5,23,61,111,223,259],"system":[6,37,62,248],"specially":[7],"designed":[8,31],"for":[9,15,72,76,84,122,134,152,252],"temperature":[10],"control":[11],"reactions":[12,125],"in":[13,64,103,181],"biomedical,":[14],"example,":[16],"polymerase":[17],"chain":[18],"reaction":[19,70,154,190],"(PCR)":[20],"applications.":[21],"The":[22,35,60,117,221],"chip":[24],"and":[25,56,79,126,129,145,173,241],"thin":[26,98,230,240],"film":[27,99,231,243],"heaters":[28,101,131,232],"have":[29],"been":[30,211,226,250],"using":[32,213,237],"COMSOL":[33],"Multiphysics.":[34],"proposed":[36],"is":[38,120],"fabricated":[39,133,222],"on":[40],"a":[41,69,74,204],"glass":[42,93,115,235],"substrate":[43,236],"of":[44,52,68,91,137,170,255],"size":[45],"5\u00d75":[46],"cm<sup":[47],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[48],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">2</sup>,":[49],"taking":[50],"advantage":[51],"the":[53,88,92,110,114,127,135,140,146,153,161,163,167,171,174,182,189,197,214,229,234,238,247,258],"thermally":[54,81],"conductive":[55],"electrically":[57],"insulating":[58],"substrate.":[59,116],"made":[63,102,212],"Polydimethylsiloxane":[65],"(PDMS)":[66],"consists":[67],"chamber":[71,148,191],"PCR,":[73],"microchannel":[75],"fluid":[77,85],"handling,":[78],"two":[80],"actuated":[82],"valves":[83],"control.":[86],"On":[87],"other":[89],"side":[90],"substrate,":[94],"it":[95],"has":[96,209,225,249],"three":[97],"metal":[100],"Cr/Al/Cr":[104],"layers":[105],"which":[106,194],"are":[107,132],"intergraded":[108],"with":[109,228],"network":[112,224],"over":[113,233],"middle":[118],"heater":[119],"used":[121],"performing":[123],"PCR":[124,147],"left":[128],"right":[130],"actuation":[136],"valves.":[138],"Therefore,":[139,185],"channel":[141,172,208],"can":[142,149],"be":[143],"closed,":[144],"become":[150],"isolated":[151],"to":[155,196],"take":[156],"place.":[157],"However,":[158],"after":[159,186],"closing":[160],"channel,":[162],"shape":[164],"mismatching":[165],"between":[166],"rectangular":[168],"cross-section":[169,206],"balloon-shaped":[175],"valve":[176],"membrane":[177],"(after":[178],"actuation)":[179],"results":[180],"sample's":[183],"leakage.":[184],"some":[187],"time":[188],"becomes":[192],"empty":[193],"leads":[195],"device":[198],"failure.":[199],"To":[200],"overcome":[201],"this":[202],"issue,":[203],"semicircular":[205],"PDMS":[207],"also":[210],"AZ":[215],"40":[216],"XT":[217],"positive":[218],"photoresist":[219],"mold.":[220],"integrated":[227],"different":[239],"thick":[242],"technological":[244],"steps.":[245],"Finally,":[246],"tested":[251],"further":[253],"verification":[254],"leakage":[256],"from":[257],"channel.":[260]},"counts_by_year":[],"updated_date":"2025-12-25T23:11:45.687758","created_date":"2024-03-20T00:00:00"}