{"id":"https://openalex.org/W2060827801","doi":"https://doi.org/10.1109/icsmc.2012.6378040","title":"Soft contact-lens biosensor for real-time tear sugar monitoring at the eye","display_name":"Soft contact-lens biosensor for real-time tear sugar monitoring at the eye","publication_year":2012,"publication_date":"2012-10-01","ids":{"openalex":"https://openalex.org/W2060827801","doi":"https://doi.org/10.1109/icsmc.2012.6378040","mag":"2060827801"},"language":"en","primary_location":{"id":"doi:10.1109/icsmc.2012.6378040","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icsmc.2012.6378040","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE International Conference on Systems, Man, and Cybernetics (SMC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007799069","display_name":"Hiroyuki Kudo","orcid":"https://orcid.org/0000-0001-7256-6554"},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hiroyuki Kudo","raw_affiliation_strings":["Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan","Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Japan"],"affiliations":[{"raw_affiliation_string":"Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046475710","display_name":"M. K. Chu","orcid":null},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"MingXing Chu","raw_affiliation_strings":["Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan","Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Japan"],"affiliations":[{"raw_affiliation_string":"Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012388913","display_name":"Kumiko Miyajima","orcid":"https://orcid.org/0000-0003-2156-3577"},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kumiko Miyajima","raw_affiliation_strings":["Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan","Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Japan"],"affiliations":[{"raw_affiliation_string":"Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010212579","display_name":"Takahiro Arakawa","orcid":"https://orcid.org/0000-0002-1555-1281"},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro Arakawa","raw_affiliation_strings":["Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan","Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Japan"],"affiliations":[{"raw_affiliation_string":"Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085932814","display_name":"Kohji Mitsubayashi","orcid":null},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kohji Mitsubayashi","raw_affiliation_strings":["Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan","Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Japan"],"affiliations":[{"raw_affiliation_string":"Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064925891","display_name":"Yoshitaka Hiranuma","orcid":null},"institutions":[{"id":"https://openalex.org/I52706244","display_name":"College of Industrial Technology","ror":"https://ror.org/054a9s036","country_code":"JP","type":"education","lineage":["https://openalex.org/I52706244"]},{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshitaka Hiranuma","raw_affiliation_strings":["Graduate School of Industrial Technology, Nihon University, Chiba, Japan","Graduate School of Industrial Technology, Nihon University, Chiba Japan"],"affiliations":[{"raw_affiliation_string":"Graduate School of Industrial Technology, Nihon University, Chiba, Japan","institution_ids":["https://openalex.org/I52706244","https://openalex.org/I104946051"]},{"raw_affiliation_string":"Graduate School of Industrial Technology, Nihon University, Chiba Japan","institution_ids":["https://openalex.org/I52706244","https://openalex.org/I104946051"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028478571","display_name":"Hideo Hiramatsu","orcid":null},"institutions":[{"id":"https://openalex.org/I52706244","display_name":"College of Industrial Technology","ror":"https://ror.org/054a9s036","country_code":"JP","type":"education","lineage":["https://openalex.org/I52706244"]},{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideo Hiramatsu","raw_affiliation_strings":["Graduate School of Industrial Technology, Nihon University, Chiba, Japan","Graduate School of Industrial Technology, Nihon University, Chiba Japan"],"affiliations":[{"raw_affiliation_string":"Graduate School of Industrial Technology, Nihon University, Chiba, Japan","institution_ids":["https://openalex.org/I52706244","https://openalex.org/I104946051"]},{"raw_affiliation_string":"Graduate School of Industrial Technology, Nihon University, Chiba Japan","institution_ids":["https://openalex.org/I52706244","https://openalex.org/I104946051"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5007799069"],"corresponding_institution_ids":["https://openalex.org/I125602781"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.11930475,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"2048","last_page":"2051"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11472","display_name":"Analytical Chemistry and Sensors","score":0.98089998960495,"subfield":{"id":"https://openalex.org/subfields/1502","display_name":"Bioengineering"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9782999753952026,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biosensor","display_name":"Biosensor","score":0.9603190422058105},{"id":"https://openalex.org/keywords/glucose-oxidase","display_name":"Glucose oxidase","score":0.7670870423316956},{"id":"https://openalex.org/keywords/contact-lens","display_name":"Contact lens","score":0.7261491417884827},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.581811785697937},{"id":"https://openalex.org/keywords/polymer","display_name":"Polymer","score":0.5617121458053589},{"id":"https://openalex.org/keywords/electrode","display_name":"Electrode","score":0.4757482707500458},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.43567219376564026},{"id":"https://openalex.org/keywords/in-situ","display_name":"In situ","score":0.42182067036628723},{"id":"https://openalex.org/keywords/adhesive","display_name":"Adhesive","score":0.41683024168014526},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2979704439640045},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.22889986634254456},{"id":"https://openalex.org/keywords/composite-material","display_name":"Composite material","score":0.14053967595100403},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.09909850358963013},{"id":"https://openalex.org/keywords/ophthalmology","display_name":"Ophthalmology","score":0.09463313221931458}],"concepts":[{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.9603190422058105},{"id":"https://openalex.org/C2777197210","wikidata":"https://www.wikidata.org/wiki/Q419321","display_name":"Glucose oxidase","level":3,"score":0.7670870423316956},{"id":"https://openalex.org/C2986805488","wikidata":"https://www.wikidata.org/wiki/Q23797","display_name":"Contact lens","level":2,"score":0.7261491417884827},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.581811785697937},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.5617121458053589},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.4757482707500458},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.43567219376564026},{"id":"https://openalex.org/C2777822432","wikidata":"https://www.wikidata.org/wiki/Q216681","display_name":"In situ","level":2,"score":0.42182067036628723},{"id":"https://openalex.org/C68928338","wikidata":"https://www.wikidata.org/wiki/Q131790","display_name":"Adhesive","level":3,"score":0.41683024168014526},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2979704439640045},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.22889986634254456},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.14053967595100403},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09909850358963013},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.09463313221931458},{"id":"https://openalex.org/C2779227376","wikidata":"https://www.wikidata.org/wiki/Q6505497","display_name":"Layer (electronics)","level":2,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/icsmc.2012.6378040","is_oa":false,"landing_page_url":"https://doi.org/10.1109/icsmc.2012.6378040","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE International Conference on Systems, Man, and Cybernetics (SMC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W86293467","https://openalex.org/W1847873908","https://openalex.org/W1968655019","https://openalex.org/W2073756357","https://openalex.org/W2094271997","https://openalex.org/W2106586766","https://openalex.org/W2108816292","https://openalex.org/W2397990356","https://openalex.org/W2419337829","https://openalex.org/W6603477467","https://openalex.org/W6639071316","https://openalex.org/W6717089221","https://openalex.org/W6736795468"],"related_works":["https://openalex.org/W2244814446","https://openalex.org/W2392949321","https://openalex.org/W2332301697","https://openalex.org/W1979328109","https://openalex.org/W2144900807","https://openalex.org/W2079066965","https://openalex.org/W2045340505","https://openalex.org/W2363119649","https://openalex.org/W2010974605","https://openalex.org/W2038983245"],"abstract_inverted_index":{"A":[0],"soft":[1],"contact-lens":[2,66],"(SCL)":[3],"biosensor":[4,38,178],"for":[5,185],"in-situ":[6,133],"tear":[7,34,122,134,155,165],"sugar":[8],"monitoring":[9,22,136],"was":[10,39,71,140,149,169,179,193],"fabricated":[11],"and":[12,33,67,82,92,110,152,171],"tested.":[13],"In":[14,97],"contrast":[15],"to":[16,47,115,173,182],"the":[17,28,56,74,78,88,98,101,107,120,131,138,147,154,163,177,196],"previously":[18],"reported":[19,121],"continuous":[20],"glucose":[21,32,68,111,123,135,156,160],"(CGM)":[23],"devices,":[24],"we":[25],"focused":[26],"on":[27,55,73,87,130],"relationship":[29,105],"between":[30,106],"blood":[31],"glucose.":[35],"The":[36,50,143,158],"SCL":[37,197],"constructed":[40],"by":[41],"applying":[42],"microelectromechanical":[43],"systems":[44],"(MEMS)":[45],"techniques":[46],"functional":[48],"polymers.":[49],"sensor":[51],"has":[52],"film":[53],"electrodes":[54,84],"surface":[57,61],"of":[58,62,77,127,146,166],"a":[59,167],"rounded":[60],"polydimethyl":[63],"siloxane":[64],"(PDMS)":[65],"oxidase":[69],"(GOD)":[70],"immobilized":[72],"sensing":[75],"region":[76],"electrodes.":[79],"Sufficiently":[80],"adhesive":[81],"flexible":[83],"were":[85],"formed":[86],"polymer":[89],"device":[90],"(PDMS":[91],"2-methacryloyloxyethyl":[93],"phosphorylcholine":[94],"(MPC)":[95],"polymer).":[96],"in-vitro":[99],"characterization,":[100],"SCL-biosensor":[102,139,148],"showed":[103],"excellent":[104],"output":[108,144],"current":[109,145],"concentration":[112],"from":[113],"0.03":[114],"10.0":[116],"mmol/L,":[117],"which":[118],"included":[119],"concentrations":[124],"(0.14":[125],"mM)":[126],"humans.":[128],"Based":[129],"result,":[132],"with":[137,195],"carried":[141],"out.":[142],"sufficiently":[150],"stable":[151],"reflected":[153],"levels.":[157],"static":[159],"level":[161],"in":[162],"basal":[164],"rabbit":[168],"measured":[170],"estimated":[172],"0.13":[174],"mmol/L.":[175],"Since":[176],"also":[180],"possible":[181],"be":[183],"sotored":[184],"more":[186],"than":[187],"50":[188],"days,":[189],"daily":[190],"disposable":[191],"application":[192],"expected":[194],"biosensor.":[198]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
